S Darvesh

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. doi request reprint Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Med Chem 51:4200-12. 2008
  2. doi request reprint Butyrylcholinesterase activity in multiple sclerosis neuropathology
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Chem Biol Interact 187:425-31. 2010
  3. pmc Probing the peripheral site of human butyrylcholinesterase
    Ian R Macdonald
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Biochemistry 51:7046-53. 2012
  4. doi request reprint Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems
    Sultan Darvesh
    Department of Medicine Neurology and Geriatric Medicine, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4R2
    Bioorg Med Chem Lett 23:3822-5. 2013
  5. doi request reprint Butyrylcholinesterase radioligands to image Alzheimer's disease brain
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Chem Biol Interact 203:354-7. 2013
  6. pmc Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neuropathol Exp Neurol 71:2-14. 2012
  7. ncbi request reprint Inhibition of human cholinesterases by drugs used to treat Alzheimer disease
    Sultan Darvesh
    Department of Medicine Neurology and Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Alzheimer Dis Assoc Disord 17:117-26. 2003
  8. ncbi request reprint Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Neurol 188:461-70. 2004
  9. ncbi request reprint Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Bioorg Med Chem 13:211-22. 2005
  10. ncbi request reprint Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues
    S Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Curr Alzheimer Res 7:386-400. 2010

Detail Information

Publications45

  1. doi request reprint Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Med Chem 51:4200-12. 2008
    ....
  2. doi request reprint Butyrylcholinesterase activity in multiple sclerosis neuropathology
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Chem Biol Interact 187:425-31. 2010
    ..This suggests that BuChE could be a potential target for novel disease-modifying strategies for MS...
  3. pmc Probing the peripheral site of human butyrylcholinesterase
    Ian R Macdonald
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Biochemistry 51:7046-53. 2012
    ....
  4. doi request reprint Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems
    Sultan Darvesh
    Department of Medicine Neurology and Geriatric Medicine, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4R2
    Bioorg Med Chem Lett 23:3822-5. 2013
    ..We demonstrate that phenothiazines can be prepared without significant neurotransmitter receptor interactions while retaining high potency as cholinesterase ligands for treatment of Alzheimer's disease...
  5. doi request reprint Butyrylcholinesterase radioligands to image Alzheimer's disease brain
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Chem Biol Interact 203:354-7. 2013
    ..Radioligands targeting unusual BuChE activity in the brain may represent a means for early diagnosis and treatment monitoring of AD...
  6. pmc Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neuropathol Exp Neurol 71:2-14. 2012
    ..These observations suggest that BuChE is associated with a subpopulation of Aβ plaques and may play a role in AD plaque maturation. A further study of this animal model could clarify the role of BuChE in AD pathology...
  7. ncbi request reprint Inhibition of human cholinesterases by drugs used to treat Alzheimer disease
    Sultan Darvesh
    Department of Medicine Neurology and Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Alzheimer Dis Assoc Disord 17:117-26. 2003
    ....
  8. ncbi request reprint Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Neurol 188:461-70. 2004
    ....
  9. ncbi request reprint Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Bioorg Med Chem 13:211-22. 2005
    ..This study describes two distinct mechanisms for binding phenothiazine amide derivatives to BuChE and AChE. Molecular volume was found to be an important parameter for BuChE-specific inhibition...
  10. ncbi request reprint Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues
    S Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Curr Alzheimer Res 7:386-400. 2010
    ....
  11. ncbi request reprint On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, NS, Canada
    Bioorg Med Chem 14:4586-99. 2006
    ..Based on the substrate structure-activity relationships and kinetic studies, the hydrolysis of anilides and esters of choline appears to utilize the same catalytic site in BuChE...
  12. ncbi request reprint Homocysteine thiolactone and human cholinesterases
    Sultan Darvesh
    Department of Medicine Neurology and Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Cell Mol Neurobiol 27:33-48. 2007
    ....
  13. ncbi request reprint Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, NS, Canada
    Bioorg Med Chem 15:6367-78. 2007
    ..Use of such butyrylcholinesterase inhibitors could provide direct evidence for the importance of this enzyme in the normal nervous system and in Alzheimer's disease...
  14. ncbi request reprint Differential effects of lipid-lowering agents on human cholinesterases
    Sultan Darvesh
    Division of Neurology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 2E1
    Clin Biochem 37:42-9. 2004
    ..Epidemiologic reports indicate that lipid-lowering agents (LLAs) protect against dementia. We hypothesized that LLAs might affect cholinergic systems. The effects of LLAs on the activity of cholinesterases were examined...
  15. doi request reprint Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Bioorg Med Chem 18:2232-44. 2010
    ..The effect of such compounds on cholinesterase activity at high substrate concentration supports ionic interaction of aminoureas at the peripheral anionic site...
  16. ncbi request reprint Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus
    Sultan Darvesh
    Department of Medicine Neurology and Geriatric Medicine, Dalhousie University, Halifax B3H 1X5, Nova Scotia, Canada
    J Comp Neurol 463:25-43. 2003
    ..Involvement of thalamic nuclei in diseases of the nervous system such as Alzheimer's disease and schizophrenia suggests that BuChE could be a potential target for therapeutic intervention in these disorders...
  17. ncbi request reprint Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases
    Sultan Darvesh
    Department of Medicine Neurology and Geriatric Medicine Dalhousie University, Halifax, Nova Scotia
    Cell Mol Neurobiol 23:93-100. 2003
    ..8. The two huperzine enantiomers may prove to be useful tools to examine the function of aryl acylamidase activity, including its role in Alzheimer pathology...
  18. ncbi request reprint Neurobiology of butyrylcholinesterase
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Nat Rev Neurosci 4:131-8. 2003
  19. ncbi request reprint Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity
    S Darvesh
    Department of Anatomy, Dalhousie University, Halifax, Nova Scotia, Canada
    J Auton Nerv Syst 71:75-84. 1998
    ....
  20. ncbi request reprint Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin
    S Darvesh
    Department of Medicine, Halifax, Nova Scotia, Canada
    Cell Mol Neurobiol 21:285-96. 2001
    ..6. We suggest that, in addition to its esterase activity, BuChE may assume a regulatory role by interacting with other proteins...
  21. ncbi request reprint Retrospective diagnosis of dementia using an informant interview based on the Brief Cognitive Rating Scale
    K Rockwood
    Department of Medicine, Dalhousie University, Halifax, Canada
    Int Psychogeriatr 10:53-60. 1998
    ..The RetroBCRS used by an expert physician with a reliable informant is a valid method of detecting dementia and determining whether AD was present...
  22. doi request reprint Butyrylcholinesterase and the cholinergic system
    G A Reid
    Department of Medical Neuroscience Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroscience 234:53-68. 2013
    ..These observations provide further neuroanatomical evidence of a role for BuChE in the regulation of acetylcholine levels in the CNS...
  23. ncbi request reprint Butyrylcholinesterase and cognitive function
    S Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 13:461-4. 2001
    ..We suggest that, because neurons expressing BuChE may be involved in cognition, there is merit to further evaluation of selective BuChE inhibitors in treating cognitive dysfunction...
  24. ncbi request reprint Spectrum of disease in vascular cognitive impairment
    K Rockwood
    Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroepidemiology 18:248-54. 1999
    ..To better understand and treat ischaemic causes of cognitive impairment, the concept of VaD should be expanded to include patients who do not meet traditional dementia criteria...
  25. ncbi request reprint A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase
    Ryan Walsh
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Biochim Biophys Acta 1770:733-46. 2007
    ..Given that butyrylcholinesterase inhibition can antagonize stimulation of this enzyme by homocysteine thiolactone, cholinesterase inhibition may have a role in treating Alzheimer and vascular diseases related to hyperhomocysteinemia...
  26. ncbi request reprint Lipid-lowering agents and the risk of cognitive impairment that does not meet criteria for dementia, in relation to apolipoprotein E status
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    Neuroepidemiology 29:201-7. 2007
    ..Adjusting for apolipoprotein E4 status did not change the point estimates of the ORs. The greatest impact of LLAs was seen in the CIND subtype circumscribed memory impairment...
  27. ncbi request reprint The risk of dementia in relation to statins and other lipid lowering agents
    Kenneth Rockwood
    Divisions of Geriatric Medicine and Neurology, Dalhousie University, Halifax, Canada
    Neurol Res 25:601-4. 2003
    ..Dedicated clinical trials are now under way, and their results are awaited with great interest...
  28. ncbi request reprint Relation between butyrylcholinesterase K variant, paraoxonase 1 (PON1) Q and R and apolipoprotein E epsilon 4 genes in early-onset coronary artery disease
    Bassam A Nassar
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Biochem 35:205-9. 2002
    ..Paraoxonase 1 (PON1), located within HDL, is an enzyme which also metabolizes organophosphates and may be antiatherogenic. The R192 variant of PON1 (PON1-R) has been associated with CAD...
  29. ncbi request reprint Progressive anomia without semantic or phonological impairment
    Janet L Ingles
    School of Human Communication Disorders, Dalhousie University, Halifax, Canada
    Cortex 43:558-64. 2007
    ..These features are not typical of either fluent or non-fluent forms of neurodegenerative language disturbance. The cognitive mechanisms that may underlie this case are discussed...
  30. ncbi request reprint The behavioural neurology assessment
    S Darvesh
    Department Neurology and Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 32:167-77. 2005
    ..The BNA-Short Form consists of 13 subtests within the domains of Attention, Memory, Naming, Visuospatial Function and Executive Function. In addition to individual domain indices, a Grand Total score was calculated for both BNA versions...
  31. ncbi request reprint Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation
    S Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Comp Neurol 393:374-90. 1998
    ..The distinct distribution of BuChE suggests that it may have specific functions including coregulation of cholinergic and noncholinergic neurotransmission in human amygdala and hippocampal formation...
  32. ncbi request reprint Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic model
    Bassam A Nassar
    Department of Pathology, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada B3H 4H7
    Clin Biochem 39:109-14. 2006
    ....
  33. ncbi request reprint Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases
    Ivar Mendez
    Department of Surgery Neurosurgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Neurosurg 96:589-96. 2002
    ..The authors demonstrate the feasibility of reinnervating the SN and striatum by using a double transplant strategy in humans...
  34. pmc Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI
    Clifford R Jack
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurobiol Aging 29:1285-95. 2008
    ..000). Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI...
  35. ncbi request reprint Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0949, USA
    J Mol Neurosci 20:241-8. 2003
    ..We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains...
  36. ncbi request reprint Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease
    Changiz Geula
    Laboratory for Neurodegenerative and Aging Research, Department of Medicine Neuroscience, Harvard Medical School and Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Drugs Today (Barc) 40:711-21. 2004
    ..Therefore, inhibition of butyrylcholinesterase will not only lead to enhanced cholinergic transmission but also has the potential to interfere with the disease process in Alzheimer's disease and other dementing disorders...
  37. ncbi request reprint Cholinesterases: roles in the brain during health and disease
    Clive G Ballard
    Department of Biomedical Sciences, Wolfson Centre for Age Related Diseases, Hodgkin Building, Guy s Campus, King s College, London, SE1 1UL, UK
    Curr Alzheimer Res 2:307-18. 2005
    ..Focusing on new findings relating to BuChE, we review recent evidence that has extended knowledge into the roles of ChEs in health, disease and aging...
  38. ncbi request reprint Disconnection of language and memory in semantic dementia: a comparative and theoretical analysis
    Michael J Passmore
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Curr Alzheimer Res 2:435-48. 2005
    ....
  39. ncbi request reprint Tomographic visualization of cholinesterase
    Rodrigo O Kuljis
    Ann Neurol 60:745-6. 2006
  40. ncbi request reprint Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides
    Patrick Masson
    Centre de Recherches du Service de Sante des Armees, Departement de Toxicologie, Unite d Enzymologie, BP 87, 38702 La Tronche Cedex, France
    Biochim Biophys Acta 1774:1139-47. 2007
    ..It was concluded that the active sites for esterase and AAA activities are identical, i.e. S198. This excludes any other residue present in the gorge for being the catalytic nucleophile pole...
  41. ncbi request reprint Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission
    Ellen G Duysen
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Toxicology 233:60-9. 2007
    ..Thus, BChE has a function in neurotransmission. People with BChE deficiency are expected to be intolerant of standard doses of the anti-Alzheimer's drugs, (--)-huperzine A and donepezil...
  42. ncbi request reprint Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity
    Rathanam Boopathy
    Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India
    Clin Chim Acta 380:151-6. 2007
    ..AST and gamma GT values were taken into account in this study as known markers for liver disorders...
  43. ncbi request reprint Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate
    Patrick Masson
    Centre de Recherches du Service de Sante des Armees, Unite d Enzymologie, BP 87, 38702 La Tronche Cedex, France
    J Enzyme Inhib Med Chem 22:463-9. 2007
    ..6-1 mM), albumin may participate in hydrolysis of aryl acylamides through second-order kinetics. This suggests that albumin may have a role in the metabolism of endogenous and exogenous aromatic amides, including drugs and xenobiotics...
  44. ncbi request reprint A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India
    Indumathi Manoharan
    Bharathiar University, Department of Biotechnology, Coimbatore 641046, Tamil Nadu, India
    Clin Chim Acta 378:128-35. 2007
    ..A physiological function of BChE is to inactivate octanoyl ghrelin. We determined the health effect of complete absence of BChE in humans...
  45. ncbi request reprint Corticobasal degeneration substantiated by imaging studies
    Jennifer Martin
    Am J Geriatr Psychiatry 13:333-4. 2005