Richard E Brown

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. doi request reprint Improving animal models for nervous system disorders
    R E Brown
    Department of Psychology and Neuroscience, Dalhousie Uni versity, Halifax Nova Scotia, Canada
    Genes Brain Behav 11:753-6. 2012
  2. doi request reprint Behavioural phenotyping of transgenic mice
    Richard E Brown
    Dalhousie University
    Can J Exp Psychol 61:328-44. 2007
  3. pmc The influence of visual ability on learning and memory performance in 13 strains of mice
    Richard E Brown
    Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada
    Learn Mem 14:134-44. 2007
  4. ncbi request reprint The life and work of Donald Olding Hebb
    Richard E Brown
    Department of Psychology, Dalhousie University Halifax, Nova Scotia, Canada
    Acta Neurol Taiwan 15:127-42. 2006
  5. ncbi request reprint The legacy of Donald O. Hebb: more than the Hebb synapse
    Richard E Brown
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Nat Rev Neurosci 4:1013-9. 2003
  6. doi request reprint Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease
    Timothy P O'Leary
    Psychology Department, Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Brain Res 201:120-7. 2009
  7. doi request reprint Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze
    Timothy P O'Leary
    Psychology Department and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Behav Brain Res 216:531-42. 2011
  8. doi request reprint Optimization of apparatus design and behavioral measures for the assessment of visuo-spatial learning and memory of mice on the Barnes maze
    Timothy P O'Leary
    Psychology and Neuroscience Department, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Learn Mem 20:85-96. 2013
  9. doi request reprint What are we measuring when we test strain differences in anxiety in mice?
    Timothy P O'Leary
    Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4R2, Canada
    Behav Genet 43:34-50. 2013
  10. doi request reprint Maternal genotype influences behavioral development of 3×Tg-AD mouse pups
    Caitlin E Blaney
    Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Behav Brain Res 252:40-8. 2013

Collaborators

Detail Information

Publications34

  1. doi request reprint Improving animal models for nervous system disorders
    R E Brown
    Department of Psychology and Neuroscience, Dalhousie Uni versity, Halifax Nova Scotia, Canada
    Genes Brain Behav 11:753-6. 2012
    ..The proceedings of this workshop will be of great interest to those doing research in genes, brain and behaviour...
  2. doi request reprint Behavioural phenotyping of transgenic mice
    Richard E Brown
    Dalhousie University
    Can J Exp Psychol 61:328-44. 2007
    ....
  3. pmc The influence of visual ability on learning and memory performance in 13 strains of mice
    Richard E Brown
    Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada
    Learn Mem 14:134-44. 2007
    ..These results have significant implications for the search for the neural and genetic basis of learning and memory in mice...
  4. ncbi request reprint The life and work of Donald Olding Hebb
    Richard E Brown
    Department of Psychology, Dalhousie University Halifax, Nova Scotia, Canada
    Acta Neurol Taiwan 15:127-42. 2006
    ..When he retired from McGill, he moved back to Nova Scotia, and became a Professor Emeritus at Dalhousie University. This paper reviews Hebb's life and work and the impact of his ideas in psychology and neuroscience...
  5. ncbi request reprint The legacy of Donald O. Hebb: more than the Hebb synapse
    Richard E Brown
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Nat Rev Neurosci 4:1013-9. 2003
    ..Here, we review the work of Hebb and its lasting influence on neuroscience in honour of the 2004 centenary of his birth...
  6. doi request reprint Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease
    Timothy P O'Leary
    Psychology Department, Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Brain Res 201:120-7. 2009
    ..Overall, these results replicate previous findings using the MWM, and indicate that APPswe/PS1dE9 mice have impaired visuo-spatial learning and memory at 16 months of age...
  7. doi request reprint Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze
    Timothy P O'Leary
    Psychology Department and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Behav Brain Res 216:531-42. 2011
    ..These results indicate that the design of the Barnes maze has a significant effect on learning and memory processes...
  8. doi request reprint Optimization of apparatus design and behavioral measures for the assessment of visuo-spatial learning and memory of mice on the Barnes maze
    Timothy P O'Leary
    Psychology and Neuroscience Department, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Learn Mem 20:85-96. 2013
    ..This experiment demonstrates that both apparatus design and the behavioral measures used as indicators of learning and memory can influence the ability of the Barnes maze to detect visuo-spatial learning and memory impairments in mice...
  9. doi request reprint What are we measuring when we test strain differences in anxiety in mice?
    Timothy P O'Leary
    Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4R2, Canada
    Behav Genet 43:34-50. 2013
    ..These results suggest that new ways of measuring trait anxiety are required in order to determine the neural and genetic correlates of anxiety-like behaviour in mice...
  10. doi request reprint Maternal genotype influences behavioral development of 3×Tg-AD mouse pups
    Caitlin E Blaney
    Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Behav Brain Res 252:40-8. 2013
    ....
  11. doi request reprint Attenuation of maternal behavior in virgin CD-1 mice by methylphenidate hydrochloride
    Melanie P Leussis
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Physiol Behav 95:395-9. 2008
    ..Given the disruption in spontaneous maternal behavior of MPH-treated mice, further research examining the relationship between maternal behavior and MPH exposure is warranted...
  12. ncbi request reprint Measuring anxiety- and locomotion-related behaviours in mice: a new way of using old tests
    Leanne M Fraser
    Psychology Department and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4J1
    Psychopharmacology (Berl) 211:99-112. 2010
    ..However, because of the potentially confounding effects of repeated testing and natural intra-individual variations in behaviour over time, subjecting mice to a succession of tests is not ideal...
  13. doi request reprint The lonely mouse: verification of a separation-induced model of depression in female mice
    Alison L Martin
    Psychology Department and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Brain Res 207:196-207. 2010
    ..This procedure is both versatile, allowing for the study of genetic and environmental interactions, and accessible, making it useful for studying depression and testing new drugs for its treatment...
  14. doi request reprint The effect of chlordiazepoxide on measures of activity and anxiety in Swiss-Webster mice in the triple test
    Ahmed T Hussin
    Psychology Department, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada
    Neuropharmacology 63:883-9. 2012
    ..These results show that the drug effect was independent of the day effect and that there was no one-trial tolerance effect in the triple test of anxiety...
  15. ncbi request reprint Comparison of medial preoptic, amygdala, and nucleus accumbens lesions on parental behavior in California mice (Peromyscus californicus)
    Anna W Lee
    Psychology Department, Dalhousie University, Halifax, NS, Canada B3H 4J1
    Physiol Behav 92:617-28. 2007
    ..These results support a role for the MPOA and BA in both male and female parental behaviors...
  16. ncbi request reprint Sex differences in ultrasonic vocalizations and coordinated movement in the California mouse (Peromyscus californicus)
    Sandra L Wright
    Psychology Department, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Behav Processes 65:155-62. 2004
    ..Results from Experiment 1 provided some support for Geyer's (1981) hypothesis and results from Experiment 2 did not support the hypothesis that the main function of USVs in California mouse pups was to elicit parental care...
  17. doi request reprint Age-related changes in visual acuity, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease
    Kurt R Stover
    Psychology Department and Neuroscience Institute, Dalhousie University, PO Box 1500, Halifax, NS B3H 4R2, Canada
    Behav Brain Res 231:75-85. 2012
    ..These results indicate that the old APPswe/PS1dE9 mice and their wildtype littermates both have a deficit in their visual ability and that visually dependent measures alone should not be used to assess learning and memory in this strain...
  18. ncbi request reprint Age-related changes in visual acuity, learning and memory in C57BL/6J and DBA/2J mice
    Aimée A Wong
    Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Neurobiol Aging 28:1577-93. 2007
    ..Strain differences in visual task performance accounted for a significant proportion of the variance in measures of learning and memory in the water maze at 12, 18 and 24 months of age...
  19. pmc Are Sema5a mutant mice a good model of autism? A behavioral analysis of sensory systems, emotionality and cognition
    Rhian K Gunn
    Psychology Department, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Behav Brain Res 225:142-50. 2011
    ..We conclude that the Sema5a mice do not meet the behavioral criteria for a mouse model of autism...
  20. doi request reprint The effects of apparatus design and test procedure on learning and memory performance of C57BL/6J mice on the Barnes maze
    Timothy P O'Leary
    Psychology Department, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada
    J Neurosci Methods 203:315-24. 2012
    ..These results indicate that apparatus design influences search strategy use and memory performance on the Barnes maze, and that including a wall around the edge of the Barnes maze decreases visuo-spatial cue use...
  21. ncbi request reprint Long-term methylphenidate treatment down-regulates c-fos in the striatum of male CD-1 mice
    Christianne M Hawken
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Neuroreport 15:1045-8. 2004
    ..These results replicate those observed with rats and indicate that long-term use of MPH may alter neural activity by down-regulation of gene expression in the striatum...
  22. ncbi request reprint Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus)
    Timothy W Bredy
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, and Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Horm Behav 46:30-8. 2004
    ....
  23. ncbi request reprint MHC-congenic mice (C57BL/6J and B6-H-2K) show differences in speed but not accuracy in learning the Hebb-Williams Maze
    Lianne Stanford
    Department of Psychology, Dalhousie University, Halifax, NS, Canada B3H 4J1
    Behav Brain Res 144:187-97. 2003
    ..These results indicate that these two strains show differences in performance in the Hebb-Williams Maze, but do not differ in cognitive ability...
  24. ncbi request reprint Daily methylphenidate administration attenuates c-fos expression in the striatum of prepubertal rats
    Teena D Chase
    Department of Physiology and Biophysics, Dalhousie University, Halifax, NS B3 H 4H7, Canada B3J 3G9
    Neuroreport 14:769-72. 2003
    ..This is the first demonstration of methylphenidate-induced modification of gene expression in developing rat striatum and may have implications for chronic methylphenidate use in children...
  25. pmc Conservation of resources theory and research use in health systems
    Celeste Alvaro
    Atlantic Health Promotion Research Centre, Faculty of Health Professions, Dalhousie University, Canada
    Implement Sci 5:79. 2010
    ..First, resources are required for research uptake. Second, threat of resource loss fosters resistance to research use. Third, resources can be optimized, even in resource-challenged environments, to build capacity for KT...
  26. ncbi request reprint A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma
    Aimée A Wong
    Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 53:5956-66. 2012
    ....
  27. ncbi request reprint Prenatal exposure to methylphenidate hydrochloride decreases anxiety and increases exploration in mice
    Melanie P McFadyen-Leussis
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Pharmacol Biochem Behav 77:491-500. 2004
    ..Our data provide an initial overview of the possible effects occurring as a result of prenatal exposure to MPH, and strongly suggest that further studies of the in utero and developmental effects of psychostimulants are needed...
  28. ncbi request reprint Alfred McCoy, Hebb, the CIA and torture
    Richard E Brown
    Dalhousie University, Halifax, Nova Scotia, Canada
    J Hist Behav Sci 43:205-13. 2007
  29. ncbi request reprint Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice
    Melanie P McFadyen
    Department of Psychology, Dalhousie University, Halifax, NS, B3H 4J1, Canada
    Dev Psychobiol 41:123-32. 2002
    ....
  30. ncbi request reprint Nest building in nulligravid, primigravid and primiparous C57BL/6J and DBA/2J mice (Mus musculus)
    Tamara L Y Bond
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Physiol Behav 75:551-5. 2002
    ..One hypothesis to account for these results is that females of these two strains differ in their levels of or sensitivity to hormones during pregnancy and parturition...
  31. ncbi request reprint Effects of the presence of the father on pup development in California mice (Peromyscus californicus)
    Mauro L Vieira
    Departamento de Psicologia, Universidade Federal de Santa Catarina, Campus Universitario, Trindade, 88049 900 Florianopolis, Brazil
    Dev Psychobiol 42:246-51. 2003
    ..In conclusion, the results indicate that the presence of the father had a greater influence on social contact between the different members of the litter than on pup behavioral development and physical growth...
  32. ncbi request reprint Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus)
    Timothy W Bredy
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Eur J Neurosci 25:567-75. 2007
    ..Together, the results suggest that resource availability affects biparental investment strategies, with subsequent effects on hippocampal development and novel object recognition in the offspring...
  33. ncbi request reprint Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice
    Sarah A Baker
    Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40292, USA
    Brain Res 1039:177-88. 2005
    ..These results suggest that chronic deficits in BDNF alone do not affect survival or function of dopaminergic nigrostriatal neurons during aging or potentially even in Parkinson's disease...