Research Topics
| David AndersonSummaryAffiliation: Dalhousie University Country: Canada Publications
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Detail Information
Publications
Comparison of a nomogram and physician-adjusted dosage of warfarin for prophylaxis against deep-vein thrombosis after arthroplastyDavid R Anderson
Department of Medicine, Division of Hematology, Dalhousie University, Queen Elizabeth II Health Sciences Centre, Room 432, Bethune, 1172 Tower Road, Halifax, Nova Scotia B3H 1V8, Canada
J Bone Joint Surg Am 84:1992-7. 2002..The objective of this study was to compare the performance of this nomogram with that of physician-adjusted dosing of warfarin for patients undergoing total hip or knee arthroplasty...- Oral anticoagulation for the antiphospholipid antibody syndrome: can we now say less is more?D R Anderson
Department of Medicine, Dalhousie University and Capital Health, Halifax, Nova Scotia, Canada
J Thromb Haemost 3:846-7. 2005 
A randomized trial to assess the impact of an antithrombotic decision aid in patients with nonvalvular atrial fibrillation: the DAAFI trial protocol [ISRCTN14429643]Finlay A McAlister
The Division of General Internal Medicine, University of Alberta, Edmonton, Canada
BMC Cardiovasc Disord 4:5. 2004..In addition, the impact of this decision aid on patient knowledge, decisional conflict, well-being, and adherence will be assessed after 3 months, 6 months, and 12 months...- Improvements in the diagnostic approach for patients with suspected deep vein thrombosis or pulmonary embolismD R Anderson
Department of Medicine, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
Thromb Haemost 82:878-86. 1999..There is still need to improve management strategies for the diagnosis of recurrent venous thrombosis and to determine whether diagnostic testing results may be correlated with long-term patient treatment needs... - Guidelines on the use of intravenous immune globulin for hematologic conditionsDavid Anderson
QEII Health Sciences Centre and Dalhousie University, Halifax, NS, Canada
Transfus Med Rev 21:S9-56. 2007..For most hematologic conditions reviewed by the expert panel, routine use of IVIG was not recommended. Development and dissemination of evidence-based guidelines may help to facilitate appropriate use of IVIG... - Population-based evaluation of the management of antithrombotic therapy for atrial fibrillationDavid R Anderson
Queen Elizabeth II Health Science Centre, Halifax, Canada
Can J Cardiol 21:257-66. 2005..However, previous practice reviews have indicated that oral anticoagulants are often underused in this setting. Most of those reports have focused on reviews of hospitalized and institutionalized patients, or small geographical areas... 
The use of leg venous ultrasonography for the diagnosis of pulmonary embolismDavid R Anderson
Department of Medicine, Dalhousie University and Capital Health, Halifax, Nova Scotia, Canada
Semin Nucl Med 38:412-7. 2008....- Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trialDavid R Anderson
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
JAMA 298:2743-53. 2007..Ventilation-perfusion scanning has been largely replaced by CTPA in many centers despite limited comparative formal evaluations and concerns about CTPA's low sensitivity (ie, chance of missing clinically important pulmonary embuli)... - Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study)D R Anderson
Department of Medicine, QEII Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
J Thromb Haemost 1:645-51. 2003..5%) developed pulmonary embolism in the follow-up period. A diagnostic strategy for the evaluation of patients with suspected DVT based on pretest probability and d-dimer is safe and feasible in the emergency department setting... - Evaluation of polyethylene terephthalate for ABO and Rh typing and alloantibody screeningD R Anderson
Departments of Medicine and Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Transfusion 40:669-72. 2000.... - Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT studyJames Douketis
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Intern Med 168:1805-12. 2008..To challenge this premise, we evaluated if deep vein thrombosis (DVT) prophylaxis with dalteparin sodium confers an excessive anticoagulant effect in critically ill patients with severe renal insufficiency... 
Anticoagulation in atrial fibrillation. Is there a gap in care for ambulatory patients?Wayne Putnam
Dalhousie University, Department of Family Medicine, Dalhousie University, Halifax, NS
Can Fam Physician 50:1244-50. 2004..Our objectives were to clarify measures of this gap in care by including data from family physicians and to determine why eligible patients were not receiving anticoagulation therapy...- A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndromeMark A Crowther
Department of Medicine, McMaster University, Hamilton, Ont, Canada
N Engl J Med 349:1133-8. 2003..0. However, there are no prospective data to support this approach to thromboprophylaxis... - Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factorsDeborah Cook
Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
Crit Care 12:R32. 2008..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min... - The impact of warfarin use on clinical outcomes in atrial fibrillation: a population-based studyRatika Parkash
Department of Medicine, Dalhousie University and Capital Health, Halifax, Canada
Can J Cardiol 23:457-61. 2007..Atrial fibrillation (AF) is the most common adult arrhythmia, and significantly increases the risk of ischemic stroke. Oral anticoagulation may be underused and may be less effective in community settings than clinical trial settings... - The cost-effectiveness of extended-duration antithrombotic prophylaxis after total hip arthroplastyChris Skedgel
Department of Medicine, Dalhousie University, Centre for Clinical Research, University Avenue, Halifax, Canada
J Bone Joint Surg Am 89:819-28. 2007.... - The use of immunoglobulin therapy for patients undergoing solid organ transplantation: an evidence-based practice guidelineNadine Shehata
Department of Medicine, University of Toronto, Canadian Blood Services, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada
Transfus Med Rev 24:S7-S27. 2010.... - Dalteparin vs low-dose unfractionated heparin for prophylaxis against clinically evident venous thromboembolism in acute traumatic spinal cord injury: a retrospective cohort studyScott Worley
Division of Physical Medicine and Rehabilitation, Dalhousie University, Nova Scotia Rehabilitation Centre, Department of Medicine, Halifax, Nova Scotia, Canada
J Spinal Cord Med 31:379-87. 2008..Although low-molecular-weight heparin (LMWH) outperforms low-dose unfractionated heparin (LDUH) in other patient populations, the evidence in SCI remains less robust... - Venous protocols, techniques, and interpretations of the upper and lower extremitiesJames D Fraser
Department of Diagnostic Radiology, Dalhousie University, Queen Elizabeth II Health Sciences Centre, 3rd Floor, Victoria Building, 1278 Tower Road, Halifax, Nova Scotia, Canada B3H 2Y9
Radiol Clin North Am 42:279-96. 2004.... - A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Blood 119:1356-62. 2012..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)... - Inhibition of annexin V binding to cardiolipin and thrombin generation in an unselected population with venous thrombosisJohn G Hanly
Divisions of Rheumatology and Hematology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, 1341 Summer Street, Halifax, Nova Scotia, Canada B3H 4K4
J Rheumatol 30:1990-3. 2003..CONCLUSION: Our findings suggest that subtle abnormalities in annexin V physiology may contribute to the procoagulant state in patients with idiopathic venous thrombosis... - The use of immunoglobulin therapy for patients with primary immune deficiency: an evidence-based practice guidelineNadine Shehata
Department of Medicine, University of Toronto, Canadian Blood Services, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada
Transfus Med Rev 24:S28-50. 2010.... - Bridging the gap between primary and secondary care: use of a clinical pathway for the investigation and management of deep vein thrombosisSamuel Campbell
Dalhousie University, Halifax, Nova Scotia, Canada
J Health Serv Res Policy 13:15-9. 2008..In addition, urgent referrals to the ultrasound department disrupted the scheduled list of patients... - Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosisPhilip S Wells
Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
N Engl J Med 349:1227-35. 2003.... - Catheter-associated thrombosis in patients with malignancySudeep P Shivakumar
Department of Medicine, Dalhousie University and Capital District Health Authority, Halifax, Nova Scotia, Canada
J Clin Oncol 27:4858-64. 2009..The care of pediatric patients with malignancy and catheter-associated thrombosis will also be addressed... - Optimizing healthcare at the population level: results of the improving cardiovascular outcomes in Nova Scotia partnershipJafna Cox
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Healthc Q 11:28-41. 2008..Further studies are needed to better understand the drivers and modifiers of patient outcomes at the population level... - Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxisD Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Crit Care 24:168-75. 2009.... - Review of thromboprophylaxis in otolaryngology-head and neck surgeryRick Jaggi
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, NS
J Otolaryngol Head Neck Surg 40:261-5. 2011..RESEARCH TYPE: Translational... - Computerized tomographic pulmonary angiography versus ventilation perfusion lung scanning for the diagnosis of pulmonary embolismDavid R Anderson
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Curr Opin Pulm Med 15:425-9. 2009..The purpose of this review is to focus on recent research that has addressed the relative merits of computed tomographic pulmonary angiography (CTPA) and ventilation perfusion (V/Q) scanning for the diagnosis of pulmonary embolism... - Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trialS Jo Anne Wilson
Department of Pharmacy, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS
CMAJ 169:293-8. 2003..We carried out a randomized controlled trial to evaluate these 2 models of anticoagulant care... - Use of spiral computed tomography contrast angiography and ultrasonography to exclude the diagnosis of pulmonary embolism in the emergency departmentDavid R Anderson
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
J Emerg Med 29:399-404. 2005..These findings suggest that the combination of a negative spiral CT contrast angiography scan and normal venous ultrasound imaging safely excludes the diagnosis of pulmonary embolism in the Emergency Department setting... - Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancerStephen Couban
Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Room 417, Bethune Bldg, 1278 Tower Rd, Halifax, Nova Scotia B3H 2Y9, Canada
J Clin Oncol 23:4063-9. 2005..In this multicenter, randomized, placebo-controlled clinical trial, we studied whether warfarin 1 mg daily reduces the incidence of symptomatic central venous catheter (CVC) -associated thrombosis in patients with cancer... - Influence of warfarin on symptoms of fatigue: findings of a randomized trialMichael J Kovacs
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Ann Pharmacother 39:840-2. 2005..Some patients develop fatigue while taking warfarin, but causality is uncertain... - Accuracy and usefulness of a clinical prediction rule and D-dimer testing in excluding deep vein thrombosis in cancer patientsMarc Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 123:177-83. 2008.... - Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trialMichael J Kovacs
Department of Hematology, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
Ann Intern Med 138:714-9. 2003..The optimal means of achieving therapeutic oral anticoagulation in the outpatient setting has not been determined... - Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolismClive Kearon
McMaster University, Hamilton, Ont
N Engl J Med 349:631-9. 2003..The low-intensity warfarin regimen does not reduce the risk of clinically important bleeding... - Intravenous immunoglobulin utilization in the Canadian Atlantic provinces: a report of the Atlantic Collaborative Intravenous Immune Globulin Utilization Working GroupMaggie M Constantine
Capital District Health Authority and the Nova Scotia Provincial Blood Coordinating Program, Halifax, Nova Scotia, Canada
Transfusion 47:2072-80. 2007..By use of a collaborative regional strategy, baseline IVIG usage and appropriateness of utilization were determined for Atlantic Canada. The effectiveness of strategies designed to optimize utilization was also studied... - Inter-observer reliability of measures to assess the post-thrombotic syndromeMarc A Rodger
Thromb Haemost 100:164-6. 2008 - A randomized trial comparing 2 low-molecular-weight heparins for the outpatient treatment of deep vein thrombosis and pulmonary embolismPhilip S Wells
Departments of Medicine, University of Ottawa, Ottawa Health Research Institute, Ottawa, Ontario
Arch Intern Med 165:733-8. 2005..No published trials have compared LMWHs, and few studies have examined outpatient therapy for PE. Only tinzaparin sodium has demonstrated superiority to unfractionated heparin in a clinical trial... - The diagnosis of deep venous thrombosis and pulmonary embolism in medical-surgical intensive care unit patientsDeborah Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6
J Crit Care 20:314-9. 2005 - An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trialClive Kearon
McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
Ann Intern Med 144:812-21. 2006..It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) who have a negative D-dimer test, but this approach has never been evaluated in a randomized, controlled trial... - The scientific rationale for health promotionDavid R Anderson
Program Strategy and Development for StayWell Health Management
Am J Health Promot 19:suppl 3-4. 2005 - Exposure assessment of workers to airborne PCDD/Fs, PCBs and PAHs at an electric arc furnace steelmaking plant in the UKEric Aries
Corus Research, Development and Technology, Swinden Technology Centre, Moorgate, Rotherham S60 3AR, UK
Ann Occup Hyg 52:213-25. 2008..66 x 10(-6) to 1.64 x 10(-5). The cancer risks determined in this study were well within an acceptable range of excess cancer risk of 1.0 x 10(-4) to 1.0 x 10(-6), specified by the US Environmental Protection Agency... - A wake-up call for corporate AmericaR William Whitmer
Health Enhancement Research Organization (HERO) Birmingham, AL E-mail
J Occup Environ Med 45:916-25. 2003 - Effectiveness of compression stockings to prevent the post-thrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trialSusan R Kahn
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
BMC Cardiovasc Disord 7:21. 2007..Elastic compression stockings (ECS) could be helpful in preventing PTS; however, data on their effectiveness are scarce and conflicting... - Guidelines for the use of intravenous immune globulin for hematologic and neurologic conditionsHeather A Hume
Transfus Med Rev 21:S1-2. 2007