Daniel G Cyr

Summary

Country: Canada

Publications

  1. ncbi request reprint Identification of multiple claudins in the rat epididymis
    Mary Gregory
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada
    Mol Reprod Dev 73:580-8. 2006
  2. ncbi request reprint Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility
    Louis Hermo
    McGill University, Department of Anatomy and Cell Biology, 3640 University Street, Montreal, Quebec, Canada, H3A 2B2
    J Androl 28:784-97. 2007
  3. doi request reprint Development of biological tools to study claudins in the male reproductive tract
    Daniel G Cyr
    INRS Institut Armand Frappier, Laval, QC, Canada
    Methods Mol Biol 762:259-73. 2011
  4. ncbi request reprint Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans
    Daniel G Cyr
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, Quebec H9R 1G6, Canada
    Asian J Androl 9:463-75. 2007
  5. doi request reprint Oral p-tert-octylphenol exposures induce minimal toxic or estrogenic effects in adult female Sprague-Dawley rats
    Sukhdeep K Sahambi
    INRS Institut Armand Frappier, Institut National de la Recherche Scientifique, Laval, Quebec, Canada
    J Toxicol Environ Health A 73:607-22. 2010
  6. ncbi request reprint Consumption of xenoestrogen-contaminated fish during lactation alters adult male reproductive function
    Jayaprakash Aravindakshan
    INRS Institut Armand Frappier, Universite du Quebec, Montreal, Quebec, Canada H9R 1G6
    Toxicol Sci 81:179-89. 2004
  7. ncbi request reprint Influence of municipal effluents on the expression of connexins in the brook trout (Salvelinus fontinalis) testis
    Benjamin de Montgolfier
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, QC, Canada
    Aquat Toxicol 86:38-48. 2008
  8. ncbi request reprint Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt
    Isabelle Plante
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, QC, Canada H9R 1G6
    Carcinogenesis 27:1923-9. 2006
  9. doi request reprint Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia
    Evemie Dube
    INRS Institut Armand Frappier, Universite du Quebec, 531 Boulevard des Prairies, Laval, QC, Canada H7V 1B7
    Hum Reprod 27:2285-96. 2012
  10. doi request reprint Seasonal variations in testicular connexin levels and their regulation in the brook trout, Salvelinus fontinalis
    Benjamin de Montgolfier
    INRS Institut Armand Frappier, Universite du Quebec, 531 Boul des Prairies, Laval, Que, Canada H7V 1B7
    Gen Comp Endocrinol 162:276-85. 2009

Collaborators

  • Louis Hermo
  • Michel Fournier
  • Andrew A Rooney
  • Sami Haddad
  • Silvia Penuela
  • Bernard Robaire
  • Dale W Laird
  • Harri M Salo
  • Robert S Viger
  • Rex A Hess
  • Charles E Smith
  • Evemie Dube
  • Julie Dufresne
  • Mary Gregory
  • Benjamin de Montgolfier
  • Peter T K Chan
  • Isabelle Plante
  • Michel Charbonneau
  • Jayaprakash Aravindakshan
  • Celine Audet
  • David J Marcogliese
  • Stéphane Pillet
  • Patrick Turmel
  • Nancy St-Pierre
  • Sukhdeep K Sahambi
  • Kannan Krishnan
  • Robert Tardif
  • Timothy Schrader
  • Gerard M Cooke
  • Teresa Lopardo
  • Nadia Primiani
  • Michelle Picard-Aitken
  • Karine Khatchadourian
  • Johanna Barthelemy
  • Ricardo Ruz
  • Jean Marie Bouquegneau
  • Amit Grover
  • Sophie DeBellefeuille
  • Chad C Luedtke
  • Amelie Pelland
  • Patrick J Devine
  • Alexandra Lacroix
  • Aliou Faye
  • Patrick Devine
  • Nadia Lo Iacono
  • Giorgio Merlo
  • Luisa Guerrini
  • Antonio Costanzo
  • Francesca Crosti
  • Maria L Giustizieri
  • Barbara Marinari
  • Henri Fournier
  • Michael R Hayden
  • James J Nagler
  • Alain Fournier
  • Martina Metzler
  • Ye Lauren Liu
  • Myriam Letourneau
  • James R Bartles
  • Richard Pariseau
  • Adedayo Adeeko
  • Dennis B Lubahn
  • Jacques Bernier
  • Michele D'Elia
  • M Ram Sairam
  • Valérie Paquet
  • Kenneth W Finnson
  • Marc D McKee
  • Mari T Kaartinen
  • Jeannie Mui

Detail Information

Publications41

  1. ncbi request reprint Identification of multiple claudins in the rat epididymis
    Mary Gregory
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada
    Mol Reprod Dev 73:580-8. 2006
    ..These data indicate that epididymal tight junctions are composed of several Cldns, suggestive of a complex regulation of the blood-epididymal barrier...
  2. ncbi request reprint Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility
    Louis Hermo
    McGill University, Department of Anatomy and Cell Biology, 3640 University Street, Montreal, Quebec, Canada, H3A 2B2
    J Androl 28:784-97. 2007
    ....
  3. doi request reprint Development of biological tools to study claudins in the male reproductive tract
    Daniel G Cyr
    INRS Institut Armand Frappier, Laval, QC, Canada
    Methods Mol Biol 762:259-73. 2011
    ..Here we describe some of the techniques that have been used to address these critical aspects of epididymal Cldns...
  4. ncbi request reprint Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans
    Daniel G Cyr
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, Quebec H9R 1G6, Canada
    Asian J Androl 9:463-75. 2007
    ....
  5. doi request reprint Oral p-tert-octylphenol exposures induce minimal toxic or estrogenic effects in adult female Sprague-Dawley rats
    Sukhdeep K Sahambi
    INRS Institut Armand Frappier, Institut National de la Recherche Scientifique, Laval, Quebec, Canada
    J Toxicol Environ Health A 73:607-22. 2010
    ..Overall, results suggest that toxicity will occur before estrogenic effects with oral exposures to OP. Relevant environmental exposures likely pose little risk for estrogenic effects...
  6. ncbi request reprint Consumption of xenoestrogen-contaminated fish during lactation alters adult male reproductive function
    Jayaprakash Aravindakshan
    INRS Institut Armand Frappier, Universite du Quebec, Montreal, Quebec, Canada H9R 1G6
    Toxicol Sci 81:179-89. 2004
    ..These data indicate that contaminants from xenoestrogen environments may pass through the food chain and exert effects on male reproductive functions...
  7. ncbi request reprint Influence of municipal effluents on the expression of connexins in the brook trout (Salvelinus fontinalis) testis
    Benjamin de Montgolfier
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, QC, Canada
    Aquat Toxicol 86:38-48. 2008
    ..Furthermore, vegf mRNA levels were unaltered by treatment at both time points. Thus, long-term exposure to environmental concentrations of wastewater effluent can alter the expression of testicular Cxs...
  8. ncbi request reprint Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt
    Isabelle Plante
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, QC, Canada H9R 1G6
    Carcinogenesis 27:1923-9. 2006
    ..Overall, these data indicate that Cx32 is downregulated by the ILK pathway activation in rat hepatocytes and that this is mediated via the activation and nuclear translocation of Akt...
  9. doi request reprint Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia
    Evemie Dube
    INRS Institut Armand Frappier, Universite du Quebec, 531 Boulevard des Prairies, Laval, QC, Canada H7V 1B7
    Hum Reprod 27:2285-96. 2012
    ....
  10. doi request reprint Seasonal variations in testicular connexin levels and their regulation in the brook trout, Salvelinus fontinalis
    Benjamin de Montgolfier
    INRS Institut Armand Frappier, Universite du Quebec, 531 Boul des Prairies, Laval, Que, Canada H7V 1B7
    Gen Comp Endocrinol 162:276-85. 2009
    ..These results indicate that testicular Cxs vary as a function of spermatogenesis and that the expression of cx43 in the trout testis is regulated by both cAMP and TH...
  11. ncbi request reprint Sex-specific effects of neonatal exposures to low levels of cadmium through maternal milk on development and immune functions of juvenile and adult rats
    Stéphane Pillet
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, Que, Canada H9R 1G6
    Toxicology 209:289-301. 2005
    ..In conclusion, neonatal exposures to environmentally relevant levels of Cd through maternal milk represent a critical hazard liable to lead to both transitory and persistent immunotoxic effects...
  12. ncbi request reprint Immunomodulatory effects of estradiol and cadmium in adult female rats
    Stéphane Pillet
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Montreal, Quebec, Canada H9R 1G6
    Toxicol Sci 92:423-32. 2006
    ..These interactions have to be taken into consideration in evaluating the risk of Cd immunotoxicity and the possible interactions with hormonal treatments...
  13. ncbi request reprint Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymis
    Evemie Dube
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, Quebec, Canada
    Biol Reprod 76:1034-44. 2007
    ..These data indicate that the epididymis displays a complex pattern of gene expression, which includes genes that are implicated in the formation of the blood-epididymal barrier, which suggests complex regulation of this barrier...
  14. doi request reprint Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat
    Patrick Turmel
    INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
    Mol Reprod Dev 78:124-38. 2011
    ..These proteins may play a role in ATP secretion into the epididymal lumen and basal extracellular spaces for functions involving sperm transport and maturation...
  15. doi request reprint Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men
    Evemie Dube
    INRS Institut Armand Frappier, University of Quebec, Laval, Quebec, Canada
    Biol Reprod 83:584-96. 2010
    ..Together, these data indicate that epididymal cellular junctions appear to be altered in OA...
  16. ncbi request reprint The blood-epididymis barrier and human male fertility
    Evemie Dube
    INRS Institut Armand Frappier, University of Quebec, Quebec, Canada
    Adv Exp Med Biol 763:218-36. 2012
    ..Clearly, changes in the function of cellular junctions in the human epididymis are associated with male infertility...
  17. ncbi request reprint Sexual dimorphism in the regulation of liver connexin32 transcription in hexachlorobenzene-treated rats
    Isabelle Plante
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada H9R 1G6
    Toxicol Sci 96:47-57. 2007
    ..Overall, results suggest that both the sexual dimorphism and the downregulation of Cx32 in HCB-treated female rats are mediated by a reduction in the binding of activating transcription factors on the Cx32 promoter...
  18. ncbi request reprint Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men
    Evemie Dube
    INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada H7V 1B7
    Biol Reprod 78:342-51. 2008
    ....
  19. ncbi request reprint Characterization of a novel rat epididymal cell line to study epididymal function
    Julie Dufresne
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, Quebec, Canada H9R 1G6
    Endocrinology 146:4710-20. 2005
    ..3, -32, and -43). The RCE cell line displays many characteristics of epithelial principal cells, thus providing a model for studying epididymal cell functions...
  20. doi request reprint Effects of chronic exposure to octylphenol on the male rat reproductive system
    Mary Gregory
    INRS Institut Armand Frappier, Universite du Quebec, Quebec, Canada
    J Toxicol Environ Health A 72:1553-60. 2009
    ..Taken together, results from this study indicate that OP treatment of adult rats does not appear to exert major effects on male reproductive endpoints at relevant environmental exposure doses...
  21. ncbi request reprint Activation of an SP binding site is crucial for the expression of claudin 1 in rat epididymal principal cells
    Julie Dufresne
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada H9R 1G6
    Biol Reprod 76:825-32. 2007
    ..These findings indicate that SP1 and SP3 bind to the Cldn1 promoter region, and that this interaction influences the expression of Cldn1 in the rat epididymis...
  22. ncbi request reprint Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines
    Evemie Dube
    INRS Institut Armand Frappier, University of Quebec, 531 Boulevard des Prairies, Laval, Quebec, Canada
    Biol Reprod 82:1119-28. 2010
    ..Disruption of CLDN1, CLDN3, CLDN4, and CLDN7 could, therefore, lead to epididymal dysfunction, resulting in male infertility...
  23. ncbi request reprint Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal development
    Sophie DeBellefeuille
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada H9R 1G6
    Endocrinology 144:5040-9. 2003
    ....
  24. ncbi request reprint The expression of multiple connexins throughout spermatogenesis in the rainbow trout testis suggests a role for complex intercellular communication
    Benjamin de Montgolfier
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada H9R 1G6
    Biol Reprod 76:2-8. 2007
    ..Together, these results indicate that intercellular communication in the testis is complex, involves several different Cxs, and is a highly regulated process...
  25. ncbi request reprint Effects of Montreal municipal sewage effluents on immune responses of juvenile female rainbow trout (Oncorhynchus mykiss)
    Harri M Salo
    INRS Institut Armand Frappier, 245 Hymus Boul, Pointe Claire, Que H9R 1G6, Canada
    Aquat Toxicol 84:406-14. 2007
    ..In summary, this study demonstrates that sewage effluent can alter the immune functions of rainbow trout...
  26. ncbi request reprint Neonatal hypothyroidism alters the localization of gap junctional protein connexin 43 in the testis and messenger RNA levels in the epididymis of the rat
    Nancy St-Pierre
    INRS Institut Armand Frappier, Universite du Quebec, Montreal, Quebec, Canada H9R 1G6
    Biol Reprod 68:1232-40. 2003
    ..In the cauda epididymidis, however, Cx43 immunostaining in PTU-treated rats was similar to controls. These data suggest that thyroid hormones regulate Cx43-dependent gap junctional communication in the testis and epididymis...
  27. ncbi request reprint Neonatal exposure to propylthiouracil induces a shift in lymphoid cell sub-populations in the developing postnatal male rat spleen and thymus
    Andrew A Rooney
    INRS Institut Armand Frappier, Universite du Quebec, 245 boulevard Hymus, Pointe Claire, QC, Canada H9R 1G6
    Cell Immunol 223:91-102. 2003
    ..Temporary hypothyroidism induced from birth to the latter stages of the weaning period induced transitory effects on the spleen, thymus, and immune cell sub-populations--all of which recovered to normal values when the animals matured...
  28. ncbi request reprint Nonylphenol alters connexin 43 levels and connexin 43 phosphorylation via an inhibition of the p38-mitogen-activated protein kinase pathway
    Jayaprakash Aravindakshan
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada H9R 1G6
    Biol Reprod 72:1232-40. 2005
    ..Protein kinase C activity was also measured and was not influenced by nonylphenol. These results suggest that nonylphenol inhibits GJIC between Sertoli cells and that this is modulated via nonestrogenic pathways...
  29. ncbi request reprint In utero exposure to tributyltin alters the expression of E-cadherin and localization of claudin-1 in intercellular junctions of the rat ventral prostate
    Johanna Barthelemy
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Quebec, Canada
    Mol Reprod Dev 74:455-67. 2007
    ..These data indicate that in utero TBT exposure results in permanent alterations in ventral prostate and that these are associated with alterations in the expression and distribution of cell adhesion and tight junctional proteins...
  30. ncbi request reprint Thyroid disruption in walleye (Sander vitreus) exposed to environmental contaminants: cloning and use of iodothyronine deiodinases as molecular biomarkers
    Michelle Picard-Aitken
    INRS Institut Armand Frappier Université du Québec 245, Hymus boul, Pointe Claire, Que, H9R 1G6, Canada
    Aquat Toxicol 83:200-11. 2007
    ....
  31. doi request reprint Regulation of the connexin 43 promoter in the brook trout testis: role of the thyroid hormones and cAMP
    Benjamin de Montgolfier
    INRS Institut Armand Frappier, Universite du Quebec, Laval, QC, Canada
    Gen Comp Endocrinol 170:110-8. 2011
    ..Together, these data indicate that T(3) stimulates cx43 expression via direct regulation of gene transcription...
  32. ncbi request reprint Involvement of the integrin-linked kinase pathway in hexachlorobenzene-induced gender-specific rat hepatocarcinogenesis
    Isabelle Plante
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Canada
    Toxicol Sci 88:346-57. 2005
    ..The concomitant HCB-induced downregulation of intercellular communication does not occur as a result of either E-cadherin downregulation or GSK3beta inactivation...
  33. ncbi request reprint Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius)
    Jayaprakash Aravindakshan
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, Quebec, Canada H9R 1G6
    Toxicol Sci 78:156-65. 2004
    ..These data indicate that there is significant estrogenic contamination in the St. Lawrence River that is associated with impaired reproductive function in male fish...
  34. ncbi request reprint Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication
    Julie Dufresne
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard, Pointe Claire, Quebec, Canada H9R 1G6
    Am J Physiol Cell Physiol 284:C33-43. 2003
    ..The presence of multiple connexins (Cxs) and their differential regulation suggest that these play different roles in epididymal development...
  35. ncbi request reprint Effects of FSH receptor deletion on epididymal tubules and sperm morphology, numbers, and motility
    Amit Grover
    Molecular Reproduction Research Laboratory, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Mol Reprod Dev 72:135-44. 2005
    ....
  36. ncbi request reprint Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility
    Louis Hermo
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Mol Reprod Dev 75:565-77. 2008
    ..HSL(-/-) mice also show a dramatic reduction in sperm counts and motility and are infertile...
  37. ncbi request reprint Microvillar size and espin expression in principal cells of the adult rat epididymis are regulated by androgens
    Nadia Primiani
    Department of Anatomy and Cell Biology, McGill University, 3640 University St, Montreal, Quebec, H3A 2B2, Canada
    J Androl 28:659-69. 2007
    ..Taken together, these data indicate that espin is expressed in the epididymis and is regulated by androgens...
  38. ncbi request reprint Osteopontin expression and regulation in the testis, efferent ducts, and epididymis of rats during postnatal development through to adulthood
    Chad C Luedtke
    Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    Biol Reprod 66:1437-48. 2002
    ..Taken together, the data reveal cell- and region-specific expression and regulation of OPN in the epididymis...
  39. ncbi request reprint Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1-/- mice
    Karine Khatchadourian
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    Mol Reprod Dev 74:341-59. 2007
    ....
  40. pmc Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein
    Ricardo Ruz
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Mol Reprod Dev 73:226-37. 2006
    ..Taken together the data underscore the importance of estrogens and ERalpha in maintaining sperm maturation and preventing male infertility...
  41. pmc Claudin-1 is a p63 target gene with a crucial role in epithelial development
    Teresa Lopardo
    Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy
    PLoS ONE 3:e2715. 2008
    ..These findings reinforce the hypothesis that these two genes might be linked in a common regulatory pathway and that Claudin-1 may is an important p63 target gene involved in the pathogenesis of ectodermal dysplasias...