Charles Butts

Summary

Affiliation: Cross Cancer Institute
Country: Canada

Publications

  1. ncbi A multicenter open-label study to assess the safety of a new formulation of BLP25 liposome vaccine in patients with unresectable stage III non-small-cell lung cancer
    Charles Butts
    Cross Cancer Institute, Edmonton, AB, Canada
    Clin Lung Cancer 11:391-5. 2010
  2. ncbi Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
    Charles Butts
    Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
    J Clin Oncol 23:6674-81. 2005
  3. ncbi An international, multicenter, randomized phase III study of first-line erlotinib followed by second-line cisplatin/gemcitabine versus first-line cisplatin/gemcitabine followed by second-line erlotinib in advanced non-small-cell lung cancer: treatment rat
    Cesare Gridelli
    Division of Medical Oncology, SG Moscati Hospital, Avellino, Italy
    Clin Lung Cancer 9:235-8. 2008
  4. ncbi A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases
    Oliver F Bathe
    Department of Surgery, University of Calgary, Calgary, Canada
    BMC Cancer 9:156. 2009
  5. ncbi Phase II study of neoadjuvant 5-FU + leucovorin + CPT-11 in patients with resectable liver metastases from colorectal adenocarcinoma
    Oliver F Bathe
    Department of Surgery, University of Calgary, AB, Canada
    BMC Cancer 4:32. 2004
  6. ncbi Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, as first-line therapy for patients with advanced or metastatic non small-cell lung cancer
    Charles A Butts
    Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, Canada
    J Clin Oncol 25:5777-84. 2007
  7. ncbi Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10
    Charles A Butts
    Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, Canada, T6G 1Z2
    J Clin Oncol 28:29-34. 2010
  8. ncbi Clinical trial of post-chemotherapy consolidation thoracic radiotherapy for extensive-stage small cell lung cancer
    Don Yee
    Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    Radiother Oncol 102:234-8. 2012
  9. ncbi Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): phase IIB randomized, multicenter, open-label trial
    Charles Butts
    Cross Cancer Institute, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada
    J Cancer Res Clin Oncol 137:1337-42. 2011
  10. ncbi Phase I dose escalation trial of hypofractionated limited-field external beam thoracic radiotherapy for limited-stage small cell carcinoma of the lung
    Don Yee
    Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alta, Canada
    Radiother Oncol 96:78-83. 2010

Detail Information

Publications24

  1. ncbi A multicenter open-label study to assess the safety of a new formulation of BLP25 liposome vaccine in patients with unresectable stage III non-small-cell lung cancer
    Charles Butts
    Cross Cancer Institute, Edmonton, AB, Canada
    Clin Lung Cancer 11:391-5. 2010
    ..This open-label phase II study was conducted to evaluate the safety of the new formulation in patients with unresectable stage IIIA/IIIB NSCLC...
  2. ncbi Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
    Charles Butts
    Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
    J Clin Oncol 23:6674-81. 2005
    ..Secondary objectives included health-related quality of life (QOL) and immune responses elicited by L-BLP25...
  3. ncbi An international, multicenter, randomized phase III study of first-line erlotinib followed by second-line cisplatin/gemcitabine versus first-line cisplatin/gemcitabine followed by second-line erlotinib in advanced non-small-cell lung cancer: treatment rat
    Cesare Gridelli
    Division of Medical Oncology, SG Moscati Hospital, Avellino, Italy
    Clin Lung Cancer 9:235-8. 2008
    ..The study design is based on a noninferiority survival comparison with about 900 patients expected to be recruited. An early analysis of activity will be performed in the experimental arm (first-line erlotinib followed by chemotherapy)...
  4. ncbi A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases
    Oliver F Bathe
    Department of Surgery, University of Calgary, Calgary, Canada
    BMC Cancer 9:156. 2009
    ..Neoadjuvant chemotherapy may help identify patients with occult extrahepatic disease (averting unnecessary metastasectomy), and it provides in vivo chemosensitivity data...
  5. ncbi Phase II study of neoadjuvant 5-FU + leucovorin + CPT-11 in patients with resectable liver metastases from colorectal adenocarcinoma
    Oliver F Bathe
    Department of Surgery, University of Calgary, AB, Canada
    BMC Cancer 4:32. 2004
    ..The primary endpoint of the study is disease-free survival. Secondary endpoints include overall survival, safety and feasibility, response to chemotherapy, and quality of life...
  6. ncbi Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, as first-line therapy for patients with advanced or metastatic non small-cell lung cancer
    Charles A Butts
    Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, Canada
    J Clin Oncol 25:5777-84. 2007
    ..To evaluate the efficacy of cetuximab added to first-line gemcitabine/platinum in chemotherapy-naïve patients with advanced non-small-cell lung cancer (NSCLC)...
  7. ncbi Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10
    Charles A Butts
    Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, Canada, T6G 1Z2
    J Clin Oncol 28:29-34. 2010
    ..10 trial continues to show a benefit in survival for adjuvant chemotherapy. This benefit appears to be confined to N1 patients. There was no increase in death from other causes in the chemotherapy arm...
  8. ncbi Clinical trial of post-chemotherapy consolidation thoracic radiotherapy for extensive-stage small cell lung cancer
    Don Yee
    Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    Radiother Oncol 102:234-8. 2012
    ..To define the rate of development of symptomatic chest failures in extensive stage small cell lung cancer (ES-SCLC) after undergoing post-chemotherapy chest radiotherapy (RT)...
  9. ncbi Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): phase IIB randomized, multicenter, open-label trial
    Charles Butts
    Cross Cancer Institute, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada
    J Cancer Res Clin Oncol 137:1337-42. 2011
    ..To present an updated survival analysis of an open-label, parallel-group, phase IIB trial of BLP25 liposome vaccine (L-BLP25) in patients with stage IIIB or IV non-small-cell lung cancer (NSCLC)...
  10. ncbi Phase I dose escalation trial of hypofractionated limited-field external beam thoracic radiotherapy for limited-stage small cell carcinoma of the lung
    Don Yee
    Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alta, Canada
    Radiother Oncol 96:78-83. 2010
    ..To define the maximal tolerated dose of hypofractionated thoracic radiotherapy given with concurrent chemotherapy for limited-stage small cell lung cancer...
  11. ncbi Class III beta-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR.10
    Pascal Seve
    Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 13:994-9. 2007
    ..We sought to determine the effect of bTubIII on patient outcome and benefit from adjuvant chemotherapy in the JBR.10 trial...
  12. ncbi Phase I study of hypofractionated dose-escalated thoracic radiotherapy for limited-stage small-cell lung cancer
    Don Yee
    Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    Int J Radiat Oncol Biol Phys 65:466-73. 2006
    ..To determine the maximal tolerated dose of hypofractionated thoracic radiotherapy with concurrent chemotherapy for limited-stage small-cell lung cancer patients...
  13. ncbi Uptake and tolerance of adjuvant chemotherapy in early stage NSCLC patients in Alberta, Canada
    Marcy Winget
    Cancer Care, Alberta Health Services, 10123 99 Street, Suite 1500, Edmonton, Alberta, T5J 3H1 Canada
    Lung Cancer 72:52-8. 2011
    ..Efforts to improve uptake of adjuvant chemotherapy in patients with stage II NSCLC should be made as the survival advantage appears to be comparable to that found in clinical trials...
  14. ncbi Predictors of surgery and consult with an oncologist for adjuvant chemotherapy in early stage NSCLC patients in Alberta, Canada
    Marcy Winget
    Medical Affairs and Community Oncology Alberta Cancer Board, Alberta, Canada
    J Thorac Oncol 4:629-34. 2009
    ....
  15. ncbi L-BLP25: a peptide vaccine strategy in non small cell lung cancer
    Randeep Sangha
    Cross Cancer Institute, Edmonton, Alberta, Canada
    Clin Cancer Res 13:s4652-4. 2007
    ..These promising results will be tested in a phase III trial of L-BLP25 versus placebo in patients with stage III non-small cell lung cancer after response to primary chemoradiotherapy...
  16. ncbi Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers
    Scott North
    Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada
    Expert Rev Vaccines 4:249-57. 2005
    ..These clinically meaningful results with a relatively nontoxic therapeutic vaccine are very encouraging and suggest potential for L-BLP25 to fulfill an unmet medical need...
  17. ncbi Timeliness of cancer care from diagnosis to treatment: a comparison between patients with breast, colon, rectal or lung cancer
    Xue Li
    Cancer Care, Alberta Health Services, Edmonton, Alberta, Canada
    Int J Qual Health Care 25:197-204. 2013
    ....
  18. ncbi Uptake and tolerance of chemotherapy in elderly patients with small cell lung cancer and impact on survival
    Stacey Fisher
    School of Public Health, University of Alberta, Edmonton, Alberta, Canada T6G 1C9
    J Cancer Epidemiol 2012:708936. 2012
    ....
  19. ncbi Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer
    Caroline L Holloway
    Department of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alta, Canada T6G 1Z2
    Radiother Oncol 73:285-7. 2004
    ..One patient developed a grade 5 pneumonitis and the study was halted at 84 Gy in 35 fractions...
  20. ncbi Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
    Timothy Winton
    National Cancer Institute of Canada Clinical Trials Group, Kingston, Ont
    N Engl J Med 352:2589-97. 2005
    ..We undertook to determine whether adjuvant vinorelbine plus cisplatin prolongs overall survival among patients with completely resected early-stage non-small-cell lung cancer...
  21. ncbi Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR.20
    Andrew M Arnold
    National Cancer Institute of Canada Clinical Trials Group, Kingston, Ontario, Canada
    J Clin Oncol 25:4278-84. 2007
    ..This double-blind randomized phase II trial examined whether vandetanib, an inhibitor of vascular endothelial and epidermal growth factor receptors, could prolong progression-free survival in responding patients with small-cell lung cancer...
  22. ncbi Community compliance with carcinoembryonic antigen: follow-up of patients with colorectal cancer
    Jennifer L Spratlin
    Faculty of Medicine and Dentistry, Department of Medicine, Division of Medical Oncology, University of Alberta, Canada
    Clin Colorectal Cancer 7:118-25. 2008
    ....
  23. ncbi Novel agents in the treatment of lung cancer: Fourth Cambridge Conference
    Thomas J Lynch
    Division of Hematology Oncology, Massachusetts General Hospital, 55 Fruit Street, Yawkey, 7th Floor, Suite 7601, Boston, MA 02114, USA
    Clin Cancer Res 13:s4583-8. 2007
    ....
  24. ncbi XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer
    Jim Cassidy
    CRC Department of Oncology, University of Glasgow, Garscube Estate, Bearsden, Glasgow G61 1DB, United Kingdom
    J Clin Oncol 22:2084-91. 2004
    ..The present studies further characterize efficacy and safety of the XELOX regimen...