Research Topics
| S J ConnollySummaryCountry: Canada Publications
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Publications
The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncopeS J Connolly
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Am Coll Cardiol 33:16-20. 1999..This study was done to evaluate pacemaker therapy for severe recurrent vasovagal syncope...
Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodaroneS J Connolly
Departments of Medicine, McMaster University, Hamilton, Ontario, Canada
Circulation 101:1297-302. 2000..The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with medical therapy with amiodarone...
Appropriate outcome measures in trials evaluating treatment of atrial fibrillationS J Connolly
McMaster University, Hamilton, Canada
Am Heart J 139:752-60. 2000..Atrial fibrillation (AF) is a widespread disease that has only recently received the focused attention of arrhythmia specialists despite being the most frequently occurring significant cardiac arrhythmia...
Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing InvestigatorsS J Connolly
Department of Medicine, McMaster University, Hamilton, Ont, Canada
N Engl J Med 342:1385-91. 2000..These benefits have not been evaluated in a large, randomized, controlled trial...
Irbesartan in patients with atrial fibrillationSalim Yusuf
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
N Engl J Med 364:928-38. 2011..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
Apixaban in patients with atrial fibrillationStuart J Connolly
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 364:806-17. 2011..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
Cost-effectiveness of the implantable cardioverter-defibrillator: results from the Canadian Implantable Defibrillator Study (CIDS)S J Connolly
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Circulation 103:1416-21. 2001..Further research is warranted to identify the indications and patient subgroups for whom ICDs are a cost-effective use of resources...
Effect of a simple two-step warfarin dosing algorithm on anticoagulant control as measured by time in therapeutic range: a pilot studyY K Kim
Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton, ON, Canada
J Thromb Haemost 8:101-6. 2010....
Dose-response relations of azimilide in the management of symptomatic, recurrent, atrial fibrillationS J Connolly
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Cardiol 88:974-9. 2001..9% of patients receiving either of the 2 effective doses. Thus, doses of azimilide <100 mg/day are not effective for control of AF, whereas doses of 100 and 125 mg/day are effective with an acceptable risk of serious toxicity...
Randomised comparison of a simple warfarin dosing algorithm versus a computerised anticoagulation management system for control of warfarin maintenance therapyRobby Nieuwlaat
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Thromb Haemost 108:1228-35. 2012..4% to 4.1%]; p-value for non-inferiority=0.002; p-value for superiority=0.34). In conclusion, similar maintenance control of the INR was achieved with a simple one-step dosing algorithm and a commercial computerised management system...
Defibrillation testing at the time of ICD insertion: an analysis from the Ontario ICD RegistryJ S Healey
Population Health Research Institute and McMaster University, Hamilton, Canada
J Cardiovasc Electrophysiol 21:1344-8. 2010..increasingly, ICD implantation is performed without defibrillation testing (DT)...
Dabigatran versus warfarin in patients with atrial fibrillationStuart J Connolly
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 361:1139-51. 2009..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysisS Miller
Arrhythmia Services, Schulich Heart Centre, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Heart 91:618-23. 2005..22, 95% CI 0.39 to 3.77). CONCLUSION: Magnesium administration is an effective prophylactic measure for the prevention of postoperative AF. It does not significantly alter LOS or in-hospital mortality...
