S Connolly

Summary

Country: Canada

Publications

  1. ncbi request reprint Preventing stroke in patients with atrial fibrillation: current treatments and new concepts
    Stuart J Connolly
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:418-23. 2003
  2. doi request reprint The Long-Term Multicenter Observational Study of Dabigatran Treatment in Patients With Atrial Fibrillation (RELY-ABLE) Study
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton
    Circulation 128:237-43. 2013
  3. pmc Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)
    Stuart J Connolly
    Population Health Research Institute, 237 Barton Street East, Hamilton, Ontario, Canada
    Eur Heart J 34:1498-505. 2013
  4. doi request reprint Randomized cluster crossover trials for reliable, efficient, comparative effectiveness testing: design of the Prevention of Arrhythmia Device Infection Trial (PADIT)
    Stuart J Connolly
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:652-8. 2013
  5. ncbi request reprint Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
  6. doi request reprint Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 118:2029-37. 2008
  7. doi request reprint Analysis of stroke in ATHENA: a placebo-controlled, double-blind, parallel-arm trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation/atrial
    Stuart J Connolly
    FRCPC, Division of Cardiology, Hamilton Health Sciences, General Site, 502 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada
    Circulation 120:1174-80. 2009
  8. ncbi request reprint Challenges of establishing new antithrombotic therapies in atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 116:449-55. 2007
  9. doi request reprint Dronedarone in high-risk permanent atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    N Engl J Med 365:2268-76. 2011
  10. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009

Detail Information

Publications64

  1. ncbi request reprint Preventing stroke in patients with atrial fibrillation: current treatments and new concepts
    Stuart J Connolly
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:418-23. 2003
    ..A direct thrombin inhibitor, ximelagatran, has been shown to have an excellent pharmacokinetic profile and is being developed as an oral agent for stroke prevention in AF, and it will not need regular monitoring...
  2. doi request reprint The Long-Term Multicenter Observational Study of Dabigatran Treatment in Patients With Atrial Fibrillation (RELY-ABLE) Study
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton
    Circulation 128:237-43. 2013
    ..There is a need for longer-term follow-up of patients on dabigatran and for further data comparing the 2 dabigatran doses...
  3. pmc Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)
    Stuart J Connolly
    Population Health Research Institute, 237 Barton Street East, Hamilton, Ontario, Canada
    Eur Heart J 34:1498-505. 2013
    ..Patients with atrial fibrillation (AF) are at increased risk of stroke. Betrixaban is a novel oral factor Xa inhibitor administered once daily, mostly excreted unchanged in the bile and with low (17%) renal excretion...
  4. doi request reprint Randomized cluster crossover trials for reliable, efficient, comparative effectiveness testing: design of the Prevention of Arrhythmia Device Infection Trial (PADIT)
    Stuart J Connolly
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:652-8. 2013
    ..The cluster crossover randomized trial design is well suited to efficiently test comparative effectiveness of existing treatments where there is variability of practice, clinical equipoise, and minimal risk...
  5. ncbi request reprint Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
    ..However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation. We assessed whether clopidogrel plus aspirin was non-inferior to oral anticoagulation therapy for prevention of vascular events...
  6. doi request reprint Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 118:2029-37. 2008
    ..This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC therapy...
  7. doi request reprint Analysis of stroke in ATHENA: a placebo-controlled, double-blind, parallel-arm trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation/atrial
    Stuart J Connolly
    FRCPC, Division of Cardiology, Hamilton Health Sciences, General Site, 502 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada
    Circulation 120:1174-80. 2009
    ....
  8. ncbi request reprint Challenges of establishing new antithrombotic therapies in atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 116:449-55. 2007
  9. doi request reprint Dronedarone in high-risk permanent atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    N Engl J Med 365:2268-76. 2011
    ..It also lowers heart rate and blood pressure and has antiadrenergic and potential ventricular antiarrhythmic effects. We hypothesized that dronedarone would reduce major vascular events in high-risk permanent atrial fibrillation...
  10. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  11. ncbi request reprint Depression and risk of sudden cardiac death after acute myocardial infarction: testing for the confounding effects of fatigue
    J Irvine
    Toronto General Hospital, University Health Network, Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychosom Med 61:729-37. 1999
    ..This study examined the impact of depressive symptoms and social support on 2-year sudden cardiac death (SCD) risk, controlling for fatigue symptoms...
  12. ncbi request reprint Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events
    S Connolly
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am Heart J 151:1187-93. 2006
    ..Irbesartan is an angiotensin receptor-blocking agent that reduces blood pressure and has other vascular protective effects...
  13. doi request reprint Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation
    Jeffrey I Weitz
    Thrombosis and Atherosclerosis Research Institute, Hamilton General Hospital, Ontario, Canada
    Thromb Haemost 104:633-41. 2010
    ..In contrast, the edoxaban bid regimens were associated with more bleeding than warfarin. These results suggest that in this three-month study, edoxaban 30 or 60 mg qd are safe and well-tolerated...
  14. ncbi request reprint Prevention of vascular events in patients with atrial fibrillation: evidence, guidelines, and practice
    Stuart J Connolly
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Cardiovasc Electrophysiol 14:S52-5. 2003
    ..Many patients do not receive anticoagulation therapy despite its proven benefits...
  15. doi request reprint Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...
  16. doi request reprint Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment
    John W Eikelboom
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Am Heart J 159:348-353.e1. 2010
    ..Apixaban may be an attractive alternative to ASA for prevention of stroke in patients with AF who cannot or will not take a VKA...
  17. ncbi request reprint Long-term amiodarone therapy and the risk of complications after cardiac surgery: results from the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT)
    Eugene Crystal
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 125:633-7. 2003
    ....
  18. ncbi request reprint Poor adherence to placebo or amiodarone therapy predicts mortality: results from the CAMIAT study. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial
    J Irvine
    The Toronto Hospital, Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychosom Med 61:566-75. 1999
    ..This study examined the relationship between adherence, mortality, and psychosocial factors...
  19. doi request reprint Underuse of evidence-based warfarin dosing methods for atrial fibrillation patients
    Robby Nieuwlaat
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Thromb Res 125:e128-31. 2010
    ..We assessed to what extent generalist and specialist physicians use evidence-based methods for warfarin maintenance dosing...
  20. doi request reprint Atrial fibrillation in 2010: advances in treatment and management
    Stuart J Connolly
    McMaster University, Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario, Canada
    Nat Rev Cardiol 8:67-8. 2011
    ..In 2010, important advances have been made in stroke prevention with new anticoagulants and in atrial fibrillation rhythm management...
  21. doi request reprint Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  22. pmc Role of oral anticoagulation in management of atrial fibrillation
    Eugene Crystal
    Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Heart 90:813-7. 2004
  23. ncbi request reprint Prognostic differences between atrial fibrillation and atrial flutter
    Paul Lelorier
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am J Cardiol 93:647-9. 2004
    ..We also evaluated warfarin use over time and compared left atrial dimensions in patients with atrial flutter with those with atrial fibrillation...
  24. ncbi request reprint Symptoms at the time of arrhythmia recurrence in patients receiving azimilide for control of atrial fibrillation or flutter: results from randomized trials
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 146:489-93. 2003
    ..This paper examines the data collected during those studies regarding the symptoms reported by patients at the time of AF recurrence..
  25. doi request reprint Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 363:1704-14. 2010
    ....
  26. ncbi request reprint Atrial fibrillation after cardiac surgery: update on the evidence on the available prophylactic interventions
    Eugene Crystal
    Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Card Electrophysiol Rev 7:189-92. 2003
    ..Amiodarone and bi-atrial pacing may decrease the length of hospital stay...
  27. ncbi request reprint Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 295:165-71. 2006
    ..Implantable cardioverter defibrillator (ICD) therapy is effective but is associated with high-voltage shocks that are painful...
  28. ncbi request reprint Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis
    Eugene Crystal
    Division of Cardiology, Faculty of Health Sciences, McMaster University, Ontario, Hamilton, Canada
    Circulation 106:75-80. 2002
    ..To better understand the role of various prophylactic therapies against postoperative AF, a systematic review of evidence from randomized trials was performed...
  29. ncbi request reprint Quality of life improves with treatment in the Canadian Trial of Atrial Fibrillation
    Paul Dorian
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 143:984-90. 2002
    ..The impact of atrial fibrillation (AF) and its treatment on health-related quality of life (QOL) is not well understood. We assessed QOL in patients with symptomatic AF participating in the Canadian Trial of Atrial Fibrillation...
  30. ncbi request reprint Therapies for the prevention of stroke and other vascular events in atrial fibrillation and atrial flutter
    Stuart J Connolly
    McMaster University, Hamilton, Ontario
    Can J Cardiol 21:71B-73B. 2005
    ..Acetylsalicylic acid is less effective than oral anticoagulants but better tolerated. Anticoagulants are recommended for AF patients with risk factors for stroke...
  31. doi request reprint A systematic review of randomized trials comparing radiofrequency ablation with antiarrhythmic medications in patients with atrial fibrillation
    Girish M Nair
    Division of Cardiology, Arrhythmia Service, McMaster University and Hamilton Health Sciences, Ontario, Canada
    J Cardiovasc Electrophysiol 20:138-44. 2009
    ..Several randomized trials comparing RF ablation with antiarrhythmic medications have now been published...
  32. ncbi request reprint Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 289:2224-9. 2003
    ..However, because these trials were not double blind, they may have been biased in their assessment of outcomes and had a placebo effect of surgery...
  33. ncbi request reprint Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-Blocker Length Of Stay (BLOS) study
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:226-32. 2003
    ..No previous trials have been primarily directed at demonstrating that the use of drugs that prevent AF would shorten length of stay and reduce the costs of postoperative care...
  34. ncbi request reprint Left Atrial Appendage Occlusion Study (LAAOS): a randomized clinical trial of left atrial appendage occlusion during routine coronary artery bypass graft surgery for long-term stroke prevention
    Eugene Crystal
    McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:174-8. 2003
    ..The left atrial appendage (LAA) is a main source of thrombus coming from the left atrium. LAA occlusion should be tested as a means to reduce future cerebral ischemic events in these patients...
  35. ncbi request reprint Quality of life in the Canadian Implantable Defibrillator Study (CIDS)
    Jane Irvine
    Department of Psychology, York University, University of Toronto, Ontario, Canada
    Am Heart J 144:282-9. 2002
    ..A secondary aim was to evaluate the effects on quality-of-life outcomes of receiving shocks from the device...
  36. ncbi request reprint Role of the renin-angiotensin-aldosterone system in atrial fibrillation and cardiac remodeling
    Jeff S Healey
    McMaster University, Hamilton, Ontario, Canada
    Curr Opin Cardiol 20:31-7. 2005
    ..It then explores the possible mechanisms for this effect based on current animal models and limited human study...
  37. ncbi request reprint Atrial overdrive pacing in sleep apnoea: a meta-analysis
    Adrian Baranchuk
    Cardiac Electrophysiology and Pacing, Kingston General Hospital, Queen s University, FAPC 3, 76 Stuart Street, Kingston, ON, Canada
    Europace 11:1037-40. 2009
    ....
  38. doi request reprint Postoperative low-molecular-weight heparin bridging is associated with an increase in wound hematoma following surgery for pacemakers and implantable defibrillators
    Marlene Robinson
    Department of Medicine, McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada
    Pacing Clin Electrophysiol 32:378-82. 2009
    ..Low-molecular-weight heparin (LMWH) is often used; however, wound hematoma is a common complication...
  39. ncbi request reprint Canadian Trial of Physiological Pacing: Effects of physiological pacing during long-term follow-up
    Charles R Kerr
    Room 344, Division of Cardiology, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada, V6Z 1Y6
    Circulation 109:357-62. 2004
    ..However, the occurrence of atrial fibrillation was significantly less frequent with physiological pacemakers. To assess a potential delayed benefit of physiological pacing, follow-up of patients in this study was extended to 6 years...
  40. ncbi request reprint Left Atrial Appendage Occlusion Study (LAAOS): results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for stroke
    Jeff S Healey
    McMaster University, Hamilton, Ontario, Canada
    Am Heart J 150:288-93. 2005
    ..This pilot study assessed the safety and efficacy of left atrial appendage (LAA) occlusion, performed at the time of coronary artery bypass grafting (CABG)...
  41. ncbi request reprint Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential therapeutic target
    Jeff S Healey
    McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 91:9G-14G. 2003
    ..Specific pharmacotherapy could potentially play a major role in the primary and secondary prevention of atrial fibrillation and its complications...
  42. pmc Stroke prevention in patients with atrial fibrillation: the diagnosis and management of hypertension by specialists
    Jeff S Healey
    McMaster University, Hamilton, Ontario
    Can J Cardiol 22:485-8. 2006
    ..Hypertension is common in patients with atrial fibrillation (AF) and is an important cause of stroke...
  43. ncbi request reprint Diminishing proportional risk of sudden death with advancing age: implications for prevention of sudden death
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 147:837-40. 2004
    ..We sought to determine the effect of advancing age on the mode of death in the Amiodarone Trialists Metanalysis...
  44. ncbi request reprint Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis
    Jeff S Healey
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 45:1832-9. 2005
    ....
  45. ncbi request reprint Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data
    Jeffrey S Healey
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada, L8L 2X2
    Circulation 114:11-7. 2006
    ..No trial has shown a mortality reduction, and only 1 small trial suggested a reduction in stroke. The goal of this review was to determine whether atrial-based pacing prevents major cardiovascular events...
  46. ncbi request reprint The association of left atrial size and occurrence of atrial fibrillation: a prospective cohort study from the Canadian Registry of Atrial Fibrillation
    Ratika Parkash
    University of Ottawa, Ottawa, Ontario, Canada
    Am Heart J 148:649-54. 2004
    ..We evaluated the effect of LA dimension on the occurrence of AF using 2- and 4-year echocardiographic data in a large cohort of patients with new onset AF...
  47. ncbi request reprint Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy
    Stefan H Hohnloser
    Department of Cardiology, Division of Electrophysiology, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 50:2156-61. 2007
    ..Our goal was to determine the risk of stroke or non-cerebral embolism associated with paroxysmal compared with sustained atrial fibrillation (AF)...
  48. doi request reprint Antithrombotic drug development for atrial fibrillation: proceedings, Washington, DC, July 25-27, 2005
    Kevin Jackson
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 155:829-40. 2008
    ..With this summary document, we hope to provide a helpful resource for future drug development for AF...
  49. ncbi request reprint Combined antiplatelet therapy in atrial fibrillation: review of the literature and future avenues
    Stefan H Hohnloser
    Department of Medicine, J W Goethe University Hospital, Frankfurt, Germany
    J Cardiovasc Electrophysiol 14:S60-3. 2003
    ..The ACTIVE program began patient enrollment in spring 2003...
  50. ncbi request reprint Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: an exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials
    Greg C Flaker
    Department of Medicine, University of Missouri Columbia, Columbia, MO, USA
    Am Heart J 152:967-73. 2006
    ..Aspirin is used in combination with anticoagulant therapy in patients with atrial fibrillation (AF), but evidence of additional efficacy is not available...
  51. ncbi request reprint Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: results from the Canadian Registry of Atrial Fibrillation
    Charles R Kerr
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Am Heart J 149:489-96. 2005
    ..After its initial diagnosis, atrial fibrillation (AF) may progress from paroxysmal to chronic AF (CAF). The rate of progression and risk factors for progression are not clearly defined...
  52. ncbi request reprint Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillation
    Edward L C Pritchett
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Clin Pharmacol 42:388-94. 2002
    ..It was concluded that in patients with a history of atrial fibrillation or flutter, azimilide was associated with statistically significant increases in RR, QT, QTc(Bazett), and QTc(Fridericia) when patients were in sinus rhythm...
  53. ncbi request reprint Asymptomatic or "silent" atrial fibrillation: frequency in untreated patients and patients receiving azimilide
    Richard L Page
    Cardiovascular Division, Clinical Cardiac Electrophysiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, USA
    Circulation 107:1141-5. 2003
    ....
  54. ncbi request reprint Atrial fibrillation: guiding lessons from epidemiology
    Eugene Crystal
    University of Toronto, Schulich Heart Centre, Sunnybrook and Women s College Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Cardiol Clin 22:1-8. 2004
    ..Hypertension may be the most common primary etiology of AF, and the possibility of effective primary prevention of AF by strict control of hypertension needs to be evaluated adequately...
  55. ncbi request reprint Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 114:104-9. 2006
    ..The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial...
  56. ncbi request reprint Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart disease
    Charles R Kerr
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 98:215-8. 2006
    ..56, p=0.11), and overall group (hazard ratio 1.22, 95% confidence interval 1.00 to 1.49, p=0.053). No patient died. In conclusion, azimilide showed a nonsignificant trend toward efficacy in maintaining sinus rhythm in patients with AF...
  57. ncbi request reprint ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT)
    Stefan H Hohnloser
    Division of Electrophysiology, Department of Cardiology, J W Goethe University, Frankfurt, Germany
    Am Heart J 152:442-7. 2006
    ..This substudy will determine if atrial electrical remodeling is detectable in pacemaker patients and if it is associated with the development of AF...
  58. ncbi request reprint Worsening of symptoms before presentation with vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada
    J Cardiovasc Electrophysiol 18:954-9. 2007
    ..Much of the natural history of vasovagal syncope is unknown. We determined whether patients presenting for care have had a recently worsened syncope frequency...
  59. ncbi request reprint Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter
    Bramah N Singh
    Cardiology Division, Veterans Affairs Greater Los Angeles Healthcare System and the David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    N Engl J Med 357:987-99. 2007
    ..Dronedarone is a new antiarrhythmic agent pharmacologically related to amiodarone but developed to reduce the risk of side effects...
  60. ncbi request reprint Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atria
    Stefan H Hohnloser
    J W Goethe University, Department of Cardiology, Frankfurt, Germany
    J Cardiovasc Electrophysiol 19:69-73. 2008
    ..There is a continued need for new antiarrhythmic drugs to treat the ever-increasing number of patients with this arrhythmia. Dronedarone is a new antiarrhythmic compound currently being developed for treatment of AF...
  61. ncbi request reprint Atrial deformation: the key to maintenance of sinus rhythm in patients with atrial fibrillation?
    Hisham Dokainish
    Eur Heart J 29:1483-4. 2008
  62. ncbi request reprint Rhythm control versus rate control for atrial fibrillation and heart failure
    Denis Roy
    Montreal Heart Institute and the Université de Montréal, Montreal, QC H1T 1C8, Canada
    N Engl J Med 358:2667-77. 2008
    ..However, the benefits and risks of this approach have not been adequately studied...
  63. doi request reprint Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
    Jose Antonio Marin-Neto
    Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Am Heart J 156:37-43. 2008
    ..However, the efficacy of trypanocidal therapy in preventing clinical complications in patients with preexisting cardiac disease is unknown...