J Stewart

Summary

Affiliation: Concordia University
Country: Canada

Publications

  1. ncbi request reprint Stress and relapse to drug seeking: studies in laboratory animals shed light on mechanisms and sources of long-term vulnerability
    Jane Stewart
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Am J Addict 12:1-17. 2003
  2. ncbi request reprint Disentangling the sources of opioid withdrawal responses: comment on McDonald and Siegel (2004)
    Jane Stewart
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, PQ, Canada
    Exp Clin Psychopharmacol 12:20-2; discussion 23-6. 2004
  3. ncbi request reprint Modulation of the subjective and physiological effects of drugs by contexts and expectations--the search for mechanisms: comment on Alessi, Roll, Reilly, and Johanson (2002)
    Jane Stewart
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Exp Clin Psychopharmacol 10:96-8; discussion 101-3. 2002
  4. ncbi request reprint The effects of gonadal hormones on the development and expression of the stimulant effects of morphine in male and female rats
    J Stewart
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Behav Brain Res 102:89-98. 1999
  5. pmc Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking
    J Stewart
    Department of Psychology, Concordia University, Montreal, Que
    J Psychiatry Neurosci 25:125-36. 2000
  6. ncbi request reprint Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking
    S Erb
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Quebec, Montreal, Canada
    Neuropsychopharmacology 23:138-50. 2000
  7. doi request reprint Double-stranded RNA-mediated suppression of Period2 expression in the suprachiasmatic nucleus disrupts circadian locomotor activity in rats
    A M Gavrila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, QC, Canada
    Neuroscience 154:409-14. 2008
  8. ncbi request reprint Restricted access to food, but not sucrose, saccharine, or salt, synchronizes the expression of Period2 protein in the limbic forebrain
    E Waddington Lamont
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, Quebec, Canada
    Neuroscience 144:402-11. 2007
  9. ncbi request reprint Drug-induced reinstatement to heroin and cocaine seeking: a rodent model of relapse in polydrug use
    F Leri
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
    Exp Clin Psychopharmacol 9:297-306. 2001
  10. ncbi request reprint Differential regulation of the expression of Period2 protein in the limbic forebrain and dorsomedial hypothalamus by daily limited access to highly palatable food in food-deprived and free-fed rats
    M Verwey
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, 7141 Sherbrooke Street West, Montreal, Quebec, Canada H4B 1R6
    Neuroscience 147:277-85. 2007

Research Grants

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Stress and relapse to drug seeking: studies in laboratory animals shed light on mechanisms and sources of long-term vulnerability
    Jane Stewart
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Am J Addict 12:1-17. 2003
    ..One implication of such findings for the treatment of addiction is that whatever approach is taken, treatment will have to be multifaceted and maintained over an extended period of time after the initial termination of drug use...
  2. ncbi request reprint Disentangling the sources of opioid withdrawal responses: comment on McDonald and Siegel (2004)
    Jane Stewart
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, PQ, Canada
    Exp Clin Psychopharmacol 12:20-2; discussion 23-6. 2004
    ..In this comment, some puzzling features of the data are discussed, and alternative explanations are suggested...
  3. ncbi request reprint Modulation of the subjective and physiological effects of drugs by contexts and expectations--the search for mechanisms: comment on Alessi, Roll, Reilly, and Johanson (2002)
    Jane Stewart
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Exp Clin Psychopharmacol 10:96-8; discussion 101-3. 2002
    ..It must be considered, however, that even the acute effects of drugs can be significantly altered by the context in which they are administered. The challenge is to determine the mechanisms operating to bring about these changes...
  4. ncbi request reprint The effects of gonadal hormones on the development and expression of the stimulant effects of morphine in male and female rats
    J Stewart
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Behav Brain Res 102:89-98. 1999
    ....
  5. pmc Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking
    J Stewart
    Department of Psychology, Concordia University, Montreal, Que
    J Psychiatry Neurosci 25:125-36. 2000
    ..By contrast, relapse induced by "priming" injections of drugs is relatively unaffected by manipulation of CRF and NE systems of the brain...
  6. ncbi request reprint Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking
    S Erb
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Quebec, Montreal, Canada
    Neuropsychopharmacology 23:138-50. 2000
    ..The results point to an important role for NE systems in the effects of footshock on relapse to cocaine seeking...
  7. doi request reprint Double-stranded RNA-mediated suppression of Period2 expression in the suprachiasmatic nucleus disrupts circadian locomotor activity in rats
    A M Gavrila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, QC, Canada
    Neuroscience 154:409-14. 2008
    ..These results constitute evidence for a direct link between PER2 expression in the SCN and the expression of behavioral circadian rhythms in mammals...
  8. ncbi request reprint Restricted access to food, but not sucrose, saccharine, or salt, synchronizes the expression of Period2 protein in the limbic forebrain
    E Waddington Lamont
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, Quebec, Canada
    Neuroscience 144:402-11. 2007
    ....
  9. ncbi request reprint Drug-induced reinstatement to heroin and cocaine seeking: a rodent model of relapse in polydrug use
    F Leri
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
    Exp Clin Psychopharmacol 9:297-306. 2001
    ..These results suggest that in this type of polydrug use, drugs have the capacity to activate drug-seeking behavior selectively oriented toward stimuli previously associated with their administration...
  10. ncbi request reprint Differential regulation of the expression of Period2 protein in the limbic forebrain and dorsomedial hypothalamus by daily limited access to highly palatable food in food-deprived and free-fed rats
    M Verwey
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, 7141 Sherbrooke Street West, Montreal, Quebec, Canada H4B 1R6
    Neuroscience 147:277-85. 2007
    ..These findings demonstrate that mechanisms leading to changes in the expression of PER2 and those affecting the induction of Fos under RF and RT are, at least in part, dissociable...
  11. doi request reprint Effects of chronic buprenorphine treatment on levels of nucleus accumbens glutamate and on the expression of cocaine-induced behavioral sensitization in rats
    F M Placenza
    Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada
    Psychopharmacology (Berl) 200:347-55. 2008
    ..Chronic treatment with the mu-opioid receptor agonist, buprenorphine, reduces cocaine-induced behaviors in rats with a history of cocaine self-administration. The mechanisms underlying these actions of buprenorphine remain unclear...
  12. ncbi request reprint Stress-induced relapse to drug seeking in the rat: role of the bed nucleus of the stria terminalis and amygdala
    S Erb
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 De Maisonneuve Blvd W, Montreal, Que, Canada
    Stress 4:289-303. 2001
    ....
  13. ncbi request reprint Methadone maintenance reduces heroin- and cocaine-induced relapse without affecting stress-induced relapse in a rodent model of poly-drug use
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada
    Neuropsychopharmacology 29:1312-20. 2004
    ..These results suggest that although methadone maintenance may not reduce the direct stimulatory effects of cocaine, it has the potential to reduce both spontaneous and cocaine-primed cocaine-seeking behavior...
  14. ncbi request reprint Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area
    D Rodaros
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Room SP244, 7141 Sherbrooke Street West, Montreal, Quebec, Canada H4B 1R6
    Neuroscience 150:8-13. 2007
    ..The percent of fluorogold-labeled cells in each region that were CRF-positive was 30.8, 28.0 and 16.7% respectively. These data point to diffusely distributed sources of CRF-containing fibers in the VTA...
  15. ncbi request reprint A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats
    S Erb
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 158:360-5. 2001
    ..CONCLUSION: These results suggest that the CRF-containing pathway from CeA to BNST is involved in mediating the effects of CRF and its receptor antagonist in the BNST on the reinstatement of cocaine seeking...
  16. ncbi request reprint Amphetamine induces dendritic growth in ventral tegmental area dopaminergic neurons in vivo via basic fibroblast growth factor
    D Mueller
    Center for Studies in Behavioral Neurobiology SP 244, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec, Canada H4B 1R6
    Neuroscience 137:727-35. 2006
    ..We propose that the amphetamine-induced elaboration of the dendritic arbor of dopaminergic neurons leads to their increased excitability and contributes to compulsive drug-seeking and relapse...
  17. ncbi request reprint Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine
    C Flores
    Department of Neurology and Neurosurgery, Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Mol Psychiatry 10:606-12. 2005
    ....
  18. ncbi request reprint Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatement
    Robert E Sorge
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
    Neuropsychopharmacology 30:1681-92. 2005
    ....
  19. doi request reprint Region-specific modulation of PER2 expression in the limbic forebrain and hypothalamus by nighttime restricted feeding in rats
    Michael Verwey
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Neurosci Lett 440:54-8. 2008
    ....
  20. doi request reprint Daily morphine injection and withdrawal disrupt 24-h wheel running and PERIOD2 expression patterns in the rat limbic forebrain
    S Hood
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada
    Neuroscience 186:65-75. 2011
    ....
  21. ncbi request reprint Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction
    J Stewart
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 108:79-84. 1992
    ..These observations support the view that opioid-seeking behavior is primed by the proponent or opioid-like actions of opioids and not by the opponent or drug-opposite effects associated with opioid withdrawal...
  22. ncbi request reprint Effects of sex and hormonal status on astrocytic basic fibroblast growth factor-2 and tyrosine hydroxylase immunoreactivity after medial forebrain bundle 6-hydroxydopamine lesions of the midbrain dopamine neurons
    I A Moroz
    Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard West, Montreal, Quebec H3G 1M8, Canada
    Neuroscience 118:463-76. 2003
    ....
  23. ncbi request reprint In rats, odor-induced Fos in the olfactory pathways depends on the phase of the circadian clock
    S Amir
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Neurosci Lett 272:175-8. 1999
    ..These findings are consistent with the idea that odor-induced neuronal activation in the olfactory pathways is modulated by the phase of the circadian clock...
  24. ncbi request reprint Modes of plasticity within the mammalian circadian system
    Shimon Amir
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard, West, Montreal, QC, H3G 1M8, Canada
    Prog Brain Res 138:191-203. 2002
  25. ncbi request reprint The effects of chronic buprenorphine on intake of heroin and cocaine in rats and its effects on nucleus accumbens dopamine levels during self-administration
    Robert E Sorge
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, Quebec, H4B 1R6, Canada
    Psychopharmacology (Berl) 188:28-41. 2006
    ..Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear...
  26. ncbi request reprint Blockade of stress-induced but not cocaine-induced reinstatement by infusion of noradrenergic antagonists into the bed nucleus of the stria terminalis or the central nucleus of the amygdala
    Francesco Leri
    Center for Studies in Behavioral Neurobiology, Concordia University, H3G 1M8, Montreal, Quebec, Canada
    J Neurosci 22:5713-8. 2002
    ....
  27. ncbi request reprint Automatic and effortful emotional information processing regulates different aspects of the stress response
    Mark A Ellenbogen
    Centre for Research in Human Development, Department of Psychology, Concordia University, 7141 Sherbrooke Street, Montreal, Que, Canada H4B 1R6
    Psychoneuroendocrinology 31:373-87. 2006
    ..Effortful and automatic processing appears to regulate different aspects of the stress response...
  28. pmc Review. Psychological and neural mechanisms of relapse
    Jane Stewart
    Department of Psychology, Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, Canada
    Philos Trans R Soc Lond B Biol Sci 363:3147-58. 2008
    ..This paper reviews advances in our understanding of how these systems mediate the effects of events that precipitate relapse and of how lasting changes in these systems can perpetuate vulnerability to relapse...
  29. doi request reprint Behavioral and hormonal regulation of expression of the clock protein, PER2, in the central extended amygdala
    Shimon Amir
    Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, Montreal, QC, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 33:1321-8. 2009
    ....
  30. pmc The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2
    Elaine Waddington Lamont
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
    Proc Natl Acad Sci U S A 102:4180-4. 2005
    ..Thus, cells within these areas are strategically positioned to integrate the inputs from the SCN and emotional states to modulate circadian rhythms downstream from the SCN clock...
  31. doi request reprint Motivational Modulation of Rhythms of the Expression of the Clock Protein PER2 in the Limbic Forebrain
    Shimon Amir
    Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6 Canada
    Biol Psychiatry 65:829-34. 2009
    ..Thus, circadian information from the SCN and homeostatic signals are integrated in these regions of the limbic forebrain to affect the temporal organization of motivational and emotional processes...
  32. ncbi request reprint Pathways to relapse: factors controlling the reinitiation of drug seeking after abstinence
    Jane Stewart
    Concordia University, Montreal, Quebec, Canada
    Nebr Symp Motiv 50:197-234. 2004
  33. ncbi request reprint The consequences of different "lapses" on relapse to heroin seeking in rats
    Francesco Leri
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
    Exp Clin Psychopharmacol 10:339-49. 2002
    ..Simple exposure to heroin, or to heroin-related stimuli, during the lapse had little effect on responding in the test for relapse...
  34. ncbi request reprint A circadian rhythm in the expression of PERIOD2 protein reveals a novel SCN-controlled oscillator in the oval nucleus of the bed nucleus of the stria terminalis
    Shimon Amir
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Neurosci 24:781-90. 2004
    ....
  35. ncbi request reprint Daily restricted feeding rescues a rhythm of period2 expression in the arrhythmic suprachiasmatic nucleus
    E W Lamont
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Room SP244, 7141 Sherbrooke Street West, Montreal, Quebec, Canada H4B 1R6
    Neuroscience 132:245-8. 2005
    ..These findings challenge the idea that the SCN is invulnerable to feeding schedules and call for a reevaluation of the role of the SCN clock in the circadian effects of such schedules...
  36. ncbi request reprint Excitotoxic lesions of the prefrontal cortex reduce dopamine D1-like receptors in the ventral tegmental area
    K M Dewar
    Centre de Recherche Fernand Seguin, Hopital Louis H Lafontaine, Montreal, Quebec, Canada
    Eur J Pharmacol 336:155-8. 1997
    ..These results suggest that a significant number of ventral tegmental D1-like receptors are localized on afferent terminals from the medial prefrontal cortex...
  37. ncbi request reprint Glucocorticoid rhythms control the rhythm of expression of the clock protein, Period2, in oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats
    L A Segall
    Department of Biology, Concordia University, Montreal, Quebec, Canada
    Neuroscience 140:753-7. 2006
    ....
  38. doi request reprint Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors
    Suzanne Hood
    Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Neurosci 30:14046-58. 2010
    ..These observations may have implications for circadian abnormalities seen in Parkinson's disease...
  39. ncbi request reprint Effects of cocaine in rats exposed to heroin
    Francesco Leri
    Department of Psychology, University of Guelph, Canada
    Neuropsychopharmacology 28:2102-16. 2003
    ..In response to cocaine, however, DA activity in the Acb was significantly lower in rats withdrawn from the highest dose of heroin...
  40. ncbi request reprint Stress and selective attention: the interplay of mood, cortisol levels, and emotional information processing
    Mark A Ellenbogen
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Psychophysiology 39:723-32. 2002
    ..These findings point to information-processing strategies as a means to regulate emotion, and to atypical features of cognitive and adrenocortical function that may serve as putative risk markers of depression...
  41. ncbi request reprint Recovery of function is associated with increased spine density in cortical pyramidal cells after frontal lesions and/or noradrenaline depletion in neonatal rats
    B Kolb
    Department of Psychology, University of Lethbridge, AB, Canada
    Behav Brain Res 89:61-70. 1997
    ..These results suggest that recovery from neonatal cortical injury and from neonatal noradrenaline depletion may be supported by changes in both the dendritic arborization and the spine density in the remaining cortex...
  42. ncbi request reprint Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine
    Alanna Grant
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada, H4H 1R3
    Eur J Neurosci 26:3215-28. 2007
    ..These findings demonstrate that reduced DCC during development results in a behavioural phenotype opposite to that observed in developmental models of schizophrenia and identify DCC as a critical factor in the development of DA function...
  43. ncbi request reprint Understanding polydrug use: review of heroin and cocaine co-use
    Francesco Leri
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Montreal, Canada
    Addiction 98:7-22. 2003
    ..Once clearly identified, pharmacological and neuroanatomical methods can be employed in self-administering laboratory animals to uncover the neurobiological correlates of specific patterns of co-use...
  44. ncbi request reprint Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder
    Patrick N Augustyniak
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, SP244, Montreal, Que, Canada H4B 1R6
    Behav Brain Res 167:379-82. 2006
    ..Our results indicate that early exposure to methylphenidate diminishes sensitivity to the incentive properties of cocaine in adulthood, but it does so without altering the response of the mesolimbic dopamine system...
  45. doi request reprint The facilitative effects of D-cycloserine on extinction of a cocaine-induced conditioned place preference can be long lasting and resistant to reinstatement
    G Paolone
    Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, SP 244, 7141 Sherbrooke Street West, Montreal, QC H4B1R6, Canada
    Psychopharmacology (Berl) 202:403-9. 2009
    ..Here, we studied the effects of DCS in rats given spaced-extinction sessions at 3- or 7-day intervals using two different extinction procedures...
  46. ncbi request reprint The effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats
    Robert E Sorge
    Department of Psychology, Center for Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
    Pharmacol Biochem Behav 84:300-5. 2006
    ..Therefore, although these studies do not explain the mechanism whereby buprenorphine reduces heroin and cocaine intake, they do indicate that there is little tolerance to the presence of chronic buprenorphine...
  47. ncbi request reprint d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference
    Fanny Botreau
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP A 244, 7141 Sherbrooke Street West, Montreal, Que, Canada H4B 1R6
    Behav Brain Res 172:173-8. 2006
    ..The facilitative effect of d-cycloserine on the extinction of appetitive conditioning is consistent with the idea of the formation of new learned associations during extinction...
  48. ncbi request reprint Sparing of behavior and basal extracellular dopamine after 6-hydroxydopamine lesions of the nigrostriatal pathway in rats exposed to a prelesion sensitizing regimen of amphetamine
    Isabella Anna Moroz
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, PQ, Canada
    Exp Neurol 189:78-93. 2004
    ..The potential role of amphetamine-induced endogenous neurotrophic factors in the behavioral sparing and normalization of basal extracellular DA levels observed after subsequent 6-OHDA lesions is discussed...
  49. ncbi request reprint Dopamine has bidirectional effects on synaptic responses to cortical inputs in layer II of the lateral entorhinal cortex
    Douglas A Caruana
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke Street W, Rm SP 244, Montreal, Quebec, Canada H4B 1R6
    J Neurophysiol 96:3006-15. 2006
    ..We propose here that dopamine release in the lateral entorhinal cortex, acting through D(1) receptors, can lead to an enhancement of the salience of sensory representations carried to this region from adjacent sensory cortices...
  50. ncbi request reprint A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats
    Nancy Capriles
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Blvd, Montreal, Quebec, Canada H3G 1M8
    Psychopharmacology (Berl) 168:66-74. 2003
    ..Here we studied the role of the medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC) in foot-shock stress-induced reinstatement of cocaine seeking...
  51. ncbi request reprint Persistence and drug-induced reinstatement of a morphine-induced conditioned place preference
    Devin Mueller
    Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, 1455 De Maisonneuve Blvd W, Montreal, Que, Canada H3G 1M8
    Behav Brain Res 136:389-97. 2002
    ..5 mg/kg) given immediately or 15 min before a 30 min test; no reinstatement was seen after injections of saline. These results show that a morphine-induced CPP is persistent over time and can be reinstated by morphine after extinction...
  52. ncbi request reprint Predictable and unpredictable rewards produce similar changes in dopamine tone
    Giovanni Hernandez
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, PQ, Canada
    Behav Neurosci 121:887-95. 2007
    ..Nonetheless, indistinguishable changes in DA concentration were observed in the 2 groups. Thus, reward predictability had no discernable effect on a measure believed to track the slower components of DA signaling...
  53. ncbi request reprint Astrocytic basic fibroblast growth factor expression in dopaminergic regions after perinatal anoxia
    Cecilia Flores
    Center for Studies in Behavioral Neurobiology Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Biol Psychiatry 52:362-70. 2002
    ....
  54. ncbi request reprint Patterns of opioid and cocaine co-use: a descriptive study in a Canadian sample of untreated opioid-dependent individuals
    Francesco Leri
    Department of Psychology, College of Social and Applied Human Sciences, University of Guelph, ON, Canada
    Exp Clin Psychopharmacol 13:303-10. 2005
    ..These findings indicate that different individuals display different patterns of opioids and cocaine co-use...
  55. ncbi request reprint Dopamine tone increases similarly during predictable and unpredictable administration of rewarding brain stimulation at short inter-train intervals
    Giovanni Hernandez
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Behav Brain Res 188:227-32. 2008
    ..This finding is consistent with the idea that tonic DA signaling is insensitive to the predictability of rewards...
  56. ncbi request reprint The contribution of drug history and time since termination of drug taking to footshock stress-induced cocaine seeking in rats
    Robert E Sorge
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 183:210-7. 2005
    ..There is reason to think that footshock stress-induced reinstatement of cocaine may be affected by the history of drug use and time since termination of drug taking...
  57. ncbi request reprint Chronic buprenorphine reduces the response to sucrose-associated cues in non food-deprived rats
    Suzanne Hood
    Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
    Pharmacol Biochem Behav 86:566-75. 2007
    ..Consistent with previous studies with heroin and cocaine, chronic BUP reduced responding in the presence of reward-related cues...
  58. ncbi request reprint Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences
    Giovanni Hernandez
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, PQ, Canada
    Behav Neurosci 120:888-904. 2006
    ..These results support the idea that dopamine tone plays an enabling role in brain stimulation reward and is elevated similarly by predictable and unpredictable stimulation...
  59. ncbi request reprint Impact of basic FGF expression in astrocytes on dopamine neuron synaptic function and development
    Caroline Forget
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, C P 6128, succursale Centre Ville Montreal, Quebec, Canada, H3C 3J7
    Eur J Neurosci 23:608-16. 2006
    ..The effects of bFGF seen here on DA neurons are thus likely to be mediated through more indirect glial-neuronal interactions, leading to enhanced DA release without a necessary change in synapse number...
  60. doi request reprint Amphetamine pretreatment facilitates appetitive sexual behaviors in the female rat
    Veronica M Afonso
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC, Canada
    Psychopharmacology (Berl) 205:35-43. 2009
    ..This sensitization involves an increase in mesolimbic and nigrostriatal dopamine release, and in male rats, facilitates sexual behavior...
  61. pmc Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:1-16. 2006
    ..The reinstatement model is widely used to study relapse to drug addiction. However, the model's validity is open to question...
  62. ncbi request reprint High-dose methadone maintenance in rats: effects on cocaine self-administration and behavioral side effects
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada NIG 2WI
    Neuropsychopharmacology 32:2290-300. 2007
    ..Taken together, these results from studies in rats support the usefulness of larger doses of methadone to reduce severe cocaine abuse in opioid-dependent individuals and possibly in the management of pure-cocaine addiction...
  63. ncbi request reprint The reinstatement model of drug relapse: history, methodology and major findings
    Yavin Shaham
    Behavioral Neuroscience Branch, NIDA IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:3-20. 2003
    ..Finally, there appears to be a good correspondence between the events that induce reinstatement in laboratory animals and those that provoke relapse in humans...
  64. ncbi request reprint An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991)
    Robert Combes
    FRAME, 96 98 North Sherwood Street, Nottingham NG1 4EE, UK
    Altern Lab Anim 30:365-406. 2002
  65. ncbi request reprint "Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time
    Anne Noël Samaha
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 27:2979-86. 2007
    ..These findings provide a model and a mechanism for antipsychotic treatment failure and suggest new directions for the development of more effective antipsychotics...

Research Grants7

  1. NEUROBIOLOGY OF RELAPSE INDUCED BY STRESS AND DRUGS
    Jane Stewart; Fiscal Year: 2001
    ..Further characterization of the relapse processes in our preclinical model may lead to a better understanding of relapse to drug taking and to the development of medications to prevent relapse in humans. ..