James Pfaus

Summary

Affiliation: Concordia University
Country: Canada

Publications

  1. doi request reprint Pathways of sexual desire
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada
    J Sex Med 6:1506-33. 2009
  2. doi request reprint Who, what, where, when (and maybe even why)? How the experience of sexual reward connects sexual desire, preference, and performance
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, H4B 1R6, Canada
    Arch Sex Behav 41:31-62. 2012
  3. ncbi request reprint Effects of pelvic, pudendal, or hypogastric nerve cuts on Fos induction in the rat brain following vaginocervical stimulation
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
    Physiol Behav 89:627-36. 2006
  4. ncbi request reprint Bremelanotide: an overview of preclinical CNS effects on female sexual function
    James Pfaus
    Concordia University Psychology, Montreal, Canada
    J Sex Med 4:269-79. 2007
  5. doi request reprint Inhibitory and disinhibitory effects of psychomotor stimulants and depressants on the sexual behavior of male and female rats
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
    Horm Behav 58:163-76. 2010
  6. doi request reprint Conditioned ejaculatory preference in male rats paired with haloperidol-treated females
    Nafissa Ismail
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
    Physiol Behav 100:116-21. 2010
  7. doi request reprint Dopamine: helping males copulate for at least 200 million years: theoretical comment on Kleitz-Nelson et al. (2010)
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
    Behav Neurosci 124:877-80; discussion 881-3. 2010
  8. doi request reprint Vaginocervical stimulation induces Fos in glutamate neurons in the ventromedial hypothalamus: attenuation by estrogen and progesterone
    Michaela Georgescu
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
    Horm Behav 56:450-6. 2009
  9. doi request reprint Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat
    Nafissa Ismail
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC H4B 1R6 Canada
    Behav Neurosci 123:992-9. 2009
  10. ncbi request reprint Olfactory conditioned partner preference in the female rat
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Behav Neurosci 119:716-25. 2005

Collaborators

Detail Information

Publications36

  1. doi request reprint Pathways of sexual desire
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada
    J Sex Med 6:1506-33. 2009
    ..Sexual desire is controlled by brain systems involved in sexual excitation and inhibition. Hypoactive sexual desire disorder (HSDD) may result from hypofunctional excitation, hyperfunctional inhibition, or some mix of the two...
  2. doi request reprint Who, what, where, when (and maybe even why)? How the experience of sexual reward connects sexual desire, preference, and performance
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, H4B 1R6, Canada
    Arch Sex Behav 41:31-62. 2012
    ..Thus, a critical period exists during an individual's early sexual experience that creates a "love map" or Gestalt of features, movements, feelings, and interpersonal interactions associated with sexual reward...
  3. ncbi request reprint Effects of pelvic, pudendal, or hypogastric nerve cuts on Fos induction in the rat brain following vaginocervical stimulation
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
    Physiol Behav 89:627-36. 2006
    ..These data confirm that the pelvic nerve is largely responsible for the neural and behavioral effects of VCS, and support a separate function for the hypogastric nerve...
  4. ncbi request reprint Bremelanotide: an overview of preclinical CNS effects on female sexual function
    James Pfaus
    Concordia University Psychology, Montreal, Canada
    J Sex Med 4:269-79. 2007
    ..Bremelanotide is an analogue of the naturally occurring peptide alpha-melanocyte-stimulating hormone (alpha-MSH). It stimulates erection in men and male rats, and is currently in clinical trials for the treatment of erectile dysfunction...
  5. doi request reprint Inhibitory and disinhibitory effects of psychomotor stimulants and depressants on the sexual behavior of male and female rats
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
    Horm Behav 58:163-76. 2010
    ....
  6. doi request reprint Conditioned ejaculatory preference in male rats paired with haloperidol-treated females
    Nafissa Ismail
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
    Physiol Behav 100:116-21. 2010
    ..We conclude that copulation to ejaculation at a male's preferred rate is essential for the development of CEP, as it is for the development of a sexually-conditioned place preference...
  7. doi request reprint Dopamine: helping males copulate for at least 200 million years: theoretical comment on Kleitz-Nelson et al. (2010)
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
    Behav Neurosci 124:877-80; discussion 881-3. 2010
    ..Those data suggest that the steroid-dependent role of hypothalamic DA in male sexual behavior has been conserved through evolutionary time...
  8. doi request reprint Vaginocervical stimulation induces Fos in glutamate neurons in the ventromedial hypothalamus: attenuation by estrogen and progesterone
    Michaela Georgescu
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
    Horm Behav 56:450-6. 2009
    ..In turn, this may allow females to receive a sufficient number of intromissions for the activation of sexual reward and the facilitation of pregnancy...
  9. doi request reprint Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat
    Nafissa Ismail
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC H4B 1R6 Canada
    Behav Neurosci 123:992-9. 2009
    ..These findings suggest that activation of opioid, but not dopamine, systems during sexual interaction are necessary for conditioned ejaculatory preference in male rats...
  10. ncbi request reprint Olfactory conditioned partner preference in the female rat
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Behav Neurosci 119:716-25. 2005
    ..Females in the paired group solicited the scented male more frequently, and most chose the scented male for their 1st ejaculation. Thus, an odor paired with paced copulation elicits conditioned partner preference in female rats...
  11. ncbi request reprint Sensory mediation of female-male mounting in the rat: II. Role of tactile and conspecific cues
    Veronica M Afonso
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke St W, Montreal, QC, Canada H4B 1R6
    Physiol Behav 87:863-9. 2006
    ..A positive linear relationship was found between male activity level and FMM. These data indicate that both tactile cues and cues associated with locomotor activity of the stimulus male modulate FMM...
  12. doi request reprint Neurochemical basis of conditioned partner preference in the female rat: II. Disruption by flupenthixol
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Behav Neurosci 122:396-406. 2008
    ..The role of dopamine in conditioned partner preference depends on the type of stimuli to be learned...
  13. ncbi request reprint Sensory mediation of female-male mounting in the rat: I. Role of olfactory cues
    Veronica M Afonso
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke St W, Montreal, QC, Canada H4B 1R6
    Physiol Behav 87:857-62. 2006
    ..These data indicate that the olfactory sense is a prime mediator of FMM, and that prior mounting experience does not offset the disruption of FMM caused by the elimination of olfactory cues...
  14. doi request reprint Context-dependent acquisition of copulatory behavior in the male rat: role of female availability
    Nafissa Ismail
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Behav Neurosci 122:991-7. 2008
    ..Males ejaculated preferentially with females associated with the 4-hole pacing condition. Copulatory behavior in male rats is sensitive to female availability, and females associated with greater availability are preferred...
  15. ncbi request reprint What can animal models tell us about human sexual response?
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke St W Montréal, QC H4B 1R6, Canada
    Annu Rev Sex Res 14:1-63. 2003
    ....
  16. pmc Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist
    James G Pfaus
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
    Proc Natl Acad Sci U S A 101:10201-4. 2004
    ..Accordingly, PT-141 may be the first identified pharmacological agent with the capability to treat female sexual desire disorders...
  17. doi request reprint Clitoral stimulation induces conditioned place preference and Fos activation in the rat
    Mayte Parada
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC Canada
    Horm Behav 57:112-8. 2010
    ..These data indicate that CLS induces a reward state in the rat and a pattern of Fos activation in regions of the brain that process genitosensory input, incentive salience, and reward...
  18. doi request reprint Estrogen and the neural mediation of female-male mounting in the rat
    Veronica M Afonso
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada H4B 1R6
    Behav Neurosci 123:369-81. 2009
    ..These data indicate that the ventromedial hypothalamus is a critical area of convergence of hormonal, olfactory, and somatosensory inputs for FMM...
  19. ncbi request reprint The Sexual Arousal and Desire Inventory (SADI): a multidimensional scale to assess subjective sexual arousal and desire
    Rachel Toledano
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    J Sex Med 3:853-77. 2006
    ..There are few subjective scales that assess sexual arousal and desire specifically in both men and women...
  20. doi request reprint Neurochemical basis of conditioned partner preference in the female rat: I. Disruption by naloxone
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec
    Behav Neurosci 122:385-95. 2008
    ..The authors concluded that opioids mediated the conditioned partner preference induced by paced copulation...
  21. doi request reprint Pacing conditions contribute to the conditioned ejaculatory preference for a familiar female in the male rat
    Nafissa Ismail
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
    Physiol Behav 96:201-8. 2009
    ..These findings indicate that pacing conditions in which males have restricted access to the female contribute to the conditioned ejaculatory preference for familiar females bearing a neutral odor...
  22. doi request reprint Amphetamine pretreatment facilitates appetitive sexual behaviors in the female rat
    Veronica M Afonso
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC, Canada
    Psychopharmacology (Berl) 205:35-43. 2009
    ..This sensitization involves an increase in mesolimbic and nigrostriatal dopamine release, and in male rats, facilitates sexual behavior...
  23. doi request reprint Sexual behavior in lactating rats: role of estrogen-induced progesterone receptors
    Erica Barbosa-Vargas
    CSBN GRNC, Concordia University, Montreal H4B 1R6, Canada
    Horm Behav 56:246-53. 2009
    ....
  24. ncbi request reprint Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors I. Behavioral effects of glutamate and its selective receptor agonists AMPA, NMDA and kainate
    Michaela Georgescu
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R2
    Pharmacol Biochem Behav 83:322-32. 2006
    ..These data indicate that the activation of glutamate receptors in the VMH is inhibitory for both appetitive and consummatory aspects of sexual behavior in the female rat...
  25. ncbi request reprint Conditioned partner preference in female rats for strain of male
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
    Physiol Behav 88:529-37. 2006
    ....
  26. ncbi request reprint Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors. II. Behavioral effects of selective glutamate receptor antagonists AP-5, CNQX, and DNQX
    Michaela Georgescu
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R2
    Pharmacol Biochem Behav 83:333-41. 2006
    ..These data support the notion that glutamate receptors in the VMH contribute a strong inhibitory influence in the control of female sexual behavior...
  27. ncbi request reprint Opposing roles of the nucleus accumbens and anterior lateral hypothalamic area in the control of sexual behaviour in the male rat
    Tod E Kippin
    Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, H3G 1M8, Canada
    Eur J Neurosci 19:698-704. 2004
    ..These findings indicate that the aLHA plays an inhibitory role in the regulation of sexual arousal and an excitatory role in the regulation of ejaculation. Conversely, the NAc plays an excitatory role in the regulation in sexual arousal...
  28. ncbi request reprint Timing between ejaculations changes paternity success
    Genaro A Coria-Avila
    Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, H4B 1R6, Canada
    Physiol Behav 80:733-7. 2004
    ..After 5 min, a second male has no advantage in fathering pups...
  29. ncbi request reprint Fecal bulking in a frequently mated female rat. Colonic obstruction due to severe vaginal distension
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke West, Montreal, Quebec H4B 1R6, Canada
    Lab Anim (NY) 35:20-3. 2006
  30. ncbi request reprint Hormonal and experiential control of female-male mounting in the female rat
    Veronica M Afonso
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, QC, Canada
    Horm Behav 49:30-7. 2006
    ..These data suggest that FMM occurs naturally in rats as a "super-solicitational" behavior that is modified by hormone treatment and prior heterosexual experience...
  31. ncbi request reprint Sudden bladder distention in a female rat
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Psychology Department, Concordia University, Montreal, Quebec, Canada
    Lab Anim (NY) 34:22-3, 24-5. 2005
  32. ncbi request reprint Cecum location in rats and the implications for intraperitoneal injections
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke West, Montreal, QC H4B 1R6, Canada
    Lab Anim (NY) 36:25-30. 2007
    ..Of the rats they investigated, 71.8% had ceca on the left side of the abdomen. The authors also found that injections on the left side were more likely to result in punctured ceca...
  33. ncbi request reprint Scrotal enlargement and constipation in a male rat. Scrotal fecal (or rectoscrotal) fistula
    Genaro A Coria-Avila
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke West, Montreal, QC H4B 1R6, Canada
    Lab Anim (NY) 36:17, 18-9. 2007
  34. ncbi request reprint The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat
    Anne Sophie Rössler
    Pelvipharm Laboratories, CNRS, Bat 5, 1 Avenue de la Terrasse, 91190, Gif sur Yvette, France
    Pharmacol Biochem Behav 85:514-21. 2006
    ....
  35. ncbi request reprint A sexually dimorphic hypothalamic nucleus in a macaque species with frequent female-female mounting and same-sex sexual partner preference
    Paul L Vasey
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 157:265-72. 2005
    ..This study is the first to examine the relationship between sex-atypical sexual activity and the cytoarchitecture of a hypothalamic nucleus in hormonally unmanipulated females...
  36. ncbi request reprint High-dose methadone maintenance in rats: effects on cocaine self-administration and behavioral side effects
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada NIG 2WI
    Neuropsychopharmacology 32:2290-300. 2007
    ..Taken together, these results from studies in rats support the usefulness of larger doses of methadone to reduce severe cocaine abuse in opioid-dependent individuals and possibly in the management of pure-cocaine addiction...