Alan A Cohen

Summary

Country: Canada

Publications

  1. doi request reprint Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
    Alan A Cohen
    Groupe de recherche Primus, Dept of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 3001 12 e Ave N, Sherbrooke, QC J1H 5N4, Canada Electronic address
    Exp Gerontol 57:203-10. 2014
  2. pmc A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 3001 12e Avenue North, Sherbrooke, QC J1H 5N4, Canada
    Mech Ageing Dev 134:110-7. 2013
  3. doi request reprint Specialized cardiological care may be overutilized in urban areas of Quebec
    Alan A Cohen
    University of Sherbrooke, Sherbrooke, QC, Canada
    Eur J Prev Cardiol 19:731-7. 2012
  4. doi request reprint Physiological regulatory networks: ecological roles and evolutionary constraints
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 12ème Ave N, Sherbrooke, QC J1H 5N4, Canada
    Trends Ecol Evol 27:428-35. 2012
  5. doi request reprint Inflamm-aging does not simply reflect increases in pro-inflammatory markers
    Vincent Morrisette-Thomas
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 3001 12eAvenue North, Sherbrooke, QC J1H 5N4, Canada
    Mech Ageing Dev 139:49-57. 2014
  6. doi request reprint Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada
    PLoS ONE 10:e0122541. 2015
  7. doi request reprint Detection of a novel, integrative aging process suggests complex physiological integration
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada
    PLoS ONE 10:e0116489. 2015
  8. pmc Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations
    Emmanuel Milot
    Department of Chemistry, Biochemistry and Physics, Universite du Quebec a Trois Rivieres, 3351 Boul des Forges, CP 500, Trois Rivieres, QC, G9A 5H7, Canada
    Mech Ageing Dev 141:56-63. 2014
  9. doi request reprint Validating metabolic syndrome through principal component analysis in a medically diverse, realistic cohort
    Francis Dusseault-Bélanger
    Departement de Mathematiques, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Metab Syndr Relat Disord 11:21-8. 2013
  10. doi request reprint Does elapsed time between first diagnosis of schizophrenia and migration between health territories vary by place of residence? A survival analysis approach
    André Ngamini Ngui
    Groupe PRIMUS, Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada, J1H 5N4
    Health Place 20:66-74. 2013

Collaborators

Detail Information

Publications13

  1. doi request reprint Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
    Alan A Cohen
    Groupe de recherche Primus, Dept of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 3001 12 e Ave N, Sherbrooke, QC J1H 5N4, Canada Electronic address
    Exp Gerontol 57:203-10. 2014
    ..We conclude that statistical distance as a measure of physiological dysregulation is stable across populations in Europe and North America. ..
  2. pmc A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 3001 12e Avenue North, Sherbrooke, QC J1H 5N4, Canada
    Mech Ageing Dev 134:110-7. 2013
    ..Biomarkers from multiple systems were implicated. These results support hypotheses of simultaneous dysregulation in multiple systems and confirm the need for longitudinal, multivariate approaches to understanding biomarkers in aging...
  3. doi request reprint Specialized cardiological care may be overutilized in urban areas of Quebec
    Alan A Cohen
    University of Sherbrooke, Sherbrooke, QC, Canada
    Eur J Prev Cardiol 19:731-7. 2012
    ....
  4. doi request reprint Physiological regulatory networks: ecological roles and evolutionary constraints
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 12ème Ave N, Sherbrooke, QC J1H 5N4, Canada
    Trends Ecol Evol 27:428-35. 2012
    ..We discuss how PRN structure and its system-level properties could determine both individual performance and patterns of physiological evolution...
  5. doi request reprint Inflamm-aging does not simply reflect increases in pro-inflammatory markers
    Vincent Morrisette-Thomas
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 3001 12eAvenue North, Sherbrooke, QC J1H 5N4, Canada
    Mech Ageing Dev 139:49-57. 2014
    ..These results show that PCA can uncover a novel biological structure in the relationships among inflammatory markers, and that key axes of this structure play important roles in chronic disease. ..
  6. doi request reprint Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada
    PLoS ONE 10:e0122541. 2015
    ..Biologically, the lack of sensitivity to marker choice and better performance of younger, healthier RPs confirm an interpretation of DM physiological dysregulation and as an emergent property of a complex system. ..
  7. doi request reprint Detection of a novel, integrative aging process suggests complex physiological integration
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada
    PLoS ONE 10:e0116489. 2015
    ..If this is correct, detection of this process has substantial implications for physiological organization more generally...
  8. pmc Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations
    Emmanuel Milot
    Department of Chemistry, Biochemistry and Physics, Universite du Quebec a Trois Rivieres, 3351 Boul des Forges, CP 500, Trois Rivieres, QC, G9A 5H7, Canada
    Mech Ageing Dev 141:56-63. 2014
    ..Therefore, the study of dysregulation trajectories should allow important insights into aging physiology and provide clinically meaningful predictors of outcomes. ..
  9. doi request reprint Validating metabolic syndrome through principal component analysis in a medically diverse, realistic cohort
    Francis Dusseault-Bélanger
    Departement de Mathematiques, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Metab Syndr Relat Disord 11:21-8. 2013
    ....
  10. doi request reprint Does elapsed time between first diagnosis of schizophrenia and migration between health territories vary by place of residence? A survival analysis approach
    André Ngamini Ngui
    Groupe PRIMUS, Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada, J1H 5N4
    Health Place 20:66-74. 2013
    ..Migrant patients were also more likely to stay in or migrate to the most socially or materially deprived territories...
  11. doi request reprint Beta-blockers are associated with increased risk of first cardiovascular events in non-diabetic hypertensive elderly patients
    Frederieke M Brouwers
    Département de médecine de famille et de médecine d urgence, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Pharmacoepidemiol Drug Saf 23:1139-46. 2014
    ..This study's objective is to assess the relative effectiveness of BBs in elderly primary prevention patients with uncomplicated HTN...
  12. ncbi request reprint Rural-urban disparities in the management and health issues of chronic diseases in Quebec (Canada) in the early 2000s
    Alain Vanasse
    Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Rural Remote Health 10:1548. 2010
    ....
  13. doi request reprint Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable
    Jean Louis Barnwell-Ménard
    Department of Economics, University of Sherbrooke, Sherbrooke, QC, Canada
    Stat Med 34:936-49. 2015
    ..We provide online tools that can help researchers estimate the potential error inflation and understand how serious a problem this is...