Andre Veillette

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. ncbi request reprint The SAP family: a new class of adaptor-like molecules that regulates immune cell functions
    Andre Veillette
    Laboratory of Molecular Oncology, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
    Sci STKE 2002:pe8. 2002
  2. pmc SLAM-family receptors: immune regulators with or without SAP-family adaptors
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Cold Spring Harb Perspect Biol 2:a002469. 2010
  3. doi request reprint Importance and mechanism of 'switch' function of SAP family adapters
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 232:229-39. 2009
  4. doi request reprint PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 228:312-24. 2009
  5. pmc SAP expression in T cells, not in B cells, is required for humoral immunity
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:1273-8. 2008
  6. ncbi request reprint Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Immunity 27:698-710. 2007
  7. ncbi request reprint NK cell regulation by SLAM family receptors and SAP-related adapters
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 214:22-34. 2006
  8. ncbi request reprint Immune regulation by SLAM family receptors and SAP-related adaptors
    Andre Veillette
    Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada
    Nat Rev Immunol 6:56-66. 2006
  9. ncbi request reprint Specialised adaptors in immune cells
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada
    Curr Opin Cell Biol 16:146-55. 2004
  10. ncbi request reprint Negative regulation of immunoreceptor signaling
    Andre Veillette
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Annu Rev Immunol 20:669-707. 2002

Collaborators

Detail Information

Publications39

  1. ncbi request reprint The SAP family: a new class of adaptor-like molecules that regulates immune cell functions
    Andre Veillette
    Laboratory of Molecular Oncology, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
    Sci STKE 2002:pe8. 2002
    ..Veillette discusses new findings on the functions of EAT-2 and SAP and how they might regulate signals emanating from the SLAM family of receptors...
  2. pmc SLAM-family receptors: immune regulators with or without SAP-family adaptors
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Cold Spring Harb Perspect Biol 2:a002469. 2010
    ..The molecular basis and significance of this mechanism are discussed herein...
  3. doi request reprint Importance and mechanism of 'switch' function of SAP family adapters
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 232:229-39. 2009
    ..Thus, SAP family adapters are molecular switches that regulate immunity as a result of their capacity to control the type of signals and functions emanating from SLAM family receptors...
  4. doi request reprint PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 228:312-24. 2009
    ..These mutations abrogate the ability of PSTPIP1 to bind PTP-PEST and PTP-HSCF, suggesting that these two PTPs may be negative regulators of inflammation...
  5. pmc SAP expression in T cells, not in B cells, is required for humoral immunity
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:1273-8. 2008
    ..These data provide a critical insight into the mechanism by which SAP regulates humoral immunity. They also help elucidate the basis of a severe human immunodeficiency...
  6. ncbi request reprint Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Immunity 27:698-710. 2007
    ..The importance of the SLAM-SAP pathway in normal immunity is highlighted by the finding that SAP is mutated in humans suffering from the immunodeficiency X-linked lymphoproliferative disease...
  7. ncbi request reprint NK cell regulation by SLAM family receptors and SAP-related adapters
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 214:22-34. 2006
    ....
  8. ncbi request reprint Immune regulation by SLAM family receptors and SAP-related adaptors
    Andre Veillette
    Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada
    Nat Rev Immunol 6:56-66. 2006
    ..Recent observations indicate that SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. The latest progress in this field is reviewed here...
  9. ncbi request reprint Specialised adaptors in immune cells
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada
    Curr Opin Cell Biol 16:146-55. 2004
    ..Lastly, they have highlighted the plasticity of protein-protein interaction modules, and have shed light onto the mechanisms dictating the specificity of adaptor-mediated signals...
  10. ncbi request reprint Negative regulation of immunoreceptor signaling
    Andre Veillette
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Annu Rev Immunol 20:669-707. 2002
    ..Genetic evidence indicates that this inhibitory machinery is crucial for normal immune cell homeostasis...
  11. ncbi request reprint SAP: a molecular switch regulating the immune response through a unique signaling mechanism
    Andre Veillette
    Laboratory of Molecular Oncology, IRCM and the Department of Medicine, University of Montreal, Quebec, Canada
    Eur J Immunol 33:1141-4. 2003
  12. pmc SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute on Montreal, Quebec, Canada
    J Exp Med 199:1175-8. 2004
    ..The findings provide definitive evidence of the importance of SLAM-related receptors in the regulation of T cell, macrophage, and natural killer cell functions...
  13. ncbi request reprint The SLAM family of immune-cell receptors
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Curr Opin Immunol 15:277-85. 2003
    ..The existence of the SLAM family broadens the spectrum of receptors known to be involved in immunomodulation...
  14. ncbi request reprint Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
    Romain Roncagalli
    Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    Nat Immunol 6:1002-10. 2005
    ..These data identify a previously unknown mechanism of NK cell inhibition. Moreover, they indicate that EAT-2 and SAP have distinct and at times opposing functions in natural immunity...
  15. doi request reprint Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
    Zhongjun Dong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Nat Immunol 10:973-80. 2009
    ..Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells...
  16. pmc Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors
    Riyan Chen
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Quebec, Canada
    Mol Cell Biol 24:5144-56. 2004
    ....
  17. pmc Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor
    Riyan Chen
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 26:5559-68. 2006
    ..Together, these data elucidate further the events initiating SLAM-SAP signaling in immune cells. Moreover, they identify a strictly inducible interaction mediated by an SH3 domain...
  18. doi request reprint Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
    Mario Ernesto Cruz-Munoz
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Nat Immunol 10:297-305. 2009
    ..CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins...
  19. ncbi request reprint Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation
    Dominique Davidson
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    Immunity 21:707-17. 2004
    ..These data imply that SAP is necessary for T(H)2 cytokine regulation primarily as a result of its capacity to recruit FynT. They also establish a previously unappreciated role for FynT in SAP-dependent T(H)2 cytokine regulation...
  20. doi request reprint The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells
    Zhongjun Dong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunity 36:974-85. 2012
    ..These data showed that SAP secures NK cell activation by a dichotomous molecular mechanism, which is required for conjugate formation. These findings may have implications for the role of SAP in other immune cell types...
  21. pmc PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
    Dominique Davidson
    IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada
    Mol Cell Biol 27:1960-73. 2007
    ..These data improve our comprehension of the function of PAG in T cells. They also further implicate FynT in T-cell anergy...
  22. ncbi request reprint EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization
    Luis Alberto Pérez-Quintero
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Exp Med 211:727-42. 2014
    ..Hence, EAT-2 promotes NK cell activation by molecular and cellular mechanisms distinct from those of SAP. These findings explain the cooperative and essential function of these two adaptors in NK cell activation. ..
  23. pmc Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12
    Inmoo Rhee
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 33:2458-69. 2013
    ..This function is seemingly due to the ability of PTP-PEST to control phosphorylation of Pyk2 and paxillin, thereby regulating cell polarization, migration, and spreading...
  24. ncbi request reprint Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation
    Sylvain Latour
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
    Nat Cell Biol 5:149-54. 2003
    ..These observations characterize a biologically important signalling mechanism in which an adaptor molecule composed only of an SH2 domain links a receptor devoid of intrinsic catalytic activity to the kinase required for its function...
  25. ncbi request reprint Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells
    Inmoo Rhee
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 34:888-99. 2014
    ..This is due primarily to the role of PTPN12 in DC migration from peripheral sites to secondary lymphoid organs through regulation of Pyk2. ..
  26. doi request reprint Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity
    Ming Chao Zhong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7
    J Biol Chem 283:19255-64. 2008
    ..Together these data provided a molecular explanation for the involvement of Ly108 in lupus susceptibility in mice...
  27. pmc Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells
    Oliver Utting
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 24:6067-75. 2004
    ..The results of our studies demonstrated that Clnk is dispensable for normal differentiation and function of T cells, mast cells, and NK cells. Hence, unlike its relatives, Clnk is not essential for normal immune functions...
  28. doi request reprint The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2
    Dominique Davidson
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    Immunity 33:167-80. 2010
    ..Thus, PTP-PEST controls Pyk2 activity and is a positive regulator of secondary T cell activation. These data illustrate the critical role of protein tyrosine phosphatases in T cell regulation...
  29. pmc The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability
    Cleiton Martins Souza
    Laboratories of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 287:43180-90. 2012
    ..This function explains at least in part the essential role of PTP-PEST in embryonic development and viability...
  30. pmc Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor
    Dominique Davidson
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 23:2017-28. 2003
    ..They also suggest that the inhibitory function of PAG in T cells is suppressed by CD45. Lastly, they support the idea that dephosphorylation of proteins on tyrosine residues is critical for the initiation of T-cell activation...
  31. pmc Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3
    Jeffrey D Robson
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 24:2332-43. 2004
    ..Together, these data elucidate the mechanism by which Dok-3 inhibits B-cell activation. Furthermore, they provide evidence that SHIP-1 can be a negative regulator of JNK signaling in B cells...
  32. pmc The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis
    Ming Chao Zhong
    From the Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 288:31423-36. 2013
    ..Together, these results indicate that SAP plays an essential role in CIA because of Fyn-independent and Fyn-dependent effects on TFH cells and, possibly, other T cell types. ..
  33. ncbi request reprint SLAM family receptors and SAP-related adaptors: matters arising
    Andre Veillette
    Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Trends Immunol 27:228-34. 2006
    ..We address these issues and discuss the recent progress in this research area...
  34. pmc Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity
    Ming Chao Zhong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 33:1223-32. 2013
    ..Thus, SAP is pivotal for nearly all phases, but not for maintenance, of T cell-driven B cell humoral immunity. These findings may have implications for the treatment of immune disorders by targeting the SAP pathway...
  35. doi request reprint Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation
    Fanny Guimont-Desrochers
    Department of Microbiology and Immunology, University of Montreal, and Maisonneuve Rosemont Hospital Research Center, Montreal, QC
    Blood 119:4349-57. 2012
    ..The characterization of these novel attributes to B220+ NK cells will guide the identification of their ortholog in humans, contributing to the design of potent cancer immunotherapies...
  36. doi request reprint How do SAP family deficiencies compromise immunity?
    Zhongjun Dong
    Clinical Research Institute of Montreal, Quebec, Canada
    Trends Immunol 31:295-302. 2010
    ....
  37. ncbi request reprint X-linked lymphoproliferative syndromes and related autosomal recessive disorders
    Andre Veillette
    aLaboratory of Molecular Oncology, Clinical Research Institute of Montréal bDepartment of Medicine, University of Montréal cDepartment of Medicine, McGill University, Montreal, Quebec, Canada dUnité INSERM 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    Curr Opin Allergy Clin Immunol 13:614-22. 2013
    ..Recent findings reviewed herein provided key new insights into the genetic and immunological basis of these diseases. They also improved our comprehension of the immunological mechanisms controlling EBV infection...
  38. ncbi request reprint [EAT-2: a novel regulator of natural killer cell functions]
    Romain Roncagalli
    Institut de recherches cliniques de Montreal IRCM, Quebec, Canada
    Med Sci (Paris) 22:22-4. 2006
  39. doi request reprint Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
    Inmoo Rhee
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Nat Immunol 13:439-47. 2012
    ..Here we discuss recent progress in elucidating the roles and mechanisms of action of PTPs in lymphocyte activation. We also review the accumulating evidence that genetic alterations in PTPs are involved in human autoimmunity...