Research Topics
Genomes and Genes
| Andre VeilletteSummaryAffiliation: Clinical Research Institute of Montreal Country: Canada Publications
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Detail Information
Publications
The SAP family: a new class of adaptor-like molecules that regulates immune cell functionsAndre Veillette
Laboratory of Molecular Oncology, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
Sci STKE 2002:pe8. 2002..Veillette discusses new findings on the functions of EAT-2 and SAP and how they might regulate signals emanating from the SLAM family of receptors...- Immune regulation by SLAM family receptors and SAP-related adaptorsAndre Veillette
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada
Nat Rev Immunol 6:56-66. 2006..Recent observations indicate that SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. The latest progress in this field is reviewed here... - Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytesAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
Immunity 27:698-710. 2007..The importance of the SLAM-SAP pathway in normal immunity is highlighted by the finding that SAP is mutated in humans suffering from the immunodeficiency X-linked lymphoproliferative disease... 
SAP expression in T cells, not in B cells, is required for humoral immunityAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, QC, Canada
Proc Natl Acad Sci U S A 105:1273-8. 2008..These data provide a critical insight into the mechanism by which SAP regulates humoral immunity. They also help elucidate the basis of a severe human immunodeficiency...
PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disordersAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Immunol Rev 228:312-24. 2009..These mutations abrogate the ability of PSTPIP1 to bind PTP-PEST and PTP-HSCF, suggesting that these two PTPs may be negative regulators of inflammation...- Specialised adaptors in immune cellsAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada
Curr Opin Cell Biol 16:146-55. 2004..Lastly, they have highlighted the plasticity of protein-protein interaction modules, and have shed light onto the mechanisms dictating the specificity of adaptor-mediated signals... - NK cell regulation by SLAM family receptors and SAP-related adaptersAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Immunol Rev 214:22-34. 2006.... - SLAM Family Receptors Regulate Immunity with and without SAP-related AdaptorsAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute on Montreal, Quebec, Canada
J Exp Med 199:1175-8. 2004..The findings provide definitive evidence of the importance of SLAM-related receptors in the regulation of T cell, macrophage, and natural killer cell functions... - The SLAM family of immune-cell receptorsAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Curr Opin Immunol 15:277-85. 2003..The existence of the SLAM family broadens the spectrum of receptors known to be involved in immunomodulation... - SAP: a molecular switch regulating the immune response through a unique signaling mechanismAndre Veillette
Laboratory of Molecular Oncology, IRCM and the Department of Medicine, University of Montreal, Quebec, Canada
Eur J Immunol 33:1141-4. 2003 - Importance and mechanism of 'switch' function of SAP family adaptersAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Immunol Rev 232:229-39. 2009..Thus, SAP family adapters are molecular switches that regulate immunity as a result of their capacity to control the type of signals and functions emanating from SLAM family receptors... - SLAM-family receptors: immune regulators with or without SAP-family adaptorsAndre Veillette
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Cold Spring Harb Perspect Biol 2:a002469. 2010..The molecular basis and significance of this mechanism are discussed herein... - Negative regulation of immunoreceptor signalingAndre Veillette
Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
Annu Rev Immunol 20:669-707. 2002..Genetic evidence indicates that this inhibitory machinery is crucial for normal immune cell homeostasis... - Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptorRomain Roncagalli
Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
Nat Immunol 6:1002-10. 2005..These data identify a previously unknown mechanism of NK cell inhibition. Moreover, they indicate that EAT-2 and SAP have distinct and at times opposing functions in natural immunity... - Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cellsZhongjun Dong
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Nat Immunol 10:973-80. 2009..Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells... - Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptorsRiyan Chen
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Quebec, Canada
Mol Cell Biol 24:5144-56. 2004.... - Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptorRiyan Chen
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Mol Cell Biol 26:5559-68. 2006..Together, these data elucidate further the events initiating SLAM-SAP signaling in immune cells. Moreover, they identify a strictly inducible interaction mediated by an SH3 domain... - Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulationDominique Davidson
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
Immunity 21:707-17. 2004..These data imply that SAP is necessary for T(H)2 cytokine regulation primarily as a result of its capacity to recruit FynT. They also establish a previously unappreciated role for FynT in SAP-dependent T(H)2 cytokine regulation... - Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell functionMario Ernesto Cruz-Munoz
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
Nat Immunol 10:297-305. 2009..CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins... - The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cellsZhongjun Dong
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Immunity 36:974-85. 2012..These data showed that SAP secures NK cell activation by a dichotomous molecular mechanism, which is required for conjugate formation. These findings may have implications for the role of SAP in other immune cell types... - PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytesDominique Davidson
IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada
Mol Cell Biol 27:1960-73. 2007..These data improve our comprehension of the function of PAG in T cells. They also further implicate FynT in T-cell anergy... - Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunityMing Chao Zhong
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7
J Biol Chem 283:19255-64. 2008..Together these data provided a molecular explanation for the involvement of Ly108 in lupus susceptibility in mice... - Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulationSylvain Latour
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
Nat Cell Biol 5:149-54. 2003..These observations characterize a biologically important signalling mechanism in which an adaptor molecule composed only of an SH2 domain links a receptor devoid of intrinsic catalytic activity to the kinase required for its function... - Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cellsOliver Utting
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
Mol Cell Biol 24:6067-75. 2004..The results of our studies demonstrated that Clnk is dispensable for normal differentiation and function of T cells, mast cells, and NK cells. Hence, unlike its relatives, Clnk is not essential for normal immune functions... - The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2Dominique Davidson
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
Immunity 33:167-80. 2010..Thus, PTP-PEST controls Pyk2 activity and is a positive regulator of secondary T cell activation. These data illustrate the critical role of protein tyrosine phosphatases in T cell regulation... - SLAM family receptors and SAP-related adaptors: matters arisingAndre Veillette
Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
Trends Immunol 27:228-34. 2006..We address these issues and discuss the recent progress in this research area... - Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptorDominique Davidson
Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
Mol Cell Biol 23:2017-28. 2003..They also suggest that the inhibitory function of PAG in T cells is suppressed by CD45. Lastly, they support the idea that dephosphorylation of proteins on tyrosine residues is critical for the initiation of T-cell activation... - Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3Jeffrey D Robson
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
Mol Cell Biol 24:2332-43. 2004..Together, these data elucidate the mechanism by which Dok-3 inhibits B-cell activation. Furthermore, they provide evidence that SHIP-1 can be a negative regulator of JNK signaling in B cells... - Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiationFanny Guimont-Desrochers
Department of Microbiology and Immunology, University of Montreal, and Maisonneuve Rosemont Hospital Research Center, Montreal, QC
Blood 119:4349-57. 2012..The characterization of these novel attributes to B220+ NK cells will guide the identification of their ortholog in humans, contributing to the design of potent cancer immunotherapies... - How do SAP family deficiencies compromise immunity?Zhongjun Dong
Clinical Research Institute of Montreal, Quebec, Canada
Trends Immunol 31:295-302. 2010.... - Protein tyrosine phosphatases in lymphocyte activation and autoimmunityInmoo Rhee
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Nat Immunol 13:439-47. 2012..Here we discuss recent progress in elucidating the roles and mechanisms of action of PTPs in lymphocyte activation. We also review the accumulating evidence that genetic alterations in PTPs are involved in human autoimmunity... - The Phosphatase PTP-PEST/PTPN12 Regulates Endothelial Cell Migration and Adhesion, but Not Permeability, and Controls Vascular Development and Embryonic ViabilityCleiton Martins Souza
From the Laboratories of Molecular Oncology and
J Biol Chem 287:43180-90. 2012..This function explains at least in part the essential role of PTP-PEST in embryonic development and viability... - [EAT-2: a novel regulator of natural killer cell functions]Romain Roncagalli
, , Canada
Med Sci (Paris) 22:22-4. 2006