R M Touyz

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. ncbi Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats
    Rhian M Touyz
    Multidisciplinary Group on Hypertension, Clinical Research Institute of Montrel, Quebec, Canada
    J Hypertens 21:337-44. 2003
  2. ncbi Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 44:248-52. 2004
  3. ncbi Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase
    Carmine Savoia
    Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Hypertens 24:2417-22. 2006
  4. ncbi Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo
    Christine Daigle
    Faculty of Pharmacy, Universite de Montreal, PO Box 6128, Station Centre Ville, Montreal, Quebec, H3C 3J7 Canada
    BMC Cardiovasc Disord 4:6. 2004
  5. ncbi Recent advances in angiotensin II signaling
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Braz J Med Biol Res 35:1001-15. 2002
  6. ncbi Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:1141-9. 2004
  7. ncbi Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats
    Rhian M Touyz
    Laboratory of Experimental Hypertension, bLaboratory of Experimental Cardiovascular Biology, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 20:1127-34. 2002
  8. ncbi Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Canada
    Hypertension 39:479-85. 2002
  9. ncbi Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular disease
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Canadian Institute of Health Research, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Braz J Med Biol Res 37:1263-73. 2004
  10. ncbi Reactive oxygen species in vascular biology: implications in hypertension
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada
    Histochem Cell Biol 122:339-52. 2004

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats
    Rhian M Touyz
    Multidisciplinary Group on Hypertension, Clinical Research Institute of Montrel, Quebec, Canada
    J Hypertens 21:337-44. 2003
    ..To investigate whether imipramine and quinidine, inhibitors of the Na /Mg exchanger, influence development of hypertension in rats infused with angiotensin (Ang) II...
  2. ncbi Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 44:248-52. 2004
    ..Finally, important avenues for future research in the field of ROS, oxidative stress, and redox signaling in hypertension are considered...
  3. ncbi Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase
    Carmine Savoia
    Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Hypertens 24:2417-22. 2006
    ..We previously demonstrated that AT2R-mediated effects involve inhibition of the RhoA/Rho kinase pathway. However, molecular mechanisms underlying this phenomenon are unknown...
  4. ncbi Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo
    Christine Daigle
    Faculty of Pharmacy, Universite de Montreal, PO Box 6128, Station Centre Ville, Montreal, Quebec, H3C 3J7 Canada
    BMC Cardiovasc Disord 4:6. 2004
    ..The aim of the present study was to determine some of the signaling pathways mediating angiotensin II (Ang II)-induced protein synthesis in vivo in large and small arteries...
  5. ncbi Recent advances in angiotensin II signaling
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Braz J Med Biol Res 35:1001-15. 2002
    ....
  6. ncbi Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:1141-9. 2004
    ..The role of reactive oxygen species (ROS) in mitogen-activated protein kinase (MAPK) signaling by angiotensin (Ang) II and endothelin-1 (ET-1) in human vascular smooth muscle cells (VSMC) was investigated...
  7. ncbi Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats
    Rhian M Touyz
    Laboratory of Experimental Hypertension, bLaboratory of Experimental Cardiovascular Biology, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 20:1127-34. 2002
    ..In the present in vivo study, we investigated whether short-term inhibition of ERK1/2-dependent signaling pathways influences vascular function and blood pressure (BP) in spontaneously hypertensive rats (SHR)...
  8. ncbi Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Canada
    Hypertension 39:479-85. 2002
    ..In conclusion, altered regulation of Ang II type 1 receptor-activated c-Src by Csk may be an important upstream modulator of abnormal ERK1/2 signaling in VSMCs from SHR...
  9. ncbi Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular disease
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Canadian Institute of Health Research, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Braz J Med Biol Res 37:1263-73. 2004
    ..The present review focuses on the biology of ROS in Ang II signaling in vascular cells and discusses how oxidative stress contributes to vascular damage in cardiovascular disease...
  10. ncbi Reactive oxygen species in vascular biology: implications in hypertension
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada
    Histochem Cell Biol 122:339-52. 2004
    ..The present chapter focuses on the importance of ROS in vascular biology and discusses the role of oxidative stress in vascular damage in hypertension...
  11. ncbi Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 38:56-64. 2001
    ..Because AT(1) receptor expression was unaltered in HTs, increased Ang II signaling may be a postreceptor phenomenon. These data define a signal transduction pathway whereby Ang II mediates exaggerated growth in VSMCs from HTs...
  12. ncbi Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways
    R M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Canada
    J Hypertens 19:1245-54. 2001
    ....
  13. ncbi Magnesium in clinical medicine
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Front Biosci 9:1278-93. 2004
    ..Future research, both at the fundamental and clinical levels, will certainly facilitate our understanding of how magnesium contributes to pathological processes and under what circumstances it should be used therapeutically...
  14. ncbi Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats: role of reactive oxygen species
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Canada
    J Hypertens 20:2221-32. 2002
    ....
  15. ncbi Role of magnesium in the pathogenesis of hypertension
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Que, Canada H2W IR7
    Mol Aspects Med 24:107-36. 2003
    ..Alterations in magnesium regulation in experimental and clinical hypertension and the potential antihypertensive therapeutic actions of magnesium will also be addressed...
  16. ncbi Role of endothelin in human hypertension
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, QC H2W 1R7, Canada
    Can J Physiol Pharmacol 81:533-41. 2003
    ..Thus, targeting the endothelin system may have important therapeutic potential in the treatment of hypertension, particularly by contributing to the prevention of target organ damage and the management of cardiovascular disease...
  17. ncbi Reactive oxygen species in vascular biology: role in arterial hypertension
    Rhian M Touyz
    Clinical Research Institute of Montreal, Quebec, Canada
    Expert Rev Cardiovasc Ther 1:91-106. 2003
    ....
  18. ncbi Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Ave West, Montreal, Quebec, Canada H2W 1R7
    Clin Sci (Lond) 105:235-42. 2003
    ..The findings from this study suggest a possible role for the Na(+)/Mg(2+) exchanger in vascular signalling events associated with blood pressure elevation in Ang II-dependent hypertension...
  19. ncbi Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, QC H2W 1R7, Canada
    Can J Physiol Pharmacol 81:159-67. 2003
    ..These findings suggest that Ang II activates p38MAP kinase and ERK5 via redox-dependent cascades that are regulated by IGF-1R and EGFR transactivation. ERK1/2 regulation by Ang II is via redox-insensitive pathways...
  20. ncbi c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Canada
    Arterioscler Thromb Vasc Biol 23:981-7. 2003
    ..The aim of this study was to determine molecular mechanisms whereby c-Src regulates angiotensin II (Ang II)-mediated NAD(P)H oxidase-derived *O2- in human vascular smooth muscle cells (VSMCs)...
  21. ncbi The role of angiotensin II in regulating vascular structural and functional changes in hypertension
    Rhian M Touyz
    Clinical Research Institute of Montreal, 110 Pine Avenue West, Canada
    Curr Hypertens Rep 5:155-64. 2003
    ..In addition, cellular processes whereby Ang II influences vessels in hypertension are discussed. Finally, novel concepts related to signaling pathways by which Ang II regulates vascular smooth muscle cells in hypertension are introduced...
  22. ncbi Recent advances in intracellular signalling in hypertension
    Rhian M Touyz
    Canadian Institute of Health Research Multidisciplinary Research Group on Hypertension, Quebec, Canada
    Curr Opin Nephrol Hypertens 12:165-74. 2003
    ..These pathways are emerging as critical mediators of hypertensive vascular disease because they influence multiple cellular responses that are involved in structural remodelling, vascular inflammation and altered tone...
  23. ncbi Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Sungkyun Kwan University School of Medicine, Seoul, Korea
    J Hypertens 19:441-9. 2001
    ..We hypothesize here that c-Src, a non-receptor tyrosine kinase, is an important upstream regulator of vascular smooth muscle cell (VSMC) Ca2+ signaling and associated vascular contraction induced by Ang II...
  24. ncbi Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 276:13657-63. 2001
    ....
  25. ncbi Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Canada
    Circ Res 90:1205-13. 2002
    ..These novel findings provide insight into the molecular regulation of NAD(P)H oxidase by Ang II in HVSMCs. Furthermore, we identify differences in gp91phox homologue expression in VSMCs from rats and human small and large arteries...
  26. ncbi Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 45:530-7. 2005
    ....
  27. ncbi Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II
    Rhian M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Curr Opin Nephrol Hypertens 14:125-31. 2005
    ..This review focuses on the role of inflammation, oxidative stress and angiotensin II in vascular injury and discusses implications of these processes in hypertension...
  28. ncbi Modulation of vascular smooth muscle cell growth by magnesium-role of mitogen-activated protein kinases
    Rhian M Touyz
    Canadian Institute for Health Research, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Cell Physiol 197:326-35. 2003
    ..These data demonstrate the novel findings that cell cycle activation and growth regulation by Mg(2+) occurs via ERK1/2-dependent, p38 MAP kinase-independent pathways...
  29. ncbi Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 17:907-16. 1999
    ..This study investigates the growth effects and associated signaling pathways of angiotensin II (Ang II) in human vascular smooth muscle cells...
  30. ncbi Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats
    R M Touyz
    Department of Medicine, University of Witwatersrand, Johannesburg, South Africa
    Am J Hypertens 12:757-65. 1999
    ..In conclusion, long-term Mg2+ supplementation significantly attenuates, but does not prevent, the development of hypertension in SHR. Furthermore, intracellular Mg2+ deficiency and Ca2+ overload in SHR are normalized by Mg2+ treatment...
  31. ncbi Activation of the Na(+)-H+ exchanger modulates angiotensin II-stimulated Na(+)-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 34:442-9. 1999
    ..These data demonstrate that in VSMCs [Mg2+]i regulation is Na+ dependent, that activation of NHE modulates Na(+)-Mg2+ transport, and that increased activity of NHE may play a role in altered Na(+)-dependent regulation of [Mg2+]i in SHR...
  32. ncbi p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Canada
    Arterioscler Thromb Vasc Biol 25:512-8. 2005
    ....
  33. ncbi Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension
    Rhian M Touyz
    Canadian Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Clin Exp Pharmacol Physiol 30:860-6. 2003
    ..7. In the present review, we discuss the role of ROS as second messengers in AngII signalling and focus on the implications of these events in the processes underlying vascular remodelling in hypertension...
  34. ncbi Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells
    Rhian M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Montreal, QC, Canada
    Can J Physiol Pharmacol 83:91-7. 2005
    ..Together, these studies suggest that the cytoskeleton may be a central point of crosstalk in growth- and redox-signaling pathways by Ang II, which may be important in the regulation of VSMC function...
  35. ncbi p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Hypertension 37:574-80. 2001
    ..These results indicate differential roles of ERK1/2 and p38 MAP kinase in AT(1)-stimulated VSMC growth and collagen production, which may contribute to vascular remodeling in hypertension...
  36. ncbi Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
    R M Touyz
    Medical Research Council of Canada Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Pharmacol Rev 52:639-72. 2000
    ....
  37. ncbi Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 36:S300-4. 2000
    ..These data suggest that interruption of the endothelin (ET) system by blockade of ETA-receptors may achieve protection from target-organ damage despite lack of a reduction in blood pressure...
  38. ncbi Molecular and cellular mechanisms regulating vascular function and structure--implications in the pathogenesis of hypertension
    R M Touyz
    Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    Can J Cardiol 16:1137-46. 2000
    ..The present review discusses recent developments in the understanding of cellular and molecular mechanisms underlying vascular regulation in hypertension...
  39. ncbi Oxidative stress and vascular damage in hypertension
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    Curr Hypertens Rep 2:98-105. 2000
    ..This review focuses on the vascular effects of reactive oxygen species and the role of oxidative stress in vascular damage in hypertension...
  40. ncbi Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    J Hypertens 19:553-9. 2001
    ....
  41. ncbi Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries
    R M Touyz
    Medical Research Council Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Circulation 99:392-9. 1999
    ..We assessed the role of extracellular signal-regulated kinases (ERKs) in Ang II-stimulated contraction and associated signaling pathways in vascular smooth muscle cells (VSMCs) from human small arteries...
  42. ncbi Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR
    M El Mabrouk
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 281:H30-9. 2001
    ..In SHR VSMCs, PI3 kinase plays a role in augmented angiotensin II-induced ERK1/2 phosphorylation. These angiotensin II-mediated signaling events could contribute to vascular remodeling in SHR...
  43. ncbi Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR
    R M Touyz
    Medical Research Council Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal and Université de Montréal, Montreal, Quebec
    Hypertension 33:366-72. 1999
    ....
  44. ncbi Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR
    X Chen
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 38:606-11. 2001
    ..These effects may be mediated via modulation of enzyme systems that generate free radicals...
  45. ncbi Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells
    R M Touyz
    Experimental Hypertension Laboratory, Medical Research Council Multidisciplinary Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Circ Res 84:505-15. 1999
    ..MAP/ERK inhibition abrogated sustained contraction and normalized Ang II effects in SHR. These data suggest that ERK-dependent signaling pathways influence contraction and that they play a role in vascular hyperresponsiveness in SHR...
  46. ncbi Expression of cell cycle proteins in blood vessels of angiotensin II-infused rats: role of AT(1) receptors
    Q N Diep
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 37:604-8. 2001
    ..Reduction in cell cycle kinase inhibitors p21 and p27 may contribute to activation of growth induced by in vivo AT(1) receptor stimulation...
  47. ncbi Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan
    E L Schiffrin
    Medical Research Council Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Circulation 101:1653-9. 2000
    ....
  48. ncbi Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
    Farhad Amiri
    Experimental Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 110:2233-40. 2004
    ..To directly test the role of endothelium-derived ET-1 in cardiovascular pathophysiology, we specifically targeted expression of the human preproET-1 gene to the endothelium by using the Tie-2 promoter in C57BL/6 mice...
  49. ncbi Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats
    D Endemann
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 12:716-23. 1999
    ..These findings indicate attenuation, as hypertension progresses, of the initially enhanced vascular reactivity to Ang II that is present during the development of hypertension in SHR...
  50. ncbi Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause
    Talin Ebrahimian
    Lady Davis Institute for Medical Research, McGill University, Quebec, Canada
    Am J Physiol Heart Circ Physiol 295:H1481-8. 2008
    ..Our data suggest that in a model of menopause, protective actions of TRX may be blunted, which could contribute to cardiac remodeling independently of oxidative stress and hypertension...
  51. ncbi Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats
    Dierk H Endemann
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Hypertension 43:1252-7. 2004
    ..These effects were attenuated by eplerenone, particularly in the salt-loaded state, underlining the pathophysiological role of aldosterone in salt-sensitive hypertension...
  52. ncbi Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice
    Agostino Virdis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:535-42. 2004
    ..Our findings suggest that NAD(P)H oxidase activity plays an important role in vascular functional and structural changes and in the composition of the vascular wall in Ang II-dependent hypertension...
  53. ncbi Spironolactone improves angiotensin-induced vascular changes and oxidative stress
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 40:504-10. 2002
    ..Our findings suggest that aldosterone may mediate some of angiotensin II-induced vascular effects in hypertension, in part via increased oxidative stress...
  54. ncbi PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation
    Quy N Diep
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 40:866-71. 2002
    ..These effects are associated with decreased oxidative stress and inflammation in the vascular wall...
  55. ncbi Mesenteric vascular smooth muscle cells from spontaneously hypertensive rats display increased calcium responses to angiotensin II but not to endothelin-1
    R M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 12:663-73. 1994
    ..The differential effects of these two vasoconstrictor peptides may contribute to their relative roles in modulating vascular smooth muscle cell cytosolic free calcium in SHR...
  56. ncbi Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis
    Pierre Beaucage
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    J Hypertens 23:329-35. 2005
    ..Since Src tyrosine kinases can be activated by both agonists, we studied their role in the trophic action of angiotensin II, endothelin and their interaction in rat small mesenteric arteries...
  57. ncbi Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats
    Emilie C Viel
    Lady Davis Institute for Medical Research, Montreal, QC, Canada H3T 1E2
    Am J Physiol Heart Circ Physiol 295:H281-8. 2008
    ..Our findings demonstrate the involvement of ET(A) receptor-modulated O(2)(*-) derived from XO and from mitochondrial oxidative enzymes in arteries from DOCA-salt rats...
  58. ncbi Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system
    Marc Iglarz
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 17:597-603. 2004
    ..CONCLUSIONS: Our data suggest that the profibrotic but not the hypertrophic action of aldosterone are mediated at least in part by reactive oxygen species generation and involve an interaction with the renin-angiotensin system...
  59. ncbi Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats
    Fatiha Tabet
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:2005-12. 2005
    ..The upregulation of these processes may contribute to enhanced redox-dependent MAP kinase signaling in SHR VSMC...
  60. ncbi Growth factors mediate intracellular signaling in vascular smooth muscle cells through protein kinase C-linked pathways
    R M Touyz
    Experimental Hypertension Laboratory, MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal and Université de Montréal, Quebec, Canada
    Hypertension 30:1440-7. 1997
    ..The underlying pathways that mediate these responses are partially dependent on Na+/ Ca2+ transporters and the Na+/H+ exchanger, both of which are linked to PKC activation...
  61. ncbi Treatment of non-insulin-dependent diabetic hypertensive patients with Ca2+ channel blockers is associated with increased platelet sensitivity to insulin
    R M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 8:1214-21. 1995
    ....
  62. ncbi Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension
    Danesh Javeshghani
    CIHR Multidisciplinary Research Group on Hypertension, Canada
    J Hypertens 24:1365-73. 2006
    ..Our findings suggest that in FORKO mice Ang II may be more important in influencing vascular tone and endothelial function, possibly through oxidative stress and altered ERalpha signaling, than in arterial remodeling and BP elevation...
  63. ncbi Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats
    Carmine Savoia
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:1037-45. 2005
    ....
  64. ncbi Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension
    Danesh Javeshghani
    Experimental Hypertension, Clinical Research Institute of Montreal, Quebec, 110 Pine Ave West, Montreal, H2W 1R7, Canada
    Hypertension 42:761-7. 2003
    ..Our findings suggest that vascular Ang II signaling is downregulated in female FORKO mice and that Ang II may not play an important role in blood pressure elevation in this model of menopause-associated hypertension...
  65. ncbi Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells
    R M Touyz
    Experimental Hypertension Laboratory, MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal and Université de Montréal, Montreal, Quebec, Canada H2W 1R7
    Hypertension 34:976-82. 1999
    ..These cascades may function as second messengers in long-term Ang II-mediated growth-signaling events...
  66. ncbi Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart
    Chantal Mercure
    Clinical Research Institute of Montreal IRCM, Montreal, Canada
    Circ Res 103:1319-26. 2008
    ....
  67. ncbi Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats
    Qian Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    J Hypertens 20:899-907. 2002
    ..NEP inhibition is involved to a large extent in the effect of omapatrilat in DOCA-salt rats. These actions of omapatrilat may confer protection against end-organ damage characteristic of severe hypertension...
  68. ncbi Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II
    Ying He
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Circ Res 96:207-15. 2005
    ..These novel findings identify TRPM7 as a functionally important regulator of Mg2+ homeostasis and growth in VSMCs...
  69. ncbi Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury
    Carolina De Ciuceis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 25:2106-13. 2005
    ..We therefore investigated Ang II effects on vascular structure, function, and oxidant stress generation in this model...
  70. ncbi Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension
    Marc Iglarz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 42:737-43. 2003
    ..Taken together, these data indicate a modulatory role of PPAR activators on cardiac remodeling in mineralocorticoid-induced hypertension, in part associated with decreased ET-1 production...
  71. ncbi Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
    Qian Pu
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Hypertension 42:49-55. 2003
    ..Endothelin blockade may exert beneficial effects on vascular remodeling, fibrosis, oxidative stress, and adhesion molecule expression in aldosterone-induced hypertension...
  72. ncbi SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension
    Mohammed El Mabrouk
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 286:H1954-62. 2004
    ..Our data demonstrate that PI3K and SAM68 are involved in ANG II signaling and that SAM68 is differentially regulated in VSMCs from SHR. These processes may contribute to the enhanced ANG II signaling and altered VSMC growth in SHR...
  73. ncbi Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats
    J Fareh
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
    J Mol Cell Cardiol 32:665-76. 2000
    ....
  74. ncbi Synergistic vascular protective effects of combined low doses of PPARalpha and PPARgamma activators in angiotensin II-induced hypertension in rats
    C De Ciuceis
    Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Br J Pharmacol 151:45-53. 2007
    ....
  75. ncbi Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats
    Jeong Bae Park
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 15:78-84. 2002
    ..Our data suggest that oxidative stress plays an important role in vascular damage associated with severe hypertension in salt-loaded SHRSP...
  76. ncbi Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:1352-7. 2003
    ..We evaluated the effect of hyperhomocystinemia and angiotensin (Ang) II on vascular function and structure in methylenetetrahydrofolate reductase knockout mice (Mthfr+/-)...
  77. ncbi Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice
    Eun A Ko
    1Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 292:H1789-95. 2007
    ....
  78. ncbi Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 49:341-6. 2007
    ....
  79. ncbi alpha 8 Integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype
    Ramin Zargham
    Institut de Recherches Cliniques de Montreal, Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 195:303-12. 2007
    ..Our findings suggest a dynamic role for alpha 8 beta 1 integrin to induce contractile phenotype as well as suppression of VSMC migration, a key player during arterial stenosis...
  80. ncbi Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats
    Fatiha Tabet
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 44:200-8. 2004
    ..These effects may relate to differential activation of Ca2+ channels by H2O2 and *O2-. Enhanced activation of L-type Ca2+ channels and increased Ca2+ influx by H2O2 may contribute to increased Ca2+ signaling in VSMCs from SHR...
  81. ncbi Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood
    Catherine Yzydorczyk
    Department of Pediatrics, Research Center, CHU Sainte Justine, Universite de Montreal, Montreal, Quebec, Canada
    Hypertension 52:889-95. 2008
    ..Our findings support the hypothesis of developmental programming of adult cardiovascular and renal diseases and provide new insights into the potential role of oxidative stress in this process...
  82. ncbi Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension
    Marc Iglarz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:45-51. 2003
    ..CONCLUSIONS: PPAR-alpha and -gamma activators were able to modulate endogenous production of ET-1 and had beneficial vascular effects in endothelin-dependent hypertension...
  83. ncbi Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats
    Dierk Endemann
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 40:123-32. 2002
    ..These processes do not seem to play an important role in AVP-induced hypercontractility in SHR with established hypertension...
  84. ncbi The 2004 Canadian recommendations for the management of hypertension: Part III--Lifestyle modifications to prevent and control hypertension
    R M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Can J Cardiol 20:55-9. 2004
    ..To provide updated, evidence-based recommendations regarding the role of lifestyle modification in the treatment and prevention of hypertension...
  85. ncbi Racial differences in cell membrane ATPases and cellular cation content in urban South African normotensive and hypertensive subjects
    R M Touyz
    Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa
    Am J Hypertens 6:693-700. 1993
    ..These results suggest possible racial differences in cellular cation regulation in essential hypertension...
  86. ncbi Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist
    Nadheige Lochard
    Laboratories of Molecular Biochemistry of Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    Circ Res 94:1451-7. 2004
    ..These results suggest that chronic elevation of Ang IV in the brain can induce hypertension that can be treated with angiotensin II AT1 receptor antagonists...
  87. ncbi Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 51:432-9. 2008
    ....
  88. ncbi Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src
    Glaucia E Callera
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Canada
    Hypertension 45:773-9. 2005
    ..Taken together, our findings demonstrate that nongenomic signaling by aldosterone occurs through c-Src-dependent pathways. These processes may play an important role in profibrotic actions of aldosterone...
  89. ncbi Thioredoxin in vascular biology: role in hypertension
    Talin Ebrahimian
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Hypertension and Vascular Research Unit, McGill University, Montreal, Quebec, Canada
    Antioxid Redox Signal 10:1127-36. 2008
    ..In addition, the pathopysiological role of TRX in hypertension and other cardiovascular diseases is addressed...
  90. ncbi From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension
    Ernesto L Schiffrin
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension and Hypertension Clinic, , Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 287:H435-46. 2004
  91. ncbi Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II
    Rhian M Touyz
    Canadian Institutes for Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Exp Physiol 90:449-55. 2005
    ..The present review discusses the role of Ang II in remodelling of resistance arteries, focusing on some signalling pathways involved in vascular growth and inflammation in hypertension...
  92. ncbi Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support
    Michel White
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada, H1T 1C8
    Clin Sci (Lond) 110:483-9. 2006
    ..Short-term inotropic support improves functional status and reduces indices of inflammation and oxidative stress in patients with decompensated CHF...
  93. ncbi Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment
    Dierk H Endemann
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 43:399-404. 2004
    ....
  94. ncbi Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice
    Talin Ebrahimian
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec
    J Hypertens 25:1263-71. 2007
    ..As oestrogen may protect against oxidative stress, we also evaluated whether the thioredoxin system, particularly in the heart, is differentially regulated between females and males...
  95. ncbi Vascular biology of endothelin
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertention, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 32:S2-13. 1998
    ....
  96. ncbi Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients
    Carmine Savoia
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 48:271-7. 2006
    ....
  97. ncbi Structural features and expression of an alternatively spliced growth factor type I receptor for follitropin signaling in the developing ovary
    P S Babu
    Molecular Reproduction Research Laboratory, Clinical Research Institute of Montreal, Quebec, Canada
    Mol Cell Biol Res Commun 2:21-7. 1999
    ..This is the first documentation of alternative splicing of a G protein coupled receptor gene creating a different signaling motif for cellular signaling...
  98. ncbi Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications
    Rhian M Touyz
    Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, and Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Vascul Pharmacol 45:19-28. 2006
    ..The present chapter focuses on the role of PPARs in vascular biology and discusses the clinical implications of using PPAR agonists in the management of vascular disease...
  99. ncbi Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells
    Elisandra Gava
    Division of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Nephrol Dial Transplant 24:1766-73. 2009
    ..In the proximal tubule, angiotensin-(1-7) [Ang-(1-7)] blocks activation of MAPKs by angiotensin II. We studied the effect of Ang-(1-7) on signalling responses in LLC-PK(1) cells in normal (5 mM) or high (25 mM) glucose...
  100. ncbi Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone?
    Rhian M Touyz
    J Hypertens 21:2235-8. 2003
  101. ncbi Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation?
    Ernesto L Schiffrin
    Arterioscler Thromb Vasc Biol 23:707-9. 2003