E L Schiffrin

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. ncbi request reprint Relationship between small-artery structure and systolic, diastolic and pulse pressure in essential hypertension
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    J Hypertens 17:381-7. 1999
  2. ncbi request reprint Good news for patients with type 2 diabetes: angiotensin receptor blocker treatment delays progression of diabetic nephropathy
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 11:173-5. 2002
  3. ncbi request reprint State-of-the-Art lecture. Role of endothelin-1 in hypertension
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal IRCM, Quebec, Canada
    Hypertension 34:876-81. 1999
  4. ncbi request reprint Effects of antihypertensive drugs on vascular remodeling: do they predict outcome in response to antihypertensive therapy?
    E L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 10:617-24. 2001
  5. ncbi request reprint Effect of crossing over hypertensive patients from a beta-blocker to an angiotensin receptor antagonist on resistance artery structure and on endothelial function
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Hypertens 20:71-8. 2002
  6. ncbi request reprint Effect of antihypertensive treatment on small artery remodeling in hypertension
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada
    Can J Physiol Pharmacol 81:168-76. 2003
  7. ncbi request reprint Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan
    E L Schiffrin
    Medical Research Council Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Circulation 101:1653-9. 2000
  8. ncbi request reprint A critical review of the role of endothelial factors in the pathogenesis of hypertension
    E L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 38:S3-6. 2001
  9. ncbi request reprint Aldosterone: a risk factor for vascular disease
    Mario Fritsch Neves
    Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Curr Hypertens Rep 5:59-65. 2003
  10. ncbi request reprint Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertensive patients
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 15:105-10. 2002

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Relationship between small-artery structure and systolic, diastolic and pulse pressure in essential hypertension
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    J Hypertens 17:381-7. 1999
    ..A study of small arteries has suggested that this is not the case in human essential hypertension. We therefore investigated the role of hemodynamic determinants on small-artery structure in hypertensive patients...
  2. ncbi request reprint Good news for patients with type 2 diabetes: angiotensin receptor blocker treatment delays progression of diabetic nephropathy
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 11:173-5. 2002
  3. ncbi request reprint State-of-the-Art lecture. Role of endothelin-1 in hypertension
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal IRCM, Quebec, Canada
    Hypertension 34:876-81. 1999
    ..This remains to be demonstrated in humans...
  4. ncbi request reprint Effects of antihypertensive drugs on vascular remodeling: do they predict outcome in response to antihypertensive therapy?
    E L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 10:617-24. 2001
    ..Thus, current evidence does not support the rational expectation that vasculoprotective antihypertensive agents will be associated with better outcomes in hypertensive patients, possibly because of limitations of these trials...
  5. ncbi request reprint Effect of crossing over hypertensive patients from a beta-blocker to an angiotensin receptor antagonist on resistance artery structure and on endothelial function
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Hypertens 20:71-8. 2002
    ....
  6. ncbi request reprint Effect of antihypertensive treatment on small artery remodeling in hypertension
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada
    Can J Physiol Pharmacol 81:168-76. 2003
    ..The vascular protective action of some antihypertensive agents may contribute to improve outcome for hypertensive patients, although this is presently unproven...
  7. ncbi request reprint Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan
    E L Schiffrin
    Medical Research Council Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Circulation 101:1653-9. 2000
    ....
  8. ncbi request reprint A critical review of the role of endothelial factors in the pathogenesis of hypertension
    E L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 38:S3-6. 2001
    ..Endothelin-1 may play a similar role in human hypertension...
  9. ncbi request reprint Aldosterone: a risk factor for vascular disease
    Mario Fritsch Neves
    Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Curr Hypertens Rep 5:59-65. 2003
    ....
  10. ncbi request reprint Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertensive patients
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 15:105-10. 2002
    ..Whether the vascular protective effect of amlodipine will result in improved outcomes in hypertension remains to be demonstrated...
  11. ncbi request reprint Small artery remodeling in hypertension: can it be corrected?
    E L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    Am J Med Sci 322:7-11. 2001
    ..Improved outcomes in hypertensive patients demonstrated in recent trials with some but not others of these agents could be a consequence, at least in part, of vascular protection offered by some antihypertensive agents...
  12. ncbi request reprint Role of endothelin-1 in hypertension and vascular disease
    E L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal IRCM, Quebec, Canada
    Am J Hypertens 14:83S-89S. 2001
    ..Endothelin antagonists could become effective disease-modifying agents in different forms of cardiovascular disease...
  13. ncbi request reprint Beyond blood pressure: the endothelium and atherosclerosis progression
    Ernesto L Schiffrin
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Am J Hypertens 15:115S-122S. 2002
    ..This may help to explain the positive results of recently completed trials such as Heart Outcomes Prevention Evaluation (HOPE) and Losartan Intervention for Endpoint Reduction in Hypertension (LIFE)...
  14. ncbi request reprint p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Hypertension 37:574-80. 2001
    ..These results indicate differential roles of ERK1/2 and p38 MAP kinase in AT(1)-stimulated VSMC growth and collagen production, which may contribute to vascular remodeling in hypertension...
  15. ncbi request reprint Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    J Hypertens 19:553-9. 2001
    ....
  16. ncbi request reprint Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries
    R M Touyz
    Medical Research Council Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Circulation 99:392-9. 1999
    ..We assessed the role of extracellular signal-regulated kinases (ERKs) in Ang II-stimulated contraction and associated signaling pathways in vascular smooth muscle cells (VSMCs) from human small arteries...
  17. ncbi request reprint Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR
    R M Touyz
    Medical Research Council Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal and Université de Montréal, Montreal, Quebec
    Hypertension 33:366-72. 1999
    ....
  18. ncbi request reprint ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats
    J B Park
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 37:1444-9. 2001
    ..These results suggest a role for endothelin-1 in BP elevation and structural alterations of large and small vessels in aldosterone and salt-induced hypertension...
  19. ncbi request reprint Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR
    M El Mabrouk
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 281:H30-9. 2001
    ..In SHR VSMCs, PI3 kinase plays a role in augmented angiotensin II-induced ERK1/2 phosphorylation. These angiotensin II-mediated signaling events could contribute to vascular remodeling in SHR...
  20. ncbi request reprint Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells
    R M Touyz
    Experimental Hypertension Laboratory, Medical Research Council Multidisciplinary Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Circ Res 84:505-15. 1999
    ..MAP/ERK inhibition abrogated sustained contraction and normalized Ang II effects in SHR. These data suggest that ERK-dependent signaling pathways influence contraction and that they play a role in vascular hyperresponsiveness in SHR...
  21. ncbi request reprint Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR
    X Chen
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 38:606-11. 2001
    ..These effects may be mediated via modulation of enzyme systems that generate free radicals...
  22. doi request reprint Interleukin-2 enhances angiogenesis and preserves cardiac function following myocardial infarction
    M Bouchentouf
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Cytokine 56:732-8. 2011
    ..2%. Here we show that a single IV injection of rhIL-2 positively impacted cardiac function by improving angiogenesis through a process involving NK cells...
  23. ncbi request reprint Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 17:907-16. 1999
    ..This study investigates the growth effects and associated signaling pathways of angiotensin II (Ang II) in human vascular smooth muscle cells...
  24. ncbi request reprint Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 38:56-64. 2001
    ..Because AT(1) receptor expression was unaltered in HTs, increased Ang II signaling may be a postreceptor phenomenon. These data define a signal transduction pathway whereby Ang II mediates exaggerated growth in VSMCs from HTs...
  25. ncbi request reprint Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 36:S300-4. 2000
    ..These data suggest that interruption of the endothelin (ET) system by blockade of ETA-receptors may achieve protection from target-organ damage despite lack of a reduction in blood pressure...
  26. ncbi request reprint Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats
    D Endemann
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 12:716-23. 1999
    ..These findings indicate attenuation, as hypertension progresses, of the initially enhanced vascular reactivity to Ang II that is present during the development of hypertension in SHR...
  27. doi request reprint A novel and simplified method of culture of human blood-derived early endothelial progenitor cells for the treatment of ischemic vascular disease
    M Bouchentouf
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Cell Transplant 20:1431-43. 2011
    ....
  28. ncbi request reprint Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism
    F Ammarguellat
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, , , Canada
    Circulation 103:319-24. 2001
    ..These results support the hypothesis of a role for endothelin-1 in cardiac collagen deposition in mineralocorticoid hypertension, which may have pathophysiological and pharmacological implications in hypertensive heart disease...
  29. ncbi request reprint Renal and vascular effects of chronic endothelin receptor antagonism in malignant hypertensive rats
    J S Li
    Multidisciplinary Research Group on Hypertension, , , Canada
    Am J Hypertens 9:803-11. 1996
    ..Further studies will be necessary to determine whether endothelin antagonists may indeed offer some degree of renal protection and have therapeutic potential in severe or malignant hypertension...
  30. ncbi request reprint Vascular remodeling and endothelial function in hypertensive patients: effects of antihypertensive therapy
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertension, University of Montreal, Quebec, Canada
    Scand Cardiovasc J Suppl 47:15-21. 1998
    ....
  31. ncbi request reprint Treatment of non-insulin-dependent diabetic hypertensive patients with Ca2+ channel blockers is associated with increased platelet sensitivity to insulin
    R M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 8:1214-21. 1995
    ....
  32. ncbi request reprint Vasopressin receptors and inositol trisphosphate production in blood vessels of spontaneously hypertensive rats
    R Lariviere
    Experimental Hypertension Laboratory, Clinical Research Institute of Montreal, Que, Canada
    Can J Physiol Pharmacol 67:232-9. 1989
    ..These results suggest that the vascular response to AVP is increased in SHR, in spite of decreased or normal density of binding sites compared with WKY or WR.(ABSTRACT TRUNCATED AT 250 WORDS)..
  33. ncbi request reprint Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways
    R M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Canada
    J Hypertens 19:1245-54. 2001
    ....
  34. ncbi request reprint Mesenteric vascular smooth muscle cells from spontaneously hypertensive rats display increased calcium responses to angiotensin II but not to endothelin-1
    R M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 12:663-73. 1994
    ..The differential effects of these two vasoconstrictor peptides may contribute to their relative roles in modulating vascular smooth muscle cell cytosolic free calcium in SHR...
  35. ncbi request reprint p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Canada
    Arterioscler Thromb Vasc Biol 25:512-8. 2005
    ....
  36. ncbi request reprint Effect of short-term treatment of SHR with the novel calcium channel antagonist mibefradil on function of small arteries
    J S Li
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 10:94-100. 1997
    ....
  37. ncbi request reprint Increased expression of peroxisome proliferator-activated receptor-alpha and -gamma in blood vessels of spontaneously hypertensive rats
    Q N Diep
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 38:249-54. 2001
    ..Changes (increases) in PPAR expression may play a compensatory role in the remodeling of blood vessels in SHR...
  38. ncbi request reprint Correlation of endothelial function in large and small arteries in human essential hypertension
    J B Park
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 19:415-20. 2001
    ..Ultrasound measurement of endothelial dysfunction in the brachial artery appears to be less sensitive than in-vitro measurement in resistance arteries...
  39. ncbi request reprint Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats
    J S Li
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 11:554-62. 1998
    ....
  40. ncbi request reprint Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells
    R M Touyz
    Experimental Hypertension Laboratory, MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal and Université de Montréal, Montreal, Quebec, Canada H2W 1R7
    Hypertension 34:976-82. 1999
    ..These cascades may function as second messengers in long-term Ang II-mediated growth-signaling events...
  41. ncbi request reprint Effect of ACE/NEP inhibition on cardiac and vascular collagen in stroke-prone spontaneously hypertensive rats
    Q Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 14:1067-72. 2001
    ..1 +/- 2.8 v 58.8 +/- 6.1 x 10(3) microm2/mm section, respectively, P < .05). In conclusion, in addition to being a potent antihypertensive agent, omapatrilat significantly improves cardiac and vascular fibrosis in SHRSP...
  42. ncbi request reprint Endothelin and endothelin antagonists in hypertension
    E L Schiffrin
    Clinical Research Institute of Montreal IRCM, Quebec, Canada
    J Hypertens 16:1891-5. 1998
    ....
  43. ncbi request reprint Resistance artery structure and neuroeffector mechanisms in hypertension induced by inhibition of nitric oxide synthase
    J S Li
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 7:996-1004. 1994
    ..abstract truncated at 250 words)..
  44. pmc Synergistic vascular protective effects of combined low doses of PPARalpha and PPARgamma activators in angiotensin II-induced hypertension in rats
    C De Ciuceis
    Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Br J Pharmacol 151:45-53. 2007
    ....
  45. ncbi request reprint Growth factors mediate intracellular signaling in vascular smooth muscle cells through protein kinase C-linked pathways
    R M Touyz
    Experimental Hypertension Laboratory, MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal and Université de Montréal, Quebec, Canada
    Hypertension 30:1440-7. 1997
    ..The underlying pathways that mediate these responses are partially dependent on Na+/ Ca2+ transporters and the Na+/H+ exchanger, both of which are linked to PKC activation...
  46. ncbi request reprint Reactive oxygen species in vascular biology: implications in hypertension
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada
    Histochem Cell Biol 122:339-52. 2004
    ..The present chapter focuses on the importance of ROS in vascular biology and discusses the role of oxidative stress in vascular damage in hypertension...
  47. ncbi request reprint Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension
    J B Park
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 19:921-30. 2001
    ..To evaluate this, we studied the prevalence of structural and functional alterations of resistance arteries and cardiac hypertrophy in patients with mild essential hypertension...
  48. ncbi request reprint Expression of cell cycle proteins in blood vessels of angiotensin II-infused rats: role of AT(1) receptors
    Q N Diep
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 37:604-8. 2001
    ..Reduction in cell cycle kinase inhibitors p21 and p27 may contribute to activation of growth induced by in vivo AT(1) receptor stimulation...
  49. ncbi request reprint Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
    R M Touyz
    Medical Research Council of Canada Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Pharmacol Rev 52:639-72. 2000
    ....
  50. ncbi request reprint Inducible nitric oxide synthase in vascular smooth muscle cells from prehypertensive spontaneously hypertensive rats
    A Singh
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 9:867-77. 1996
    ..These differences between VSMC from prehypertensive SHR and WKY may indicate a pathophysiological role of iNOS in early blood pressure elevation in SHR...
  51. ncbi request reprint Activation of the Na(+)-H+ exchanger modulates angiotensin II-stimulated Na(+)-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 34:442-9. 1999
    ..These data demonstrate that in VSMCs [Mg2+]i regulation is Na+ dependent, that activation of NHE modulates Na(+)-Mg2+ transport, and that increased activity of NHE may play a role in altered Na(+)-dependent regulation of [Mg2+]i in SHR...
  52. ncbi request reprint Apoptosis in vasculature of spontaneously hypertensive rats: effect of an angiotensin converting enzyme inhibitor and a calcium channel antagonist
    A M Sharifi
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 11:1108-16. 1998
    ....
  53. ncbi request reprint Endothelin: role in hypertension
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Biol Res 31:199-208. 1998
    ..These agents could contribute to reduce the long-term complications of hypertension, which remains to be demonstrated in humans...
  54. doi request reprint Monocyte derivatives promote angiogenesis and myocyte survival in a model of myocardial infarction
    M Bouchentouf
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Cell Transplant 19:369-86. 2010
    ..Transplanted MDs and their secretome participate in preserving functional myocardium after ischemic insult and attenuate pathological remodeling...
  55. ncbi request reprint Vascular and cardiac overexpression of endothelin-1 gene in one-kidney, one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension
    P Sventek
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 14:57-64. 1996
    ....
  56. ncbi request reprint Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Sungkyun Kwan University School of Medicine, Seoul, Korea
    J Hypertens 19:441-9. 2001
    ..We hypothesize here that c-Src, a non-receptor tyrosine kinase, is an important upstream regulator of vascular smooth muscle cell (VSMC) Ca2+ signaling and associated vascular contraction induced by Ang II...
  57. ncbi request reprint Resistance arteries as endpoints in hypertension
    E L Schiffrin
    Clinical Research Institute of Montreal, Universite de Montreal, Quebec, Canada
    Blood Press Suppl 2:24-30. 1997
    ..these results suggest that these small resistance arteries may serve as surrogate endpoints in hypertension...
  58. ncbi request reprint Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats
    J Fareh
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
    J Mol Cell Cardiol 32:665-76. 2000
    ....
  59. ncbi request reprint Vascular biology of endothelin
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertention, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 32:S2-13. 1998
    ....
  60. ncbi request reprint c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Canada
    Arterioscler Thromb Vasc Biol 23:981-7. 2003
    ..The aim of this study was to determine molecular mechanisms whereby c-Src regulates angiotensin II (Ang II)-mediated NAD(P)H oxidase-derived *O2- in human vascular smooth muscle cells (VSMCs)...
  61. doi request reprint Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 51:432-9. 2008
    ....
  62. ncbi request reprint Peroxisome proliferator-activated receptor gamma regulates angiotensin II-stimulated phosphatidylinositol 3-kinase and mitogen-activated protein kinase in blood vessels in vivo
    Karim Benkirane
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 47:102-8. 2006
    ..Effects of PPAR-gamma activators on these pathways could contribute to regression of vascular remodeling in models of hypertension and diabetes and, accordingly, in hypertensive diabetic patients...
  63. ncbi request reprint Role of angiotensin type-1 and angiotensin type-2 receptors in the expression of vascular integrins in angiotensin II-infused rats
    Pascal Brassard
    Experimental Hypertension Laboratory, Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 47:122-7. 2006
    ..These results demonstrate that AT1 and AT2 receptors have countervailing effects on vascular integrin subunit expression that may influence their effects on vascular remodeling and extracellular matrix composition...
  64. ncbi request reprint c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats
    Glaucia E Callera
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Hypertension 46:1032-8. 2005
    ..Upregulation of c-Src signaling may be important in the profibrotic and proinflammatory actions of aldosterone in this genetic model of hypertension...
  65. ncbi request reprint PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1
    Karim Benkirane
    Clinical Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 290:H390-7. 2006
    ..PPAR-gamma activation reduced ANG II-induced growth associated with inhibition of ERK 1/2, Akt, 4E-BP1, and SHIP2. Modulation of these pathways by PPAR-gamma activators may contribute to regression of vascular remodeling in hypertension...
  66. ncbi request reprint Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury
    Carolina De Ciuceis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 25:2106-13. 2005
    ..We therefore investigated Ang II effects on vascular structure, function, and oxidant stress generation in this model...
  67. ncbi request reprint Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy
    Hiroshi Yokoyama
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Hypertens 18:922-9. 2005
    ....
  68. ncbi request reprint Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats
    Carmine Savoia
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:1037-45. 2005
    ..To test whether angiotensin II (Ang II) through the Ang II type 2 receptor (AT2R), downregulates RhoA/Rho kinase, which plays a role in AT1 receptor (AT1R)-mediated function...
  69. ncbi request reprint Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells
    Rhian M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Montreal, QC, Canada
    Can J Physiol Pharmacol 83:91-7. 2005
    ..Together, these studies suggest that the cytoskeleton may be a central point of crosstalk in growth- and redox-signaling pathways by Ang II, which may be important in the regulation of VSMC function...
  70. ncbi request reprint Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation
    Montserrat C Cruzado
    Department of Morphophysiology, School of Medicine, Universidad Nacional de Cuyo, Mendoza, Argentina
    Am J Hypertens 18:81-7. 2005
    ....
  71. ncbi request reprint Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy
    Mario Fritsch Neves
    Clinical Research Institute of Montreal, QC, Canada
    Can J Physiol Pharmacol 83:999-1006. 2005
    ....
  72. ncbi request reprint Inflammation in hypertension
    Carmine Savoia
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 15:152-8. 2006
    ..In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension...
  73. doi request reprint Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP
    Qian Pu
    Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Hypertens 26:322-33. 2008
    ..We evaluated the effects of combining an angiotensin II type 1 (AT1) receptor blocker (ARB, valsartan) and a NEPI (CGS 25354) in comparison with a dual ACEI/NEPI (CGS 30440) in stroke-prone spontaneously hypertensive rats (SHRSP)...
  74. ncbi request reprint Chronic kidney disease: effects on the cardiovascular system
    Ernesto L Schiffrin
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Circulation 116:85-97. 2007
    ..Prevention and treatment of cardiovascular disease are major considerations in the management of individuals with chronic kidney disease...
  75. pmc Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats
    Emilie C Viel
    Lady Davis Institute for Medical Research, Montreal, QC, Canada H3T 1E2
    Am J Physiol Heart Circ Physiol 295:H281-8. 2008
    ..Our findings demonstrate the involvement of ET(A) receptor-modulated O(2)(*-) derived from XO and from mitochondrial oxidative enzymes in arteries from DOCA-salt rats...
  76. pmc Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR
    Fatiha Tabet
    Kidney Research Institute, OHRI University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada
    Circ Res 103:149-58. 2008
    ..We identify a novel redox-sensitive SHP-2-dependent pathway for Ang II in VSMCs. SHP-2 dysregulation by increased Nox1-derived ROS in SHR is associated with altered Ang II-AKT signaling...
  77. ncbi request reprint Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, QC, Canada
    Clin Sci (Lond) 112:375-84. 2007
    ....
  78. ncbi request reprint Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 49:341-6. 2007
    ....
  79. ncbi request reprint Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats
    Qian Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:401-9. 2005
    ..The relative roles of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) inhibition on cardiac and renal fibrosis in deoxycorticosterone acetate (DOCA)-salt hypertensive rats were studied...
  80. ncbi request reprint Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice
    Eun A Ko
    1Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 292:H1789-95. 2007
    ....
  81. ncbi request reprint The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics
    Ronald D Smith
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiovasc Drugs 6:335-42. 2006
    ..Remodeling of small resistance vessels may be the earliest pathologic finding associated with hypertension. It may predate the onset of clinically apparent hypertension...
  82. ncbi request reprint Inhibition of the renin angiotensin system: implications for the endothelium
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Curr Diab Rep 6:274-8. 2006
    ....
  83. ncbi request reprint Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension
    Danesh Javeshghani
    CIHR Multidisciplinary Research Group on Hypertension, Canada
    J Hypertens 24:1365-73. 2006
    ....
  84. ncbi request reprint Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients
    Carmine Savoia
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 48:271-7. 2006
    ....
  85. ncbi request reprint Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats
    Fatiha Tabet
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:2005-12. 2005
    ....
  86. ncbi request reprint Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
    Farhad Amiri
    Experimental Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 110:2233-40. 2004
    ..To directly test the role of endothelium-derived ET-1 in cardiovascular pathophysiology, we specifically targeted expression of the human preproET-1 gene to the endothelium by using the Tie-2 promoter in C57BL/6 mice...
  87. ncbi request reprint Peroxisome proliferator-activated receptors and cardiovascular remodeling
    Ernesto L Schiffrin
    Canadian Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 288:H1037-43. 2005
    ..Some side effects, such as weight gain, as well as documented aggravation of advanced heart failure through fluid retention by glitazones, may, however, limit their therapeutic application in prevention of cardiovascular disease...
  88. ncbi request reprint Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
    Qian Pu
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Hypertension 42:49-55. 2003
    ..Endothelin blockade may exert beneficial effects on vascular remodeling, fibrosis, oxidative stress, and adhesion molecule expression in aldosterone-induced hypertension...
  89. ncbi request reprint Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation?
    Ernesto L Schiffrin
    Arterioscler Thromb Vasc Biol 23:707-9. 2003
  90. ncbi request reprint Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism
    Mario Fritsch Neves
    Multidisciplinary Research Group on Hypertension, Canadian Institutes of Health Research, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Hypertens 21:189-98. 2003
    ..Angiotensin (Ang) II stimulates aldosterone production, which may mediate some of the effects of Ang II...
  91. ncbi request reprint Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension
    Marc Iglarz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:45-51. 2003
    ..Thus, we investigated in vivo the interaction between PPARs and ET-1 in deoxycorticosterone acetate (DOCA)-salt rats that overexpress vascular ET-1...
  92. ncbi request reprint PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation
    Quy N Diep
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 40:866-71. 2002
    ..These effects are associated with decreased oxidative stress and inflammation in the vascular wall...
  93. ncbi request reprint Spironolactone improves angiotensin-induced vascular changes and oxidative stress
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 40:504-10. 2002
    ..Our findings suggest that aldosterone may mediate some of angiotensin II-induced vascular effects in hypertension, in part via increased oxidative stress...
  94. ncbi request reprint Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension
    Rita C A Tostes
    Department of Pharmacology, Instituto de Ciencias Biomedicas, Univeridade de Sao Paulo, Av Lineu Prestes 1524, Sao Paulo 05508 900, Brazil
    Clin Sci (Lond) 103:25S-30S. 2002
    ..These processes were attenuated by BMS 182874. Our findings suggest that renal damage in aldosterone-dependent hypertension is associated with inflammatory processes that are mediated in part via ET-1...
  95. ncbi request reprint Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats
    Dierk Endemann
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 40:123-32. 2002
    ..These processes do not seem to play an important role in AVP-induced hypercontractility in SHR with established hypertension...
  96. ncbi request reprint Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats
    Qian Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    J Hypertens 20:899-907. 2002
    ..Here, we studied the relative roles of NEP and ACE inhibition and their effect on resistance artery structure and function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats...
  97. ncbi request reprint Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma
    Quy N Diep
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Montreal, Quebec, Canada
    Circulation 105:2296-302. 2002
    ..We tested the hypothesis that pioglitazone or rosiglitazone would prevent BP elevation and vascular dysfunction in angiotensin (Ang) II-infused rats by direct vascular effects...
  98. ncbi request reprint Effect of AT(1) receptor blockade on cardiac apoptosis in angiotensin II-induced hypertension
    Quy N Diep
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 282:H1635-41. 2002
    ..Bax and caspase 3 are involved in the apoptotic signaling pathway in this experimental paradigm...
  99. ncbi request reprint Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: role of ET(A) receptors
    Fatima Z Ammarguellat
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    Hypertension 39:679-84. 2002
    ....
  100. ncbi request reprint Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1
    Jeong Bae Park
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 15:164-9. 2002
    ..The ETA receptor antagonist prevented cardiac and aortic collagen deposition and aortic hypertrophy. This suggests a role for ET-1 in fibrosis of heart and large vessels in conditions associated with mineralocorticoid excess...
  101. ncbi request reprint Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:1352-7. 2003
    ..We evaluated the effect of hyperhomocystinemia and angiotensin (Ang) II on vascular function and structure in methylenetetrahydrofolate reductase knockout mice (Mthfr+/-)...