Francois Robert

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. pmc The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses
    Jeremie Poschmann
    Department of Medicine, Maisonneuve Rosemont Hospital, Research Center, University of Montreal, Montreal, Quebec, Canada
    PLoS ONE 6:e23159. 2011
  2. pmc DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes
    Simon Drouin
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    PLoS Genet 6:e1001173. 2010
  3. pmc Global position and recruitment of HATs and HDACs in the yeast genome
    Francois Robert
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 16:199-209. 2004
  4. ncbi request reprint Transcriptional regulatory networks in Saccharomyces cerevisiae
    Tong Ihn Lee
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 298:799-804. 2002
  5. ncbi request reprint Computational discovery of gene modules and regulatory networks
    Ziv Bar-Joseph
    MIT Computer Science and Artificial Intelligence Laboratory, 200 Technology Square, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 21:1337-42. 2003
  6. pmc The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition
    Sara Hardy
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    PLoS Genet 5:e1000687. 2009
  7. pmc Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning
    Benoit Guillemette
    Centre de recherche sur les mécanismes du fonctionnement cellulaire, Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS Biol 3:e384. 2005
  8. doi request reprint A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes
    Alain R Bataille
    Institut de Recherches Cliniques de Montreal, Montreal, QC H2W 1R7, Canada
    Mol Cell 45:158-70. 2012
  9. pmc Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance
    Sadri Znaidi
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Quebec, Canada
    Eukaryot Cell 7:836-47. 2008
  10. doi request reprint Profiling genome-wide histone modifications and variants by ChIP-chip on tiling microarrays in S. cerevisiae
    Alain R Bataille
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, QC, Canada, H2W 1R7
    Methods Mol Biol 543:267-79. 2009

Collaborators

Detail Information

Publications24

  1. pmc The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses
    Jeremie Poschmann
    Department of Medicine, Maisonneuve Rosemont Hospital, Research Center, University of Montreal, Montreal, Quebec, Canada
    PLoS ONE 6:e23159. 2011
    ..We propose that Rrd1 is a novel transcription elongation factor that fine-tunes the transcriptional stress response of RNAPII...
  2. pmc DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes
    Simon Drouin
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    PLoS Genet 6:e1001173. 2010
    ..Taken together, our data support a model where Set2-dependent histone H3 methylation is required for the activation of Rpd3S following its recruitment to the RNA polymerase II C-terminal domain...
  3. pmc Global position and recruitment of HATs and HDACs in the yeast genome
    Francois Robert
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 16:199-209. 2004
    ....
  4. ncbi request reprint Transcriptional regulatory networks in Saccharomyces cerevisiae
    Tong Ihn Lee
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 298:799-804. 2002
    ..Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators...
  5. ncbi request reprint Computational discovery of gene modules and regulatory networks
    Ziv Bar-Joseph
    MIT Computer Science and Artificial Intelligence Laboratory, 200 Technology Square, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 21:1337-42. 2003
    ..We also present a genome-wide location analysis data set for regulators in yeast cells treated with rapamycin, and use the GRAM algorithm to provide biological insights into this regulatory network..
  6. pmc The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition
    Sara Hardy
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    PLoS Genet 5:e1000687. 2009
    ..These results show how chromatin structure and transcription can antagonize each other, therefore shaping chromatin and controlling gene expression...
  7. pmc Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning
    Benoit Guillemette
    Centre de recherche sur les mécanismes du fonctionnement cellulaire, Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS Biol 3:e384. 2005
    ..Our data suggest that the incorporation of H2A.Z into specific promoter-bound nucleosomes configures chromatin structure to poise genes for transcriptional activation. The relevance of these findings to higher eukaryotes is discussed...
  8. doi request reprint A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes
    Alain R Bataille
    Institut de Recherches Cliniques de Montreal, Montreal, QC H2W 1R7, Canada
    Mol Cell 45:158-70. 2012
    ..We also identify Ssu72 as the Ser7 phosphatase and show that proline isomerization is a key regulator of CTD dephosphorylation at the end of genes...
  9. pmc Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance
    Sadri Znaidi
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Quebec, Canada
    Eukaryot Cell 7:836-47. 2008
    ..They also suggest that Upc2p may contribute to azole resistance by regulating the expression of drug efflux pump-encoding genes in addition to ergosterol biosynthesis genes...
  10. doi request reprint Profiling genome-wide histone modifications and variants by ChIP-chip on tiling microarrays in S. cerevisiae
    Alain R Bataille
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, QC, Canada, H2W 1R7
    Methods Mol Biol 543:267-79. 2009
    ..Here, we provide a detailed protocol for the localization of the variant histone Htz1 in the S. cerevisiae genome. This protocol can easily be adapted to fit other purposes such as profiling histone modifications...
  11. pmc Regulation of gluconeogenesis in Saccharomyces cerevisiae is mediated by activator and repressor functions of Rds2
    Nitnipa Soontorngun
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1
    Mol Cell Biol 27:7895-905. 2007
    ..Finally, we show that upon a shift to ethanol, Rds2 activation is correlated with its hyperphosphorylation by the Snf1 kinase. In summary, we have characterized Rds2 as a novel major regulator of gluconeogenesis...
  12. pmc Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production
    Marc Larochelle
    Department of Medicine, Room H7 83, Royal Victoria Hospital, McGill University, 687 Pine Ave West, Montreal, Quebec, Canada
    Mol Cell Biol 26:6690-701. 2006
    ..These data suggest that Stb5 is a key player in the control of NADPH production for resistance to oxidative stress...
  13. pmc Histone H2A.Z is essential for estrogen receptor signaling
    Nicolas Gévry
    Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Genes Dev 23:1522-33. 2009
    ..Taken together, our results provide strong mechanistic insight into how H2A.Z regulates ERalpha-mediated gene expression and provide a novel link between H2A.Z-p400 and ERalpha-dependent gene regulation and enhancer function...
  14. pmc Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes
    Ryoko Harada
    Molecular Oncology Group, McGill University Health Center, Montreal, Canada
    Nucleic Acids Res 36:189-202. 2008
    ....
  15. pmc From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response
    Josee Laganiere
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada H3A 1A1
    Proc Natl Acad Sci U S A 102:11651-6. 2005
    ....
  16. pmc Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression
    Mathieu Blanchette
    McGill Centre for Bioinformatics, Montreal, Quebec, Canada, H3A 2B4
    Genome Res 16:656-68. 2006
    ..The set of predicted CRMs, which is made available as a public database called PReMod (http://genomequebec.mcgill.ca/PReMod), will help analyze regulatory mechanisms in specific biological systems...
  17. ncbi request reprint Yeast RNase III triggers polyadenylation-independent transcription termination
    Ghada Ghazal
    RNA Group, Departement de Microbiologie et d Infectiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Mol Cell 36:99-109. 2009
    ..These results support a model for transcription termination in which cotranscriptional cleavage by Rnt1p provides access for exoribonucleases in the absence of polyadenylation signals...
  18. doi request reprint Transcriptional regulation of nonfermentable carbon utilization in budding yeast
    Bernard Turcotte
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, QC, Canada
    FEMS Yeast Res 10:2-13. 2010
    ..Finally, the role of additional regulators such as Adr1, Ert1, Oaf1, and Pip2 is also discussed...
  19. ncbi request reprint Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1
    Anne Rufiange
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec CHUQ, Quebec, Canada
    Mol Cell 27:393-405. 2007
    ..Taken together, our data underline the dynamic nature of replication-independent nucleosome assembly/disassembly, specify a link to transcription, and implicate Asf1 and H3 K56 acetylation...
  20. ncbi request reprint Random deposition of histone variants: A cellular mistake or a novel regulatory mechanism?
    Sara Hardy
    Institut de Recherches Cliniques de Montreal, QC, Canada
    Epigenetics 5:368-72. 2010
    ..Z, is a novel mechanism for localizing H2A.Z to some regions. We propose that the various functions of H2A.Z may be a consequence of the mechanism used for its incorporation, as well as its interactions with other histone variants...
  21. ncbi request reprint VAP: a versatile aggregate profiler for efficient genome-wide data representation and discovery
    Charles Coulombe
    Departement d informatique, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, J1K 2R1, Canada
    Nucleic Acids Res 42:W485-93. 2014
    ..VAP is highly efficient and designed to run on laptop computers by using a memory footprint control, but can also be easily compiled and run on servers. VAP is accessible at http://lab-jacques.recherche.usherbrooke.ca/vap/. ..
  22. doi request reprint Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice
    Samantha D Praktiknjo
    Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Endocrinology 154:4746-56. 2013
    ....
  23. pmc Kin28 regulates the transient association of Mediator with core promoters
    Célia Jeronimo
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Nat Struct Mol Biol 21:449-55. 2014
    ..We propose that Mediator is released quickly from promoters after phosphorylation of Ser5 by Kin28 (CDK7), which also allows for RNAPII to escape from the promoter...
  24. ncbi request reprint A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly
    Francois Robert
    Laboratory of Gene Transcription, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 277:9302-6. 2002
    ....