J Drouin

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. ncbi request reprint Tpit-independent function of NeuroD1(BETA2) in pituitary corticotroph differentiation
    Bruno Lamolet
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    Mol Endocrinol 18:995-1003. 2004
  2. ncbi request reprint Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency
    J Drouin
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal QC, Canada
    Clin Genet 72:175-82. 2007
  3. pmc Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells
    Steve Bilodeau
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    Mol Cell Biol 29:1895-908. 2009
  4. pmc Divergent transcriptional activities determine limb identity
    Jean François Ouimette
    Laboratory of Molecular Genetics, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada H2W 1R7
    Nat Commun 1:35. 2010
  5. doi request reprint Adult pituitary cell maintenance: lineage-specific contribution of self-duplication
    David Langlais
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110, avenue des Pins Ouest, Montreal, Quebec, H2W 1R7 Canada
    Mol Endocrinol 27:1103-12. 2013
  6. ncbi request reprint Molecular mechanisms of pituitary differentiation and regulation: implications for hormone deficiencies and hormone resistance syndromes
    Jacques Drouin
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    Front Horm Res 35:74-87. 2006
  7. doi request reprint Stem cells, differentiation and cell cycle control in pituitary
    Jacques Drouin
    Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada
    Front Horm Res 38:15-24. 2010
  8. ncbi request reprint A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins
    B Lamolet
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 des Pins Ouest, Montreal QC, Canada H2W 1R7
    Cell 104:849-59. 2001
  9. ncbi request reprint Hindlimb patterning and mandible development require the Ptx1 gene
    C Lanctot
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal Quebec, Canada H2W 1R7
    Development 126:1805-10. 1999
  10. pmc Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain
    J J Tremblay
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    EMBO J 18:3431-41. 1999

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Tpit-independent function of NeuroD1(BETA2) in pituitary corticotroph differentiation
    Bruno Lamolet
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    Mol Endocrinol 18:995-1003. 2004
    ..Taken together with a similar requirement of Tpit for corticotroph differentiation but not for commitment, the present data indicate that the POMC promoter is a point of convergence for independent corticotroph differentiating signals...
  2. ncbi request reprint Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency
    J Drouin
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal QC, Canada
    Clin Genet 72:175-82. 2007
    ..These recent advances have provided improved diagnosis and opened new perspectives for patient management and therapies...
  3. pmc Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells
    Steve Bilodeau
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    Mol Cell Biol 29:1895-908. 2009
    ....
  4. pmc Divergent transcriptional activities determine limb identity
    Jean François Ouimette
    Laboratory of Molecular Genetics, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada H2W 1R7
    Nat Commun 1:35. 2010
    ..We propose that limb identity is largely achieved by default in FL, whereas a specific repressor activity unique to Tbx4 determines HL identity...
  5. doi request reprint Adult pituitary cell maintenance: lineage-specific contribution of self-duplication
    David Langlais
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110, avenue des Pins Ouest, Montreal, Quebec, H2W 1R7 Canada
    Mol Endocrinol 27:1103-12. 2013
    ..If corticotrope reentry into cell cycle constitutes a normal mechanism to maintain the adult corticotrope pool, this same mechanism may also be perturbed during corticotrope adenoma development in Cushing's disease. ..
  6. ncbi request reprint Molecular mechanisms of pituitary differentiation and regulation: implications for hormone deficiencies and hormone resistance syndromes
    Jacques Drouin
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    Front Horm Res 35:74-87. 2006
    ..This review will summarize our current understanding of these processes and their implications for hormone deficiency and hormone resistance syndromes from a developmental perspective...
  7. doi request reprint Stem cells, differentiation and cell cycle control in pituitary
    Jacques Drouin
    Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada
    Front Horm Res 38:15-24. 2010
    ..While these data revealed a new transient intermediate between progenitors and differentiated cells, they also raised new questions and suggested that separate signals may control differentiation and cell cycle...
  8. ncbi request reprint A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins
    B Lamolet
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 des Pins Ouest, Montreal QC, Canada H2W 1R7
    Cell 104:849-59. 2001
    ..TPIT gene mutations were found in patients with isolated deficiency of pituitary POMC-derived ACTH, in support of an essential role of Tpit for differentiation of the pituitary POMC lineage...
  9. ncbi request reprint Hindlimb patterning and mandible development require the Ptx1 gene
    C Lanctot
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal Quebec, Canada H2W 1R7
    Development 126:1805-10. 1999
    ..The dual role of Ptx1 revealed by the gene knockout may reflect features of the mammalian jaw and hindlimbs that were acquired at a similar time during tetrapod evolution...
  10. pmc Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain
    J J Tremblay
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    EMBO J 18:3431-41. 1999
    ..Thus, the unmasking of SF-1 activity by Ptx1 may represent a developmental mechanism to alleviate the need for SF-1 ligand in transcription and, possibly, at critical times during organogenesis...
  11. ncbi request reprint The PTX family of homeodomain transcription factors during pituitary developments
    J Drouin
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Mol Cell Endocrinol 140:31-6. 1998
    ..The mechanisms of Ptx action on its target genes as well as its putative roles during development are reviewed with particular emphasis on its role in pituitary function...
  12. pmc Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription
    J J Tremblay
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 19:2567-76. 1999
    ..Egr-1 interacts directly with Ptx1 and with SF-1, leading to an enhancement of Ptx1- and SF-1-induced LHbeta transcription. Thus, Egr-1 is a likely transcriptional mediator of GnRH-induced signals for activation of the LHbeta gene...
  13. pmc NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene
    G Poulin
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Mol Cell Biol 17:6673-82. 1997
    ..Taken together with the restricted pattern of Ptx1 expression, these results suggest that these two factors establish the basis of a combinatorial code for the program of corticotroph-specific gene expression...
  14. ncbi request reprint The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm
    C Lanctot
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Development 124:2807-17. 1997
    ....
  15. ncbi request reprint The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3
    J J Tremblay
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Mol Endocrinol 12:428-41. 1998
    ..Thus, these experiments place Ptx1 upstream of Lim3/Lhx3 in a cascade of regulators that appear to work in a combinatorial code to direct pituitary-, lineage-, and promoter-specific transcription...
  16. ncbi request reprint Novel mechanism of action for Nur77 and antagonism by glucocorticoids: a convergent mechanism for CRH activation and glucocorticoid repression of POMC gene transcription
    J Drouin
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Que, Canada
    J Steroid Biochem Mol Biol 65:59-63. 1998
    ..Thus, the Nur77 signalling pathway appears to be a point of convergence for stimulatory signals and glucocorticoid repression in both endocrine and lymphoid systems...
  17. ncbi request reprint Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome
    M J Crawford
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Quebec, Canada
    Mamm Genome 8:841-5. 1997
    ..Taken together with the craniofacial expression pattern of Ptx1 during early development, the localization of the gene in this chromosomal area is consistent with an involvement in Treacher Collins Franceschetti Syndrome...
  18. ncbi request reprint Opposite ability of pre-TCR and alpha beta TCR to induce apoptosis
    A M Steff
    Division of Research and Development, PROCREA BioSciences, Montreal, Quebec, Canada
    J Immunol 166:5044-50. 2001
    ..Together, these results support the view that the structure of the pre-TCR and alphabetaTCR directly influences their apoptosis-inducing capabilities by activating distinct signaling pathways...
  19. pmc Tpit determines alternate fates during pituitary cell differentiation
    Anne Marie Pulichino
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada H2W 1R7
    Genes Dev 17:738-47. 2003
    ..These data suggest that antagonism between Tpit and SF1 may play a role in establishment of POMC and gonadotroph lineages and that these lineages may arise from common precursors...
  20. ncbi request reprint A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations
    S Vallette-Kasic
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Endocr Res 30:943-4. 2004
  21. doi request reprint Phenotypic homogeneity and genotypic variability in a large series of congenital isolated ACTH-deficiency patients with TPIT gene mutations
    C Couture
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada H2L 4M1
    J Clin Endocrinol Metab 97:E486-95. 2012
    ..This condition was poorly defined before we identified TPIT, a T-box transcription factor with a specific role in differentiation of the corticotroph lineage in mice and humans, as its principal molecular cause...
  22. ncbi request reprint Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma
    M Elchebly
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Nat Genet 21:330-3. 1999
    ..These results suggest that tyrosine phosphorylation-dependent signalling pathways regulated by PTP-sigma influence the proliferation and/or adhesiveness of various cell types in the developing hypothalamo-pituitary axis...
  23. pmc Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency
    Anne Marie Pulichino
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, H2W 1R7 Canada
    Genes Dev 17:711-6. 2003
    ..This work defines congenital early onset IAD as a relatively homogeneous clinical entity caused by recessive transmission of loss-of-function mutations in the TPIT gene...
  24. ncbi request reprint The T-box factor Tpit recruits SRC/p160 co-activators and mediates hormone action
    Mario Maira
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 278:46523-32. 2003
    ..Given that Tpit exhibits transcriptional synergy with NGFI-B, our results suggest that Tpit, along with NGFI-B and SRC-2, is part of a transcription regulatory complex assembled on the POMC promoter in response to hormonal stimulation...
  25. ncbi request reprint Tpit-/-NeuroD1-/- mice reveal novel aspects of corticotroph development
    Anne Marie Pulichino
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal H2W 1R7, Quebec, Canada
    Endocr Res 30:551-2. 2004
  26. ncbi request reprint Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene
    T Lamonerie
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniquesde Montréal, Quebec, Canada
    Genes Dev 10:1284-95. 1996
    ..In the adult pituitary gland, Ptx1 appears to be recruited for cell-specific transcription of the POMC gene...
  27. ncbi request reprint [Tpit mutations reveal a new model of pituitary differentiation and account for isolated ACTH deficiency]
    Anne Marie Pulichino
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, H2W 1R7 Canada
    Med Sci (Paris) 20:1009-13. 2004
    ..Thus, Tpit operates as a molecular switch to orient differentiation of a common precursor towards either POMC or gonadotroph fate. A binary choice model of pituitary cell differentiation is presented...
  28. doi request reprint Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis
    Audrey Roussel-Gervais
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    Mol Endocrinol 24:1835-45. 2010
    ..These results suggest that cyclin E up-regulation and p27(Kip1) loss-of-function act cooperatively on pituitary adenoma development...
  29. ncbi request reprint The TPIT gene mutation M86R associated with isolated adrenocorticotropin deficiency interferes with protein: protein interactions
    Sophie Vallette-Kasic
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110, avenue des Pins Ouest, Montreal, QC, Canada H2W 1R7
    J Clin Endocrinol Metab 92:3991-9. 2007
    ..The methionine 86 arginine (M86R) TPIT mutation was recently identified in compound heterozygosity with the 782delA frame-shift mutation in two siblings with early-onset IAD...
  30. ncbi request reprint Pitx1 and Pitx2 are required for development of hindlimb buds
    Alexandre Marcil
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, QC H2W 1R7, Canada
    Development 130:45-55. 2003
    ..Thus, Pitx1 and Pitx2 genes are required for sustained hindlimb bud growth and formation of hindlimbs...
  31. doi request reprint Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin
    Pierre Luc Lavoie
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montréal 110, Montreal, Quebec, Canada
    Mol Endocrinol 22:1647-57. 2008
    ..These data contrast the sustained dependence throughout development on the same regulatory elements with the highly dynamic patterns of TF expression and the modulation of their activity in response to signaling pathways...
  32. ncbi request reprint Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
    Pepijn van den Munckhof
    Unité de recherche en génétique moléculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, QC H2W 1R7, Canada
    Development 130:2535-42. 2003
    ..Similar to human PD, dorsal SN neurons (which are Pitx3 negative) are spared in mutant mice. Thus, Pitx3 defines a pathway for survival of neurons that are implicated in PD and that are required for spontaneous locomotor activity...
  33. ncbi request reprint Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development
    Aurore L'honoré
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110, avenue des Pins Ouest, Montreal, QC, Canada H2W 1R7
    Dev Biol 307:421-33. 2007
    ..These experiments suggest that Pitx genes are important for myogenesis and that Pitx2 and Pitx3 may have partly redundant roles...
  34. pmc Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease
    Steve Bilodeau
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec H2W 1R7, Canada
    Genes Dev 20:2871-86. 2006
    ..In addition to providing a molecular basis for Gc resistance, these deficiencies may also contribute to the tumorigenic process...
  35. ncbi request reprint Bone morphogenic protein (Smad)-mediated repression of proopiomelanocortin transcription by interference with Pitx/Tpit activity
    Maria Nudi
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    Mol Endocrinol 19:1329-42. 2005
    ..It is postulated that these interactions interfere with the transcriptional activity of Pitx and/or Tpit, thus resulting in transcriptional repression...
  36. ncbi request reprint Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations
    Sophie Vallette-Kasic
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 90:1323-31. 2005
    ..Identification of TPIT gene mutations as the principal molecular cause of neonatal IAD permits prenatal diagnosis for families at risk for the purpose of early glucocorticoid replacement therapy...
  37. ncbi request reprint A muscle-specific promoter directs Pitx3 gene expression in skeletal muscle cells
    Vincent Coulon
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    J Biol Chem 282:33192-200. 2007
    ..Myogenic basic helix-loop-helix regulatory factor activation of Pitx3 transcription may be part of a positive feedback loop contributing to establishment of the myogenic program...
  38. pmc Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment
    Mario Maira
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 23:763-76. 2003
    ..Taken together, these results indicate that Nur factors behave as endpoint effectors of the PKA signaling pathway acting through dimers and AF-1-dependent recruitment of coactivators...
  39. ncbi request reprint Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness
    Eric Batsche
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Biol Chem 280:19746-56. 2005
    ..Increased Rb expression upon cell differentiation may promote differentiated functions, at least in part, by potentiation of NR activity...
  40. ncbi request reprint Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription
    Eric Batsche
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 280:16088-95. 2005
    ..The action of Rb and its related proteins on POMC transcription may contribute to the establishment and/or maintenance of the differentiation phenotype...
  41. ncbi request reprint Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease
    Pepijn van den Munckhof
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal Quebec, Canada
    J Neurochem 96:160-70. 2006
    ....
  42. pmc TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77
    Juliette Rambaud
    Laboratory of Molecular Genetics, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 284:14147-56. 2009
    ..However, the actions of TIF1beta and SRC2 were mapped to different NGFI-B AF-1 subdomains. Taken together, these results indicate that TIF1beta is an important coactivator of NGFI-B-dependent transcription...
  43. doi request reprint Pitx2 defines alternate pathways acting through MyoD during limb and somitic myogenesis
    Aurore L'honoré
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, QC, Canada
    Development 137:3847-56. 2010
    ..Muscle-specific wiring of regulatory networks composed of similar transcription factors thus underlies development of distinct skeletal muscles...
  44. ncbi request reprint Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor
    Christine Martens
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110, avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    Mol Endocrinol 19:885-97. 2005
    ....
  45. ncbi request reprint Pitx1 in vivo promoter activity and mechanisms of positive autoregulation
    Cynthia G Goodyer
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110 West Pine Avenue, Montreal, Quebec H2W 1R7, Canada
    Neuroendocrinology 78:129-37. 2003
    ..PITX1 autoregulation depends on DNA-binding and trans-activation domains of Pitx1 and it may be responsible for establishment and/or maintenance of the Pitx1 expression domain...
  46. pmc Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response
    David Langlais
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    PLoS Genet 4:e1000224. 2008
    ..Thus, stressors that trigger both general stress and inflammatory responses lead to activation of a stereotypic innate cellular defense response...
  47. doi request reprint Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer
    Yuichi Shima
    Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Japan
    Mol Endocrinol 22:1633-46. 2008
    ....
  48. ncbi request reprint Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification
    Hoonkyo Suh
    Neuroscience Program, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Development 129:329-37. 2002
    ..The model developed for PITX gene function in pituitary development provides a better understanding of the etiology of Rieger syndrome and may extend to other PITX-sensitive developmental processes...
  49. ncbi request reprint Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genes
    Thimios A Mitsiadis
    Department of Structural and Orofacial Development, Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
    Dev Biol 313:887-96. 2008
    ..Taken together, these results indicate that independent genetic pathways in mandibular and maxillary processes determine tooth development and morphology...
  50. ncbi request reprint PITX genes are required for cell survival and Lhx3 activation
    Michael A Charles
    4301 MSRB III, 1500 West Medical Center Drive, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Mol Endocrinol 19:1893-903. 2005
    ..Thus, the combined dosage of these PITX family members is vital for pituitary development, and their persistent coexpression in the adult pituitary suggests a continued role in maintenance of pituitary function...
  51. ncbi request reprint Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1
    Nicoletta Bobola
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 130:3403-14. 2003
    ....
  52. ncbi request reprint Low estriol levels in the maternal triple-marker screen as a predictor of isolated adrenocorticotropic hormone deficiency caused by a new mutation in the TPIT gene
    Naomi Weintrob
    Institute for Endocrinology and Diabetes, Schneider Children s Medical Center of Israel, Petah Tiqwa 49202, Israel
    Pediatrics 117:e322-7. 2006
    ..The immediate institution of glucocorticoid therapy, with proper instructions for stress management, can prevent unnecessary neonatal death secondary to an easily treatable disease...
  53. ncbi request reprint Differential regulation of proopiomelanocortin and pituitary-restricted transcription factor (TPIT), a new marker of normal and adenomatous human corticotrophs
    Sophie Vallette-Kasic
    Unite Mixte de Recherche 6544, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Institut Federatif de Recherche Jean Roche, Faculte de Medecine Nord, 13926 Marseille, France
    J Clin Endocrinol Metab 88:3050-6. 2003
    ..In human and experimental models, TPIT and its target gene POMC were thus differentially regulated by glucocorticoids. Moreover, TPIT represents a new marker of POMC-expressing pituitary cells...
  54. pmc Repression by homeoprotein pitx1 of virus-induced interferon a promoters is mediated by physical interaction and trans repression of IRF3 and IRF7
    Marie Laure Island
    Laboratoire de Régulation de la Transcription et Maladies Génétiques, CNRS, UPR 2228, UFR Biomédicale des Saints Pères, Universite Rene Descartes, 75270 Paris Cedex 06, France
    Mol Cell Biol 22:7120-33. 2002
    ....
  55. pmc Récepteurs à la Provençale. EMBO workshop on the biology of nuclear receptors
    Johan Auwerx
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    EMBO Rep 4:1122-6. 2003
  56. pmc Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, USA
    PLoS ONE 3:e1516. 2008
    ..The role of ss-catenin signaling in mesodermal lineage formation and differentiation has been elusive...
  57. ncbi request reprint Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy
    David M Keller
    Vollum Institute, and Division of Biostatistics, Department of Public Health and Preventative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 282:32084-92. 2007
    ..We additionally show that many Pdx-1 targets also interact with NeuroD1/BETA2, including the micro-RNA miR-375, a known regulator of insulin secretion...