Christian Deschepper

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. ncbi request reprint Characterization of myocardium, isolated cardiomyocytes, and blood pressure in WKHA and WKY rats
    Christian F Deschepper
    Multidisciplinary Research Group in Hypertension, Institut de Recherches Cliniques de Montreal, 110 Pine Ave W, Montreal, Quebec H2W 1R7, Canada
    Am J Physiol Heart Circ Physiol 282:H149-55. 2002
  2. doi request reprint Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice
    Samantha D Praktiknjo
    Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Endocrinology 154:4746-56. 2013
  3. pmc Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de recherches cliniques de Montréal IRCM and Université de Montréal, Montreal, QC, Canada
    BMC Genomics 10:150. 2009
  4. ncbi request reprint Functional alterations of the Nppa promoter are linked to cardiac ventricular hypertrophy in WKY/WKHA rat crosses
    C F Deschepper
    Laboratories of Experimental Cardiovascular Biology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Circ Res 88:223-8. 2001
  5. ncbi request reprint Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains
    Christian F Deschepper
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Quebec, Canada H2W 1R7
    J Appl Physiol (1985) 97:369-76. 2004
  6. ncbi request reprint In search of cardiovascular candidate genes: interactions between phenotypes and genotypes
    Christian F Deschepper
    Experimental Cardiovascular Biology Research Unit and CIHR Multidisciplinary Research Group on Hypertension, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
    Hypertension 39:332-6. 2002
  7. doi request reprint Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood
    Catherine Yzydorczyk
    Department of Pediatrics, Research Center, CHU Sainte Justine, Universite de Montreal, Montreal, Quebec, Canada
    Hypertension 52:889-95. 2008
  8. ncbi request reprint Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montréal and Université de Montréal, Montreal, Quebec, Canada
    Physiol Genomics 31:176-82. 2007
  9. doi request reprint Early predictors of cardiac decompensation in experimental volume overload
    Christelle Oliver-Dussault
    Experimental Cardiovascular Biology Research Unit, Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada
    Mol Cell Biochem 338:271-82. 2010
  10. ncbi request reprint Hypertensive cardiac remodeling in males and females: from the bench to the bedside
    Christian F Deschepper
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Hypertension 49:401-7. 2007

Research Grants

  1. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004
  2. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2001
  3. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2002
  4. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2003

Detail Information

Publications25

  1. ncbi request reprint Characterization of myocardium, isolated cardiomyocytes, and blood pressure in WKHA and WKY rats
    Christian F Deschepper
    Multidisciplinary Research Group in Hypertension, Institut de Recherches Cliniques de Montreal, 110 Pine Ave W, Montreal, Quebec H2W 1R7, Canada
    Am J Physiol Heart Circ Physiol 282:H149-55. 2002
    ....
  2. doi request reprint Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice
    Samantha D Praktiknjo
    Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Endocrinology 154:4746-56. 2013
    ....
  3. pmc Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de recherches cliniques de Montréal IRCM and Université de Montréal, Montreal, QC, Canada
    BMC Genomics 10:150. 2009
    ....
  4. ncbi request reprint Functional alterations of the Nppa promoter are linked to cardiac ventricular hypertrophy in WKY/WKHA rat crosses
    C F Deschepper
    Laboratories of Experimental Cardiovascular Biology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Circ Res 88:223-8. 2001
    ..Taken together with the previous reports showing that ANF may protect cardiomyocytes against hypertrophy, our genetic data single out NPPA: as a strong candidate gene for the determination of LVM...
  5. ncbi request reprint Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains
    Christian F Deschepper
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Quebec, Canada H2W 1R7
    J Appl Physiol (1985) 97:369-76. 2004
    ..All data have been deposited to the Mouse Phenome Database for future integration with the Mouse Genome Database and can be further analyzed and compared with tools available on the site...
  6. ncbi request reprint In search of cardiovascular candidate genes: interactions between phenotypes and genotypes
    Christian F Deschepper
    Experimental Cardiovascular Biology Research Unit and CIHR Multidisciplinary Research Group on Hypertension, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
    Hypertension 39:332-6. 2002
    ....
  7. doi request reprint Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood
    Catherine Yzydorczyk
    Department of Pediatrics, Research Center, CHU Sainte Justine, Universite de Montreal, Montreal, Quebec, Canada
    Hypertension 52:889-95. 2008
    ..Our findings support the hypothesis of developmental programming of adult cardiovascular and renal diseases and provide new insights into the potential role of oxidative stress in this process...
  8. ncbi request reprint Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montréal and Université de Montréal, Montreal, Quebec, Canada
    Physiol Genomics 31:176-82. 2007
    ....
  9. doi request reprint Early predictors of cardiac decompensation in experimental volume overload
    Christelle Oliver-Dussault
    Experimental Cardiovascular Biology Research Unit, Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada
    Mol Cell Biochem 338:271-82. 2010
    ..Close monitoring of early changes in cardiac geometry (as well as new methods to analyze myocardial diastolic strain) might, therefore, be helpful to further improve risk stratification in humans with volume overload cardiopathies...
  10. ncbi request reprint Hypertensive cardiac remodeling in males and females: from the bench to the bedside
    Christian F Deschepper
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Hypertension 49:401-7. 2007
  11. ncbi request reprint Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats
    Rhian M Touyz
    Laboratory of Experimental Hypertension, bLaboratory of Experimental Cardiovascular Biology, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 20:1127-34. 2002
    ..In the present in vivo study, we investigated whether short-term inhibition of ERK1/2-dependent signaling pathways influences vascular function and blood pressure (BP) in spontaneously hypertensive rats (SHR)...
  12. ncbi request reprint Identification and validation of Loci and candidate genes linked to cardiac hypertrophy
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Methods Mol Med 112:321-37. 2005
    ..Identification of QTLs may lead to the identification of candidate genes whose roles can be further investigated in either transgenic, knockout, or pharmacologically manipulated animal models...
  13. ncbi request reprint Genetic determinants of systolic and pulse pressure in an intercross between normotensive inbred rats
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada H2W 1R7
    Hypertension 48:921-6. 2006
    ....
  14. ncbi request reprint Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat
    Ying Tung Sia
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 105:2549-55. 2002
    ..In this study, we tested whether the powerful antioxidant probucol would attenuate progression of CHF once it was established after MI in the rat...
  15. ncbi request reprint Fibroblast apoptosis precedes cardiomyocyte mass reduction during left ventricular remodeling in hypertensive rats treated with amlodipine
    David Duguay
    Department of Pharmacology, University of Montreal, Montreal, Quebec, Canada
    J Hypertens 25:1291-9. 2007
    ..However, the cell type undergoing apoptosis in this model and the temporal correlation with onset cardiac remodeling remain undefined...
  16. ncbi request reprint Comparisons of behavioral and neurochemical characteristics between WKY, WKHA, and Wistar rat strains
    Guy Drolet
    CHUL Research Centre, Neuroscience Unit, Universite Laval, Quebec, Canada
    Neuropsychopharmacology 27:400-9. 2002
    ..Although these characteristics may make them interesting models in their own right, it also follows that the conclusions of any study based on comparisons of one particular strain to just WKY should be interpreted very cautiously...
  17. ncbi request reprint A genetic locus accentuates the effect of volume overload on adverse left ventricular remodeling in male and female rats
    Emmanuelle Souzeau
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Hypertension 47:128-33. 2006
    ....
  18. ncbi request reprint Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood
    Emmanuelle Souzeau
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, 110 Pine Ave W, Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 289:H715-21. 2005
    ..Thus the presence of isoflavones in the maternal diet provides cardioprotection to the hearts of their offspring during adulthood...
  19. ncbi request reprint Distinct QTLs are linked to cardiac left ventricular mass in a sex-specific manner in a normotensive inbred rat inter-cross
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada, H2W 1R7
    Mamm Genome 16:700-11. 2005
    ....
  20. ncbi request reprint Expression of constitutively active guanylate cyclase in cardiomyocytes inhibits the hypertrophic effects of isoproterenol and aortic constriction on mouse hearts
    Ahmad Zahabi
    Experimental Cardiovascular Biology Unit, Canadian Institutes for Health Research Multidisciplinary Research Group in Hypertension, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 278:47694-9. 2003
    ..Altogether, our results suggest that cyclic GMP is a cardioprotective agent against hypertrophy that acts via a direct local effect on cardiomyocytes...
  21. doi request reprint Alterations in mitochondrial function as a harbinger of cardiomyopathy: lessons from the dystrophic heart
    Yan Burelle
    Department of Kinesiology, Universite de Montreal, Montreal, Quebec, Canada
    J Mol Cell Cardiol 48:310-21. 2010
    ..In fact, altogether our findings support a critical role for dystrophin in maintaining optimal coupling between metabolism and contraction in the heart...
  22. ncbi request reprint Compensated volume overload increases the vulnerability of heart mitochondria without affecting their functions in the absence of stress
    Mariannick Marcil
    Département de Kinésiologie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    J Mol Cell Cardiol 41:998-1009. 2006
    ....
  23. ncbi request reprint Dissociation of coronary artery contractile hyperreactivity from hypertension
    Wen Su
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Am J Hypertens 16:570-6. 2003
    ..The current study tests the hypothesis that coronary artery contractile hyperreactivity can be dissociated from hypertension and therefore may contribute to the etiology of CAD independent of hypertension...
  24. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...

Research Grants4

  1. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004
    ..abstract_text> ..
  2. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2001
    ..abstract_text> ..
  3. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2002
    ..abstract_text> ..
  4. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2003
    ..abstract_text> ..