Research Topics
Genomes and Genes | J DavignonSummaryAffiliation: Clinical Research Institute of Montreal Country: Canada Publications
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Publications
Emphasis on pleiotropic effects, a new paradigm shift?Jean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, and University of Montreal Hospital Medical Centre, Montreal, QC, Canada
Coron Artery Dis 15:223-5. 2004- Beneficial cardiovascular pleiotropic effects of statinsJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Circulation 109:III39-43. 2004..Understanding the pleiotropic effects of statins is important to optimize their use in treatment and prevention of cardiovascular disease... - The antioxidant effects of statinsJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, and University of Montreal Hospital Medical Centre, Montreal, QC, Canada
Coron Artery Dis 15:251-8. 2004..The antioxidant properties of statins extend to organ protection especially the myocardium and the lungs... 
Ongoing clinical trials of the pleiotropic effects of statinsJean Davignon
Clinical Research Institute of Montreal, Montreal, QC, Canada
Vasc Health Risk Manag 1:29-40. 2005..The multiple effects (ie, pleiotropic effects of statins) have received increasing recognition and may have clinical applicability across a broad range of cardiovascular and noncardiovascular conditions...- Role of endothelial dysfunction in atherosclerosisJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
Circulation 109:III27-32. 2004..Studies have elucidated several possible mechanisms by which statin therapy may improve endothelial dysfunction, including upregulation of nitric oxide production or activity and reduction of oxidative stress... 
The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosisJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal IRCM, 110 Pine Avenue West, Montreal, QC, H2W 1R7, Canada
Curr Atheroscler Rep 12:308-15. 2010..Which one will be clinically applicable will depend on long-term effects, cost, and ease of administration...
Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levelsJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W1R7, Canada
Trans Am Clin Climatol Assoc 120:163-73. 2009....- [Mechanisms of action of statins and their pleiotropic effects]J Davignon
Institut de Recherches Cliniques de Montreal, 110, Av des Pins Ouest, Montreal, Quebec, H2W 1R7 Canada
Ann Endocrinol (Paris) 62:101-12. 2001.... - The cardioprotective effects of statinsJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada
Curr Atheroscler Rep 6:27-35. 2004..Several clinical trials have confirmed these expectations and have strengthened the value of statins as valuable antiatherosclerotic and cardioprotective agents... - Low-density lipoprotein-independent effects of statinsJ Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
Curr Opin Lipidol 10:543-59. 1999..The challenge for the future will be to design and carry out appropriate clinical trials to establish their relative importance in the prevention of coronary artery disease... - Effect of micronized fenofibrate on plasma lipoprotein levels and hemostatic parameters of hypertriglyceridemic patients with low levels of high-density lipoprotein cholesterol in the fed and fasted stateJ Genest
Cardiovascular Genetics Laboratory, and the Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
J Cardiovasc Pharmacol 35:164-72. 2000.... - Comparison of the short-term efficacy and tolerability of lovastatin and pravastatin in the management of primary hypercholesterolemiaR McPherson
Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Clin Ther 14:276-91. 1992..The frequency of overall side effects, including central nervous system-related symptoms and headache, was similar and low in all groups... - Cyproterone acetate/ethinyl estradiol in the treatment of acne. A comparative dose-response study of the estrogen componentP Fugere
Hopital Saint Luc, Universite de Montreal, Quebec, Canada
Contraception 42:225-34. 1990..Plasma testosterone and DHEA-S levels paralleled the decline in the clinical severity of the acne. There was no loss of clinical effectiveness with Diane -35 and it provided the advantage of a 30% decrease in the amount of estrogen... - Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteinsJ S Cohn
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Arterioscler Thromb Vasc Biol 19:2474-86. 1999..An ongoing search is nevertheless under way for more accurate and clinically applicable remnant lipoprotein assays that will be able to better define coronary artery disease risk in patients with hypertriglyceridemia... - Advances in drug treatment of dyslipidemia: focus on atorvastatinJ Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec
Can J Cardiol 14:28B-38B. 1998..The profile of its pleiotropic effects is promising... - Fish oil supplementation reduces beta-very low density lipoprotein in type III dysbetalipoproteinemiaJ Dallongeville
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Canada
Arterioscler Thromb 11:864-71. 1991..In type III hyperlipidemics, all LDL cholesterol values remained below 120 mg/dl, whereas they were higher than 150 mg/dl after treatment in two individuals with type IV hyperlipidemia.(ABSTRACT TRUNCATED AT 250 WORDS).. - Expression of gamma-IFN responsive genes in scavenger receptor over-expressing monocytes is associated with xanthomatosisT Grewal
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
Atherosclerosis 138:335-45. 1998..Our data suggest that the inflammatory effects of gamma-IFN signaling could play a role in foam cell formation and xanthomatosis... - Advances in lipid-lowering therapy in atherosclerosisJ Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec
Adv Exp Med Biol 498:49-58. 2001..This hypothesis is currently being tested in the Lipid in Diabetes Study (LDS), an outcome trial comparing monotherapy with fenofibrate and cerivastatin to combination therapy conducted in England... - Plasma total homocysteine in healthy subjects: sex-specific relation with biological traitsS Lussier-Cacan
Hyperlipidemia and Atherosclerosis Research Group, Hotel Dieu Hospital, Montreal, Canada
Am J Clin Nutr 64:587-93. 1996..This study emphasizes the significance of sex-associated differences in the biology of homocysteine and underlines the importance of considering these in the determination of threshold values... - Moderate intake of n-3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjectsL Mabile
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
Am J Clin Nutr 74:449-56. 2001..CONCLUSION: Although they exhibit a high susceptibility to oxidation, n-3 fatty acids may preserve membrane integrity and represent an added benefit in the treatment of hypertriglyceridemic patients... - A lipid clinic associated with a research laboratory working on dyslipoproteinemias and atherosclerosisJ Davignon
Clinical Research Institute of Montreal, Quebec
Can J Cardiol 12:885-90. 1996..A lipid clinic associated with a research laboratory, a 'lipid unit', provides an optimal setting to achieve this goal... - Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearanceL Krimbou
Cardiovascular Genetics Laboratory, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
J Biol Chem 276:33241-8. 2001..Furthermore, the finding supports the possibility that the LRP receptor can act in vivo to mediate clearance of the LCAT-alpha(2)M complex and may significantly influence the bioavailability of LCAT... - Lipoprotein distribution of apolipoprotein C-III and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteinsC Marcoux
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
Metabolism 50:112-9. 2001.... - Impact of apoE deficiency on oxidative insults and antioxidant levels in the brainC Ramassamy
Neuroscience Division, Douglas Hospital Research Center, Quebec, Verdun, Canada
Brain Res Mol Brain Res 86:76-83. 2001..Taken together, these data indicate that the steady state level of apoE may influence, to a certain extent, the balance between oxidants and antioxidants in hippocampus... - Identification of a gamma-interferon-responsive element in the promoter of the human macrophage scavenger receptor A geneT Grewal
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
Arterioscler Thromb Vasc Biol 21:825-31. 2001..gamma-IFN-induced STAT1 activation, leading to increased SR-A expression, could therefore play an important role in the initial steps of foam cell formation and xanthomatosis... - Association of apolipoprotein E with alpha2-macroglobulin in human plasmaL Krimbou
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
J Lipid Res 39:2373-86. 1998.... - Apolipoprotein E and atherosclerosis: beyond lipid effectJean Davignon
Arterioscler Thromb Vasc Biol 25:267-9. 2005 - Post-transcriptional regulation of apoC-I synthesis and secretion in human HepG2 cellsCatherine Bouchard
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Que, Canada H2W 1R7
Atherosclerosis 178:257-64. 2005..These results demonstrate that cellular cholesterol rather than triglyceride levels play a role in controlling apoC-I production by HepG2 cells and that this regulation occurs at a post-transcriptional level... - Differential effects of oxidized LDL on apolipoprotein AI and B synthesis in HepG2 cellsEmmanuel Bourdon
INSERM U498, Dijon, France Faculté de Médecine, Universite de Bourgogne, 21079 Dijon, France
Free Radic Biol Med 41:786-96. 2006..Our data suggest that the increase in apoB and decrease in apoAI secretion may in part contribute to the known atherogenicity of Ox-LDL through an elevated LDL/HDL ratio, a strong predictor of coronary risk in patients... - Effect of atorvastatin on plasma apoE metabolism in patients with combined hyperlipidemiaJeffrey S Cohn
Hyperlipidemia and Atherosclerosis Research Group, Montreal, Quebec, Canada
J Lipid Res 43:1464-71. 2002..Our results demonstrate that atorvastatin causes a pronounced decrease in total plasma and VLDL apoE concentrations and a significant decrease in plasma and VLDL apoE rates of production in patients with combined hyperlipidemia... - Effect of regular exercise on homocysteine concentrations: the HERITAGE Family StudyTomohiro Okura
Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Eur J Appl Physiol 98:394-401. 2006..Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range... - Effect of exercise training on in vitro LDL oxidation and free radical-induced hemolysis: the HERITAGE Family StudyDenis Blache
INSERM U 498, Biochimie des Lipoprotéines et Interactions Vasculaires, and Faculté de Médecine, Universite de Bourgogne, Dijon, France
Antioxid Redox Signal 9:123-30. 2007..Further, smoking negates the beneficial effect of exercise training on erythrocyte resistance to free radical-induced hemolysis. These observations emphasize the importance of context in the evaluation of exercise and oxidant stress... - Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in healthAlain Piolot
, , Dijon, Canada
J Lab Clin Med 141:41-9. 2003..78, P < .001). With this study, we report for the first time the apparent interaction of n-3 fatty acids and nitric oxide on Hcy metabolism... - Two new large deletions in the low density lipoprotein receptor (LDLR) gene not revealed by PCR-based molecular diagnosis of familial hypercholesterolemiaLise Bernier
Institut de Recherches Cliniques de Montreal, Montreal, Canada
Atherosclerosis 197:118-24. 2008..The second deletion covers 5994 bp and removes exons 3-6. These deletions have not been previously reported. They would have been missed if a PCR-based method had been used instead of Southern blot analysis... - Effect of statin withdrawal on frequency of cardiac events after vascular surgeryOlaf Schouten
Department of Vascular Surgery, Erasmus Medical College, Rotterdam, The Netherlands
Am J Cardiol 100:316-20. 2007..Furthermore, there seemed to be better outcomes in patients who received statins with extended-release formulas... - Synthesis and secretion of apoC-I and apoE during maturation of human SW872 liposarcoma cellsHanny Wassef
Hyperlipidemia and Atherosclerosis Research Group, , , Quebec, Canada
J Nutr 134:2935-41. 2004..Furthermore, apoC-I and apoE production are differentially regulated at the transcriptional level, and long-term treatment with insulin has an inhibitory rather than stimulatory effect on apoC-I and apoE production... - Increased apoC-III production is a characteristic feature of patients with hypertriglyceridemiaJeffrey S Cohn
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Que, Canada H2W1R7
Atherosclerosis 177:137-45. 2004.... - Plasma kinetics of VLDL and HDL apoC-I in normolipidemic and hypertriglyceridemic subjectsJeffrey S Cohn
Hyperlipidemia and Atherosclerosis Research Group, Montreal, Quebec, Canada
J Lipid Res 43:1680-7. 2002..05). Our results demonstrate that increased levels of plasma and VLDL apoC-I in hypertriglyceridemic subjects (with or without elevated LDL-C levels) are associated with increased levels of plasma VLDL apoC-I production... - Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphismJeffrey S Cohn
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
Atherosclerosis 169:63-70. 2003.... - Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans: in vivo evidence for a link between HDL apoC-III and apoA-I metabolismJeffrey S Cohn
Hyperlipidemia and Atherosclerosis Research Group, Montreal, Quebec, Canada
J Lipid Res 44:1976-83. 2003..51, P < 0.05). Together, these results provide in vivo evidence for a link between the metabolism of HDL apoC-III and apoA-I, and suggest a role for apoC-III in the regulation of plasma HDL levels... - Effect of atorvastatin on ApoE and ApoC-I synthesis and secretion by THP-1 macrophagesLucia Nassi Castilho
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Canada H2W 1R7
J Cardiovasc Pharmacol 42:251-7. 2003..These data demonstrate that statins have the capacity to reduce the synthesis and secretion of both apoE and apoC-I in THP-1 macrophages loaded or unloaded with cholesterol... - Secreted apolipoprotein E reduces macrophage-mediated LDL oxidation in an isoform-dependent wayLaurence Mabile
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
J Cell Biochem 90:766-76. 2003..However, they also suggest the need for more experiments in order to achieve careful selection of the apoE isoform to be targeted, especially in the perspective of apoE transgene use... - Storage of human plasma samples leads to alterations in the lipoprotein distribution of apoC-III and apoEJeffrey S Cohn
Clinical Research Institute of Montreal, Quebec, Canada
J Lipid Res 45:1572-9. 2004.... - Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemiaGeneviève Dubuc
Laboratory of Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
Arterioscler Thromb Vasc Biol 24:1454-9. 2004..The 2 other known genes implicated in ADH encode the low-density lipoprotein receptor and apolipoprotein B. As an approach toward the elucidation of the physiological role(s) of NARC-1, we studied its transcriptional regulation... - Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivityJeffrey S Cohn
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada, H2W 1R7
J Clin Endocrinol Metab 89:3949-55. 2004.... - Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO)C Bourgault
McGill University, Montreal, Canada
Can J Cardiol 21:1187-93. 2005..Although statins are widely used to reduce low density lipoprotein cholesterol (LDL-C), there is little information about patient profiles, treatment patterns and goal achievement among statin-treated patients in Canada... - Severe oily ichthyosis in monozygotic twins mimicking Chanarin-Dorfman syndrome but not associated with a mutation of the CGI58 geneCrina Solomon
Arch Dermatol 142:402-3. 2006 - Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trialSteven E Nissen
Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
JAMA 295:1556-65. 2006.... - ApoE phenotype influences plasma ASP in hyperapoB subjectsKatherine Cianflone
Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, H7 30, 687 Pine Ave West, Quebec, Montreal, Canada H3A 1A1
Atherosclerosis 170:285-91. 2003..407, P=0.001. These data suggest that apoE phenotype may potentially influence ASP, although primarily in rare apoE phenotypes... - Immunochemical evidence that human apoB differs when expressed in rodent versus human cellsXingyu Wang
Lipoprotein and Atherosclerosis Research Group and the Department of Pathology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
J Lipid Res 44:547-53. 2003..Therefore, human apoB expressed by rodent hepatocytes or hepatoma cells appears to adopt a different conformation or undergoes different posttranslational modification than apoB expressed in human hepatocytes or hepatoma cells... - Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cellsAloys De Windt
Department of Neurology, Free University of Brussels, Brussels, Belgium
DNA Cell Biol 26:765-72. 2007..These results demonstrate that inhibition of SREBPs decreases cholesterol synthesis in HepG2 cells both in the absence and presence of homocysteine. SKI-1/S1P inhibition may cause widespread changes in other key metabolic pathways... - Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regenerationAhmed Zaid
Laboratorie of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated to the University of Montreal, Montreal, Quebec, Canada
Hepatology 48:646-54. 2008..CONCLUSION: Although PCSK9 is a target for controlling hypercholesterolemia, our data indicate that upon hepatic damage, patients lacking PCSK9 could be at risk...