J Davignon

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. pmc Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations
    Janice Mayne
    Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, and Department of Medicine, The Ottawa Hospital, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Lipids Health Dis 12:70. 2013
  2. doi request reprint The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal IRCM, 110 Pine Avenue West, Montreal, QC, H2W 1R7, Canada
    Curr Atheroscler Rep 12:308-15. 2010
  3. ncbi request reprint Low-density lipoprotein-independent effects of statins
    J Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    Curr Opin Lipidol 10:543-59. 1999
  4. pmc Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W1R7, Canada
    Trans Am Clin Climatol Assoc 120:163-73. 2009
  5. ncbi request reprint Emphasis on pleiotropic effects, a new paradigm shift?
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, and University of Montreal Hospital Medical Centre, Montreal, QC, Canada
    Coron Artery Dis 15:223-5. 2004
  6. pmc Ongoing clinical trials of the pleiotropic effects of statins
    Jean Davignon
    Clinical Research Institute of Montreal, Montreal, QC, Canada
    Vasc Health Risk Manag 1:29-40. 2005
  7. ncbi request reprint The cardioprotective effects of statins
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada
    Curr Atheroscler Rep 6:27-35. 2004
  8. ncbi request reprint Role of endothelial dysfunction in atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
    Circulation 109:III27-32. 2004
  9. ncbi request reprint Beneficial cardiovascular pleiotropic effects of statins
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 109:III39-43. 2004
  10. ncbi request reprint The antioxidant effects of statins
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, and University of Montreal Hospital Medical Centre, Montreal, QC, Canada
    Coron Artery Dis 15:251-8. 2004

Collaborators

Detail Information

Publications53

  1. pmc Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations
    Janice Mayne
    Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, and Department of Medicine, The Ottawa Hospital, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Lipids Health Dis 12:70. 2013
    ..Herein, we carried out full exonic sequencing of PCSK9 documenting the frequency of single and multiple PCSK9 variations and their effects on serum lipoprotein and PCSK9 levels in Caucasian Canadians...
  2. doi request reprint The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal IRCM, 110 Pine Avenue West, Montreal, QC, H2W 1R7, Canada
    Curr Atheroscler Rep 12:308-15. 2010
    ..Which one will be clinically applicable will depend on long-term effects, cost, and ease of administration...
  3. ncbi request reprint Low-density lipoprotein-independent effects of statins
    J Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    Curr Opin Lipidol 10:543-59. 1999
    ..The challenge for the future will be to design and carry out appropriate clinical trials to establish their relative importance in the prevention of coronary artery disease...
  4. pmc Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W1R7, Canada
    Trans Am Clin Climatol Assoc 120:163-73. 2009
    ....
  5. ncbi request reprint Emphasis on pleiotropic effects, a new paradigm shift?
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, and University of Montreal Hospital Medical Centre, Montreal, QC, Canada
    Coron Artery Dis 15:223-5. 2004
  6. pmc Ongoing clinical trials of the pleiotropic effects of statins
    Jean Davignon
    Clinical Research Institute of Montreal, Montreal, QC, Canada
    Vasc Health Risk Manag 1:29-40. 2005
    ..The multiple effects (ie, pleiotropic effects of statins) have received increasing recognition and may have clinical applicability across a broad range of cardiovascular and noncardiovascular conditions...
  7. ncbi request reprint The cardioprotective effects of statins
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada
    Curr Atheroscler Rep 6:27-35. 2004
    ..Several clinical trials have confirmed these expectations and have strengthened the value of statins as valuable antiatherosclerotic and cardioprotective agents...
  8. ncbi request reprint Role of endothelial dysfunction in atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
    Circulation 109:III27-32. 2004
    ..Studies have elucidated several possible mechanisms by which statin therapy may improve endothelial dysfunction, including upregulation of nitric oxide production or activity and reduction of oxidative stress...
  9. ncbi request reprint Beneficial cardiovascular pleiotropic effects of statins
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 109:III39-43. 2004
    ..Understanding the pleiotropic effects of statins is important to optimize their use in treatment and prevention of cardiovascular disease...
  10. ncbi request reprint The antioxidant effects of statins
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, and University of Montreal Hospital Medical Centre, Montreal, QC, Canada
    Coron Artery Dis 15:251-8. 2004
    ..The antioxidant properties of statins extend to organ protection especially the myocardium and the lungs...
  11. ncbi request reprint [Mechanisms of action of statins and their pleiotropic effects]
    J Davignon
    Institut de Recherches Cliniques de Montreal, 110, Av des Pins Ouest, Montreal, Quebec, H2W 1R7 Canada
    Ann Endocrinol (Paris) 62:101-12. 2001
    ....
  12. ncbi request reprint Effect of micronized fenofibrate on plasma lipoprotein levels and hemostatic parameters of hypertriglyceridemic patients with low levels of high-density lipoprotein cholesterol in the fed and fasted state
    J Genest
    Cardiovascular Genetics Laboratory, and the Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 35:164-72. 2000
    ....
  13. ncbi request reprint Comparison of the short-term efficacy and tolerability of lovastatin and pravastatin in the management of primary hypercholesterolemia
    R McPherson
    Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Clin Ther 14:276-91. 1992
    ..The frequency of overall side effects, including central nervous system-related symptoms and headache, was similar and low in all groups...
  14. ncbi request reprint Cyproterone acetate/ethinyl estradiol in the treatment of acne. A comparative dose-response study of the estrogen component
    P Fugere
    Hopital Saint Luc, Universite de Montreal, Quebec, Canada
    Contraception 42:225-34. 1990
    ..Plasma testosterone and DHEA-S levels paralleled the decline in the clinical severity of the acne. There was no loss of clinical effectiveness with Diane -35 and it provided the advantage of a 30% decrease in the amount of estrogen...
  15. ncbi request reprint Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins
    J S Cohn
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 19:2474-86. 1999
    ..An ongoing search is nevertheless under way for more accurate and clinically applicable remnant lipoprotein assays that will be able to better define coronary artery disease risk in patients with hypertriglyceridemia...
  16. ncbi request reprint Fish oil supplementation reduces beta-very low density lipoprotein in type III dysbetalipoproteinemia
    J Dallongeville
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Canada
    Arterioscler Thromb 11:864-71. 1991
    ..In type III hyperlipidemics, all LDL cholesterol values remained below 120 mg/dl, whereas they were higher than 150 mg/dl after treatment in two individuals with type IV hyperlipidemia.(ABSTRACT TRUNCATED AT 250 WORDS)..
  17. ncbi request reprint Advances in drug treatment of dyslipidemia: focus on atorvastatin
    J Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec
    Can J Cardiol 14:28B-38B. 1998
    ..The profile of its pleiotropic effects is promising...
  18. ncbi request reprint Expression of gamma-IFN responsive genes in scavenger receptor over-expressing monocytes is associated with xanthomatosis
    T Grewal
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    Atherosclerosis 138:335-45. 1998
    ..Our data suggest that the inflammatory effects of gamma-IFN signaling could play a role in foam cell formation and xanthomatosis...
  19. ncbi request reprint Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits
    S Lussier-Cacan
    Hyperlipidemia and Atherosclerosis Research Group, Hotel Dieu Hospital, Montreal, Canada
    Am J Clin Nutr 64:587-93. 1996
    ..This study emphasizes the significance of sex-associated differences in the biology of homocysteine and underlines the importance of considering these in the determination of threshold values...
  20. ncbi request reprint Advances in lipid-lowering therapy in atherosclerosis
    J Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec
    Adv Exp Med Biol 498:49-58. 2001
    ..This hypothesis is currently being tested in the Lipid in Diabetes Study (LDS), an outcome trial comparing monotherapy with fenofibrate and cerivastatin to combination therapy conducted in England...
  21. ncbi request reprint Moderate intake of n-3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects
    L Mabile
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    Am J Clin Nutr 74:449-56. 2001
    ..CONCLUSION: Although they exhibit a high susceptibility to oxidation, n-3 fatty acids may preserve membrane integrity and represent an added benefit in the treatment of hypertriglyceridemic patients...
  22. ncbi request reprint Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance
    L Krimbou
    Cardiovascular Genetics Laboratory, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 276:33241-8. 2001
    ..Furthermore, the finding supports the possibility that the LRP receptor can act in vivo to mediate clearance of the LCAT-alpha(2)M complex and may significantly influence the bioavailability of LCAT...
  23. ncbi request reprint A lipid clinic associated with a research laboratory working on dyslipoproteinemias and atherosclerosis
    J Davignon
    Clinical Research Institute of Montreal, Quebec
    Can J Cardiol 12:885-90. 1996
    ..A lipid clinic associated with a research laboratory, a 'lipid unit', provides an optimal setting to achieve this goal...
  24. ncbi request reprint Lipoprotein distribution of apolipoprotein C-III and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteins
    C Marcoux
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    Metabolism 50:112-9. 2001
    ....
  25. ncbi request reprint Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain
    C Ramassamy
    Neuroscience Division, Douglas Hospital Research Center, Quebec, Verdun, Canada
    Brain Res Mol Brain Res 86:76-83. 2001
    ..Taken together, these data indicate that the steady state level of apoE may influence, to a certain extent, the balance between oxidants and antioxidants in hippocampus...
  26. ncbi request reprint Identification of a gamma-interferon-responsive element in the promoter of the human macrophage scavenger receptor A gene
    T Grewal
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 21:825-31. 2001
    ..gamma-IFN-induced STAT1 activation, leading to increased SR-A expression, could therefore play an important role in the initial steps of foam cell formation and xanthomatosis...
  27. ncbi request reprint Association of apolipoprotein E with alpha2-macroglobulin in human plasma
    L Krimbou
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Lipid Res 39:2373-86. 1998
    ....
  28. ncbi request reprint Post-transcriptional regulation of apoC-I synthesis and secretion in human HepG2 cells
    Catherine Bouchard
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Que, Canada H2W 1R7
    Atherosclerosis 178:257-64. 2005
    ..These results demonstrate that cellular cholesterol rather than triglyceride levels play a role in controlling apoC-I production by HepG2 cells and that this regulation occurs at a post-transcriptional level...
  29. ncbi request reprint Apolipoprotein E and atherosclerosis: beyond lipid effect
    Jean Davignon
    Arterioscler Thromb Vasc Biol 25:267-9. 2005
  30. ncbi request reprint Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO)
    C Bourgault
    McGill University, Montreal, Canada
    Can J Cardiol 21:1187-93. 2005
    ..Although statins are widely used to reduce low density lipoprotein cholesterol (LDL-C), there is little information about patient profiles, treatment patterns and goal achievement among statin-treated patients in Canada...
  31. ncbi request reprint Differential effects of oxidized LDL on apolipoprotein AI and B synthesis in HepG2 cells
    Emmanuel Bourdon
    INSERM U498, Dijon, France Faculté de Médecine, Universite de Bourgogne, 21079 Dijon, France
    Free Radic Biol Med 41:786-96. 2006
    ..Our data suggest that the increase in apoB and decrease in apoAI secretion may in part contribute to the known atherogenicity of Ox-LDL through an elevated LDL/HDL ratio, a strong predictor of coronary risk in patients...
  32. ncbi request reprint Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study
    Tomohiro Okura
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Eur J Appl Physiol 98:394-401. 2006
    ..Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range...
  33. ncbi request reprint Effect of exercise training on in vitro LDL oxidation and free radical-induced hemolysis: the HERITAGE Family Study
    Denis Blache
    INSERM U 498, Biochimie des Lipoprotéines et Interactions Vasculaires, and Faculté de Médecine, Universite de Bourgogne, Dijon, France
    Antioxid Redox Signal 9:123-30. 2007
    ..Further, smoking negates the beneficial effect of exercise training on erythrocyte resistance to free radical-induced hemolysis. These observations emphasize the importance of context in the evaluation of exercise and oxidant stress...
  34. ncbi request reprint Two new large deletions in the low density lipoprotein receptor (LDLR) gene not revealed by PCR-based molecular diagnosis of familial hypercholesterolemia
    Lise Bernier
    Institut de Recherches Cliniques de Montreal, Montreal, Canada
    Atherosclerosis 197:118-24. 2008
    ..The second deletion covers 5994 bp and removes exons 3-6. These deletions have not been previously reported. They would have been missed if a PCR-based method had been used instead of Southern blot analysis...
  35. ncbi request reprint Effect of statin withdrawal on frequency of cardiac events after vascular surgery
    Olaf Schouten
    Department of Vascular Surgery, Erasmus Medical College, Rotterdam, The Netherlands
    Am J Cardiol 100:316-20. 2007
    ..Furthermore, there seemed to be better outcomes in patients who received statins with extended-release formulas...
  36. ncbi request reprint Synthesis and secretion of apoC-I and apoE during maturation of human SW872 liposarcoma cells
    Hanny Wassef
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    J Nutr 134:2935-41. 2004
    ..Furthermore, apoC-I and apoE production are differentially regulated at the transcriptional level, and long-term treatment with insulin has an inhibitory rather than stimulatory effect on apoC-I and apoE production...
  37. ncbi request reprint Increased apoC-III production is a characteristic feature of patients with hypertriglyceridemia
    Jeffrey S Cohn
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Que, Canada H2W1R7
    Atherosclerosis 177:137-45. 2004
    ....
  38. ncbi request reprint Effect of atorvastatin on plasma apoE metabolism in patients with combined hyperlipidemia
    Jeffrey S Cohn
    Hyperlipidemia and Atherosclerosis Research Group, Montreal, Quebec, Canada
    J Lipid Res 43:1464-71. 2002
    ..Our results demonstrate that atorvastatin causes a pronounced decrease in total plasma and VLDL apoE concentrations and a significant decrease in plasma and VLDL apoE rates of production in patients with combined hyperlipidemia...
  39. ncbi request reprint Plasma kinetics of VLDL and HDL apoC-I in normolipidemic and hypertriglyceridemic subjects
    Jeffrey S Cohn
    Hyperlipidemia and Atherosclerosis Research Group, Montreal, Quebec, Canada
    J Lipid Res 43:1680-7. 2002
    ..05). Our results demonstrate that increased levels of plasma and VLDL apoC-I in hypertriglyceridemic subjects (with or without elevated LDL-C levels) are associated with increased levels of plasma VLDL apoC-I production...
  40. ncbi request reprint Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism
    Jeffrey S Cohn
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Atherosclerosis 169:63-70. 2003
    ....
  41. ncbi request reprint Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans: in vivo evidence for a link between HDL apoC-III and apoA-I metabolism
    Jeffrey S Cohn
    Hyperlipidemia and Atherosclerosis Research Group, Montreal, Quebec, Canada
    J Lipid Res 44:1976-83. 2003
    ..51, P < 0.05). Together, these results provide in vivo evidence for a link between the metabolism of HDL apoC-III and apoA-I, and suggest a role for apoC-III in the regulation of plasma HDL levels...
  42. ncbi request reprint Effect of atorvastatin on ApoE and ApoC-I synthesis and secretion by THP-1 macrophages
    Lucia Nassi Castilho
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Canada H2W 1R7
    J Cardiovasc Pharmacol 42:251-7. 2003
    ..These data demonstrate that statins have the capacity to reduce the synthesis and secretion of both apoE and apoC-I in THP-1 macrophages loaded or unloaded with cholesterol...
  43. ncbi request reprint Secreted apolipoprotein E reduces macrophage-mediated LDL oxidation in an isoform-dependent way
    Laurence Mabile
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    J Cell Biochem 90:766-76. 2003
    ..However, they also suggest the need for more experiments in order to achieve careful selection of the apoE isoform to be targeted, especially in the perspective of apoE transgene use...
  44. ncbi request reprint Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health
    Alain Piolot
    Hyperlipidemia and Atherosclerosis Research Group of the Clinical Research Institute of Montreal and INSERM U498 Faculté de Médecine, Universite de Bourgogne, Dijon, Canada
    J Lab Clin Med 141:41-9. 2003
    ..78, P < .001). With this study, we report for the first time the apparent interaction of n-3 fatty acids and nitric oxide on Hcy metabolism...
  45. ncbi request reprint Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity
    Jeffrey S Cohn
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada, H2W 1R7
    J Clin Endocrinol Metab 89:3949-55. 2004
    ....
  46. ncbi request reprint Storage of human plasma samples leads to alterations in the lipoprotein distribution of apoC-III and apoE
    Jeffrey S Cohn
    Clinical Research Institute of Montreal, Quebec, Canada
    J Lipid Res 45:1572-9. 2004
    ....
  47. ncbi request reprint Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
    Geneviève Dubuc
    Laboratory of Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 24:1454-9. 2004
    ..The 2 other known genes implicated in ADH encode the low-density lipoprotein receptor and apolipoprotein B. As an approach toward the elucidation of the physiological role(s) of NARC-1, we studied its transcriptional regulation...
  48. ncbi request reprint ApoE phenotype influences plasma ASP in hyperapoB subjects
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, H7 30, 687 Pine Ave West, Quebec, Montreal, Canada H3A 1A1
    Atherosclerosis 170:285-91. 2003
    ..407, P=0.001. These data suggest that apoE phenotype may potentially influence ASP, although primarily in rare apoE phenotypes...
  49. doi request reprint Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
    Ahmed Zaid
    Laboratorie of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated to the University of Montreal, Montreal, Quebec, Canada
    Hepatology 48:646-54. 2008
    ..CONCLUSION: Although PCSK9 is a target for controlling hypercholesterolemia, our data indicate that upon hepatic damage, patients lacking PCSK9 could be at risk...
  50. ncbi request reprint Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells
    Aloys De Windt
    Department of Neurology, Free University of Brussels, Brussels, Belgium
    DNA Cell Biol 26:765-72. 2007
    ..These results demonstrate that inhibition of SREBPs decreases cholesterol synthesis in HepG2 cells both in the absence and presence of homocysteine. SKI-1/S1P inhibition may cause widespread changes in other key metabolic pathways...
  51. ncbi request reprint Immunochemical evidence that human apoB differs when expressed in rodent versus human cells
    Xingyu Wang
    Lipoprotein and Atherosclerosis Research Group and the Department of Pathology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Lipid Res 44:547-53. 2003
    ..Therefore, human apoB expressed by rodent hepatocytes or hepatoma cells appears to adopt a different conformation or undergoes different posttranslational modification than apoB expressed in human hepatocytes or hepatoma cells...
  52. ncbi request reprint Severe oily ichthyosis in monozygotic twins mimicking Chanarin-Dorfman syndrome but not associated with a mutation of the CGI58 gene
    Crina Solomon
    Arch Dermatol 142:402-3. 2006
  53. ncbi request reprint Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
    JAMA 295:1556-65. 2006
    ....