Jean Francois Cote

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. pmc GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    Jean Francois Cote
    Cytoskeletal Organization and Cell Migration Laboratory, Institut de Recherches Cliniques de Montreal, Universite de Montreal, 110 Pine Avenue West, Montreal, PQ H2W1R7, Canada
    Trends Cell Biol 17:383-93. 2007
  2. pmc G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates
    Noumeira Hamoud
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 111:3745-50. 2014
  3. pmc Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis
    Mélanie Laurin
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 110:7434-9. 2013
  4. pmc ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions
    Yoran Margaron
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 288:1184-99. 2013
  5. pmc Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting
    Malika Oubaha
    Laboratory of Endothelial Cell Biology, Institut de Recherches Cliniques de Montreal, Universite de Montreal, QC, Canada
    Blood 120:3371-81. 2012
  6. pmc An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, PQ H2W 1R7, Canada
    Curr Biol 20:2021-7. 2010
  7. pmc Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion
    Afnan Abu-Thuraia
    Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada Département de Médecine Programmes de Biologie Moléculaire, Universite de Montreal, Montreal, QC, Canada
    Mol Cell Biol 35:76-87. 2015
  8. pmc Insights into the biological functions of Dock family guanine nucleotide exchange factors
    Mélanie Laurin
    Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec H2W 1R7, Canada
    Genes Dev 28:533-47. 2014
  9. pmc The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 286:38969-79. 2011
  10. ncbi request reprint PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP
    Jean Francois Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:2973-86. 2002

Collaborators

Detail Information

Publications13

  1. pmc GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    Jean Francois Cote
    Cytoskeletal Organization and Cell Migration Laboratory, Institut de Recherches Cliniques de Montreal, Universite de Montreal, 110 Pine Avenue West, Montreal, PQ H2W1R7, Canada
    Trends Cell Biol 17:383-93. 2007
    ....
  2. pmc G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates
    Noumeira Hamoud
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 111:3745-50. 2014
    ..Collectively, our findings provide a role for BAI3 in the relay of extracellular fusion signals to their intracellular effectors, identifying it as an essential transmembrane protein for embryonic vertebrate myoblast fusion. ..
  3. pmc Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis
    Mélanie Laurin
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 110:7434-9. 2013
    ..Our work demonstrates DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis and offers a therapeutic opportunity to limit the spread of metastatic breast cancers...
  4. pmc ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions
    Yoran Margaron
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 288:1184-99. 2013
    ..In conclusion, our findings support a role for ELMO in protrusion stability by acting at the interface between the actin cytoskeleton and the microtubule network...
  5. pmc Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting
    Malika Oubaha
    Laboratory of Endothelial Cell Biology, Institut de Recherches Cliniques de Montreal, Universite de Montreal, QC, Canada
    Blood 120:3371-81. 2012
    ..These results reveal that PKCζ and β-catenin function in a complex at adherens junctions and at the leading edge of migrating endothelial cells to modulate collective and directional migration during angiogenesis...
  6. pmc An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, PQ H2W 1R7, Canada
    Curr Biol 20:2021-7. 2010
    ..Functionally, we found that ELMO mutants with impaired autoregulatory activity promote cell elongation. These results demonstrate an unsuspected level of regulation for Rac1 signaling via autoinhibition of ELMO...
  7. pmc Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion
    Afnan Abu-Thuraia
    Institut de recherches cliniques de Montreal IRCM, Montreal, QC, Canada Département de Médecine Programmes de Biologie Moléculaire, Universite de Montreal, Montreal, QC, Canada
    Mol Cell Biol 35:76-87. 2015
    ..These results define a new mechanism by which Axl promotes cell proliferation and invasion and identifies inhibition of the Elmo-Dock pathway as a potential therapeutic target to stop Axl-induced metastases. ..
  8. pmc Insights into the biological functions of Dock family guanine nucleotide exchange factors
    Mélanie Laurin
    Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec H2W 1R7, Canada
    Genes Dev 28:533-47. 2014
    ..We also discuss, when possible, how recent discoveries concerning the biological functions of these GEFs might be exploited for the development of novel therapeutic strategies. ..
  9. pmc The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 286:38969-79. 2011
    ..Furthermore, via binding of an Arf family GTPase, the ELMO-DOCK180 is uniquely positioned at the membrane to activate Rac signaling and remodel the actin cytoskeleton...
  10. ncbi request reprint PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP
    Jean Francois Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:2973-86. 2002
    ..This finding suggests a possible mechanism for PTP-PEST to directly modulate actin remodeling through the PSTPIP-WASP interaction...
  11. pmc Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis
    Rana El-Bikai
    Orthopaedic Research Laboratory, Hopital du Sacre Coeur de Montreal, Department of Surgery, University of Montreal, 5400 Gouin Blvd, West, Montreal, QC H4J 1C5, Canada
    Arthritis Res Ther 12:R201. 2010
    ....
  12. pmc The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo
    Mélanie Laurin
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 105:15446-51. 2008
    ....