Jean Francois Cote

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. ncbi GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    Jean Francois Cote
    Cytoskeletal Organization and Cell Migration Laboratory, Institut de Recherches Cliniques de Montreal, Universite de Montreal, 110 Pine Avenue West, Montreal, PQ H2W1R7, Canada
    Trends Cell Biol 17:383-93. 2007
  2. ncbi An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, PQ H2W 1R7, Canada
    Curr Biol 20:2021-7. 2010
  3. ncbi The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 286:38969-79. 2011
  4. ncbi PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP
    Jean Francois Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:2973-86. 2002
  5. ncbi Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting
    Malika Oubaha
    Laboratory of Endothelial Cell Biology, Institut de Recherches Cliniques de Montreal, Universite de Montreal, QC, Canada
    Blood 120:3371-81. 2012
  6. ncbi Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis
    Rana El-Bikai
    Orthopaedic Research Laboratory, Hopital du Sacre Coeur de Montreal, Department of Surgery, University of Montreal, 5400 Gouin Blvd, West, Montreal, QC H4J 1C5, Canada
    Arthritis Res Ther 12:R201. 2010
  7. ncbi The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo
    Mélanie Laurin
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 105:15446-51. 2008

Collaborators

  • Hassan Fahmi
  • Qin Shi
  • Kay Hofmann
  • Rana El-Bikai
  • Manishha Patel
  • Malika Oubaha
  • Yoran Margaron
  • Nadine Fradet
  • Mélanie Laurin
  • Leonard I Zon
  • Dominic Filion
  • Emily N Price
  • Jean Philippe Gratton
  • Michelle I Lin
  • Viviane Tran
  • Tsai Chen Chiang
  • Fang Jen S Lee
  • Michel Bouvier
  • Brian Wilkes
  • Qi Yang
  • Anne Blangy
  • Kristiina Vuori
  • Alan Hall

Detail Information

Publications7

  1. ncbi GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    Jean Francois Cote
    Cytoskeletal Organization and Cell Migration Laboratory, Institut de Recherches Cliniques de Montreal, Universite de Montreal, 110 Pine Avenue West, Montreal, PQ H2W1R7, Canada
    Trends Cell Biol 17:383-93. 2007
    ....
  2. ncbi An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, PQ H2W 1R7, Canada
    Curr Biol 20:2021-7. 2010
    ..Functionally, we found that ELMO mutants with impaired autoregulatory activity promote cell elongation. These results demonstrate an unsuspected level of regulation for Rac1 signaling via autoinhibition of ELMO...
  3. ncbi The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 286:38969-79. 2011
    ..Furthermore, via binding of an Arf family GTPase, the ELMO-DOCK180 is uniquely positioned at the membrane to activate Rac signaling and remodel the actin cytoskeleton...
  4. ncbi PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP
    Jean Francois Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:2973-86. 2002
    ..This finding suggests a possible mechanism for PTP-PEST to directly modulate actin remodeling through the PSTPIP-WASP interaction...
  5. ncbi Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting
    Malika Oubaha
    Laboratory of Endothelial Cell Biology, Institut de Recherches Cliniques de Montreal, Universite de Montreal, QC, Canada
    Blood 120:3371-81. 2012
    ..These results reveal that PKCζ and β-catenin function in a complex at adherens junctions and at the leading edge of migrating endothelial cells to modulate collective and directional migration during angiogenesis...
  6. ncbi Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis
    Rana El-Bikai
    Orthopaedic Research Laboratory, Hopital du Sacre Coeur de Montreal, Department of Surgery, University of Montreal, 5400 Gouin Blvd, West, Montreal, QC H4J 1C5, Canada
    Arthritis Res Ther 12:R201. 2010
    ....
  7. ncbi The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo
    Mélanie Laurin
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 105:15446-51. 2008
    ....