Nathalie Lepage

Summary

Affiliation: Children's Hospital of Eastern Ontario
Country: Canada

Publications

  1. doi request reprint Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuploidies and open neural tube defects
    Nathalie Lepage
    Department of Pathology and Laboratory Medicine, University of Ottawa and Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Clin Biochem 45:1152-7. 2012
  2. ncbi request reprint Incomplete pediatric reference intervals for the management of patients with inborn errors of metabolism
    Nathalie Lepage
    Division of Biochemistry, Department of Laboratory Medicine, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa ON, Canada, K1H 8LI
    Clin Biochem 39:595-9. 2006
  3. ncbi request reprint Chronic kidney disease stage in renal transplantation classification using cystatin C and creatinine-based equations
    Christine White
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    Nephrol Dial Transplant 22:3013-20. 2007
  4. ncbi request reprint Cystatin-C and beta trace protein as markers of renal function in pregnancy
    Ayub Akbari
    Kidney Research Centre, Ottawa, Ontario, Canada
    BJOG 112:575-8. 2005
  5. doi request reprint Estimating GFR using serum beta trace protein: accuracy and validation in kidney transplant and pediatric populations
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Kidney Int 76:784-91. 2009
  6. ncbi request reprint Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods
    Christine White
    Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Am Soc Nephrol 16:3763-70. 2005
  7. ncbi request reprint Measuring glomerular filtration rate with cystatin C and beta-trace protein in children with spina bifida
    Anne Pham-Huy
    Department of Surgery, Division of Urology, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    J Urol 169:2312-5. 2003
  8. doi request reprint Pediatric reference intervals for soluble transferrin receptor and transferrin receptor-ferritin index
    Cara Lianne Ooi
    Department of Pediatrics, Children s Hospital, London Health Science Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, 800 Commissioners Road East, London, Ontario, N6A 7W9, Canada
    World J Pediatr 5:122-6. 2009
  9. ncbi request reprint Intra-individual variation of cystatin C and creatinine in pediatric solid organ transplant recipients
    Ludmila Podracka
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    Pediatr Transplant 9:28-32. 2005
  10. ncbi request reprint Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula?
    Guido Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, K1H 8L1 Ottawa, Ontario, Canada
    Pediatr Nephrol 18:981-5. 2003

Collaborators

Detail Information

Publications26

  1. doi request reprint Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuploidies and open neural tube defects
    Nathalie Lepage
    Department of Pathology and Laboratory Medicine, University of Ottawa and Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Clin Biochem 45:1152-7. 2012
    ..Other screening modalities include first trimester screening, second trimester quad screening, serum integrated screening, and NT-Quad...
  2. ncbi request reprint Incomplete pediatric reference intervals for the management of patients with inborn errors of metabolism
    Nathalie Lepage
    Division of Biochemistry, Department of Laboratory Medicine, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa ON, Canada, K1H 8LI
    Clin Biochem 39:595-9. 2006
    ..To evaluate the status of pediatric reference intervals for several biomarkers of inborn errors of metabolism (IEM)...
  3. ncbi request reprint Chronic kidney disease stage in renal transplantation classification using cystatin C and creatinine-based equations
    Christine White
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    Nephrol Dial Transplant 22:3013-20. 2007
    ..However, creatinine-based equations are inaccurate in RTRs leading to frequent CKD stage misclassification. It is not known whether the classification of CKD stage would be improved using a cystatin C-based estimate of GFR...
  4. ncbi request reprint Cystatin-C and beta trace protein as markers of renal function in pregnancy
    Ayub Akbari
    Kidney Research Centre, Ottawa, Ontario, Canada
    BJOG 112:575-8. 2005
    ..To assess the validity of Cystatin-C (Cys-C) and beta trace protein (BTP) as clinical markers of glomerular filtration rate (GFR) in pregnant women...
  5. doi request reprint Estimating GFR using serum beta trace protein: accuracy and validation in kidney transplant and pediatric populations
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Kidney Int 76:784-91. 2009
    ..These results were an improvement compared to the MDRD and Schwartz equations, both of which had high median bias and reduced accuracy. The updated Schwartz equation also performed well...
  6. ncbi request reprint Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods
    Christine White
    Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Am Soc Nephrol 16:3763-70. 2005
    ..Further prospective studies with repetitive measurement of cystatin C are needed to determine whether cystatin C-based estimates of GFR will be sufficiently accurate to monitor long-term allograft function...
  7. ncbi request reprint Measuring glomerular filtration rate with cystatin C and beta-trace protein in children with spina bifida
    Anne Pham-Huy
    Department of Surgery, Division of Urology, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    J Urol 169:2312-5. 2003
    ..We compared the diagnostic performance of cystatin C and beta-trace protein with serum creatinine and the Schwartz formula for the estimation of glomerular filtration rate in children with spina bifida...
  8. doi request reprint Pediatric reference intervals for soluble transferrin receptor and transferrin receptor-ferritin index
    Cara Lianne Ooi
    Department of Pediatrics, Children s Hospital, London Health Science Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, 800 Commissioners Road East, London, Ontario, N6A 7W9, Canada
    World J Pediatr 5:122-6. 2009
    ..Moreover, there is a paucity of data on pediatric reference intervals for sTfR and sTfR-ferritin index...
  9. ncbi request reprint Intra-individual variation of cystatin C and creatinine in pediatric solid organ transplant recipients
    Ludmila Podracka
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    Pediatr Transplant 9:28-32. 2005
    ..We therefore conclude that measurement of CysC can be used for longitudinal intra-individual follow-up of renal function post-Tx...
  10. ncbi request reprint Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula?
    Guido Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, K1H 8L1 Ottawa, Ontario, Canada
    Pediatr Nephrol 18:981-5. 2003
    ..In conclusion, the data suggest that this novel cystatin C-based GFR estimate shows significantly less bias and serves as a better estimate for GFR in children...
  11. doi request reprint Intraindividual variability of the modified Schwartz and novel CKiD GFR equations in pediatric renal transplant patients
    Anne Tsampalieros
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada
    Pediatr Transplant 15:760-5. 2011
    ..34, p = 0.0026). In conclusion, CKiD GFR has a significantly lower intraindividual variation than mSchwartz GFR and may be better suited for longitudinal follow-up of patients post-Tx...
  12. pmc The impact of interlaboratory differences in cystatin C assay measurement on glomerular filtration rate estimation
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Clin J Am Soc Nephrol 6:2150-6. 2011
    ..This study was designed to examine the differences in CysC and GFR estimation (eGFR) using Siemens' nephelometric immunoassay and the Mayo Clinic equation. The ability of the eGFRs to predict measured GFR was also examined...
  13. ncbi request reprint Influence of commonly used drugs on the accuracy of cystatin C-derived glomerular filtration rate
    Jennifer Foster
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    Pediatr Nephrol 21:235-8. 2006
    ..CysC provides accurate data for calculating GFR independent of the drug doses studied and avoids the use of methods of direct GFR measurement...
  14. doi request reprint Pediatric reference intervals for immunoglobulin G and its subclasses with Siemens immunonephelometric assays
    Nathalie Lepage
    Department of Pathology and Laboratory Medicine, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Clin Biochem 43:694-6. 2010
    ..To determine the pediatric reference intervals for the Dade Behring IgG subclass reagents...
  15. ncbi request reprint Association between second-trimester isolated high maternal serum maternal serum human chorionic gonadotropin levels and obstetric complications in singleton and twin pregnancies
    Nathalie Lepage
    Division of Biochemistry, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada, K1H 8L1
    Am J Obstet Gynecol 188:1354-9. 2003
    ..The purpose of this study was to examine the clinical significance of high maternal serum human chorionic gonadotropin levels in the second trimester in singleton and twin pregnancies within the Ontario maternal serum screening program...
  16. ncbi request reprint The Cockcroft-Gault formula should not be used in children
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Kidney Int 67:2321-4. 2005
    ..Although designed for adults, the Cockcroft-Gault formula was recently proposed for use in children > or =13 years of age...
  17. ncbi request reprint Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure
    Guido Filler
    Department of Pediatrics, Division of Pediatric Nephrology, Children s Hospital of Easter Ontario, University of Ottawa, Ontario, Canada
    Am J Transplant 5:2005-10. 2005
    ..93). Adding SIR to TAC-based immunosuppression in young pediatric renal transplant recipients results in a significant decrease of TAC exposure. TAC trough levels should be monitored frequently...
  18. ncbi request reprint Reference intervals for anion gap and strong ion difference in pregnancy: a pilot study
    Ayub Akbari
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Hypertens Pregnancy 26:111-9. 2007
    ..Acid-base status and electrolyte levels change in normal pregnancy. We hypothesized that these physiological changes affect both anion gap and strong ion difference (SID)...
  19. ncbi request reprint To what extent does the understanding of pharmacokinetics of mycophenolate mofetil influence its prescription
    Guido Filler
    Division of Pediatric Nephrology, Children s Hospital of Eastern Ontario, Ottawa University, 401 Smyth Road, K1H 8L1, Ottawa, Ontario, Canada
    Pediatr Nephrol 19:962-5. 2004
    ..More work is required to establish specific target ranges with the various drug combinations--especially for the pediatric population...
  20. doi request reprint Measurement of plasma/serum acylcarnitines using tandem mass spectrometry
    Nathalie Lepage
    Biochemical Genetics Laboratory, Department of Genetics, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada
    Methods Mol Biol 603:9-25. 2010
    ..We describe a method for the analysis of acylcarnitines in plasma or serum samples using electrospray ionization tandem mass spectrometry...
  21. ncbi request reprint Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children
    Guido Filler
    Departments of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1 Canada
    Clin Chem 48:729-36. 2002
    ....
  22. ncbi request reprint Pharmacokinetics of mycophenolate mofetil for autoimmune disease in children
    Guido Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, K1H 8L1, Ottawa, Ontario, Canada
    Pediatr Nephrol 18:445-9. 2003
    ..There were few side effects: one episode each of diarrhea and leukocytopenia and two viral infections. We conclude that MMF at 900 mg/m(2) per day appears to be effective in these patients...
  23. ncbi request reprint A novel equation to estimate glomerular filtration rate using beta-trace protein
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Canada
    Clin Chem 53:1965-8. 2007
    ..The utility of BTP has been limited by the lack of an equation to translate BTP into an estimate of GFR. The objectives of this study were to develop a BTP-based GFR estimation equation...
  24. ncbi request reprint Outcome validation of the Beckman Coulter access analyzer in a second-trimester Down syndrome serum screening application
    Andrew R MacRae
    The Research Institute at Lakeridge Health Inc, 850 Champlain Ave, Oshawa, Ontario, L1J 8R2 Canada
    Clin Chem 49:69-76. 2003
    ..New immunoassays must generate similar distribution parameters if the accuracy of assigned risks and overall performance of prenatal screening are to be maintained...
  25. ncbi request reprint Cystatin C intrapatient variability in children with chronic kidney disease is less than serum creatinine
    Aarathi S Sambasivan
    Clin Chem 51:2215-6. 2005
  26. ncbi request reprint Pediatric reference intervals for lipids and apolipoproteins on the VITROS 5,1 FS Chemistry System
    Paul M Yip
    Division of Clinical Biochemistry, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Clin Biochem 39:978-83. 2006
    ..A comprehensive set of pediatric reference intervals for traditional or recently established lipid analytes is not currently available...