G Filler

Summary

Affiliation: Children's Hospital of Eastern Ontario
Country: Canada

Publications

  1. ncbi request reprint Treatment of nephrotic syndrome in children and controlled trials
    Guido Filler
    Department of Paediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    Nephrol Dial Transplant 18:vi75-8. 2003
  2. ncbi request reprint Effect of adding Mycophenolate mofetil in paediatric renal transplant recipients with chronical cyclosporine nephrotoxicity
    G Filler
    Department of Pediatric Nephrology, Charite Hospital, Humboldt University, Berlin, Germany
    Transpl Int 13:201-6. 2000
  3. ncbi request reprint Unexpectedly high exposure to enteric-coated mycophenolate sodium upon once-daily dosing
    Guido Filler
    Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    Pediatr Nephrol 21:1206-8. 2006
  4. ncbi request reprint Value of therapeutic drug monitoring of MMF therapy in pediatric transplantation
    G Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Pediatr Transplant 10:707-11. 2006
  5. ncbi request reprint One-year glomerular filtration rate predicts graft survival in pediatric renal recipients: a randomized trial of tacrolimus vs cyclosporine microemulsion
    G Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    Transplant Proc 34:1935-8. 2002
  6. ncbi request reprint Abbreviated mycophenolic acid AUC from C0, C1, C2, and C4 is preferable in children after renal transplantation on mycophenolate mofetil and tacrolimus therapy
    Guido Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada
    Transpl Int 17:120-5. 2004
  7. ncbi request reprint Cyclosporin twice or three times daily dosing in pediatric transplant patients - it is not the same!
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada
    Pediatr Transplant 10:953-6. 2006
  8. ncbi request reprint Universal approach to pharmacokinetic monitoring of immunosuppressive agents in children
    G Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, Canada K1H 8L1
    Pediatr Transplant 6:411-8. 2002
  9. ncbi request reprint Is there really an increase in non-minimal change nephrotic syndrome in children?
    Guido Filler
    Division of Pediatric Nephrology, Department of Pediatrics and Laboratory Medicine, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Am J Kidney Dis 42:1107-13. 2003
  10. pmc Early dialysis in a neonate with intrauterine lisinopril exposure
    G Filler
    Department of Paediatrics, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON K2H 7M9, Canada
    Arch Dis Child Fetal Neonatal Ed 88:F154-6. 2003

Detail Information

Publications93

  1. ncbi request reprint Treatment of nephrotic syndrome in children and controlled trials
    Guido Filler
    Department of Paediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    Nephrol Dial Transplant 18:vi75-8. 2003
    ..To determine the sequential therapy of childhood nephrotic syndrome (NS) with presumed minimal change nephropathy using the evidence from clinical trials...
  2. ncbi request reprint Effect of adding Mycophenolate mofetil in paediatric renal transplant recipients with chronical cyclosporine nephrotoxicity
    G Filler
    Department of Pediatric Nephrology, Charite Hospital, Humboldt University, Berlin, Germany
    Transpl Int 13:201-6. 2000
    ..Prednisolone was left unaltered at 2-4 mg/m2 per day. We conclude that MMF allows safe reduction of CyA with markedly better graft function, suggesting that chronical CyA-toxicity partially accounts for deteriorating allograft function...
  3. ncbi request reprint Unexpectedly high exposure to enteric-coated mycophenolate sodium upon once-daily dosing
    Guido Filler
    Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    Pediatr Nephrol 21:1206-8. 2006
    ..08 g of EC-MPS was 218.2 mgxh/L. EC-MPS once daily may be a well-tolerated therapeutic option for nonadherent adolescent lupus patients, but may be associated with a significantly higher exposure than the equivalent MMF BID dose...
  4. ncbi request reprint Value of therapeutic drug monitoring of MMF therapy in pediatric transplantation
    G Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Pediatr Transplant 10:707-11. 2006
    ..It is important that these provisional target levels are validated in prospective studies. The above points clearly indicate that there is a role for TDM of MPA in pediatric transplant recipients...
  5. ncbi request reprint One-year glomerular filtration rate predicts graft survival in pediatric renal recipients: a randomized trial of tacrolimus vs cyclosporine microemulsion
    G Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    Transplant Proc 34:1935-8. 2002
  6. ncbi request reprint Abbreviated mycophenolic acid AUC from C0, C1, C2, and C4 is preferable in children after renal transplantation on mycophenolate mofetil and tacrolimus therapy
    Guido Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada
    Transpl Int 17:120-5. 2004
    ..A special formula must be used for children. The AUC of MPA can be predicted by limited sampling including C0, C0.5, and C2, while an approach using C0, C1, C2, and C4 is preferable...
  7. ncbi request reprint Cyclosporin twice or three times daily dosing in pediatric transplant patients - it is not the same!
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada
    Pediatr Transplant 10:953-6. 2006
    ..i.d. dosing. Our results indicate t.i.d. dosing of CyA-ME results in significantly lower exposure when the same total dose is administered in two divided doses. This reduced exposure may potentially increase the risk for rejection...
  8. ncbi request reprint Universal approach to pharmacokinetic monitoring of immunosuppressive agents in children
    G Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, Canada K1H 8L1
    Pediatr Transplant 6:411-8. 2002
    ..The AUC can be estimated with great precision by using an identical approach for all three drugs. Target AUCs for a given time-point after transplantation remain to be established...
  9. ncbi request reprint Is there really an increase in non-minimal change nephrotic syndrome in children?
    Guido Filler
    Division of Pediatric Nephrology, Department of Pediatrics and Laboratory Medicine, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Am J Kidney Dis 42:1107-13. 2003
    ..A true increase in FSGS possibly could alter the current practice of withholding renal biopsy in childhood nephrotic syndrome (NS) unless the patient fails to respond to a 28-day course of corticosteroid therapy...
  10. pmc Early dialysis in a neonate with intrauterine lisinopril exposure
    G Filler
    Department of Paediatrics, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON K2H 7M9, Canada
    Arch Dis Child Fetal Neonatal Ed 88:F154-6. 2003
    ..Analysis of the pharmacokinetic data suggests that haemodialysis or haemofiltration would be more efficacious for removal of the drug, and these treatments should be performed if available...
  11. ncbi request reprint Pharmacokinetics of mycophenolate mofetil for autoimmune disease in children
    Guido Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, K1H 8L1, Ottawa, Ontario, Canada
    Pediatr Nephrol 18:445-9. 2003
    ..There were few side effects: one episode each of diarrhea and leukocytopenia and two viral infections. We conclude that MMF at 900 mg/m(2) per day appears to be effective in these patients...
  12. ncbi request reprint Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula?
    Guido Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, K1H 8L1 Ottawa, Ontario, Canada
    Pediatr Nephrol 18:981-5. 2003
    ..In conclusion, the data suggest that this novel cystatin C-based GFR estimate shows significantly less bias and serves as a better estimate for GFR in children...
  13. ncbi request reprint Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure
    Guido Filler
    Department of Pediatrics, Division of Pediatric Nephrology, Children s Hospital of Easter Ontario, University of Ottawa, Ontario, Canada
    Am J Transplant 5:2005-10. 2005
    ..93). Adding SIR to TAC-based immunosuppression in young pediatric renal transplant recipients results in a significant decrease of TAC exposure. TAC trough levels should be monitored frequently...
  14. ncbi request reprint Age-dependency of mycophenolate mofetil dosing in combination with tacrolimus after pediatric renal transplantation
    G Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Transplant Proc 36:1327-31. 2004
    ....
  15. ncbi request reprint Four-year data after pediatric renal transplantation: a randomized trial of tacrolimus vs. cyclosporin microemulsion
    Guido Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Pediatr Transplant 9:498-503. 2005
    ..Renal function and graft survival were also superior with Tac. Glomerular filtration rate appears to be an useful surrogate marker for long-term outcome...
  16. ncbi request reprint The Cockcroft-Gault formula should not be used in children
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Kidney Int 67:2321-4. 2005
    ..Although designed for adults, the Cockcroft-Gault formula was recently proposed for use in children > or =13 years of age...
  17. ncbi request reprint Cystatin C as a marker of GFR--history, indications, and future research
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Clin Biochem 38:1-8. 2005
    ..To summarize recent knowledge on the small molecular weight protein cystatin C (cys-C) and its use as a marker of the glomerular filtration rate (GFR)...
  18. ncbi request reprint Renal transplantation: literature review 2004-2005
    Guido Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Pediatr Transplant 10:418-28. 2006
    ..In this review, we summarize important articles on pediatric renal transplantation over the past 2 yr. The review is intended to be comprehensive but not exhaustive...
  19. ncbi request reprint Evidence-based immunosuppression after pediatric renal transplantation--a dream?
    G Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Transplant Proc 35:2125-7. 2003
  20. ncbi request reprint Effect of cyclosporine on mycophenolic acid area under the concentration-time curve in pediatric kidney transplant recipients
    G Filler
    Division of Pediatric Nephrology, Department of Pediatrics, University of Ottawa, Ottawa, Canada
    Ther Drug Monit 23:514-9. 2001
    ..The significantly higher peak in the group with a lower CyA profile supports the concept of a dose-dependent cyclosporine-induced inhibition of MPA glucuronidation...
  21. ncbi request reprint Acute renal failure in children: aetiology and management
    G Filler
    Department of Paediatrics, Division of Paediatric Nephrology, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Paediatr Drugs 3:783-92. 2001
    ..Dialysis remains the most important tool to bridge the time needed for recovery of renal function. There is increasing evidence that more intense use of dialysis may improve the overall prognosis...
  22. ncbi request reprint To what extent does the understanding of pharmacokinetics of mycophenolate mofetil influence its prescription
    Guido Filler
    Division of Pediatric Nephrology, Children s Hospital of Eastern Ontario, Ottawa University, 401 Smyth Road, K1H 8L1, Ottawa, Ontario, Canada
    Pediatr Nephrol 19:962-5. 2004
    ..More work is required to establish specific target ranges with the various drug combinations--especially for the pediatric population...
  23. ncbi request reprint Pharmacokinetics of mycophenolate mofetil are influenced by concomitant immunosuppression
    G Filler
    Department of Pediatric Nephrology, Charite Hospital, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Pediatr Nephrol 14:100-4. 2000
    ..i.d., in combination with tacrolimus at a dose of 300 mg/m(2) b.i.d., and without a calcineurin inhibitor at a dose of 500 mg/m(2) b.i.d., and adjusting doses using therapeutic drug monitoring of MPA...
  24. ncbi request reprint Optimization of immunosuppressive drug monitoring in children
    G Filler
    Department of Paediatrics, Children s Hospital of Western Ontario, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Transplant Proc 39:1241-3. 2007
    ..In children, there is added complexity because of the age dependency of drug metabolism. This review addresses the age dependency of drug metabolism in childhood on the basis of routine PK monitoring...
  25. doi request reprint Pharmacokinetics of mycophenolate mofetil and sirolimus in children
    Guido Filler
    Department of Paediatrics, Children s Hospital at London Health Science Centre, University of Western Ontario, London, Ontario, Canada
    Ther Drug Monit 30:138-42. 2008
    ..In conclusion, both Sir and MMF drug disposition vary in children and adolescents from adult patients, most likely because of developmental changes of biliary transporters and metabolic enzymes...
  26. ncbi request reprint Measuring glomerular filtration rate with cystatin C and beta-trace protein in children with spina bifida
    Anne Pham-Huy
    Department of Surgery, Division of Urology, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    J Urol 169:2312-5. 2003
    ..We compared the diagnostic performance of cystatin C and beta-trace protein with serum creatinine and the Schwartz formula for the estimation of glomerular filtration rate in children with spina bifida...
  27. ncbi request reprint Glomerular filtration rate as a putative 'surrogate end-point' for renal transplant clinical trials in children
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Pediatr Transplant 7:18-24. 2003
    ..Unfortunately, clearance of most radiolabeled markers of GFR including 125I-iothalamate remain costly and time consuming...
  28. ncbi request reprint Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods
    Christine White
    Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Am Soc Nephrol 16:3763-70. 2005
    ..Further prospective studies with repetitive measurement of cystatin C are needed to determine whether cystatin C-based estimates of GFR will be sufficiently accurate to monitor long-term allograft function...
  29. doi request reprint How to monitor renal function in pediatric solid organ transplant recipients
    Guido Filler
    Department of Paediatrics, Children s Hospital at London Health Science Centre, University of Western Ontario, London, Ontario, Canada
    Pediatr Transplant 12:393-401. 2008
    ..All pediatric solid organ transplant recipients receiving CNI should be screened regularly for high blood pressure and early evidence of renal damage using either GFR scans or cystatin C-based GFR estimations...
  30. ncbi request reprint Drug interactions between mycophenolate and cyclosporine
    Guido Filler
    Pediatr Transplant 8:201-4. 2004
  31. ncbi request reprint Abbreviated cyclosporine AUCs on Neoral--the search continues!
    G Filler
    Department of Pediatric Nephrology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Pediatr Nephrol 13:98-102. 1999
    ..From our data, we recommend a target C3 at approximately 800 ng/ml early after transplantation and 450-550 ng/ml beyond 100 days...
  32. ncbi request reprint Progress in pediatric kidney transplantation
    Guido Filler
    Department of Paediatrics, University of Western Ontario, London, Ontario, Canada
    Ther Drug Monit 32:250-2. 2010
    ..The shift in focus on long-term complications allows for improved graft outcome. Side effects of immunosuppressive medications require continued attention to further improve long-term outcomes...
  33. ncbi request reprint Intra-individual variation of cystatin C and creatinine in pediatric solid organ transplant recipients
    Ludmila Podracka
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    Pediatr Transplant 9:28-32. 2005
    ..We therefore conclude that measurement of CysC can be used for longitudinal intra-individual follow-up of renal function post-Tx...
  34. ncbi request reprint Randomized trial of tacrolimus versus cyclosporin microemulsion in renal transplantation
    Richard Trompeter
    Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    Pediatr Nephrol 17:141-9. 2002
    ..In conclusion, Tac was significantly more effective than CyA microemulsion in preventing acute rejection after renal transplantation in a pediatric population. The overall safety profiles of the two regimens were comparable...
  35. ncbi request reprint Calcineurin inhibitors in pediatric renal transplant recipients
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Paediatr Drugs 9:165-74. 2007
    ..We recommend that cyclosporine should be chosen when patients experience tacrolimus-related adverse events...
  36. ncbi request reprint Sirolimus is not always responsible for new-onset proteinuria after conversion for chronic allograft nephropathy
    Zainab Abdurrahman
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, QC, Canada
    Pediatr Transplant 11:336-9. 2007
    ..Their production appears more susceptible to MMF therapy. A thorough work-up of new-onset proteinuria after conversion to Sirolimus should be performed, including an immunological work-up and a renal biopsy...
  37. ncbi request reprint Chronic kidney disease stage in renal transplantation classification using cystatin C and creatinine-based equations
    Christine White
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    Nephrol Dial Transplant 22:3013-20. 2007
    ..However, creatinine-based equations are inaccurate in RTRs leading to frequent CKD stage misclassification. It is not known whether the classification of CKD stage would be improved using a cystatin C-based estimate of GFR...
  38. ncbi request reprint Tissue viral DNA is associated with chronic allograft nephropathy
    Katarina Sebekova
    Slovak Medical University, Institute of Preventive and Clinical Medicine, Bratislava, Slovakia
    Pediatr Transplant 9:598-603. 2005
    ..This was associated with a significantly higher Banff score for ci and ct; while renal function was not affected. Further controlled studies are required...
  39. ncbi request reprint Cystatin C intrapatient variability in children with chronic kidney disease is less than serum creatinine
    Aarathi S Sambasivan
    Clin Chem 51:2215-6. 2005
  40. ncbi request reprint Prevalence of complications in children with chronic kidney disease according to KDOQI
    H Wong
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Kidney Int 70:585-90. 2006
    ..We recommend modification of the KDOQI guidelines for children to reflect the differences described in this paper...
  41. ncbi request reprint Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate
    G Filler
    Department of Paediatric Nephrology, Charite Hospital, Humboldt University, Berlin, Germany
    Pediatr Nephrol 13:501-5. 1999
    ..We conclude that for the detection of mildly impaired GFR, a full clearance study cannot be replaced by measurement of serum Cys-C or beta2-MG concentrations...
  42. ncbi request reprint Resolution of severe, adolescent-onset hypophosphatemic rickets following resection of an FGF-23-producing tumour of the distal ulna
    L M Ward
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    Bone 34:905-11. 2004
    ....
  43. ncbi request reprint A novel equation to estimate glomerular filtration rate using beta-trace protein
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Canada
    Clin Chem 53:1965-8. 2007
    ..The utility of BTP has been limited by the lack of an equation to translate BTP into an estimate of GFR. The objectives of this study were to develop a BTP-based GFR estimation equation...
  44. doi request reprint Body mass does not have a clinically relevant effect on cystatin C eGFR in children
    Ajay P Sharma
    Department of Paediatrics, Division of Paediatric Nephrology, Children s Hospital, London Health Science Centre, University of Western Ontario, London, Canada
    Nephrol Dial Transplant 24:470-4. 2009
    ..Recent findings in adults, suggesting an improved performance of CysC-based estimated glomerular filtration rate (CysC eGFR) by accounting for body mass, necessitated a careful re-evaluation of this issue in children...
  45. doi request reprint Complications of chronic kidney disease in children post-renal transplantation - a single center experience
    Janusz Feber
    Department of Pediatrics, CHEO, Ottawa, ON, Canada
    Pediatr Transplant 12:80-4. 2008
    ..0 +/- 1.2 (T1) and -1.0 +/- 1.59 (T2, NS), with 21% at T1 and 30% at T2 below two SDS. We observed suboptimal growth, hypertension, hypercholesterolemia, bone disease, and anemia in a significant proportion of transplanted children...
  46. ncbi request reprint Pediatric nephrology patients are overweight: 20 years' experience in a single Canadian tertiary pediatric nephrology clinic
    Guido Filler
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario CHEO, University of Ottawa, Ottawa, ON, Canada
    Int Urol Nephrol 39:1235-40. 2007
    ..Obesity is an independent risk factor for chronic kidney disease (CKD). We compared the body composition of pediatric nephrology patients with that of the general child population over 2 decades...
  47. ncbi request reprint Novel HGPRT 293 A>G point mutation presenting as neonatal acute renal failure
    Hubert Wong
    Department of Paediatrics, Children s Hospital of Eastern Ontario CHEO, University of Ottawa, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    Pediatr Nephrol 23:317-21. 2008
    ..Follow-up after more than 4 years continued to show hyper-echogenic kidneys with almost normal renal glomerular function. There continues to be no neurobehavioural abnormalities...
  48. ncbi request reprint Preventing sensitization with mycophenolate mofetil in a pediatric kidney recipient
    Hubert Wong
    Division of Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada
    Pediatr Transplant 10:367-70. 2006
    ..No side effects occurred. This approach may reduce the risk of sensitization in future potential organ donor recipients in similar situations...
  49. ncbi request reprint Challenges in the management of infantile factor H associated hemolytic uremic syndrome
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, The Ottawa Hospital, University of Ottawa, 401 Smyth Road, K1H 8L1, Ottawa, Ontario, Canada
    Pediatr Nephrol 19:908-11. 2004
    ..This was addressed by intermittent plasma exchange through an arterio-venous fistula. The prognosis and therapeutic dilemmas are discussed...
  50. ncbi request reprint Changing trends in the referral patterns of pediatric nephrology patients
    Guido Filler
    Department of Paediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada
    Pediatr Nephrol 20:603-8. 2005
    ..Pediatric renal patients became progressively overweight and showed an increase in the incidence of CRI. This is the first time that this phenomenon, well known in adults, has been observed in the pediatric age group...
  51. ncbi request reprint Patients with autosomal dominant polycystic kidney disease hyperfiltrate early in their disease
    Hubert Wong
    Department of Pediatrics, Division of Pediatric Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    Am J Kidney Dis 43:624-8. 2004
    ..Angiotensin-converting enzyme (ACE) inhibitors often are used as agents to slow the progression of renal failure, although their effectiveness and starting point in ADPKD remain unclear...
  52. ncbi request reprint Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children
    Guido Filler
    Departments of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1 Canada
    Clin Chem 48:729-36. 2002
    ....
  53. ncbi request reprint One hundred percent patient and kidney allograft survival with simultaneous liver and kidney transplantation in infants with primary hyperoxaluria: a single-center experience
    Maria T Millan
    Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Transplantation 76:1458-63. 2003
    ..Although others have reported on overall results of transplantation for PH1 covering a wide age spectrum, none has specifically addressed the high-risk infantile form of the disease...
  54. ncbi request reprint How should microemulsified Cyclosporine A (Neoral) therapy in patients with nephrotic syndrome be monitored?
    Guido Filler
    Nephrol Dial Transplant 20:1032-4. 2005
  55. doi request reprint Myfortic in pediatric transplantation
    Lothar Bernd Zimmerhackl
    Pediatr Transplant 12:614-6. 2008
  56. pmc Skeletal findings in children recently initiating glucocorticoids for the treatment of nephrotic syndrome
    J Feber
    University of Ottawa, Ottawa, ON, Canada
    Osteoporos Int 23:751-60. 2012
    ..We found an inverse relationship between glucocorticoid exposure and spine areal bone mineral density (BMD) Z-score and a low rate of vertebral deformities (8%)...
  57. ncbi request reprint Renin angiotensin system gene polymorphisms in pediatric renal transplant recipients
    G Filler
    Department of Pediatric Nephrology, Charite Hospital, Humboldt University, Berlin
    Pediatr Transplant 5:166-73. 2001
    ....
  58. ncbi request reprint Glucose tolerance and insulin secretion in children before and during recombinant growth hormone treatment
    G Filler
    Department of Pediatric Nephrology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Horm Res 50:32-7. 1998
    ..We conclude that growth hormone therapy aggravates alteration of glucose metabolism in patients with KTx and not in children with CRF and UTS. Progressive hyperinsulinemia occurred only in patients with UTS...
  59. ncbi request reprint Combination of ceftriaxone and acyclovir - an underestimated nephrotoxic potential?
    Gemma Vomiero
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada
    Pediatr Nephrol 17:633-7. 2002
    ..The mechanism is tubulotoxicity. Caution should be exercised when using this potentially nephrotoxic cocktail, with clear criteria established for the initiation of combination therapy and close monitoring of serum creatinine...
  60. doi request reprint Albuminuria and estimated GFR 5 years after Escherichia coli O157 hemolytic uremic syndrome: an update
    Amit X Garg
    Division of Nephrology, University of Western Ontario, London, Canada
    Am J Kidney Dis 51:435-44. 2008
    ..Estimates in the literature are highly variable, and previous studies did not use a healthy control group to establish outcomes attributable to HUS...
  61. ncbi request reprint G protein beta3 subunit 825T genotype is not associated with differing outcome in pediatric renal transplant recipients
    Berthold Hocher
    Department of Nephrology, Charite Hospital, Humboldt University, Berlin, Germany
    Pediatr Transplant 6:141-6. 2002
    ..In addition, kidney graft function and survival was also found not to be associated with a recipient GNB3 C825T polymorphism...
  62. doi request reprint Characterization of sirolimus metabolites in pediatric solid organ transplant recipients
    Guido Filler
    Division of Nephrology, Department of Pediatrics, University of Western Ontario, London, Ontario, Canada
    Pediatr Transplant 13:44-53. 2009
    ..The metabolism of sirolimus in the children included in our study differed from that reported in adults, which should be considered when monitoring sirolimus exposure immunologically...
  63. doi request reprint Adherence to waiting-time targets for pediatric nephrology clinic referrals
    Maria Radina
    Department of Pediatrics, Division of Nephrology, Children s Hospital, London Health Science Centre, University of Western Ontario, 800 Commissioners Road East, London, ON, Canada
    Pediatr Nephrol 25:311-6. 2010
    ..Office handling was a component for patients with access target <1 week, whereas availability of clinic space was the main reason for nonadherence to access targets...
  64. ncbi request reprint Cystatin-C and beta trace protein as markers of renal function in pregnancy
    Ayub Akbari
    Kidney Research Centre, Ottawa, Ontario, Canada
    BJOG 112:575-8. 2005
    ..To assess the validity of Cystatin-C (Cys-C) and beta trace protein (BTP) as clinical markers of glomerular filtration rate (GFR) in pregnant women...
  65. ncbi request reprint Neonatal renal venous thrombosis: clinical outcomes and prevalence of prothrombotic disorders
    Stephen D Marks
    Division of Nephrology, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada
    J Pediatr 146:811-6. 2005
    ..To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (RVT)...
  66. ncbi request reprint The emerging role of gene polymorphisms determining outcome after solid-organ transplantation
    Guido Filler
    Pediatr Transplant 6:12-4. 2002
  67. ncbi request reprint Cyclosporin A monitoring and AUC determination--where do we go?
    Guido Filler
    Pediatr Transplant 6:176-9. 2002
  68. ncbi request reprint Cystatin C should be measured in pediatric renal transplant patients!
    Guido Filler
    Pediatr Transplant 6:357-60. 2002
  69. ncbi request reprint Tissue HHV6 and 7 determination in pediatric solid organ recipients--a pilot study
    M Gupta
    Department of Pediatrics, Division of Pediatric Nephrology, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Pediatr Transplant 7:458-63. 2003
    ..This may explain the high prevalence of HHV6 in transplanted kidneys. Further studies on HHV6 and 7 using molecular techniques should be supported...
  70. pmc Sonomorphologic evaluation of goiter in an iodine deficiency area in the Ivory Coast
    D Franke
    Charite Children s Hospital, Humboldt University, Berlin, Germany
    Am J Public Health 89:1857-61. 1999
    ..This study evaluated the extent of thyroid abnormalities in a remote iodine-deficient area of the Ivory Coast...
  71. doi request reprint Chronic renal disease is more prevalent in patients with hemolytic uremic syndrome who had a positive history of diarrhea
    Ajay P Sharma
    Division of Nephrology, Department of Pediatrics, Children s Hospital, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Kidney Int 78:598-604. 2010
    ..Prospective studies with appropriate controls are needed to completely resolve this issue...
  72. ncbi request reprint Influence of commonly used drugs on the accuracy of cystatin C-derived glomerular filtration rate
    Jennifer Foster
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    Pediatr Nephrol 21:235-8. 2006
    ..CysC provides accurate data for calculating GFR independent of the drug doses studied and avoids the use of methods of direct GFR measurement...
  73. ncbi request reprint Should prevention of chronic kidney disease start before pregnancy?
    Guido Filler
    Department of Paediatrics, Children s Hospital, London Health Science Centre, University of Western Ontario, 800 Commissioners Road East, London, ON, Canada N6A 5W9
    Int Urol Nephrol 40:483-8. 2008
    ....
  74. doi request reprint Development of a beta-trace protein based formula for estimation of glomerular filtration rate
    Amina Benlamri
    Department of Paediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Pediatr Nephrol 25:485-90. 2010
    ..Separate formulas according to gender did not perform better than that for the pediatric population. This BTP-based formula was found to estimate GFR with reasonable precision and provided improved accuracy over the Schwartz GFR formula...
  75. ncbi request reprint Icodextrin re-absorption varies with age in children on automated peritoneal dialysis
    Allison Dart
    Department of Pediatrics, Division of Nephrology, Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada
    Pediatr Nephrol 20:683-5. 2005
    ..Icodextrin fluid removal correlated significantly with age (Spearman rank r=0.8571, P=0.0107). The data suggest that Icodextrin behaves differently in young children...
  76. doi request reprint Remission of steroid-resistant nephrotic syndrome due to focal and segmental glomerulosclerosis using rituximab
    Megha Suri
    Department of Pediatrics, Children s Hospital of Western Ontario, University of Western Ontario, 800 Commissioners Road East, London, ON, Canada N6A 5W9
    Int Urol Nephrol 40:807-10. 2008
    ..Unlike previous reports in which rituximab was used in conjunction with a calcineurin inhibitor, we present the first case where rituximab was used as the sole therapeutic agent...
  77. doi request reprint Intravenous immunoglobulin as rescue therapy for BK virus nephropathy
    Ajay P Sharma
    Department of Paediatrics, Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Pediatr Transplant 13:123-9. 2009
    ..In addition, we review the current literature on the use of cidofovir in pediatric renal transplant patients with BKVN and the potential of IVIg use in this condition...
  78. ncbi request reprint How to assess for impaired glucose tolerance before transplantation and should these results influence the choice of calcineurin inhibitors?
    Guido Filler
    Pediatr Transplant 10:1-4. 2006
  79. pmc MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients
    Ingrid Mai
    Institute of Clinical Pharmacology, Charite University Medicine Berlin, Germany
    Br J Clin Pharmacol 58:548-53. 2004
    ....
  80. ncbi request reprint Muscle force and power in obese and overweight children
    R Rauch
    University of Western Ontario, Department of Paediatrics, London, Ontario, Canada
    J Musculoskelet Neuronal Interact 12:80-3. 2012
    ..In conclusion, obese children and adolescents have increased muscle force and power. This partly compensates for the effect of high body weight on muscle performance...
  81. doi request reprint Antibody mediated rejection associated with complement factor h-related protein 3/1 deficiency successfully treated with eculizumab
    D Noone
    Division of Nephrology, The Hospital for Sick Children, University of Toronto, ON, Canada
    Am J Transplant 12:2546-53. 2012
    ..Thus, screening for CFHR3/1 deficiency should be considered in patients with severe AMR associated with TMA...
  82. ncbi request reprint Compound deletion of the rhoGAP C1 and V2 vasopressin receptor genes in a patient with nephrogenic diabetes insipidus
    T Schoneberg
    Institut fur Pharmakologie, Freie Universitat Berlin, Berlin, Germany
    Hum Mutat 14:163-74. 1999
    ..Therefore, we postulate that the loss of rhoGAP C1 function is most likely compensated by other members of the GAP family...
  83. ncbi request reprint Growth impairment shows an age-dependent pattern in boys with chronic kidney disease
    Miroslav Zivicnjak
    Department of Pediatric Nephrology, Children s Hospital of Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Pediatr Nephrol 22:420-9. 2007
    ..This growth pattern should be considered in the evaluation of individual growth and the assessment of treatment efficacy such as rhGH therapy...
  84. doi request reprint Estimating GFR using serum beta trace protein: accuracy and validation in kidney transplant and pediatric populations
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Kidney Int 76:784-91. 2009
    ..These results were an improvement compared to the MDRD and Schwartz equations, both of which had high median bias and reduced accuracy. The updated Schwartz equation also performed well...
  85. doi request reprint Effect of clinical variables and immunosuppression on serum cystatin C and beta-trace protein in kidney transplant recipients
    Christine A White
    Department of Medicine, Division of Nephrology, Queen s University, Kingston, Canada
    Am J Kidney Dis 54:922-30. 2009
    ..The aim of this study is to examine the independent effect of various clinical parameters on serum concentrations of creatinine, cystatin C, and BTP in kidney transplant recipients...
  86. ncbi request reprint How to define anemia in children with chronic kidney disease?
    Guido Filler
    Division of Pediatric Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Pediatr Nephrol 22:702-7. 2007
    ..22, p=0.0435). There was a significant correlation between the GFR and both the Hgb Z-score (p=0.0068) and the Hct Z-score (p=0.0128). There was poor agreement between conventional and KDOQI definitions of anemia in children with CKD...
  87. ncbi request reprint Safety considerations with mycophenolate sodium
    Guido Filler
    The University of Western Ontario, Department of Paediatrics, Children s Hospital of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada
    Expert Opin Drug Saf 6:445-9. 2007
    ..EC-MPS is a safe and effective immunosuppressive agent approved for use in the prevention of acute rejection after renal transplantation. However, the anticipated improvement of GI side effects has not been forthcoming...
  88. ncbi request reprint Is decreased bone mineral density in pediatric transplant recipients really a problem?
    Janusz Feber
    Pediatr Transplant 7:342-4. 2003
  89. ncbi request reprint Glomerular endotheliosis in normal pregnancy and pre-eclampsia
    Eileen D M Gallery
    BJOG 111:193; author reply 193-5; discussion 195. 2004
  90. doi request reprint Shorter break-in period is a viable option with tighter PD catheter securing during the insertion
    Ajay P Sharma
    Department of Paediatrics, Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Nephrology (Carlton) 13:672-6. 2008
    ..These results were attributed to tight catheter securing during the insertions. Objective: To compare catheter-related outcomes after different break-in periods in the tightly secured PD catheters...
  91. ncbi request reprint Nephrotic syndrome in children: should we always use steroids for the initial therapy?
    Janusz Feber
    Division of Nephrology, Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Przegl Lek 63:12-4. 2006
  92. doi request reprint Variability of the pediatric subspecialty workforce in Canada
    Guido Filler
    Department of Pediatrics, Children s Hospital at London Health Science Center, University of Western Ontario, London, Ontario, Canada
    J Pediatr 157:844-7.e1. 2010
    ....
  93. doi request reprint Cardiac tamponade in diarrhoea-positive haemolytic uraemic syndrome
    Javed Mohammed
    Department of Paediatrics, Children s Hospital at London Health Science Centre, University of Western Ontario, London, Ontario, Canada
    Nephrol Dial Transplant 24:679-81. 2009
    ..We report a HUS-induced significant pericardial effusion that resulted in a cardiac tamponade. We also discuss the diagnostic and therapeutic implications of this complication...