Research Topics
| Jean Louis ChiassonSummaryCountry: Canada Publications
| Collaborators
|
Detail Information
Publications
Who should benefit from the use of alpha-glucosidase inhibitors?Ariane Godbout
Division of Endocrinology Nutrition and Metabolism, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Curr Diab Rep 7:333-9. 2007..AGIs should be considered whenever postprandial hyperglycemia is the dominant metabolic abnormality...- Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trialJean Louis Chiasson
Research Centre, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Department of Medicine, University of Montreal, Quebec, Canada
Lancet 359:2072-7. 2002..The worldwide increase in type 2 diabetes mellitus is becoming a major health concern. We aimed to assess the effect of acarbose in preventing or delaying conversion of impaired glucose tolerance to type 2 diabetes... - Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trialJean Louis Chiasson
Research Centre, Centre Hospitalier de l Université de Montréal Hôtel Dieu and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
JAMA 290:486-94. 2003..The worldwide explosive increase in type 2 diabetes mellitus and its cardiovascular morbidity are becoming major health concerns... - Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) TrialJean-Louis Chiasson
Department of Medicine, , , Quebec, Canada
Endocr Pract 12:25-30. 2006..It also suggested that it was associated with a reduction in hypertension and cardiovascular disease... - Physical training reverses the increased activity of the hepatic ketone body synthesis pathway in chronically diabetic ratsAdil El Midaoui
Diabetes Research Unit, Research Center of Laval University Medical Center, Ste Foy, Quebec, Canada
Am J Physiol Endocrinol Metab 290:E207-12. 2006.... - Physical training reverses defect in 3-ketoacid CoA-transferase activity in skeletal muscle of diabetic ratsAdil El Midaoui
Diabetes Research Unit, Research Center of Laval University Medical Center, Ste Foy, Canada
Am J Physiol Endocrinol Metab 288:E748-52. 2005.... 
Increased shear rate resistance and fastest kinetics of erythrocyte aggregation in diabetes measured with ultrasoundGuy Cloutier
Laboratory of Biorheology and Medical Ultrasonics, Research Center, University of Montreal Hospital, Montreal, Quebec, Canada
Diabetes Care 31:1400-2. 2008..To measure with ultrasound the increased erythrocyte aggregation (EA) kinetics and adhesion energy between erythrocytes in patients with type 2 diabetes and poor metabolic control...- Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar stateJean Louis Chiasson
Division of Endocrinology Metabolism, Centre Hospitalier de l Universite de Montreal, and the Department of Medicine, Universite de Montreal, Montreal, QC
CMAJ 168:859-66. 2003..The diagnosis is confirmed by the blood pH, serum bicarbonate level and serum osmolality. Treatment consists of adequate correction of the dehydration, hyperglycemia, ketoacidosis and electrolyte deficits... - Prevention of Type 2 diabetes: fact or fiction?Jean Louis Chiasson
Universite de Montreal, Research Group on Diabetes and Metabolic Regulation Research Centre, CHUM Hotel Dieu, Department of Medicine, Montreal, Canada
Expert Opin Pharmacother 8:3147-58. 2007..It can be concluded that Type 2 diabetes can be prevented or delayed through lifestyle modifications and/or pharmacologic interventions. This is a fact... 
Tissue- and fibre-specific modifications of insulin-signalling molecules in cardiac and skeletal muscle of diabetic ratsDemiana Ekladous
Research Centre, Centre Hospitalier de l Université de Montréal Hôtel Dieu and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
Clin Exp Pharmacol Physiol 35:971-8. 2008..4. In conclusion, the results of the present study demonstrate that adaptation to STZ-induced diabetes varies among skeletal muscle fibre types and the heart, emphasizing the complex tissue-specific responses to diabetes...- Acarbose in the prevention of cardiovascular disease in subjects with impaired glucose tolerance and type 2 diabetes mellitusSophie Delorme
Division of Endocrinology-Metabolism and Nutrition, , Quebec, Canada
Curr Opin Pharmacol 5:184-9. 2005..It is proposed that the mechanism by which acarbose can lower the risk of cardiovascular events is through diminution of oxidative stress induced by postprandial glycemic excursion... - Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trialLaura Andrulionyte
Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
Diabetes 56:1181-6. 2007..7- and 2.7-fold increased risk for diabetes. Our data indicate that SNPs of PPARA increase the risk of type 2 diabetes alone and in combination with the SNPs of other genes acting closely with PPAR-alpha... - [Screening and prevention of diabetes]Jean-Louis Chiasson
,
Perspect Infirm 4:18-21. 2006 - Increased glucose excursion in cystic fibrosis and its association with a worse clinical statusMyriam Costa
Diabetes Research Group, CHUM Research Center Hôtel Dieu, Montreal QC, Canada H2W 1T7
J Cyst Fibros 6:376-83. 2007..The objectives are to investigate (a) the relative contribution of insulinopenia and insulin resistance (IR) for glucose tolerance and (b) the association between various glucose parameters and CF clinical status... - Tumor necrosis factor alpha -238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitusBénédicte Fontaine-Bisson
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Metabolism 56:649-55. 2007..19 +/- 1.24 vs 1.97 +/- 0.90, P = .6). Our findings suggest that the -238G>A and -308G>A polymorphisms of TNF-alpha alter circulating free fatty acids and insulin resistance in obese subjects with type 2 diabetes mellitus... - The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive proteinThomas M S Wolever
Department of Nutritional Sciences, University of Toronto, and the Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Am J Clin Nutr 87:114-25. 2008..The optimal source and amount of dietary carbohydrate for managing type 2 diabetes (T2DM) are unknown... - Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trialLaura Andrulionyte
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
J Mol Med (Berl) 84:701-8. 2006..Our results suggest that SNPs of HNF4A and their haplotypes predispose to type 2 diabetes mellitus in female subjects of the STOP-NIDDM study population... - Pharmacological and surgical intervention for the prevention of diabetesJean-Louis Chiasson
Research Group on Diabetes and Metabolic Regulation, Research Center, , , Montreal, Que, Canada
Nestle Nutr Workshop Ser Clin Perform Programme 11:31-9; discussion 39-42. 2006..With this new information, we need to design new strategies to screen high-risk populations and to implement the new treatments that have proven effective in the prevention of type-2 diabetes... - Under-utilization of capillary glucose monitoring by type 2 diabetic patientsMarie Claude Brindisi
Research Group on Diabetes and Metabolic Regulation, Research Center, Centre Hospitalier de l Universite de Montreal CHUM, Canada
Diabetes Res Clin Pract 75:123-5. 2007..Furthermore, postprandial plasma glucose (PPG) is an independent risk factor for cardiovascular disease. We have evaluated the frequency of monitoring and the level of PPG in type 2 diabetic patients followed by their family physician... - Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trialPriscilla A Hollander
Baylor University Medical Center, Endocrinology Center, 3600 Gaston Ave, Wadley Tower, Dallas, TX 75246, USA
Diabetes Care 27:2356-62. 2004.... - Effect of acarbose treatment on the risk of silent myocardial infarctions in patients with impaired glucose tolerance: results of the randomised STOP-NIDDM trial electrocardiography substudyUwe Zeymer
Medizinische Klinik B, Herzzentrum Ludwigshafen, Ludwigshafen, Germany
Eur J Cardiovasc Prev Rehabil 11:412-5. 2004..In the randomised STOP-NIDDM trial, we could demonstrate that lowering postprandial plasma glucose with acarbose in subjects with impaired oral glucose tolerance could reduce the risk of diabetes... - Leptin receptor gene variation predicts weight change in subjects with impaired glucose toleranceJelena Zacharova
Department of Medicine, University of Kuopio, Finland
Obes Res 13:501-6. 2005..However, this polymorphism was associated with a significant weight change, suggesting that it may potentially modulate the risk for type 2 diabetes... - The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trialJelena Zacharova
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
Diabetes 54:893-9. 2005..004). In conclusion, the G-allele of SNP +45 is a predictor for the conversion to type 2 diabetes. Furthermore, the combined effect of SNP +45 and SNP +276 on the development of type 2 diabetes was stronger than that of each SNP alone... - Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complicationsMarion J Franz
Diabetes Care 26:S51-61. 2003 - Nutrition principles and recommendations in diabetesMarion J Franz
Diabetes Care 27:S36-46. 2004 - Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrationsBénédicte Fontaine-Bisson
Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, Canada
Am J Clin Nutr 86:768-74. 2007..Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that can induce hyperlipidemia and is known to be modulated by dietary PUFAs... - The TNF-alpha-238G > a single-nucleotide polymorphism protects against memory decline in older adults with type 2 diabetesMichael H Chui
Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
Behav Neurosci 121:619-24. 2007..Therefore, inflammatory mediators may be important modulators of memory function in individuals with T2DM... - Alpha-glucosidase inhibitors for patients with type 2 diabetes: response to van de Laar et alMarkolf Hanefeld
Diabetes Care 28:1840; author reply 1841. 2005 - Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trialLaura Andrulionyte
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
Diabetes 55:2148-52. 2006..We conclude that SNPs in PPARD modify the conversion from IGT to type 2 diabetes, particularly in combination with the SNPs of PGC-1A and PPARG2... - Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjectsEmmanuelle Meugnier
UMR INSERM870 INRA1235, Faculté de Médecine R Laennec, Rue G Paradin, F 69372 Lyon Cedex 08, France
Diabetes 56:992-9. 2007.... - Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-KAmélie Pelletier
Montreal Diabetes Research Centre, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, 3850 St Urbain, Montreal, Que, Canada, H2W 1T7
Mol Cell Biochem 296:97-108. 2007..Furthermore, vanadate can bypass insulin resistance and stimulate glucose uptake in OHB-treated cardiomyocytes... - Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complicationsMarion J Franz
Nutrition Concepts by Franz, Inc, Minneapolis, Minnesota 55439, USA
Diabetes Care 25:148-98. 2002