J L Chiasson

Summary

Country: Canada

Publications

  1. ncbi Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state
    Jean Louis Chiasson
    Division of Endocrinology Metabolism, Centre Hospitalier de l Universite de Montreal, and the Department of Medicine, Universite de Montreal, Montreal, QC
    CMAJ 168:859-66. 2003
  2. ncbi Prevention of type 2 diabetes: insulin resistance and beta-cell function
    J L Chiasson
    Research Centre CHUM Hôtel Dieu, 3850 St Urbain St, Rm 8 202, Montreal Quebec H2W 1T7, Canada
    Diabetes 53:S34-8. 2004
  3. ncbi Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data
    J L Chiasson
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Department of Medicine, University of Montreal, 3850 St Urbain Street, Rm 8 202, Montreal, Quebec H2W 1T7, Canada
    Diabetologia 47:969-75; discussion 976-7. 2004
  4. ncbi Prevention of Type 2 diabetes: fact or fiction?
    Jean Louis Chiasson
    Universite de Montreal, Research Group on Diabetes and Metabolic Regulation Research Centre, CHUM Hotel Dieu, Department of Medicine, Montreal, Canada
    Expert Opin Pharmacother 8:3147-58. 2007
  5. ncbi Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial
    Jean Louis Chiasson
    Research Centre, Centre Hospitalier de l Université de Montréal Hôtel Dieu and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    JAMA 290:486-94. 2003
  6. ncbi The prevention of type 2 diabetes: what is the evidence?
    J L Chiasson
    Research Group on Diabetes and Metabolic, Regulation Research Center, Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Minerva Endocrinol 30:179-91. 2005
  7. ncbi The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes
    J L Chiasson
    Research Group on Diabetes and Metabolic Regulation, Research Center, Centre Hospitalier de l Universite de Montreal, 3850 St Urbain, 8 202, Montreal, Quebec, Canada H2W 1T8
    Diabetes Care 24:989-94. 2001
  8. ncbi The STOP-NIDDM Trial: an international study on the efficacy of an alpha-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data. Study to Prevent Non-Insulin-Depe
    J L Chiasson
    Centre Hospitalier de l Universite de Montreal, Department of Medicine, University of Montreal, Quebec, Canada
    Diabetes Care 21:1720-5. 1998
  9. ncbi Normal adiponectin levels despite abnormal glucose tolerance (or diabetes) and inflammation in adult patients with cystic fibrosis
    I Hammana
    Diabetes Research Group, Research Center, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Montreal, Quebec, Canada
    Diabetes Metab 33:213-9. 2007
  10. ncbi Guidelines for premeal insulin dose reduction for postprandial exercise of different intensities and durations in type 1 diabetic subjects treated intensively with a basal-bolus insulin regimen (ultralente-lispro)
    R Rabasa-Lhoret
    , Department of Medicine, University of Montreal, , Canada
    Diabetes Care 24:625-30. 2001

Collaborators

Detail Information

Publications51

  1. ncbi Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state
    Jean Louis Chiasson
    Division of Endocrinology Metabolism, Centre Hospitalier de l Universite de Montreal, and the Department of Medicine, Universite de Montreal, Montreal, QC
    CMAJ 168:859-66. 2003
    ..The diagnosis is confirmed by the blood pH, serum bicarbonate level and serum osmolality. Treatment consists of adequate correction of the dehydration, hyperglycemia, ketoacidosis and electrolyte deficits...
  2. ncbi Prevention of type 2 diabetes: insulin resistance and beta-cell function
    J L Chiasson
    Research Centre CHUM Hôtel Dieu, 3850 St Urbain St, Rm 8 202, Montreal Quebec H2W 1T7, Canada
    Diabetes 53:S34-8. 2004
    ..By reducing insulin resistance, they protect and preserve the beta-cell function. No intervention has yet shown any direct effect on beta-cell function...
  3. ncbi Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data
    J L Chiasson
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Department of Medicine, University of Montreal, 3850 St Urbain Street, Rm 8 202, Montreal, Quebec H2W 1T7, Canada
    Diabetologia 47:969-75; discussion 976-7. 2004
    ..The investigators stand strongly behind these results demonstrating that acarbose treatment is associated with a delay in the development of diabetes, hypertension and cardiovascular complications in a high-risk population with IGT...
  4. ncbi Prevention of Type 2 diabetes: fact or fiction?
    Jean Louis Chiasson
    Universite de Montreal, Research Group on Diabetes and Metabolic Regulation Research Centre, CHUM Hotel Dieu, Department of Medicine, Montreal, Canada
    Expert Opin Pharmacother 8:3147-58. 2007
    ..It can be concluded that Type 2 diabetes can be prevented or delayed through lifestyle modifications and/or pharmacologic interventions. This is a fact...
  5. ncbi Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial
    Jean Louis Chiasson
    Research Centre, Centre Hospitalier de l Université de Montréal Hôtel Dieu and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    JAMA 290:486-94. 2003
    ..The worldwide explosive increase in type 2 diabetes mellitus and its cardiovascular morbidity are becoming major health concerns...
  6. ncbi The prevention of type 2 diabetes: what is the evidence?
    J L Chiasson
    Research Group on Diabetes and Metabolic, Regulation Research Center, Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Minerva Endocrinol 30:179-91. 2005
    ..Prevention of the disease is our only chance to alleviate the ever growing burden of diabetes mellitus in the world...
  7. ncbi The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes
    J L Chiasson
    Research Group on Diabetes and Metabolic Regulation, Research Center, Centre Hospitalier de l Universite de Montreal, 3850 St Urbain, 8 202, Montreal, Quebec, Canada H2W 1T8
    Diabetes Care 24:989-94. 2001
    ..To investigate the efficacy and safety of miglitol in combination with metformin in improving glycemic control in outpatients in whom type 2 diabetes is insufficiently controlled by diet alone...
  8. ncbi The STOP-NIDDM Trial: an international study on the efficacy of an alpha-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data. Study to Prevent Non-Insulin-Depe
    J L Chiasson
    Centre Hospitalier de l Universite de Montreal, Department of Medicine, University of Montreal, Quebec, Canada
    Diabetes Care 21:1720-5. 1998
    ....
  9. ncbi Normal adiponectin levels despite abnormal glucose tolerance (or diabetes) and inflammation in adult patients with cystic fibrosis
    I Hammana
    Diabetes Research Group, Research Center, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Montreal, Quebec, Canada
    Diabetes Metab 33:213-9. 2007
    ..Since these conditions are common in cystic fibrosis (CF), we examined whether adiponectin values are altered in these patients...
  10. ncbi Guidelines for premeal insulin dose reduction for postprandial exercise of different intensities and durations in type 1 diabetic subjects treated intensively with a basal-bolus insulin regimen (ultralente-lispro)
    R Rabasa-Lhoret
    , Department of Medicine, University of Montreal, , Canada
    Diabetes Care 24:625-30. 2001
    ....
  11. ncbi Effect of acarbose on insulin sensitivity in elderly patients with diabetes
    G S Meneilly
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Diabetes Care 23:1162-7. 2000
    ..To study the effect of acarbose, an alpha-glucosidase inhibitor, on insulin release and insulin sensitivity in elderly patients with type 2 diabetes...
  12. ncbi The effect of acarbose on insulin sensitivity in subjects with impaired glucose tolerance
    J L Chiasson
    Research Center, Hotel Dieu de Montreal, Toronto, Canada
    Diabetes Care 19:1190-3. 1996
    ..To study the effect of acarbose, an alpha-glucosidase inhibitor, on postprandial plasma glucose and insulin and insulin sensitivity in subjects with impaired glucose tolerance (IGT)...
  13. ncbi No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes
    A Godbout
    Endocrinology Division, Department of Medicine, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Diabetes Metab 34:568-73. 2008
    ..This study aimed to examine the relationship between mean plasma glucose and HbA(1c) or fructosamine in stable patients with CFRD...
  14. ncbi Use of an alpha-glucosidase inhibitor to maintain glucose homoeostasis during postprandial exercise in intensively treated Type 1 diabetic subjects
    R Rabasa-Lhoret
    Research Group on Diabetes and Metabolic Regulation, Research Centre, , Montreal, Quebec, Canada
    Diabet Med 18:739-44. 2001
    ....
  15. ncbi Dichotomy between postprandial glucose and lipid profiles in adults with cystic fibrosis: a pilot study
    I Hammana
    Diabetes and Metabolic Diseases Research Group, Research Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, QC, Canada
    J Cyst Fibros 8:128-34. 2009
    ..We examined postprandial glucose and lipid profiles during an oral glucose tolerance test (OGTT) and following a standardized high-fat test meal (TM)...
  16. ncbi Measuring insulin sensitivity in youth: How do the different indices compare with the gold-standard method?
    M Henderson
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Diabetes Metab 37:72-8. 2011
    ....
  17. ncbi Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial
    Jean-Louis Chiasson
    Department of Medicine, , , Quebec, Canada
    Endocr Pract 12:25-30. 2006
    ..It also suggested that it was associated with a reduction in hypertension and cardiovascular disease...
  18. ncbi Postprandial hyperglycaemia: to treat or not to treat?
    M C Brindisi
    Research Group on Diabetes and Metabolic Regulation, Research Center, Centre hospitalier de l Université de Montréal CHUM and Department of Medicine, Universite de Montreal, Quebec, Canada
    Diabetes Metab 32:105-11. 2006
    ..There is growing evidence that treating postprandial hyperglycaemia should probably be part of the strategies for the prevention and management of cardiovascular diseases in pre-diabetes as well as in diabetes...
  19. ncbi Who should benefit from the use of alpha-glucosidase inhibitors?
    Ariane Godbout
    Division of Endocrinology Nutrition and Metabolism, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Curr Diab Rep 7:333-9. 2007
    ..AGIs should be considered whenever postprandial hyperglycemia is the dominant metabolic abnormality...
  20. ncbi Estimating insulin secretion in youth using simple indices derived from the oral glucose tolerance test
    M Henderson
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020, Pine Avenue West, Room 27, Montreal, Quebec, H3A 1A2, Canada
    Diabetes Metab 38:309-15. 2012
    ..For this reason, this study examined the correlation between OGTT-derived and fasting-based indices of insulin secretion against the acute insulin response to glucose (AIRg) in children...
  21. ncbi Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
    G R Dagenais
    Laval University Heart and Lung Institute, 2725 Chemin Ste Foy, Quebec, Quebec City, Canada
    Diabetes Care 31:1007-14. 2008
    ..We determined the effects of ramipril and rosiglitazone on combined and individual CVD and renal outcomes in people with IGT and/or IFG in the Diabetes REduction Assessment With ramipril and rosiglitazone Medication (DREAM) trial...
  22. ncbi Glucose turnover and gluconeogenesis during pregnancy in women with and without insulin-dependent diabetes mellitus
    J L Chiasson
    Research Group on Diabetes and Metabolic Regulation, Institut de Recherches Cliniques de Montreal, Que
    Clin Invest Med 20:140-51. 1997
    ..To characterize the effect of pregnancy on glucose turnover and gluconeogenesis in healthy women and in women with well-controlled insulin-dependent diabetes mellitus (IDDM)...
  23. ncbi Increased shear rate resistance and fastest kinetics of erythrocyte aggregation in diabetes measured with ultrasound
    Guy Cloutier
    Laboratory of Biorheology and Medical Ultrasonics, Research Center, University of Montreal Hospital, Montreal, Quebec, Canada
    Diabetes Care 31:1400-2. 2008
    ..To measure with ultrasound the increased erythrocyte aggregation (EA) kinetics and adhesion energy between erythrocytes in patients with type 2 diabetes and poor metabolic control...
  24. ncbi The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, and the Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 87:114-25. 2008
    ..The optimal source and amount of dietary carbohydrate for managing type 2 diabetes (T2DM) are unknown...
  25. ncbi Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
    Jean Louis Chiasson
    Research Centre, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Department of Medicine, University of Montreal, Quebec, Canada
    Lancet 359:2072-7. 2002
    ..The worldwide increase in type 2 diabetes mellitus is becoming a major health concern. We aimed to assess the effect of acarbose in preventing or delaying conversion of impaired glucose tolerance to type 2 diabetes...
  26. ncbi The use of information technology for the management of intensive insulin therapy in type 1 diabetes mellitus
    Y Boukhors
    Research Group on Diabetes and Metabolic Regulation, Research Centre, , , , 3850 St. Urbain Street, Montreal, Quebec, Canada H2W 1T7
    Diabetes Metab 29:619-27. 2003
    ..CONCLUSIONS: The study demonstrated that the use of computer software by the patient to adjust insulin doses for intensive insulin therapy is feasible and is not associated with increased adverse events...
  27. ncbi Acarbose in the prevention of cardiovascular disease in subjects with impaired glucose tolerance and type 2 diabetes mellitus
    Sophie Delorme
    Division of Endocrinology-Metabolism and Nutrition, , Quebec, Canada
    Curr Opin Pharmacol 5:184-9. 2005
    ..It is proposed that the mechanism by which acarbose can lower the risk of cardiovascular events is through diminution of oxidative stress induced by postprandial glycemic excursion...
  28. ncbi Pharmacological and surgical intervention for the prevention of diabetes
    Jean-Louis Chiasson
    Research Group on Diabetes and Metabolic Regulation, Research Center, , , Montreal, Que, Canada
    Nestle Nutr Workshop Ser Clin Perform Programme 11:31-9; discussion 39-42. 2006
    ..With this new information, we need to design new strategies to screen high-risk populations and to implement the new treatments that have proven effective in the prevention of type-2 diabetes...
  29. ncbi Effect of hypercorticism on regulation of skeletal muscle glycogen metabolism by epinephrine
    L Coderre
    Clinical Research Institutes of Montreal, University of Montreal, Quebec, Canada
    Am J Physiol 262:E434-9. 1992
    ..It is suggested that this abnormality could be due to the inhibition of phosphorylase a by increased muscle adenosine levels...
  30. ncbi Under-utilization of capillary glucose monitoring by type 2 diabetic patients
    Marie Claude Brindisi
    Research Group on Diabetes and Metabolic Regulation, Research Center, Centre Hospitalier de l Universite de Montreal CHUM, Canada
    Diabetes Res Clin Pract 75:123-5. 2007
    ..Furthermore, postprandial plasma glucose (PPG) is an independent risk factor for cardiovascular disease. We have evaluated the frequency of monitoring and the level of PPG in type 2 diabetic patients followed by their family physician...
  31. ncbi Chronic exposure to beta-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes
    A Tardif
    Department of Medicine, Research Center, , University of Montreal, Montreal H2W 1T8, Canada
    Am J Physiol Endocrinol Metab 281:E1205-12. 2001
    ..These results indicate that prolonged exposure to ketone bodies altered insulin action in cardiomyocytes and suggest that this substrate could play a role in the development of insulin resistance in the heart...
  32. ncbi Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K
    Amélie Pelletier
    Montreal Diabetes Research Centre, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, 3850 St Urbain, Montreal, Que, Canada, H2W 1T7
    Mol Cell Biochem 296:97-108. 2007
    ..Furthermore, vanadate can bypass insulin resistance and stimulate glucose uptake in OHB-treated cardiomyocytes...
  33. ncbi Tissue- and fibre-specific modifications of insulin-signalling molecules in cardiac and skeletal muscle of diabetic rats
    Demiana Ekladous
    Research Centre, Centre Hospitalier de l Université de Montréal Hôtel Dieu and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Clin Exp Pharmacol Physiol 35:971-8. 2008
    ..4. In conclusion, the results of the present study demonstrate that adaptation to STZ-induced diabetes varies among skeletal muscle fibre types and the heart, emphasizing the complex tissue-specific responses to diabetes...
  34. ncbi Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial
    Priscilla A Hollander
    Baylor University Medical Center, Endocrinology Center, 3600 Gaston Ave, Wadley Tower, Dallas, TX 75246, USA
    Diabetes Care 27:2356-62. 2004
    ....
  35. ncbi The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Jelena Zacharova
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 54:893-9. 2005
    ..004). In conclusion, the G-allele of SNP +45 is a predictor for the conversion to type 2 diabetes. Furthermore, the combined effect of SNP +45 and SNP +276 on the development of type 2 diabetes was stronger than that of each SNP alone...
  36. ncbi Increased glucose excursion in cystic fibrosis and its association with a worse clinical status
    Myriam Costa
    Diabetes Research Group, CHUM Research Center Hôtel Dieu, Montreal QC, Canada H2W 1T7
    J Cyst Fibros 6:376-83. 2007
    ..The objectives are to investigate (a) the relative contribution of insulinopenia and insulin resistance (IR) for glucose tolerance and (b) the association between various glucose parameters and CF clinical status...
  37. ncbi Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Diabetes 56:1181-6. 2007
    ..7- and 2.7-fold increased risk for diabetes. Our data indicate that SNPs of PPARA increase the risk of type 2 diabetes alone and in combination with the SNPs of other genes acting closely with PPAR-alpha...
  38. ncbi [Screening and prevention of diabetes]
    Jean-Louis Chiasson
    ,
    Perspect Infirm 4:18-21. 2006
  39. ncbi Effect of acarbose treatment on the risk of silent myocardial infarctions in patients with impaired glucose tolerance: results of the randomised STOP-NIDDM trial electrocardiography substudy
    Uwe Zeymer
    Medizinische Klinik B, Herzzentrum Ludwigshafen, Ludwigshafen, Germany
    Eur J Cardiovasc Prev Rehabil 11:412-5. 2004
    ..In the randomised STOP-NIDDM trial, we could demonstrate that lowering postprandial plasma glucose with acarbose in subjects with impaired oral glucose tolerance could reduce the risk of diabetes...
  40. ncbi Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Mol Med (Berl) 84:701-8. 2006
    ..Our results suggest that SNPs of HNF4A and their haplotypes predispose to type 2 diabetes mellitus in female subjects of the STOP-NIDDM study population...
  41. ncbi Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance
    Jelena Zacharova
    Department of Medicine, University of Kuopio, Finland
    Obes Res 13:501-6. 2005
    ..However, this polymorphism was associated with a significant weight change, suggesting that it may potentially modulate the risk for type 2 diabetes...
  42. ncbi Tumor necrosis factor alpha -238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Metabolism 56:649-55. 2007
    ..19 +/- 1.24 vs 1.97 +/- 0.90, P = .6). Our findings suggest that the -238G>A and -308G>A polymorphisms of TNF-alpha alter circulating free fatty acids and insulin resistance in obese subjects with type 2 diabetes mellitus...
  43. ncbi Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications
    Marion J Franz
    Nutrition Concepts by Franz, Inc, Minneapolis, Minnesota 55439, USA
    Diabetes Care 25:148-98. 2002
  44. ncbi Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications
    Marion J Franz
    Diabetes Care 26:S51-61. 2003
  45. ncbi Nutrition principles and recommendations in diabetes
    Marion J Franz
    Diabetes Care 27:S36-46. 2004
  46. ncbi Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, Canada
    Am J Clin Nutr 86:768-74. 2007
    ..Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that can induce hyperlipidemia and is known to be modulated by dietary PUFAs...
  47. ncbi Alpha-glucosidase inhibitors for patients with type 2 diabetes: response to van de Laar et al
    Markolf Hanefeld
    Diabetes Care 28:1840; author reply 1841. 2005
  48. ncbi Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects
    Emmanuelle Meugnier
    UMR INSERM870 INRA1235, Faculté de Médecine R Laennec, Rue G Paradin, F 69372 Lyon Cedex 08, France
    Diabetes 56:992-9. 2007
    ....
  49. ncbi Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 55:2148-52. 2006
    ..We conclude that SNPs in PPARD modify the conversion from IGT to type 2 diabetes, particularly in combination with the SNPs of PGC-1A and PPARG2...
  50. ncbi The TNF-alpha-238G > a single-nucleotide polymorphism protects against memory decline in older adults with type 2 diabetes
    Michael H Chui
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Behav Neurosci 121:619-24. 2007
    ..Therefore, inflammatory mediators may be important modulators of memory function in individuals with T2DM...