Hai Ying Mary Cheng

Summary

Country: Canada

Publications

  1. ncbi request reprint When the DREAM is gone: from basic science to future prospectives in pain management and beyond
    Hai Ying M Cheng
    University Health Network Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Expert Opin Ther Targets 7:249-63. 2003
  2. ncbi request reprint DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine
    Hai Ying M Cheng
    Departments of Medical Biophysics and Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Eur J Neurosci 19:3033-41. 2004
  3. ncbi request reprint Revealing a role of microRNAs in the regulation of the biological clock
    Hai Ying Mary Cheng
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Cell Cycle 6:3034-5. 2007
  4. ncbi request reprint Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock
    Hai Ying M Cheng
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna
    Neuron 43:715-28. 2004
  5. pmc microRNA modulation of circadian-clock period and entrainment
    Hai Ying M Cheng
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Neuron 54:813-29. 2007
  6. ncbi request reprint Dexras1: shaping the responsiveness of the circadian clock
    Hai Ying Mary Cheng
    Department of Medical Biophysics, The University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada M5G 2M9
    Semin Cell Dev Biol 17:345-51. 2006
  7. ncbi request reprint The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock
    Hai Ying M Cheng
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 26:12984-95. 2006
  8. ncbi request reprint DREAM is a critical transcriptional repressor for pain modulation
    Hai Ying M Cheng
    Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
    Cell 108:31-43. 2002
  9. ncbi request reprint Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism
    Greg Q Butcher
    Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 25:5305-13. 2005
  10. pmc Regulation of MAPK/ERK signaling and photic entrainment of the suprachiasmatic nucleus circadian clock by Raf kinase inhibitor protein
    Ghadi Antoun
    Department of Biology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
    J Neurosci 32:4867-77. 2012

Collaborators

Detail Information

Publications11

  1. ncbi request reprint When the DREAM is gone: from basic science to future prospectives in pain management and beyond
    Hai Ying M Cheng
    University Health Network Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Expert Opin Ther Targets 7:249-63. 2003
    ..The potential for the involvement of DREAM in other processes beyond pain modulation is considered at the end of this review...
  2. ncbi request reprint DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine
    Hai Ying M Cheng
    Departments of Medical Biophysics and Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Eur J Neurosci 19:3033-41. 2004
    ..Finally, whereas the absence of DREAM reduced the analgesic efficacy of THC, morphine analgesia was unaffected in dream(-/-) mice...
  3. ncbi request reprint Revealing a role of microRNAs in the regulation of the biological clock
    Hai Ying Mary Cheng
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Cell Cycle 6:3034-5. 2007
    ..In this review, we will discuss the specific roles of miRNA-(miR-)132 and miR-219 in the SCN, as well as a more general outlook on this newly elucidated layer of circadian clock regulation: inducible translation control via miRNAs...
  4. ncbi request reprint Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock
    Hai Ying M Cheng
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna
    Neuron 43:715-28. 2004
    ..These results identify a signaling molecule that serves as a differential modulator of the gated photic and nonphotic input pathways to the circadian timekeeping system...
  5. pmc microRNA modulation of circadian-clock period and entrainment
    Hai Ying M Cheng
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Neuron 54:813-29. 2007
    ..Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and entrainment...
  6. ncbi request reprint Dexras1: shaping the responsiveness of the circadian clock
    Hai Ying Mary Cheng
    Department of Medical Biophysics, The University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada M5G 2M9
    Semin Cell Dev Biol 17:345-51. 2006
    ..This review will attempt to provide mechanistic insights into the involvement of Dexras1 in biological timing processes based on its role as a modulator of signal transduction...
  7. ncbi request reprint The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock
    Hai Ying M Cheng
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 26:12984-95. 2006
    ..Daytime photic phase advances are mediated by a novel signaling pathway that does not affect the SCN core but rather stimulates ERK/MAPK in the SCN shell and triggers downregulation of clock protein expression...
  8. ncbi request reprint DREAM is a critical transcriptional repressor for pain modulation
    Hai Ying M Cheng
    Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
    Cell 108:31-43. 2002
    ..Thus, DREAM appears to be a critical transcriptional repressor in pain processing...
  9. ncbi request reprint Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism
    Greg Q Butcher
    Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 25:5305-13. 2005
    ..Together, these data identify MSK1 as both a downstream target of the MAPK cascade within the SCN and a regulator of clock gene expression...
  10. pmc Regulation of MAPK/ERK signaling and photic entrainment of the suprachiasmatic nucleus circadian clock by Raf kinase inhibitor protein
    Ghadi Antoun
    Department of Biology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
    J Neurosci 32:4867-77. 2012
    ..Collectively, our data reveal an important role of RKIP in the regulation of MAPK/ERK signaling in the SCN and photic entrainment of the SCN clock...
  11. ncbi request reprint MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence
    Teiji Wada
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohrgasse 3 5, A 1030 Vienna, Austria
    Nat Cell Biol 6:215-26. 2004
    ..These data show that the MKK7-JNK-c-Jun signalling pathway couples developmental and environmental cues to CDC2 expression, G2/M cell cycle progression and cellular senescence in fibroblasts...