Sylvain Chemtob

Summary

Country: Canada

Publications

  1. ncbi request reprint Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus
    Asmaa Bouayad
    FRCP C Research Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
    Am J Physiol Regul Integr Comp Physiol 286:R903-9. 2004
  2. doi request reprint The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration
    Chun Yang
    Department of Paediatrics, Research Center of Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 50:1290-8. 2009
  3. ncbi request reprint Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1
    Fernand Gobeil
    Departments of Pediatrics, Ophthalmology and Pharmacology, Research Center of Hôpital Sainte Justine, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 278:38875-83. 2003
  4. ncbi request reprint Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy
    Martin H Beauchamp
    Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Ste Justine, Montreal, Quebec H3T 1C5, Canada
    Free Radic Biol Med 37:1885-94. 2004
  5. ncbi request reprint Platelet activating factor receptors
    A Marilise Marrache
    Research Center, Sainte Justine Hospital, Montreal, Quebec, Canada
    Adv Exp Med Biol 525:161-4. 2003
  6. pmc Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:26695-707. 2009
  7. doi request reprint Functional and structural changes resulting from strain differences in the rat model of oxygen-induced retinopathy
    Allison Lindsay Dorfman
    Department of Pharmacology and Therapeutics, University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 50:2436-50. 2009
  8. doi request reprint Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration
    Tang Zhu
    Department of Pediatrics, Maisonneuve Rosemont Hospital Research Centre, University of Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 300:R577-85. 2011
  9. pmc Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a
    Karine Zaniolo
    Department of Pediatrics, Hôpital Sainte Justine Research Center, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 52:5376-86. 2011
  10. doi request reprint Understanding retinopathy of prematurity: update on pathogenesis
    Jose Carlos Rivera
    Department of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Que, Canada
    Neonatology 100:343-53. 2011

Detail Information

Publications81

  1. ncbi request reprint Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus
    Asmaa Bouayad
    FRCP C Research Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
    Am J Physiol Regul Integr Comp Physiol 286:R903-9. 2004
    ..It is concluded that PAF contributes in regulating DA tone by governing mPGES, COX-2, and ensuing PGE(2) levels in the perinate...
  2. doi request reprint The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration
    Chun Yang
    Department of Paediatrics, Research Center of Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 50:1290-8. 2009
    ..By using an immortalized RGC line (RGC-5), primary neonatal RGC cultures, and oxygen-induced retinopathy (OIR) to model ROP, the authors explored whether LPA(1) receptor induces RGC degeneration and the potential mechanisms thereof...
  3. ncbi request reprint Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1
    Fernand Gobeil
    Departments of Pediatrics, Ophthalmology and Pharmacology, Research Center of Hôpital Sainte Justine, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 278:38875-83. 2003
    ..This study describes for the first time the nucleus as a potential organelle for LPA intracrine signaling in the regulation of pro-inflammatory gene expression...
  4. ncbi request reprint Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy
    Martin H Beauchamp
    Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Ste Justine, Montreal, Quebec H3T 1C5, Canada
    Free Radic Biol Med 37:1885-94. 2004
    ..Data disclose that the dual effects of NO on newborn retinal microvascular integrity in response to hyperoxia in vivo depend on the redox state and seem mediated at least in part by VEGFR-2...
  5. ncbi request reprint Platelet activating factor receptors
    A Marilise Marrache
    Research Center, Sainte Justine Hospital, Montreal, Quebec, Canada
    Adv Exp Med Biol 525:161-4. 2003
  6. pmc Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:26695-707. 2009
    ..Together, our findings indicate a novel mechanism by which hypoxia induces CD36 expression via activation of HIF-1 and the phosphatidylinositol 3-kinase pathway...
  7. doi request reprint Functional and structural changes resulting from strain differences in the rat model of oxygen-induced retinopathy
    Allison Lindsay Dorfman
    Department of Pharmacology and Therapeutics, University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 50:2436-50. 2009
    ..The structural and functional consequences of postnatal hyperoxia (oxygen-induced retinopathy; OIR) were compared in albino Sprague-Dawley (SD) and pigmented Long-Evans (LE) rats to verify this finding...
  8. doi request reprint Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration
    Tang Zhu
    Department of Pediatrics, Maisonneuve Rosemont Hospital Research Centre, University of Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 300:R577-85. 2011
    ..Overall, we demonstrate a novel regulation and role for cortactin in FVIIa/TF-mediated endothelial cell migration that occurs through a PAR2 and RhoA dependent mechanism...
  9. pmc Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a
    Karine Zaniolo
    Department of Pediatrics, Hôpital Sainte Justine Research Center, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 52:5376-86. 2011
    ..Given the metabolic discordance associated with these diseases, the authors explored the role of ghrelin and its growth hormone secretagogue receptor 1a (GHSR-1a) in proliferative retinopathy...
  10. doi request reprint Understanding retinopathy of prematurity: update on pathogenesis
    Jose Carlos Rivera
    Department of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Que, Canada
    Neonatology 100:343-53. 2011
    ....
  11. pmc Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A
    Jean Sebastien Joyal
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Blood 117:6024-35. 2011
    ..Our findings may be applicable to other neurovascular ischemic conditions such as stroke...
  12. doi request reprint Genetic ablation of CD36 induces age-related corneal neovascularization
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Cornea 27:1037-41. 2008
    ..In the current study, we tested the hypothesis that the CD36+/+ antiangiogenic receptor contributes toward the maintenance of corneal avascularity...
  13. ncbi request reprint Hypercapnia prevents neovascularization via nitrative stress
    Daniella Checchin
    Department of Pediatrics, Department of Ophthalmology, and Department of Pharmacology, Research Center, Hopital Ste Justine, Montreal, QC, Canada H3T 1C5
    Free Radic Biol Med 40:543-53. 2006
    ..These results establish a previously unexplored means by which hypercapnia hinders efficient neovascularization, a mechanism that may contribute to ischemic tissue injury...
  14. ncbi request reprint Isomer-specific contractile effects of a series of synthetic f2-isoprostanes on retinal and cerebral microvasculature
    Xin Hou
    Centre de Recherche de l Hôpital Sainte Justine, Department of Pediatrics and Department of Pharmacology, Universite de Montreal, 3175 Cote Sainte Catherine, PQ, H3T 1C5, Montreal, Canada
    Free Radic Biol Med 36:163-72. 2004
    ..These new findings broaden the scope of our understanding regarding the potential involvement of F2-IsoP's as mediators of oxidant injury...
  15. doi request reprint Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress
    Jean Claude Honoré
    Department of Pediatrics, Research Center Centre Hospitalier Universitaire Ste Justine, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R1522-30. 2010
    ..In summary, hypercapnia at values frequently observed in preterm infants with chronic lung disease results in increased nitrative stress, which leads to cerebral cortical microvascular degeneration and curtails brain growth...
  16. ncbi request reprint Lymphocytic microparticles inhibit angiogenesis by stimulating oxidative stress and negatively regulating VEGF-induced pathways
    Chun Yang
    Research Center of CHU Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 294:R467-76. 2008
    ..In summary, LMPs potently suppress neovascularization in vivo and in vitro by augmenting ROS generation via NOX and interfering with the VEGF signaling pathway...
  17. ncbi request reprint Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain
    Alejandro Vazquez-Tello
    Deptartment of Pediatrics, Research Center of Hôpital Sainte Justine, 3175, Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Am J Physiol Regul Integr Comp Physiol 287:R1155-63. 2004
    ..Hence, contrary to a previously proposed model of exclusive COX-2/mPGES-1 coordination, COX-2 can coordinate with mPGES-1 and/or cPGES in the brain, depending on the cell compartment and the age group...
  18. ncbi request reprint Lysophosphatidic acid induces endothelial cell death by modulating the redox environment
    Sonia Brault
    Department of Pediatrics, Research Center, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Am J Physiol Regul Integr Comp Physiol 292:R1174-83. 2007
    ..Data implicate novel properties for LPA as a modulator of the cell redox environment, which partakes in endothelial cell death and ensued neuromicrovascular rarefaction...
  19. ncbi request reprint New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy
    Pierre Hardy
    Department of Obstetrics, Research Center Sainte Justine Hospital and University of Montreal, Montreal, Quebec, Canada, H3T 1C5
    Prostaglandins Leukot Essent Fatty Acids 72:301-25. 2005
    ..This review focuses on mechanisms that precede the development of neovascularization, most notably regarding the role of lipid mediators that partake in microvascular degeneration...
  20. ncbi request reprint Selective neuromicrovascular endothelial cell death by 8-Iso-prostaglandin F2alpha: possible role in ischemic brain injury
    Sonia Brault
    Centre de Recherche de l Hôpital Sainte Justine, Department of Pediatrics and Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    Stroke 34:776-82. 2003
    ..Isoprostanes are major peroxidation products. Since microvascular dysfunction seems to contribute to ischemic encephalopathies, we studied the cytotoxicity of 8-iso-prostaglandin F2alpha (PGF2alpha) on cerebral microvascular cells...
  21. ncbi request reprint Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTF
    Sandrine Joly
    Departments of Biological Sciences, University of Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 48:2311-20. 2007
    ..The purpose of the present study was to investigate the cellular and molecular mechanisms underlying this endogenous resistance to light-induced damage...
  22. pmc Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure
    Martin Leduc
    Research Center University Hospital Centre Sainte Justine, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 304:R10-22. 2013
    ..Our results demonstrate that THG213.29 represents a novel class of diuretic agent with noncompetitive allosteric modulator effects on EP(4) receptor, resulting in improved renal function and integrity following acute renal failure...
  23. ncbi request reprint trans-Arachidonic acids induce a heme oxygenase-dependent vasorelaxation of cerebral microvasculature
    Amna Kooli
    Department of Paediatrics, Research Center of Hôpital Ste Justine, Montreal, Quebec, Canada
    Free Radic Biol Med 44:815-25. 2008
    ..Our findings provide new insights into the characterization of nitrative stress-derived TAA products, by showing they can act as acute mediators of nitrative stress on neurovascular tone...
  24. doi request reprint Interleukin-1 and ischemic brain injury in the newborn: development of a small molecule inhibitor of IL-1 receptor
    Christiane Quiniou
    Department of Pediatrics and Pharmacology, Hopital Ste Justine, Research Center, Montreal, Quebec, CA
    Semin Perinatol 32:325-33. 2008
    ..101.10 (and small alike compounds) may be suitable alternatives to IL-1ra...
  25. doi request reprint Early manifestations of postnatal hyperoxia on the retinal structure and function of the neonatal rat
    Allison Dorfman
    Department of Pharmacology and Therapeutics, McGill University Montreal Children s Hospital Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 49:458-66. 2008
    ..Previous studies focused on consequences of postnatal hyperoxia at time points substantially removed from the hyperoxic insult. In this study, the earliest manifestations of this retinopathy were examined...
  26. doi request reprint The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
    Przemyslaw Sapieha
    Research Center of Centre Hospitalier Universitaire Sainte Justine, Department of Pediatrics, Universite de Montreal, Montreal, Quebec H3T 1C5, Canada
    Nat Med 14:1067-76. 2008
    ..These findings provide a new therapeutic target for modulating revascularization...
  27. ncbi request reprint Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependent
    Tang Zhu
    Department of Pediatrics, Research Center of Hôpital Ste Justine, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 26:744-50. 2006
    ..Activation of protease-activated receptor 2 (PAR2) leads to a proangiogenic response, but its mechanisms have yet to be specifically described. Here, we investigated the mode of action of PAR2 in retinal angiogenesis...
  28. doi request reprint Choroidal involution is a key component of oxygen-induced retinopathy
    Zhuo Shao
    Department of Ophthalmology and Pharmacology, Hôpital Sainte Justine Research Center, Montreal, Canada
    Invest Ophthalmol Vis Sci 52:6238-48. 2011
    ..Given that choroidal circulation is the major source of oxygen and nutrients to the photoreceptors, the authors set out to investigate whether the choroidal vasculature system may be affected in OIR...
  29. ncbi request reprint Structural and functional consequences of trolox C treatment in the rat model of postnatal hyperoxia
    Allison Lindsay Dorfman
    Department of Pharmacology and Therapeutics, McGill University Montreal Children s Hospital Research Institute, Quebec, Canada
    Invest Ophthalmol Vis Sci 47:1101-8. 2006
    ..The aim of this study was to investigate whether trolox C could also help prevent the functional (electroretinography) and structural (retinal histology) consequences associated with oxygen-induced retinopathy (OIR)...
  30. pmc Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions
    Sandra Favret
    Department of Ophthalmology, Hopital Maisonneuve Rosemont Research Centre, University of Montreal, Montreal, Quebec, H1T 2M4, Canada
    Aging (Albany NY) 5:427-44. 2013
    ..Our findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry AMD and thus broaden our understanding of this clinically unmet need. ..
  31. ncbi request reprint Potential role of microglia in retinal blood vessel formation
    Daniella Checchin
    Department of Pediatrics, Research Center, Hopital Ste Justine, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 47:3595-602. 2006
    ..The role of microglia, present in the retina early in development before vascularization, remains ill defined. The authors investigated whether microglia are implicated in retinal blood vessel formation...
  32. ncbi request reprint Hypercapnia- and trans-arachidonic acid-induced retinal microvascular degeneration: implications in the genesis of retinopathy of prematurity
    Martin Leduc
    Department of Pediatrics, Ophthalmology and Pharmacology, Research Center, Hopital Ste Justine, 3175 Ch Côte Sainte Catherine, Montreal, Quebec, Canada
    Semin Perinatol 30:129-38. 2006
    ....
  33. doi request reprint Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents
    Jean Claude Honoré
    Department of Pediatrics, Research Center CHU Ste Justine, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 33:954-61. 2013
    ..We hypothesized that TAAs play a significant role in neonatal HI-induced cerebral microvascular degeneration through GPR40 activation...
  34. ncbi request reprint Activation of CD36 inhibits and induces regression of inflammatory corneal neovascularization
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 47:4356-64. 2006
    ..This study was undertaken to investigate the role of the antiangiogenic receptor CD36 during inflammatory corneal neovascularization (CNV)...
  35. ncbi request reprint Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor
    A Marilise Marrache
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Immunol 169:6474-81. 2002
    ..This study describes for the first time the nucleus as a putative organelle capable of generating PAF and expresses its receptor, which upon stimulation induces the expression of the proinflammatory gene COX-2...
  36. ncbi request reprint Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration and diminished brain mass and function in the immature subject
    Mirna Sirinyan
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Stroke 37:2807-15. 2006
    ..Hyperoxia is known to elicit injury to premature lung and retina. Because data on the exposure of the brain to hyperoxia are limited, we studied the effects of high oxygen on this tissue...
  37. pmc CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits
    Emilie Picard
    Department of Pediatrics, Hospitals Ste Justine and Maisonneuve Rosemont, Universite de Montreal, Montreal, Quebec, Canada
    Aging (Albany NY) 2:981-9. 2010
    ..In conclusion, our data uncover a new role for CD36 in the clearance of oxidized lipids from BM and in the prevention of age-dependent sub-retinal laminar deposits...
  38. ncbi request reprint Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration
    Elsa Kermorvant-Duchemin
    Department of Pediatrics, Ophthalmology and Pharmacology, Research Center, Hopital Ste Justine, 3175 Côte de Ste Catherine, Montreal, Quebec, H3T1C5, Canada
    Nat Med 11:1339-45. 2005
    ....
  39. doi request reprint Role of receptor-mediated endocytosis in the antiangiogenic effects of human T lymphoblastic cell-derived microparticles
    Chun Yang
    Departments of Pediatrics and Pharmacology, Research Center of Centre Hospitalier Universitaire Sainte Justine, University of Montreal, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 302:R941-9. 2012
    ....
  40. doi request reprint Postmenopausal hormone therapy increases retinal blood flow and protects the retinal nerve fiber layer
    Micheline C Deschenes
    Department of Ophthalmology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 51:2587-600. 2010
    ..The effect of estradiol (E(2)) treatment on retinal tissue perfusion was also investigated in ovariectomized rats, an animal model for menopause...
  41. ncbi request reprint Developmental differences in HO-induced oligodendrocyte cell death: role of glutathione, mitogen-activated protein kinases and caspase 3
    Gabriela Fragoso
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Neurochem 90:392-404. 2004
    ....
  42. ncbi request reprint Field stimulation-induced tetrodotoxin-resistant vasorelaxation is mediated by sodium hypochlorite
    Daya R Varma
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
    Can J Physiol Pharmacol 84:1097-105. 2006
    ..We conclude that electric pulses generate the oxidant OCl- from the salt solution, which causes vasorelaxation by increasing K+ conductance...
  43. ncbi request reprint [Hypercapnia- and trans-arachidonic acid-induced retinal microvascular degeneration: implications in the genesis of retinopathy of prematurity]
    Martin Leduc
    Départements de Pédiatrie, d Ophtalmologie et de Pharmacologie, Centre de Recherche, CHU Sainte Justine, Montreal, Quebec, H3T 1C5 Canada
    Med Sci (Paris) 23:939-43. 2007
    ....
  44. ncbi request reprint Intracellular signaling of lipid mediators via cognate nuclear G protein-coupled receptors
    Anne Marilise Marrache
    Department of Pediatrics, Universite de Montreal, Montreal, Quebec, Canada
    Endothelium 12:63-72. 2005
    ..Intracrine signaling for lipid mediators uncover novel pathways to elicit their effects; moreover, intracellular GPCRs constitute a distinctive mode of action for gene regulation...
  45. ncbi request reprint Structural and functional consequences of bright light exposure on the retina of neonatal rats
    Sandrine Joly
    Department of Biological Sciences, University of Montreal, Montreal, QC, Canada
    Doc Ophthalmol 113:93-103. 2006
    ..Our results confirm that, in spite of closed eyelids, postnatal exposure to bright environment did trigger a slow degenerative process...
  46. ncbi request reprint Altered vascular function in fetal programming of hypertension
    Delphine Lamireau
    Research Center, Hopital Sainte Justine, Department of Pediatrics and Pharmacology, Universite de Montreal, Montreal, Canada
    Stroke 33:2992-8. 2002
    ..The present studies were undertaken to investigate whether endothelial dysfunction associated with altered NO-dependent vasodilatation pathways is also observed in a model of in utero programming of hypertension...
  47. ncbi request reprint Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy
    Martin Hervé Beauchamp
    Department of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Ste Justine, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 43:3327-37. 2002
    ..To test whether platelet-activating factor (PAF) directly causes retinovascular endothelial cell (EC) death...
  48. ncbi request reprint Development of a novel noncompetitive antagonist of IL-1 receptor
    Christiane Quiniou
    St Justine Hospital Research Centre, Montreal, Quebec, Canada
    J Immunol 180:6977-87. 2008
    ..Findings describe the discovery of a potent and specific small (peptide) antagonist of IL-1RI, with properties in line with an allosteric negative modulator...
  49. doi request reprint Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A
    Jean Sebastien Joyal
    Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste Justine Research Center, Montreal, QC, Canada
    Acta Paediatr 101:819-26. 2012
    ..These hypoxia-generated mediators include the Krebs cycle intermediate, succinate acting via GPR91, and the neuronal guidance molecule Semaphorin 3A...
  50. doi request reprint Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using β-amino γ-lactams
    Nicolas Boutard
    Chemistry Department, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Pept Sci 17:288-96. 2011
    ..Results indicate that the presence of a fold about the central residues of the parent peptide may be important for activity...
  51. doi request reprint G-protein-coupled receptor 91 and succinate are key contributors in neonatal postcerebral hypoxia-ischemia recovery
    David Hamel
    From the Department of Pediatrics, Research Center CHU Ste Justine, Montreal, Quebec, Canada D H, O R, J C H, T Z, X H, J C L, G A M, S C Departments of Pharmacology D H, F D, S C and Biomedical Sciences O R, M N V, Universite de Montreal, Montreal, Quebec, Canada and Department of Pharmacology and Therapeutics M S, B N, S C, Goodman Cancer Research and Metabolomics Core Facility O A M, McGill University, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 34:285-93. 2014
    ..We postulate that succinate/GPR91 enhances post-HI vascularization and reduces infarct size in a model of newborn HI brain injury...
  52. doi request reprint Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function
    Sophie Tremblay
    Department of Ophthalmology, Maisonneuve Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 54:8125-39. 2013
    ..In this study, we set out to determine the consequences of severe systemic inflammatory stress on developmental retinal vascularization and evaluate the subsequent outcome on retinal function in later life...
  53. doi request reprint p75 neurotrophin receptor participates in the choroidal antiangiogenic and apoptotic effects of T-lymphocyte-derived microparticles
    Houda Tahiri
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 54:6084-92. 2013
    ..We investigated how LMPs modulate pro- and antiangiogenic microenvironments during choroidal angiogenesis...
  54. doi request reprint Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a
    Caroline Proulx
    Departement de Chimie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Med Chem 55:6502-11. 2012
    ..In a microvascular sprouting assay using a choroid explant, [azaTyr(4)]-GHRP-6 (15), [Ala(1), azaPhe(2)]-GHRP-6 (16), and [azaLeu(3), Ala(6)]-GHRP-6 (33) all exhibited antiangiogenic activity...
  55. doi request reprint Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns
    Luisa Ronga
    Department de Chimie, Universite de Montreal, C P, 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Biopolymers 94:183-91. 2010
    ..Peptides bearing an Agl residue exhibited curve shapes indicative of turn conformations in their circular dichroism spectra...
  56. doi request reprint Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides
    Andrew G Jamieson
    Chemistry Department, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Am Chem Soc 131:7917-27. 2009
    ....
  57. ncbi request reprint PGE(2)-mediated eNOS induction in prolonged hypercapnia
    Daniella Checchin
    Department of Pediatrics, Research Center, Hopital Ste Justine, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
    Invest Ophthalmol Vis Sci 43:1558-66. 2002
    ....
  58. ncbi request reprint Light-induced retinopathy: comparing adult and juvenile rats
    Sandrine Joly
    Department of Biological Sciences, University of Montreal, and Department of Ophthalmology, McGill University Montreal Children s Hospital Research Institute, Quebec, Canada
    Invest Ophthalmol Vis Sci 47:3202-12. 2006
    ..To investigate the effect of chronic exposure to a bright, luminous environment, starting at the opening of the eyes, on the retinal structure and function of the suckling rat...
  59. doi request reprint Immunohistochemical evidence of synaptic retraction, cytoarchitectural remodeling, and cell death in the inner retina of the rat model of oygen-induced retinopathy (OIR)
    Allison Lindsay Dorfman
    Department of Pharmacology, McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 52:1693-708. 2011
    ..Postnatal exposure to hyperoxia destroys the plexiform layers of the neonatal rat retina, resulting in significant electroretinographic anomalies. The purpose of this study was to identify the mechanisms at the origin of this loss...
  60. doi request reprint Quantitative and regional measurement of retinal blood flow in rats using N-isopropyl-p-[14C]-iodoamphetamine ([14C]-IMP)
    Mylène Pouliot
    School of Optometry, University of Montreal, C P 6128, Succursale Centre Ville, Montreal, QC H3C 3J7, Canada
    Exp Eye Res 89:960-6. 2009
    ..This technique is a powerful tool to study how retinal blood flow is regulated in different regions of the rat retina...
  61. doi request reprint Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands
    Martin Leduc
    Department of Biochemistry, Universite de Montreal, Quebec, Canada
    J Pharmacol Exp Ther 331:297-307. 2009
    ..The BRET-based methodology used for this first systematic assessment of a set of EP(4) agonists should be applicable for the study of other GPCRs...
  62. doi request reprint Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical administration
    Frank Cloutier
    Department of Pediatrics, Ophthalmology, Pharmacology, Hopital Ste Justine, Universite de Montreal, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 53:1195-203. 2012
    ..In this study, the authors aimed to demonstrate the antiangiogenic activity of aganirsen in animal models of retinal neovascularization...
  63. ncbi request reprint The photopic ERG luminance-response function (photopic hill): method of analysis and clinical application
    Marianne Rufiange
    Department of Ophthalmology D 164, McGill University, Montreal Children s Hospital Research Institute, 2300 Tupper Street, Que, H3H 1P3, Montreal, Canada
    Vision Res 43:1405-12. 2003
    ..The clinical usefulness of these parameters is illustrated with selected cases of retinal disorders...
  64. ncbi request reprint Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity
    Xin Hou
    Centre de Recherche de l Hôpital Sainte Justine, Department of Pediatrics and Pharmacology, Universite de Montreal, Montreal, H3T 1C5
    Am J Physiol Regul Integr Comp Physiol 284:R928-35. 2003
    ..The resulting decrease in blood flow may contribute to the increased vulnerability of the PV brain regions to oxidant stress-induced injury in immature subjects...
  65. ncbi request reprint Cytotoxicity of the E(2)-isoprostane 15-E(2t)-IsoP on oligodendrocyte progenitors
    Sonia Brault
    Research Center of Hôpital Sainte Justine, Department of Pediatrics and Pharmacology, Universite de Montreal, Quebec, Canada
    Free Radic Biol Med 37:358-66. 2004
    ..These novel data implicate 15-E(2t)-IsoP as a product of oxidative stress that may contribute in the genesis of PVL...
  66. ncbi request reprint Dominant role for calpain in thromboxane-induced neuromicrovascular endothelial cytotoxicity
    Christiane Quiniou
    Department of Pediatrics, Centre de Recherche de l Hôpital Ste Justine, Universite de Montreal, Quebec, Canada
    J Pharmacol Exp Ther 316:618-27. 2006
    ..Overall, this work identifies (specifically) m-calpain as a dominant protease in TXA(2)-induced neurovascular endothelial cell death...
  67. ncbi request reprint Influence of NO downregulation on oscillatory evoked responses in developing rat superior colliculus
    Jamila Aitoubah
    Departement de sciences biologiques, Universite de Montreal, C P 6128, Succursale Centre Ville, Quebec, H3C 3J7, Montreal, Canada
    Brain Res Dev Brain Res 138:155-65. 2002
    ..Slow oscillatory components (7-12 Hz) were unaffected in all experiments. Our data together with results reported in the literature suggest that rhythmic patterns of activity are NO-dependent...
  68. ncbi request reprint Influence of the state of alertness on the pattern visual evoked potentials (PVEP) in very young infant
    Marie Sylvie Roy
    Department of Ophthalmology, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
    Brain Dev 26:197-202. 2004
    ..This suggest that the LS condition enhances the clinical feasibility of PVEP testing in very young infants and should be used to optimize the evaluation of visual development in high risk infants in this age group...
  69. ncbi request reprint Evidence for a brief period of enhanced oxygen susceptibility in the rat model of oxygen-induced retinopathy
    Olga Dembinska
    Department of Neurology and Neurosurgery, Montreal Children s Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    Invest Ophthalmol Vis Sci 43:2481-90. 2002
    ..Also examined was whether the oscillatory potentials (OPs) were affected by postnatal hyperoxia...
  70. ncbi request reprint Mechanism of the negative inotropic effects of alpha 1-adrenoceptor agonists on mouse myocardium
    Daya R Varma
    Department of Pharmacology and Theraputics, McGill University, Montreal, QC H3G 1Y6, Canada
    Can J Physiol Pharmacol 81:783-9. 2003
    ..PE and A61603 increased the translocation of PKCdelta, which was prevented by rottlerin. These data suggest that the alpha1AR-mediated negative inotropy on adult mouse myocardium is signaled by Ca2+-independent PKCdelta...
  71. ncbi request reprint Dark adaptation is faster in pigmented than albino rats
    Darren Behn
    Department of Neurology Neurosurgery, McGill University Montreal Children s Hospital, Montreal, Quebec, Canada
    Doc Ophthalmol 106:153-9. 2003
    ..The purpose of this study was to reinvestigate this issue by comparing the dark-adaptation process of the pigmented Long-Evans (LE) and albino Sprague Dawley (SD) rats...
  72. ncbi request reprint THG113: a novel selective FP antagonist that delays preterm labor
    Krishna G Peri
    Department of Pediatrics, Research Center of Hôpital Ste Justine, Montreal, Quebec
    Semin Perinatol 26:389-97. 2002
    ..05 g), and appeared healthy. This study describes an effective and selective noncompetitive FP antagonist, THG113, which significantly delays preterm delivery; this provides the basis for future investigations for its use in tocolysis...
  73. ncbi request reprint Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1
    Fernand Gobeil
    Department of Pharmacology, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 281:16058-67. 2006
    ..Moreover, our findings strongly support the concept of the nucleus as an autonomous signaling compartment...
  74. ncbi request reprint The pharmacologic closure of the patent ductus arteriosus
    Bart Van Overmeire
    Department of Pediatrics, Neonatal Intensive Care Unit, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Semin Fetal Neonatal Med 10:177-84. 2005
    ..This chapter focuses on some of the basic mechanisms underlying ductal patency and the clinical attempts to diminish side effects associated with indomethacin, including the alternative use of ibuprofen...
  75. ncbi request reprint Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors
    Tang Zhu
    Department of Pediatrics, Research Center of Hôpital Sainte Justine, Universite de Montreal, QC, Canada
    Can J Physiol Pharmacol 84:377-91. 2006
    ..Intracrine signaling for lipid mediators uncover novel pathways to elicit their effects; accordingly, intracellular GPCRs constitute a distinctive mode of action for gene regulation...
  76. ncbi request reprint Prostaglandins are responsible for the inhibition of breathing observed with a placental extract in fetal sheep
    Ruben E Alvaro
    Departments of Pediatrics, Physiology and Reproductive Medicine, University of Manitoba, WR004 Women s Hospital, 735 Notre Dame Avenue, Winnipeg, Man, Canada R3E 0L8
    Respir Physiol Neurobiol 144:35-44. 2004
    ..These findings suggest that the inhibition of breathing observed with the placental extract is likely related to prostaglandins...
  77. pmc CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    Christophe Combadiere
    INSERM U543, Laboratoire d Immunologie Cellulaire, Paris, France
    J Clin Invest 117:2920-8. 2007
    ..These findings reveal what we believe to be a novel pathogenic process with important implications for the development of new therapies for AMD...
  78. ncbi request reprint Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control
    Nahid Waleh
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, Calif 94143 0544, USA
    Circulation 110:2326-32. 2004
    ..We explored these pathways to identify the mechanisms responsible for the increased sensitivity of the immature ductus to PGE2...
  79. ncbi request reprint Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors
    Fernand Gobeil
    Departments of Pediatrics, Research Center of Hôpital Sainte Justine, Montreal
    Circ Res 90:682-9. 2002
    ....
  80. ncbi request reprint Nuclear prostaglandin signaling system: biogenesis and actions via heptahelical receptors
    Fernand Gobeil
    Department of Pharmacology, Universite de Sherbrooke, 3001, 12th North Avenue, Fleurimont, Sherbrooke, QC J1H 5N4, Canada
    Can J Physiol Pharmacol 81:196-204. 2003
    ..The expressional control of G-protein-coupled receptors located at the perinuclear envelope constitutes a novel and distinctive mode of gene regulation...
  81. ncbi request reprint Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro
    Sean S Davies
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Ocul Pharmacol Ther 19:45-54. 2003
    ..Our findings suggest that bimatoprost can act as prodrug for FP receptor activation and questions the concept of a "prostamide receptor" agonist...