Sylvain Chemtob

Summary

Country: Canada

Publications

  1. Nadeau Vallée M, Chin P, Belarbi L, Brien M, Pundir S, Berryer M, et al. Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice. J Immunol. 2017;198:2047-2062 pubmed publisher
    ..10 treatment. The results implicate IL-1 as an important driver of neonatal morbidity in PTB and identify 101.10 as a safe and effective candidate therapeutic. ..
  2. Nadeau Vallée M, Quiniou C, Palacios J, Hou X, Erfani A, Madaan A, et al. Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth. J Immunol. 2015;195:3402-15 pubmed publisher
    ..In this work, biased signaling modulation of IL-1R by 101.10 uncovers a novel strategy to prevent PTB without inhibiting NF-κB. ..
  3. Beaudry Richard A, Nadeau Vallée M, Prairie É, Maurice N, Heckel E, Nezhady M, et al. Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny. Sci Rep. 2018;8:11875 pubmed publisher
    ..10 to suppress deleterious inflammation. ..
  4. Sitaras N, Rivera J, Noueihed B, Bien Aimé M, Zaniolo K, Omri S, et al. Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2. Am J Pathol. 2015;185:581-95 pubmed publisher
    ..Timely activation of Par2 may be a promising therapeutic avenue in ischemic retinopathies. ..
  5. Nadeau Vallée M, Obari D, Quiniou C, Lubell W, Olson D, Girard S, et al. A critical role of interleukin-1 in preterm labor. Cytokine Growth Factor Rev. 2016;28:37-51 pubmed publisher
  6. Joyal J, Bhosle V, Chemtob S. Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity. Expert Opin Ther Targets. 2015;19:717-21 pubmed publisher
    ..Targeting subcellular compartments to improve drug selectivity may therefore inspire novel therapeutic strategies for transmembrane receptors. ..
  7. Nadeau Vallée M, Boudreault A, Leimert K, Hou X, Obari D, Madaan A, et al. Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth. Biol Reprod. 2016;95:72 pubmed
    ..Altogether, our data suggest a critical role for NmU-R2 and its ligands NmU and NmS in preterm labor triggered by infection. We hereby identify NmU-R2 as a relevant target for preterm birth. ..
  8. Zhou T, Rivera J, Bhosle V, Lahaie I, Shao Z, Tahiri H, et al. Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1?. Am J Pathol. 2016;186:3100-3116 pubmed publisher
    ..Neonatal therapy using IL-1 receptor antagonist preserves choroid and prevents protracted outer neuroretinal anomalies in OIR, suggesting IL-1? as a potential therapeutic target in ROP. ..
  9. Quiniou C, Domínguez Punaro M, Cloutier F, Erfani A, Ennaciri J, Sivanesan D, et al. Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1216-30 pubmed publisher

More Information

Publications12

  1. Madaan A, Nadeau Vallée M, Rivera J, Obari D, Hou X, Sierra E, et al. Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1). Am J Obstet Gynecol. 2017;216:60.e1-60.e17 pubmed publisher
    ..This discovery may represent a novel feedback mechanism to regulate inflammation during labor, and conveys a potential rationale for the use of GPR81 agonists to attenuate inflammation and resulting preterm birth. ..
  2. Rivera J, Holm M, Austeng D, Morken T, Zhou T, Beaudry Richard A, et al. Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies. J Neuroinflammation. 2017;14:165 pubmed publisher
    ..We propose that ROP should no longer be considered an inner retinal vasculopathy only, but also a disease of choroidal degeneration affecting both retinal pigment epithelium and photoreceptor integrity. ..
  3. Rivera J, Noueihed B, Madaan A, Lahaie I, Pan J, Belik J, et al. Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina. J Neuroinflammation. 2017;14:181 pubmed publisher
    ..Our findings reveal that BH4 is a key cofactor in regulating the expression of inflammatory and anti-angiogenic factors that play an important function in the maintenance of retinal microvasculature. ..