Nadeau Vallée M, Chin P, Belarbi L, Brien M, Pundir S, Berryer M, et al
. Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice. J Immunol. 2017;198:2047-2062 pubmed publisher
..10 treatment. The results implicate IL-1 as an important driver of neonatal morbidity in PTB and identify 101.10 as a safe and effective candidate therapeutic. ..
Nadeau VallÃ©e M, Quiniou C, Palacios J, Hou X, Erfani A, Madaan A, et al
. Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth. J Immunol. 2015;195:3402-15 pubmed publisher
..In this work, biased signaling modulation of IL-1R by 101.10 uncovers a novel strategy to prevent PTB without inhibiting NF-ÎºB. ..
Beaudry Richard A, Nadeau Vallée M, Prairie É, Maurice N, Heckel E, Nezhady M, et al
. Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny. Sci Rep. 2018;8:11875 pubmed publisher
..10 to suppress deleterious inflammation. ..
Sitaras N, Rivera J, Noueihed B, Bien AimÃ© M, Zaniolo K, Omri S, et al
. Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2. Am J Pathol. 2015;185:581-95 pubmed publisher
..Timely activation of Par2 may be a promising therapeutic avenue in ischemic retinopathies. ..
Nadeau VallÃ©e M, Obari D, Quiniou C, Lubell W, Olson D, Girard S, et al
. A critical role of interleukin-1 in preterm labor. Cytokine Growth Factor Rev. 2016;28:37-51 pubmed publisher
Joyal J, Bhosle V, Chemtob S. Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity. Expert Opin Ther Targets. 2015;19:717-21 pubmed publisher
..Targeting subcellular compartments to improve drug selectivity may therefore inspire novel therapeutic strategies for transmembrane receptors. ..
Nadeau Vallée M, Boudreault A, Leimert K, Hou X, Obari D, Madaan A, et al
. Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth. Biol Reprod. 2016;95:72 pubmed
..Altogether, our data suggest a critical role for NmU-R2 and its ligands NmU and NmS in preterm labor triggered by infection. We hereby identify NmU-R2 as a relevant target for preterm birth. ..
Zhou T, Rivera J, Bhosle V, Lahaie I, Shao Z, Tahiri H, et al
. Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1?. Am J Pathol. 2016;186:3100-3116 pubmed publisher
..Neonatal therapy using IL-1 receptor antagonist preserves choroid and prevents protracted outer neuroretinal anomalies in OIR, suggesting IL-1? as a potential therapeutic target in ROP. ..
Quiniou C, DomÃnguez Punaro M, Cloutier F, Erfani A, Ennaciri J, Sivanesan D, et al
. Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1216-30 pubmed publisher