Yvon C Chagnon

Summary

Country: Canada

Publications

  1. ncbi request reprint The human obesity gene map: the 2002 update
    Yvon C Chagnon
    Psychiatric Genetic Unit, Laval University Robert Giffard Research Center, Beauport, Quebec, Canada
    Obes Res 11:313-67. 2003
  2. ncbi request reprint A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses
    Y C Chagnon
    Laval University Research Center Robert Giffard, Beauport, Québec G1J 2B3, Canada
    Mol Psychiatry 9:1067-74. 2004
  3. ncbi request reprint Susceptibility genes for the side effect of antipsychotics on body weight and obesity
    Yvon C Chagnon
    Laval University Robert Giffard Research Center, Beauport, Quebec, Canada
    Curr Drug Targets 7:1681-95. 2006
  4. ncbi request reprint Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine
    Y C Chagnon
    Laval University Robert Giffard Research Center, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:1063-9. 2007
  5. doi request reprint Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes
    Y C Chagnon
    Laval University Research Center Robert Giffard, Quebec, Quebec, Canada
    Schizophr Res 100:281-90. 2008
  6. doi request reprint Detection of phenotype modifier genes using two-locus linkage analysis in complex disorders such as major psychosis
    Alexandre Bureau
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Universite Laval, Quebec, Quebec, Canada
    Hum Hered 73:195-207. 2012
  7. ncbi request reprint Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study
    Christophe Garenc
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Obes Res 11:612-8. 2003
  8. ncbi request reprint The human obesity gene map: the 2004 update
    Louis Perusse
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 13:381-490. 2005
  9. pmc Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study
    C M Lanouette
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 7:433-41. 2001
  10. doi request reprint Replication of linkage with bipolar disorder on chromosome 16p in the Eastern Quebec population
    Chantal Mérette
    Department of Psychiatry, Laval University, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:737-44. 2008

Collaborators

Detail Information

Publications54

  1. ncbi request reprint The human obesity gene map: the 2002 update
    Yvon C Chagnon
    Psychiatric Genetic Unit, Laval University Robert Giffard Research Center, Beauport, Quebec, Canada
    Obes Res 11:313-67. 2003
    ..More than 300 genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the map with links to useful sites can be found at http://obesitygene.pbrc.edu...
  2. ncbi request reprint A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses
    Y C Chagnon
    Laval University Research Center Robert Giffard, Beauport, Québec G1J 2B3, Canada
    Mol Psychiatry 9:1067-74. 2004
    ..PMCH encodes a neuropeptide involved in the control of food intake, energy expenditure, and in anxiety/depression. This first genome scan targeting the obesity side effect of antipsychotics identified 12q24 as a susceptibility region...
  3. ncbi request reprint Susceptibility genes for the side effect of antipsychotics on body weight and obesity
    Yvon C Chagnon
    Laval University Robert Giffard Research Center, Beauport, Quebec, Canada
    Curr Drug Targets 7:1681-95. 2006
    ..Finally, pharmacogenomic approaches have allowed to detect more then 300 possible candidate genes for antipsychotic-induced body weight gain...
  4. ncbi request reprint Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine
    Y C Chagnon
    Laval University Robert Giffard Research Center, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:1063-9. 2007
    ..No association was observed for those over 50 years, or for rs11111201. These results suggest that the common allele of PMCH rs7973796 may be associated with a greater BMI in olanzapine-treated SZ patients...
  5. doi request reprint Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes
    Y C Chagnon
    Laval University Research Center Robert Giffard, Quebec, Quebec, Canada
    Schizophr Res 100:281-90. 2008
    ..86, respectively), but was slightly repressed by olanzapine in controls (-8%; p=0.008) but not in SZ (+1%; p=0.91). These results are in agreement with those observed in post-mortem brain when the isoforms involved are considered...
  6. doi request reprint Detection of phenotype modifier genes using two-locus linkage analysis in complex disorders such as major psychosis
    Alexandre Bureau
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Universite Laval, Quebec, Quebec, Canada
    Hum Hered 73:195-207. 2012
    ....
  7. ncbi request reprint Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study
    Christophe Garenc
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Obes Res 11:612-8. 2003
    ....
  8. ncbi request reprint The human obesity gene map: the 2004 update
    Louis Perusse
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 13:381-490. 2005
    ..The electronic version of the map with links to useful publications and genomic and other relevant sites can be found at http://obesitygene.pbrc.edu...
  9. pmc Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study
    C M Lanouette
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 7:433-41. 2001
    ..Human UCP3 is mainly expressed in skeletal muscle, which plays an important role in energy homeostasis and substrate oxidation. Therefore, UCP3 is a good candidate gene for obesity...
  10. doi request reprint Replication of linkage with bipolar disorder on chromosome 16p in the Eastern Quebec population
    Chantal Mérette
    Department of Psychiatry, Laval University, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:737-44. 2008
    ....
  11. doi request reprint A new strategy for linkage analysis under epistasis taking into account genetic heterogeneity
    Alexandre Bureau
    Centre de Recherche, Université Laval Robert Giffard, Quebec, Que, Canada
    Hum Hered 68:231-42. 2009
    ..We propose a complete three-step strategy for parametric linkage analysis under epistasis and heterogeneity in extended pedigrees...
  12. doi request reprint Genome-wide linkage analysis for circulating levels of adipokines and C-reactive protein in the Quebec family study (QFS)
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec, Canada
    J Hum Genet 53:629-36. 2008
    ..No evidence of linkage was found for TNF-alpha plasma levels. These results suggest that several QTLs can influence plasma levels of adiponectin and CRP, partly via their effects on adiposity...
  13. ncbi request reprint Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels
    Yohan Bosse
    Lipid Research Center, Laval University Medical Research Center, Quebec, Canada
    J Lipid Res 45:2174-84. 2004
    ..However, concerns arise when displaying all data on the same map, because a large portion of the genome is now covered with loci supported by at least suggestive evidence of linkage...
  14. ncbi request reprint Evidence of a quantitative trait locus for energy and macronutrient intakes on chromosome 3q27.3: the Quebec Family Study
    Anne C Choquette
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Am J Clin Nutr 88:1142-8. 2008
    ..Little is known about the genes influencing dietary energy and nutrient intakes, despite evidence that these intakes are influenced by genetic factors...
  15. pmc Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype
    Michel Maziade
    Department of Psychiatry, Laval University, Quebec, QC, Canada
    Eur J Hum Genet 17:1034-42. 2009
    ..Our data suggest a susceptibility locus in 13q13-q14 that is shared by schizophrenia and mood disorder. That locus would be additional to another well documented and more distal 13q locus where the G72/G30 gene is mapped...
  16. ncbi request reprint The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
    ....
  17. doi request reprint Follow-up of a Major Psychosis Linkage Site in 13q13-q14 Reveals Significant Association in Both Case-Control and Family Samples
    Alexandre Bureau
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Universite Laval, Quebec, Canada Département de médecine sociale et préventive, Universite Laval, Quebec, Canada Electronic address
    Biol Psychiatry 74:444-50. 2013
    ..We previously reported a genome-wide significant linkage for major psychosis in chromosome 13q13-q14...
  18. ncbi request reprint Evidence for a major quantitative trait locus on chromosome 17q21 affecting low-density lipoprotein peak particle diameter
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Sainte Foy, Quebec, G1V 4G2, Canada
    Circulation 107:2361-8. 2003
    ..However, association and linkage analyses have thus far been inconclusive in identifying the underlying gene(s)...
  19. pmc The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study
    Christophe Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:88-94. 2002
    ..A C-1291G polymorphism is located in the alpha2-adrenergic receptor gene (ADRA2A) but no association with body fat accumulation has been reported yet...
  20. ncbi request reprint Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Hum Mol Genet 6:1887-9. 1997
    ..The evidence is strong enough to warrant a search for DNA sequence variation in the gene itself...
  21. ncbi request reprint Genetics of obesity: advances from rodent studies
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Trends Genet 12:441-4. 1996
  22. ncbi request reprint The human obesity gene map: the 2000 update
    L Perusse
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 9:135-69. 2001
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...
  23. ncbi request reprint Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE
    Y C Chagnon
    Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 90:1777-87. 2001
    ..This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss...
  24. ncbi request reprint A genome-wide scan for abdominal fat assessed by computed tomography in the Québec Family Study
    L Perusse
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:614-21. 2001
    ....
  25. ncbi request reprint Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene
    S J Weisnagel
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:697-702. 2001
    ....
  26. ncbi request reprint The human obesity gene map: the 1999 update
    Y C Chagnon
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 8:89-117. 2000
    ..The number of genes, markers, and chromosomal regions that have been associated or linked with human obesity phenotypes continues to increase and is now well above 200...
  27. ncbi request reprint Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 85:29-34. 2000
    ..0001), SF8 (+30 mm, P = 0.01), FM (+7 kg, P = 0.0004), %FAT (+5%, P = 0.0002), and leptin (+4 ng/mL, P = 0.0006). These results indicate a significant effect of leptin receptor on adiposity in middle-aged Caucasian males...
  28. ncbi request reprint Summary of human linkage and association studies
    L Perusse
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Behav Genet 27:359-72. 1997
    ..With genomewide searches for obesity genes actually under way, together with the 16,000 genes and transcripts included in the recent human gene map, this number is likely to increase rapidly in the next few years...
  29. pmc Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Mol Med 3:663-73. 1997
    ....
  30. ncbi request reprint Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families
    M Maziade
    Department of Psychiatry, Laval University, Quebec G1J 2G3, Canada
    Mol Psychiatry 10:486-99. 2005
    ..The present results support the relevance of investigating concurrently SZ and BP within the same study and have implications for the modelling of genetic effects...
  31. ncbi request reprint Shared susceptibility region on chromosome 15 between autism and catatonia
    Yvon C Chagnon
    Laval University Robert Giffard Research Center, Beauport, Quebec, Canada
    Int Rev Neurobiol 72:165-78. 2006
    ..Further, fine mapping and candidate gene analyses are needed to highlight potential common genes between ASD and catatonia for this chromosome...
  32. ncbi request reprint Shared chromosomal susceptibility regions between autism and other mental disorders
    Yvon C Chagnon
    Genetic and Molecular Psychiatry Unit, Robert Giffard Research Center, Laval University, Beauport, Quebec, Canada
    Int Rev Neurobiol 71:419-43. 2005
  33. ncbi request reprint [Genetics of schizophrenia and bipolar disorder: recent success of linkage studies with evidence of specific and shared susceptibility loci]
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, 2601, chemin de la Canardiere, Beauport, Quebec, G1J 2G3 Canada
    Med Sci (Paris) 19:960-6. 2003
    ..Hence, we report several genomics susceptibility loci for SZ and BP, some of them being probably shared by the two major psychiatric illnesses whereas others could be specific to each...
  34. pmc A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence
    N Boucher
    Laval Hospital Research Center and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:158-65. 2002
    ....
  35. ncbi request reprint Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study
    Y Bosse
    Lipid Research Center, Laval University Medical Research Center, and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    J Lipid Res 45:419-26. 2004
    ..In conclusion, this genome scan provides evidence for several QTLs influencing lipid and lipoprotein levels. Promising candidate genes were located in the vicinity of the genomic regions showing evidence of linkage...
  36. ncbi request reprint Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA
    J Lipid Res 46:281-6. 2005
    ..As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed...
  37. ncbi request reprint Evidence of linkage and association with body fatness and abdominal fat on chromosome 15q26
    Luigi Bouchard
    Lipid Research Center, Nutraceuticals and Functional Foods Institute, Laval University, Canada
    Obesity (Silver Spring) 15:2061-70. 2007
    ....
  38. ncbi request reprint Meta-analysis of genome-wide linkage studies in BMI and obesity
    Catherine L Saunders
    King s College London, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Obesity (Silver Spring) 15:2263-75. 2007
    ..The objective was to provide an overall assessment of genetic linkage data of BMI and BMI-defined obesity using a nonparametric genome scan meta-analysis...
  39. ncbi request reprint The human obesity gene map: the 2003 update
    Eric E Snyder
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 12:369-439. 2004
    ..Overall, more than 430 genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the map with links to useful sites can be found at http://obesitygene.pbrc.edu...
  40. ncbi request reprint A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
    ..The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle...
  41. ncbi request reprint Genomic scan of glucose and insulin metabolism phenotypes: the HERITAGE Family Study
    Ping An
    Division of Biostatistics, and the Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 52:246-53. 2003
    ..Fine mapping and association studies of candidate genes within these genomic regions are warranted...
  42. ncbi request reprint Quantitative trait locus on 15q for a metabolic syndrome variable derived from factor analysis
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec G1V 4G2, Canada
    Obesity (Silver Spring) 15:544-50. 2007
    ..75) was also observed on chromosomes 1p, 3p, 3q, 6q, 7p, 19q, and 21q. These quantitative trait loci may harbor genes contributing to the clustering of the metabolic syndrome-related phenotypes...
  43. ncbi request reprint Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study
    Christian Marc Lanouette
    Hôpital Laval and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 92:1111-8. 2002
    ..0006), with a borderline result for body mass index (P = 0.06). We concluded that UCP3 could be involved in body composition changes after regular exercise...
  44. ncbi request reprint Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans
    Daniel L Marks
    Department of Pediatrics, Oregon Health and Science University, Portland, USA
    Am J Med Genet A 126:267-71. 2004
    ..We did not observe any difference in the stability or cellular distribution of the mutant protein in a heterologous expression system, thus the mechanism of this effect requires further investigation...
  45. ncbi request reprint Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41
    Katerina Hodanova
    Center for Applied Genomics, Institute for Inherited Metabolic Disorders, Charles University 1st School of Medicine, Prague, Czech Republic
    Kidney Int 68:1472-82. 2005
    ..Linkage studies also reveal families that do not show linkage to any of the identified loci. To identify additional UAKD loci, we analyzed one of these families, with features suggestive of FJHN...
  46. ncbi request reprint A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:848-55. 2002
    ..Additional work in an independent sample is needed to verify the linkages for baseline AVF as well as the response measures...
  47. ncbi request reprint The human obesity gene map: the 2005 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obesity (Silver Spring) 14:529-644. 2006
    ..The obesity gene map shows putative loci on all chromosomes except Y. The electronic version of the map with links to useful publications and relevant sites can be found at http://obesitygene.pbrc.edu...
  48. ncbi request reprint A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: linkage and association studies
    Brahim Aissani
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1605-15. 2006
    ..To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat-free mass phenotypes in the Quebec Family Study cohort...
  49. ncbi request reprint Resting metabolic rate and respiratory quotient: results from a genome-wide scan in the Quebec Family Study
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 84:1527-33. 2006
    ....
  50. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  51. ncbi request reprint Evidence of QTLs on chromosomes 13q and 14q for triglycerides before and after 20 weeks of exercise training: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Campus Box 8067 Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110 1093, USA
    Atherosclerosis 182:349-60. 2005
    ..It is interesting that the strongest signals were found for the LDL-TG and HDL-TG subfractions, given their particular relationships with the atherogenic lipid profile including dense LDL and HDL particles...
  52. ncbi request reprint Familial resemblance for plasma leptin: sample homogeneity across adiposity and ethnic groups
    Treva Rice
    Division of Biostatistics, Departments of Genetics, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Obes Res 10:351-60. 2002
    ..Therefore, the purpose of this study was to investigate heterogeneity hypotheses across ethnic groups and by adiposity level, using the same statistical methods...
  53. ncbi request reprint Genomewide linkage scan of resting blood pressure: HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hypertension 39:1037-43. 2002
    ....
  54. ncbi request reprint The human obesity gene map: the 2001 update
    Tuomo Rankinen
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:196-243. 2002
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...