Y C Chagnon

Summary

Country: Canada

Publications

  1. ncbi Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE
    Y C Chagnon
    Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol (1985) 90:1777-87. 2001
  2. ncbi Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 85:29-34. 2000
  3. ncbi The human obesity gene map: the 1999 update
    Y C Chagnon
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 8:89-117. 2000
  4. pmc Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study
    C M Lanouette
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 7:433-41. 2001
  5. ncbi The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
  6. ncbi Evidence of LPL gene-exercise interaction for body fat and LPL activity: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste-Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 91:1334-40. 2001
  7. ncbi A genome-wide scan for abdominal fat assessed by computed tomography in the Québec Family Study
    L Perusse
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:614-21. 2001
  8. ncbi Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene
    S J Weisnagel
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:697-702. 2001
  9. doi Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes
    Y C Chagnon
    Laval University Research Center Robert Giffard, Quebec, Quebec, Canada
    Schizophr Res 100:281-90. 2008
  10. ncbi Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Hum Mol Genet 6:1887-9. 1997

Collaborators

Detail Information

Publications27

  1. ncbi Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE
    Y C Chagnon
    Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol (1985) 90:1777-87. 2001
    ..This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss...
  2. ncbi Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 85:29-34. 2000
    ..0001), SF8 (+30 mm, P = 0.01), FM (+7 kg, P = 0.0004), %FAT (+5%, P = 0.0002), and leptin (+4 ng/mL, P = 0.0006). These results indicate a significant effect of leptin receptor on adiposity in middle-aged Caucasian males...
  3. ncbi The human obesity gene map: the 1999 update
    Y C Chagnon
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 8:89-117. 2000
    ..The number of genes, markers, and chromosomal regions that have been associated or linked with human obesity phenotypes continues to increase and is now well above 200...
  4. pmc Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study
    C M Lanouette
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 7:433-41. 2001
    ..Human UCP3 is mainly expressed in skeletal muscle, which plays an important role in energy homeostasis and substrate oxidation. Therefore, UCP3 is a good candidate gene for obesity...
  5. ncbi The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
    ....
  6. ncbi Evidence of LPL gene-exercise interaction for body fat and LPL activity: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste-Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 91:1334-40. 2001
    ..05) and a greater increase in post-heparin LPL activity (P = 0.02). These results suggest that the LPL S447X polymorphism influences the training-induced changes in body fat and post-heparin LPL activity in women but not in men...
  7. ncbi A genome-wide scan for abdominal fat assessed by computed tomography in the Québec Family Study
    L Perusse
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:614-21. 2001
    ....
  8. ncbi Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene
    S J Weisnagel
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:697-702. 2001
    ....
  9. doi Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes
    Y C Chagnon
    Laval University Research Center Robert Giffard, Quebec, Quebec, Canada
    Schizophr Res 100:281-90. 2008
    ..86, respectively), but was slightly repressed by olanzapine in controls (-8%; p=0.008) but not in SZ (+1%; p=0.91). These results are in agreement with those observed in post-mortem brain when the isoforms involved are considered...
  10. ncbi Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Hum Mol Genet 6:1887-9. 1997
    ..The evidence is strong enough to warrant a search for DNA sequence variation in the gene itself...
  11. pmc A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence
    N Boucher
    Laval Hospital Research Center and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:158-65. 2002
    ....
  12. ncbi Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine
    Y C Chagnon
    Laval University Robert Giffard Research Center, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:1063-9. 2007
    ..No association was observed for those over 50 years, or for rs11111201. These results suggest that the common allele of PMCH rs7973796 may be associated with a greater BMI in olanzapine-treated SZ patients...
  13. ncbi Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study
    Y Bosse
    Lipid Research Center, Laval University Medical Research Center, and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    J Lipid Res 45:419-26. 2004
    ..In conclusion, this genome scan provides evidence for several QTLs influencing lipid and lipoprotein levels. Promising candidate genes were located in the vicinity of the genomic regions showing evidence of linkage...
  14. ncbi The human obesity gene map: the 2000 update
    L Perusse
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 9:135-69. 2001
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...
  15. ncbi Summary of human linkage and association studies
    L Perusse
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Behav Genet 27:359-72. 1997
    ..With genomewide searches for obesity genes actually under way, together with the 16,000 genes and transcripts included in the recent human gene map, this number is likely to increase rapidly in the next few years...
  16. ncbi A new gene related to human obesity identified by suppression subtractive hybridization
    M Larose
    Kinesiology, Physical Activity Sciences Laboratory, Laval University, Sainte-Foy, , Canada G1K 7P4
    Int J Obes Relat Metab Disord 25:770-6. 2001
    ..CONCLUSION: Using the SSH technique, we have identified a new gene, called Adipogene, which is overexpressed in the adipose tissue of the obese individuals and could be involved in obesity...
  17. pmc Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Mol Med 3:663-73. 1997
    ....
  18. ncbi A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses
    Y C Chagnon
    Laval University Research Center Robert Giffard, Beauport, Québec G1J 2B3, Canada
    Mol Psychiatry 9:1067-74. 2004
    ..PMCH encodes a neuropeptide involved in the control of food intake, energy expenditure, and in anxiety/depression. This first genome scan targeting the obesity side effect of antipsychotics identified 12q24 as a susceptibility region...
  19. ncbi Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families
    M Maziade
    Department of Psychiatry, Laval University, Quebec G1J 2G3, Canada
    Mol Psychiatry 10:486-99. 2005
    ..The present results support the relevance of investigating concurrently SZ and BP within the same study and have implications for the modelling of genetic effects...
  20. ncbi Genetics of obesity: advances from rodent studies
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Trends Genet 12:441-4. 1996
  21. ncbi Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA
    Eur J Clin Nutr 55:1008-15. 2001
    ..A longer period of exposure to chronic positive energy balance conditions may be necessary before sequence variation in UCP2 and UCP3 makes an impact on thyroid metabolism to influence body mass and composition changes...
  22. ncbi Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 25:1332-9. 2001
    ....
  23. pmc Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q
    A V Lembertas
    Department of Medicine, Molecular Biology Institute, University of California, Los Angeles, California 90095 1679, USA
    J Clin Invest 100:1240-7. 1997
    ..These data provide evidence that a locus on human chromosome 20q contributes to body fat and insulin in a human population, and demonstrate the utility of using interspecies syntenic relationships to find relevant disease loci in humans...
  24. ncbi Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women
    M Wauters
    Department of Endocrinology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Int J Obes Relat Metab Disord 25:714-20. 2001
    ....
  25. ncbi Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    J Hum Hypertens 15:553-8. 2001
    ..Paranoid or schizoid personality disorders is also associated with a polymorphism of the DRD2, which might be associated with a previously demonstrated low density of this receptor...
  26. ncbi NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE family study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA, USA
    Hypertension 36:885-9. 2000
    ....
  27. ncbi The Na(+)-K(+)-ATPase alpha2 gene and trainability of cardiorespiratory endurance: the HERITAGE family study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol (1985) 88:346-51. 2000
    ..017). These data suggest that genetic variation at the Na(+)-K(+)-ATPase alpha2 locus influences the trainability of VO(2 max) in sedentary Caucasian subjects...