Chabane N, Zayed N, Benderdour M, Martel Pelletier J, Pelletier J, Duval N, et al
. Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis. Arthritis Res Ther. 2009;11:R44 pubmed publisher
..These data suggest that 15-lipoxygenases may have chondroprotective properties by reducing MMP-1 and MMP-13 expression. ..
Zayed N, Li X, Chabane N, Benderdour M, Martel Pelletier J, Pelletier J, et al
. Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage. Arthritis Res Ther. 2008;10:R146 pubmed publisher
..IL-1beta may be responsible for this upregulation through activation of the JNK and p38 MAPK and NF-kappaB signalling pathways. These data suggest that L-PGDS might have an important role in the pathophysiology of OA. ..