Alan A Wilson

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 47:123-33. 2003
  2. pmc Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography
    Alan A Wilson
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
    J Med Chem 56:201-9. 2013
  3. ncbi request reprint Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Ontario, Canada
    J Med Chem 48:4153-60. 2005
  4. doi request reprint [11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Nucl Med Biol 38:247-53. 2011
  5. doi request reprint Synthesis and application of isocyanates radiolabeled with carbon-11
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario, Canada
    Chemistry 17:259-64. 2011
  6. doi request reprint Direct fixation of [(11)C]-CO(2) by amines: formation of [(11)C-carbonyl]-methylcarbamates
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Canada
    Org Biomol Chem 8:428-32. 2010
  7. doi request reprint Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Nucl Med Biol 35:305-14. 2008
  8. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
  9. pmc Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, Toronto, Canada
    J Cereb Blood Flow Metab 32:443-6. 2012
  10. doi request reprint Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009

Collaborators

Detail Information

Publications86

  1. ncbi request reprint [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 47:123-33. 2003
    ..These studies indicate that [(11)C]-DASB is a suitable PET radioligand for measuring drug occupancy of the SERT in vivo and has potential for monitoring in vivo changes in serotonin levels...
  2. pmc Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography
    Alan A Wilson
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
    J Med Chem 56:201-9. 2013
    ..These promising results are discussed in terms of the requirements of a suitable radiotracer for the in vivo imaging of FAAH using PET...
  3. ncbi request reprint Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Ontario, Canada
    J Med Chem 48:4153-60. 2005
    ....
  4. doi request reprint [11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Nucl Med Biol 38:247-53. 2011
    ..We here determine the suitability of a novel carbon-11-labeled inhibitor of FAAH via ex vivo biodistribution studies in rat brain in conjunction with pharmacological challenges...
  5. doi request reprint Synthesis and application of isocyanates radiolabeled with carbon-11
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario, Canada
    Chemistry 17:259-64. 2011
    ..This is demonstrated by using the method to make [carbonyl-(11) C]-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate which is a novel radiotracer for PET imaging of fatty acid amide hydrolase...
  6. doi request reprint Direct fixation of [(11)C]-CO(2) by amines: formation of [(11)C-carbonyl]-methylcarbamates
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Canada
    Org Biomol Chem 8:428-32. 2010
    ..The usefulness of the method is illustrated by the efficient radiosynthesis of a kappa opioid receptor imaging radiotracer, useful in positron emission tomography (PET)...
  7. doi request reprint Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Nucl Med Biol 35:305-14. 2008
    ..A novel [18F]-radiolabelled phenoxyanilide, [18F]-FEPPA, has been synthesized and evaluated, in vitro and ex vivo, as a potential positron emission tomography imaging agent for the peripheral benzodiazepine receptor (PBR)...
  8. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
    ..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease...
  9. pmc Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, Toronto, Canada
    J Cereb Blood Flow Metab 32:443-6. 2012
    ..007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels...
  10. doi request reprint Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009
    ..The relationship between MAO-A levels and selective serotonin reuptake inhibitor (SSRI) treatment, recovery, and recurrence in MDD is unknown...
  11. ncbi request reprint In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system
    Laurent Galineau
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 60:172-83. 2006
    ..These results substantiate the use of [11C]-(+)-PHNO as an agonist radiotracer for D2-imaging. The sensitivity of its binding to competition with endogenous DA suggests an association with the subset of high affinity state D2-receptors...
  12. ncbi request reprint Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Center for Addiction and Mental Health, Toronto, Canada
    J Neurochem 97:1089-103. 2006
    ....
  13. ncbi request reprint Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre and Mood and Anxiety Disorders Division, Clarke Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 63:1209-16. 2006
    ..Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine...
  14. ncbi request reprint Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study
    Jeffrey H Meyer
    Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 161:826-35. 2004
    ..The relationship between dose and occupancy was also investigated...
  15. doi request reprint Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Synapse 64:417-20. 2010
    ..Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required...
  16. doi request reprint Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
    ....
  17. ncbi request reprint Radiosynthesis, ex vivo and in vivo evaluation of [11C]preclamol as a partial dopamine D2 agonist radioligand for positron emission tomography
    Neil Vasdev
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, M5T 1R8
    Synapse 60:314-8. 2006
    ..6). The binding potential value was only 0.34 over a 1 hour time course, suggesting that [11C]preclamol is not suitable for cerebral PET studies...
  18. ncbi request reprint High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 59:389-94. 2006
    ....
  19. doi request reprint Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1776-80. 2008
    ....
  20. ncbi request reprint Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff Positron Emission Tomography Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 62:327-31. 2007
    ..We examined the possible influence of the long (A/G) variant on 5-HTT density in the living human brain using 3-(11)C-amino-4-(2-dimethylaminomethylphenyl-sulfanyl) benzonitrile ([(11)C]DASB) positron emission tomography...
  21. pmc Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase
    Oleg Sadovski
    Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada
    Bioorg Med Chem 21:4351-7. 2013
    ..We infer from these results that [(18)F]5 is a highly promising candidate radiotracer with which to image FAAH in human subjects using PET and clinical studies are proceeding...
  22. ncbi request reprint Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography
    Aristotle N Voineskos
    Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 193:539-45. 2007
    ..11)C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine positron emission tomography ([(11)C]DASB PET) is currently the best method available to quantify 5-HTT occupancy in humans...
  23. ncbi request reprint First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 33:279-89. 2008
    ..11)C]-(+)-PHNO PET might be a superior measure for release of endogenous dopamine than PET employing conventional D(2/3) antagonist radioligands...
  24. ncbi request reprint A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease
    Krista L Lanctot
    Neuropharmacology Research Program and Geriatric Psychiatry, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:888-98. 2007
    ..Postmortem studies suggest decreased 5-HT(1A) receptors in patients with Alzheimer disease (AD), but this has not been confirmed in vivo. Our primary objective was to assess the extent of 5-HT(1A) receptor losses in mild to moderate AD...
  25. ncbi request reprint Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [(18)F]F-PHNO
    Neil Vasdev
    PET Centre for Addiction and Mental Health, Toronto, Ontario, Canada, M5T 1R8
    Nucl Med Biol 34:195-203. 2007
    ..The present study reports the preparation and evaluation of fluorinated (+)-PHNO derivatives...
  26. pmc Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Brain 133:1779-97. 2010
    ....
  27. ncbi request reprint Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 27:857-71. 2007
    ..This study demonstrates that [11C]-(+)-PHNO can be used for the quantitative measurement of D2/3 densities and should enable further studies of potential D2/3 dysregulation in several important psychiatric and neurologic illnesses...
  28. ncbi request reprint Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia
    Ofer Agid
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1209-15. 2007
    ....
  29. ncbi request reprint Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 61:1271-9. 2004
    ..Our recent publication of increased serotonin2 BP in MDE with severely negativistic dysfunctional attitudes suggests that this subgroup of MDE subjects has very low levels of extracellular serotonin...
  30. pmc Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 36:375-82. 2011
    ..John's wort, an herb purported to have MAO-A inhibitor properties...
  31. doi request reprint Development of new radiopharmaceuticals for imaging monoamine oxidase B
    Neil Vasdev
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 38:933-43. 2011
    ....
  32. doi request reprint Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking
    Ingrid Bacher
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College St, Toronto, ON, Canada
    Arch Gen Psychiatry 68:817-26. 2011
    ..Dysphoria during cigarette withdrawal predicts relapse. It is unknown whether MAO-A binding increases during early cigarette withdrawal...
  33. doi request reprint Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNO
    Romina Mizrahi
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 131:63-8. 2011
    ..11)C]-(+)-PHNO offer new opportunities for exploring the potential therapeutic significance of the D(3) receptor in schizophrenia and the action of antipsychotics...
  34. ncbi request reprint Effects of tryptophan depletion on the serotonin transporter in healthy humans
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Canada
    Biol Psychiatry 58:825-30. 2005
    ..Adaptive decreases in 5-HTT density and/or affinity during TD would be a possible compensatory mechanism to maintain sufficient extracellular serotonin levels during TD, thereby preventing a depressive relapse...
  35. ncbi request reprint Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
    ..It was hypothesized that putamen D(2) binding potential would be higher during major depressive episodes featuring motor retardation...
  36. pmc Mapping human brain fatty acid amide hydrolase activity with PET
    Pablo M Rusjan
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:407-14. 2013
    ..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake...
  37. doi request reprint Whole-body distribution and radiation dosimetry of 11C-(+)-PHNO, a D2/3 agonist ligand
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Nucl Med 53:1802-6. 2012
    ..Using PET, we measured the whole-body distribution of (11)C-(+)-PHNO ((11)C-(+)-4-propyl-9-hydroxynaphthoxazine), a D(2/3) agonist, as a function of time in adult subjects in order to determine the internal radiation dose...
  38. doi request reprint Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traits
    Ivonne Suridjan
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Psychiatr Res 46:890-7. 2012
    ..Previous studies have reported inter-individual variability in the dopamine (DA) response to stress. This variability might be related to individual differences in the vulnerability to experience the negative effect of stress...
  39. doi request reprint Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation
    Justin W Hicks
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Institute of Medical Science, University of Toronto, 250 College St, Toronto, ON, Canada M5T 1R8
    Bioorg Med Chem Lett 22:2099-101. 2012
    ..The [(11)C]CO(2) fixation methodology described herein should prove generally applicable to preparing 1-aryl-3-benzyl-[(11)C-carbonyl] ureas as radiotracers for positron emission tomography...
  40. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
    ..Pharmacological studies are needed to establish whether normalization of D3 receptor function could reduce vulnerability to relapse in stimulant abuse...
  41. doi request reprint Elevated brain monoamine oxidase A binding in the early postpartum period
    Julia Sacher
    Vivian M Rakoff PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 67:468-74. 2010
    ..However, MAO-A levels have never been measured in the early postpartum period...
  42. ncbi request reprint Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 30:85-92. 2003
    ..S,S)-[(11)C]-MeNER has the potential to be the first successful PET ligand to image NET...
  43. ncbi request reprint Amphetamine pretreatment induces a change in both D2-Receptor density and apparent affinity: a [11C]raclopride positron emission tomography study in cats
    Nathalie Ginovart
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 55:1188-94. 2004
    ..To test this, we used PET and a Scatchard approach to investigate whether the decrease in [11C]raclopride binding following amphetamine results from competitive or noncompetitive interactions with DA...
  44. pmc Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography
    Pablo M Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1807-16. 2011
    ..The excellent identifiability of V(T) values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of V(T) as an appropriate and feasible outcome measure for [(18)F]-FEPPA...
  45. doi request reprint The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 34:1078-86. 2009
    ..It is possible that receptors with high affinity are not accessible by [(11)C]-(+)-PHNO because they are occupied by endogenous dopamine, a possibility that can be ruled out in future experiments...
  46. doi request reprint The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Addiction 108:953-63. 2013
    ....
  47. doi request reprint Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors
    Matthew D Moran
    Centre for Addiction and Mental Health and University of Toronto, 250 College St, Toronto, ON, Canada M5T 1R8
    Bioorg Med Chem 20:4482-8. 2012
    ..In conclusion, [(11)C]5 is worthy of further evaluation in higher species for imaging GABA(A) receptors in the central nervous system...
  48. pmc The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro
    Patrick N McCormick
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 35:1826-35. 2010
    ..This unforeseen finding suggests that their clinical effects cannot be attributed to D3 receptor blockade...
  49. ncbi request reprint Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre and the Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 56:587-91. 2004
    ..This 5-HT(1A)BP measurement is sensitive to changes in extracellular 5-HT in animal models...
  50. doi request reprint D2-receptor upregulation is dependent upon temporal course of D2-occupancy: a longitudinal [11C]-raclopride PET study in cats
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health and University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 34:662-71. 2009
    ..This suggests that as far as antipsychotics are concerned, not only dose but disbursment throughout the day have an impact on eventual pharmacodynamic and behavioral outcomes...
  51. doi request reprint Synthesis and preliminary evaluation of [(18)F]-fluoro-(2S)-Exaprolol for imaging cerebral beta-adrenergic receptors with PET
    Karin A Stephenson
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Neurochem Int 53:173-9. 2008
    ..These results indicate that [(18)F]-(2S)-1 is not a suitable candidate for PET imaging of cerebral beta-ARs...
  52. doi request reprint Acutely administered antipsychotic drugs are highly selective for dopamine D2 over D3 receptors
    Patrick N McCormick
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Pharmacol Res 70:66-71. 2013
    ..These results suggest that D3 receptor blockade is not necessary for the therapeutic effects of the antipsychotic drugs examined...
  53. pmc Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Cereb Blood Flow Metab 33:863-71. 2013
    ..However, compared with in vitro data, the latter PET measures underestimated regional contrast by ∼2-fold. Further studies are needed to address cause of the in vivo vs. in vitro nonproportionality...
  54. pmc Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PET
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    J Cereb Blood Flow Metab 33:348-50. 2013
    ..We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume...
  55. doi request reprint Increased stress-induced dopamine release in psychosis
    Romina Mizrahi
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 71:561-7. 2012
    ..However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis...
  56. ncbi request reprint Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies
    Neil Vasdev
    PET Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, Ont, Canada M5T 1R8
    Bioorg Med Chem Lett 15:5270-3. 2005
    ..Furthermore, the specific pharmacological mechanism(s) of antidepressant-like activity attributed to AR-A014418 should be investigated...
  57. doi request reprint Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro
    Patrick N McCormick
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S1A8
    Synapse 63:998-1009. 2009
    ..The potential implications of this discrepancy are discussed...
  58. doi request reprint Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 62:873-6. 2008
    ..We suggest that in vivo (+)-[11C]DTBZ binding in imaging studies is subject to competition by vesicular dopamine and, in this respect, is not a "stable" dopamine biomarker as is generally assumed...
  59. pmc Serotonin2A receptor binding potential in people with aggressive and violent behaviour
    Jeffrey H Meyer
    Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 33:499-508. 2008
    ..The objective of this study was to investigate prefrontal cortex 5-HT2A binding potential (BPND), an index of 5-HT2A density, in an unbiased sample of people with violent aggressive behaviour...
  60. pmc Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task
    Ivonne Suridjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
    J Psychiatry Neurosci 38:98-106. 2013
    ..Preclinical studies in animal models of psychosis have shown a selective increase of D2 high as the common factor in psychosis, and the D3 receptor has been suggested to be involved in the pathophysiology of schizophrenia...
  61. pmc Fluorodeoxyglucose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot study
    Tiffany W Chow
    Division of Neurology, Baycrest, Toronto, Canada
    Int J Geriatr Psychiatry 28:319-25. 2013
    ..To follow up on the increases we reported in normalized metabolic activity in salience network hubs from a 2-month open-label study of memantine in frontotemporal dementia (FTD)...
  62. pmc Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA
    Romina Mizrahi
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 32:968-72. 2012
    ..Testing for the rs6971 polymorphism may allow quantitative interpretation of TSPO PET studies with new generation of TSPO PET radioligands...
  63. ncbi request reprint Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Cereb Blood Flow Metab 26:330-44. 2006
    ..These results indicate the suitability of using [(11)C]-harmine for quantitative evaluation of MAO-A densities using PET and should enable further studies of potential MAO-A dysregulation in several psychiatric and neurologic illnesses...
  64. doi request reprint Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
    ..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine...
  65. ncbi request reprint Bupropion occupancy of the dopamine transporter is low during clinical treatment
    Jeffrey H Meyer
    Department of Psychiatry, PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Psychopharmacology (Berl) 163:102-5. 2002
    ..The validity of this mechanism has been questioned because the affinity of bupropion for the DAT is quite low...
  66. ncbi request reprint Dopamine D2 receptor radiotracers [(11)C](+)-PHNO and [(3)H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo
    Patrick N McCormick
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Nucl Med Biol 35:11-7. 2008
    ....
  67. doi request reprint Isoflurane anaesthesia differentially affects the amphetamine sensitivity of agonist and antagonist D2/D3 positron emission tomography radiotracers: implications for in vivo imaging of dopamine release
    Patrick Neil McCormick
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Mol Imaging Biol 13:737-46. 2011
    ..Herein we tested whether isoflurane differentially affects the AMPH sensitivity of [(11)C]-(+)-PHNO and [(3)H]-raclopride...
  68. doi request reprint Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide
    Neil Vasdev
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ont, Canada M5T 1R8
    Bioorg Med Chem 16:5277-84. 2008
    ..Radioactivity from all excised brain regions was <0.2%ID/g at all time points. The modest brain penetration of [(11)C]5 may limit its use for studying PKA in the central nervous system...
  69. doi request reprint Convergent effects of acute stress and glucocorticoid exposure upon MAO-A in humans
    Alexandra Soliman
    CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Neurosci 32:17120-7. 2012
    ..Since MAO-A metabolizes monoamines, this phenomenon may explain why acute stressors benefit healthy animals even though chronic stress is associated with illness...
  70. ncbi request reprint Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosine
    David Mamo
    Department of Psychiatry, University of Toronto, Canada
    Synapse 52:153-62. 2004
    ..Our results suggest that 6-[18F]-L-m-tyrosine PET may not be a useful tool in the study of the effect of antipsychotics on dopamine synthesis in human subjects...
  71. ncbi request reprint Serotonin-1A receptors in frontotemporal dementia compared with controls
    Krista L Lanctot
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Psychiatry Res 156:247-50. 2007
    ..These pilot data suggest that profound 5-HT(1A) BP losses may be present and contribute to symptomatology and treatment response in FTLD...
  72. ncbi request reprint In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
    Nicolaas P L G Verhoeff
    Vivian Rakoff PET Centre, Centre for Addiction and Mental Health, Ontario, Canada
    Am J Geriatr Psychiatry 12:584-95. 2004
    ..The authors' aim was to develop a novel Abeta-specific positron-emission tomography (PET) tracer...
  73. doi request reprint An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP
    Erik M van Oosten
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
    Appl Radiat Isot 67:611-6. 2009
    ..This methodology offers higher yields, faster synthesis times, an optimized precursor, and simpler automation than previously reported...
  74. doi request reprint Synthesis and in vitro evaluation of derivatives of the β₁-adrenergic receptor antagonist HX-CH 44
    Karin A Stephenson
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Bioorg Med Chem Lett 21:5506-9. 2011
    ..An X-ray crystallographic characterization of the fluorinated analog is also reported...
  75. doi request reprint Facile radiosynthesis of fluorine-18 labeled beta-blockers. Synthesis, radiolabeling, and ex vivo biodistribution of [18F]-(2S and 2R)-1-(1-fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol
    Karin A Stephenson
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
    J Med Chem 51:5093-100. 2008
    ..9-1.1 Ci/micromol (EOS). Ex vivo biodistribution studies with the radiotracers demonstrated excessively rapid washout that may limit their use for cerebral PET imaging...
  76. pmc Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:2065-75. 2011
    ....
  77. ncbi request reprint In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 29:509-15. 2002
    ..Together with previous studies, the present findings indicate that [11C]-DASB is a very useful radiopharmaceutical for probing changes in SERT densities using PET imaging in the living human brain...
  78. doi request reprint Seasonal variation in human brain serotonin transporter binding
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada
    Arch Gen Psychiatry 65:1072-8. 2008
    ..The serotonin transporter is a key element in regulating intensity and spread of the serotonin signal...
  79. ncbi request reprint Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Clarke Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St, Toronto, ON, M5T 1R8, Canada
    Am J Psychiatry 160:90-9. 2003
    ....
  80. ncbi request reprint Quantitative validation of an intracerebral beta-sensitive microprobe system to determine in vivo drug-induced receptor occupancy using [11C]raclopride in rats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 52:89-99. 2004
    ....
  81. ncbi request reprint Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
    ....
  82. ncbi request reprint Misunderstandings about how to choose a reference region
    Jeffrey H Meyer
    Biol Psychiatry 61:1314; author reply 1314-5. 2007
  83. pmc Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions
    Zsolt Szabo
    Division of Nuclear Medicine, Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 43:678-92. 2002
    ..The purpose of this study was to compare and contrast (+)-(11)C-McN5652 and (11)C-DASB under various experimental conditions...
  84. ncbi request reprint Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 22:1377-98. 2002
    ....
  85. ncbi request reprint Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain
    Débora C Hipólide
    Department of Psychobiology, Universidade Federal de Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 29:297-303. 2005
    ....
  86. ncbi request reprint Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics
    Johannes Tauscher
    University of Toronto Department of Psychiatry, Schizophrenia Program
    Am J Psychiatry 161:1620-5. 2004
    ....