A A Wilson

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines
    A A Wilson
    PET Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Med Chem 43:3103-10. 2000
  2. ncbi Carbon-11 labelled cholecystokininB antagonists: radiosynthesis and evaluation in rats
    A A Wilson
    PET Centre, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Life Sci 68:1223-30. 2001
  3. ncbi An admonition when measuring the lipophilicity of radiotracers using counting techniques
    A A Wilson
    The Vivian M Rackoff PET Centre, Centre for Addiction and Mental Health, Toronto, Ont, Canada
    Appl Radiat Isot 54:203-8. 2001
  4. ncbi Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method
    A A Wilson
    PET Centre, The Centre for Addiction and Mental Health and Dept of Psychiatry, University of Toronto Faculty of Medicine, 250 College St, Toronto, ON M5T 1R8, Canada
    Nucl Med Biol 27:529-32. 2000
  5. ncbi In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 29:509-15. 2002
  6. ncbi Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 30:85-92. 2003
  7. ncbi Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies
    N Ginovart
    PET Center, Center for Addiction and Mental Health, and University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 21:1342-53. 2001
  8. ncbi The D2 receptor occupancy profile of loxapine determined using PET
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, ON, Canada
    Neuropsychopharmacology 15:562-6. 1996
  9. ncbi Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging study
    J H Meyer
    Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, Ont, Canada
    Am J Psychiatry 156:1029-34. 1999
  10. ncbi Derivatives of WAY 100635 as potential imaging agents for 5-HT1A receptors: syntheses, radiosyntheses, and in vitro and in vivo evaluation
    A A Wilson
    PET Centre, Clarke Institute of Psychiatry, Toronto, Ontario, Canada
    Nucl Med Biol 25:769-76. 1998

Detail Information

Publications59

  1. ncbi Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines
    A A Wilson
    PET Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Med Chem 43:3103-10. 2000
    ..Two of the tested radiotracers, 15 and 16, have highly favorable properties for imaging SERT and will be used in pilot human PET imaging studies...
  2. ncbi Carbon-11 labelled cholecystokininB antagonists: radiosynthesis and evaluation in rats
    A A Wilson
    PET Centre, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Life Sci 68:1223-30. 2001
    ..In light of the very poor brain penetration of these compounds, reports on the central nervous system activity of this class of CCKB antagonists should be viewed with caution...
  3. ncbi An admonition when measuring the lipophilicity of radiotracers using counting techniques
    A A Wilson
    The Vivian M Rackoff PET Centre, Centre for Addiction and Mental Health, Toronto, Ont, Canada
    Appl Radiat Isot 54:203-8. 2001
    ..However, pre-washing the radiotracer-containing organic phase with aqueous phase can, in many cases, allay doubts about the validity of such measurements...
  4. ncbi Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method
    A A Wilson
    PET Centre, The Centre for Addiction and Mental Health and Dept of Psychiatry, University of Toronto Faculty of Medicine, 250 College St, Toronto, ON M5T 1R8, Canada
    Nucl Med Biol 27:529-32. 2000
    ....
  5. ncbi In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 29:509-15. 2002
    ..Together with previous studies, the present findings indicate that [11C]-DASB is a very useful radiopharmaceutical for probing changes in SERT densities using PET imaging in the living human brain...
  6. ncbi Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 30:85-92. 2003
    ..S,S)-[(11)C]-MeNER has the potential to be the first successful PET ligand to image NET...
  7. ncbi Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies
    N Ginovart
    PET Center, Center for Addiction and Mental Health, and University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 21:1342-53. 2001
    ....
  8. ncbi The D2 receptor occupancy profile of loxapine determined using PET
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, ON, Canada
    Neuropsychopharmacology 15:562-6. 1996
    ..This dose range is much lower than that used in most clinical settings and points to the potential efficacy of loxapine at lower doses...
  9. ncbi Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging study
    J H Meyer
    Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, Ont, Canada
    Am J Psychiatry 156:1029-34. 1999
    ..The objective of this study was to evaluate 5-HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts...
  10. ncbi Derivatives of WAY 100635 as potential imaging agents for 5-HT1A receptors: syntheses, radiosyntheses, and in vitro and in vivo evaluation
    A A Wilson
    PET Centre, Clarke Institute of Psychiatry, Toronto, Ontario, Canada
    Nucl Med Biol 25:769-76. 1998
    ..Blocking studies with a variety of drugs demonstrated that the binding of [11C]-7 in vivo was selective for 5-HT1A receptors. [11C]-7 is a promising candidate as a ligand for imaging 5-HT1A receptors by PET...
  11. ncbi 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 155:921-8. 1998
    ..The purpose of this study was to investigate olanzapine's binding to the serotonin 5-HT2 and dopamine D2 receptors in schizophrenic patients being treated with clinically relevant doses...
  12. ncbi Lower dopamine transporter binding potential in striatum during depression
    J H Meyer
    PET Imaging Centre, and Mood Division, Centre for Addiction and Mental Health, Department of Psychiatry and University of Toronto, 250 College St, Toronto, Ont. M5T1R8, Canada
    Neuroreport 12:4121-5. 2001
    ..Lower DAT BP itself reduces extracellular clearance of dopamine. Patients who did not decrease their striatal DAT BP failed to compensate for low dopamine and showed greater impairment on dopamine related tests...
  13. ncbi Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study
    J H Meyer
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:1843-9. 2001
    ..This study measured the proportion of 5-HTT sites blocked during paroxetine and citalopram treatment of depression and assessed the relationship between serum paroxetine levels and the proportion of 5-HTT sites blocked...
  14. ncbi Characterization of r-(11)C]rolipram for PET imaging of phosphodieterase-4: in vito binding, metabolism, and dosimetry studies in rats
    C M Lourenco
    Vivian M. Rakoff Pet Centre, Centre for Addiction and Mental Health, Department of Pharmacology, University of Toronto, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
    Nucl Med Biol 28:347-58. 2001
    ..Additionally, the estimated absorbed radiation dose extrapolated to humans was low. These results support further investigation of R-[(11)C]rolipram in studying PDE4 in vivo by positron emission tomography imaging...
  15. ncbi Dopamine D1 agonist R-[11C]SKF 82957: synthesis and in vivo characterization in rats
    J N DaSilva
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Nucl Med Biol 26:537-42. 1999
    ..No labeled metabolites were detected in rat brain. These results indicate that R-[11C]SKF 82957 will provide more sensitive measurements of D1 receptors in in vivo studies than the racemic mixture...
  16. ncbi Neuromodulation of frontal and temporal cortex by intravenous d-fenfluramine: an [15O]H2O PET study in humans
    J H Meyer
    Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, Ontario, Canada
    Neurosci Lett 207:25-8. 1996
    ..These results support further investigation with intravenous d-fenfluramine to study the net functional effects of serotonergic stimulation in health and illness...
  17. ncbi The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study
    J H Meyer
    Clarke Division, Centre for Addictions and Mental Health, Department ofPsychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:78-85. 2001
    ..The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT(2A) receptors in depressed patients...
  18. ncbi Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans
    N P L G Verhoeff
    Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Mol Psychiatry 7:233, 322-8. 2002
    ..Thus, while DA depletion "uncovers" D(2)receptors, it does not do so for D(1) receptors. The implications of this finding for measuring endogenous DA and its effects on in vivo receptor binding in humans are discussed...
  19. ncbi Imaging the 5-HT(1A) receptors with PET: WAY-100635 and analogues
    S Houle
    Vivian M Rakoff PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Nucl Med Biol 27:463-6. 2000
    ....
  20. doi Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits
    A Soliman
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychol Med 41:1051-60. 2011
    ..We hypothesized that prefrontal MAOA binding would correlate negatively with angry-hostility, a trait related to aggression/anger, and positively with traits intuitively related to adaptive investigative behavior...
  21. ncbi Misunderstandings about how to choose a reference region
    Jeffrey H Meyer
    Biol Psychiatry 61:1314; author reply 1314-5. 2007
  22. ncbi Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
    ..It was hypothesized that putamen D(2) binding potential would be higher during major depressive episodes featuring motor retardation...
  23. ncbi In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system
    Laurent Galineau
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 60:172-83. 2006
    ..These results substantiate the use of [11C]-(+)-PHNO as an agonist radiotracer for D2-imaging. The sensitivity of its binding to competition with endogenous DA suggests an association with the subset of high affinity state D2-receptors...
  24. ncbi Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Center for Addiction and Mental Health, Toronto, Canada
    J Neurochem 97:1089-103. 2006
    ....
  25. ncbi High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 59:389-94. 2006
    ....
  26. ncbi Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre and Mood and Anxiety Disorders Division, Clarke Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 63:1209-16. 2006
    ..Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine...
  27. ncbi Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff Positron Emission Tomography Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 62:327-31. 2007
    ..We examined the possible influence of the long (A/G) variant on 5-HTT density in the living human brain using 3-(11)C-amino-4-(2-dimethylaminomethylphenyl-sulfanyl) benzonitrile ([(11)C]DASB) positron emission tomography...
  28. ncbi Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [(18)F]F-PHNO
    Neil Vasdev
    PET Centre for Addiction and Mental Health, Toronto, Ontario, Canada, M5T 1R8
    Nucl Med Biol 34:195-203. 2007
    ..The present study reports the preparation and evaluation of fluorinated (+)-PHNO derivatives...
  29. ncbi Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography
    Aristotle N Voineskos
    Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 193:539-45. 2007
    ..11)C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine positron emission tomography ([(11)C]DASB PET) is currently the best method available to quantify 5-HTT occupancy in humans...
  30. ncbi Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
    ..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease...
  31. ncbi A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease
    Krista L Lanctot
    Neuropharmacology Research Program and Geriatric Psychiatry, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:888-98. 2007
    ..Postmortem studies suggest decreased 5-HT(1A) receptors in patients with Alzheimer disease (AD), but this has not been confirmed in vivo. Our primary objective was to assess the extent of 5-HT(1A) receptor losses in mild to moderate AD...
  32. doi Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Nucl Med Biol 35:305-14. 2008
    ..A novel [18F]-radiolabelled phenoxyanilide, [18F]-FEPPA, has been synthesized and evaluated, in vitro and ex vivo, as a potential positron emission tomography imaging agent for the peripheral benzodiazepine receptor (PBR)...
  33. doi Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
    ..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine...
  34. ncbi Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 27:857-71. 2007
    ..This study demonstrates that [11C]-(+)-PHNO can be used for the quantitative measurement of D2/3 densities and should enable further studies of potential D2/3 dysregulation in several important psychiatric and neurologic illnesses...
  35. ncbi Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies
    Neil Vasdev
    PET Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, Ont, Canada M5T 1R8
    Bioorg Med Chem Lett 15:5270-3. 2005
    ..Furthermore, the specific pharmacological mechanism(s) of antidepressant-like activity attributed to AR-A014418 should be investigated...
  36. ncbi Effects of tryptophan depletion on the serotonin transporter in healthy humans
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Canada
    Biol Psychiatry 58:825-30. 2005
    ..Adaptive decreases in 5-HTT density and/or affinity during TD would be a possible compensatory mechanism to maintain sufficient extracellular serotonin levels during TD, thereby preventing a depressive relapse...
  37. pmc Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions
    Zsolt Szabo
    Division of Nuclear Medicine, Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 43:678-92. 2002
    ..The purpose of this study was to compare and contrast (+)-(11)C-McN5652 and (11)C-DASB under various experimental conditions...
  38. ncbi [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 47:123-33. 2003
    ..These studies indicate that [(11)C]-DASB is a suitable PET radioligand for measuring drug occupancy of the SERT in vivo and has potential for monitoring in vivo changes in serotonin levels...
  39. ncbi Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Clarke Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St, Toronto, ON, M5T 1R8, Canada
    Am J Psychiatry 160:90-9. 2003
    ....
  40. ncbi Bupropion occupancy of the dopamine transporter is low during clinical treatment
    Jeffrey H Meyer
    Department of Psychiatry, PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Psychopharmacology (Berl) 163:102-5. 2002
    ..The validity of this mechanism has been questioned because the affinity of bupropion for the DAT is quite low...
  41. ncbi Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study
    Jeffrey H Meyer
    Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 161:826-35. 2004
    ..The relationship between dose and occupancy was also investigated...
  42. ncbi Amphetamine pretreatment induces a change in both D2-Receptor density and apparent affinity: a [11C]raclopride positron emission tomography study in cats
    Nathalie Ginovart
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 55:1188-94. 2004
    ..To test this, we used PET and a Scatchard approach to investigate whether the decrease in [11C]raclopride binding following amphetamine results from competitive or noncompetitive interactions with DA...
  43. ncbi Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics
    Johannes Tauscher
    University of Toronto Department of Psychiatry, Schizophrenia Program
    Am J Psychiatry 161:1620-5. 2004
    ....
  44. ncbi Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre and the Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 56:587-91. 2004
    ..This 5-HT(1A)BP measurement is sensitive to changes in extracellular 5-HT in animal models...
  45. ncbi Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Ontario, Canada
    J Med Chem 48:4153-60. 2005
    ....
  46. ncbi Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain
    Débora C Hipólide
    Department of Psychobiology, Universidade Federal de Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 29:297-303. 2005
    ....
  47. ncbi Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 22:1377-98. 2002
    ....
  48. ncbi Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 61:1271-9. 2004
    ..Our recent publication of increased serotonin2 BP in MDE with severely negativistic dysfunctional attitudes suggests that this subgroup of MDE subjects has very low levels of extracellular serotonin...
  49. ncbi In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
    Nicolaas P L G Verhoeff
    Vivian Rakoff PET Centre, Centre for Addiction and Mental Health, Ontario, Canada
    Am J Geriatr Psychiatry 12:584-95. 2004
    ..The authors' aim was to develop a novel Abeta-specific positron-emission tomography (PET) tracer...
  50. ncbi Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
    ....
  51. ncbi Dopamine D2 receptor radiotracers [(11)C](+)-PHNO and [(3)H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo
    Patrick N McCormick
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Nucl Med Biol 35:11-7. 2008
    ....
  52. doi Facile radiosynthesis of fluorine-18 labeled beta-blockers. Synthesis, radiolabeling, and ex vivo biodistribution of [18F]-(2S and 2R)-1-(1-fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol
    Karin A Stephenson
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
    J Med Chem 51:5093-100. 2008
    ..9-1.1 Ci/micromol (EOS). Ex vivo biodistribution studies with the radiotracers demonstrated excessively rapid washout that may limit their use for cerebral PET imaging...
  53. doi Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide
    Neil Vasdev
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ont, Canada M5T 1R8
    Bioorg Med Chem 16:5277-84. 2008
    ..Radioactivity from all excised brain regions was <0.2%ID/g at all time points. The modest brain penetration of [(11)C]5 may limit its use for studying PKA in the central nervous system...
  54. ncbi First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 33:279-89. 2008
    ..11)C]-(+)-PHNO PET might be a superior measure for release of endogenous dopamine than PET employing conventional D(2/3) antagonist radioligands...
  55. ncbi Quantitative validation of an intracerebral beta-sensitive microprobe system to determine in vivo drug-induced receptor occupancy using [11C]raclopride in rats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 52:89-99. 2004
    ....
  56. ncbi Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosine
    David Mamo
    Department of Psychiatry, University of Toronto, Canada
    Synapse 52:153-62. 2004
    ..Our results suggest that 6-[18F]-L-m-tyrosine PET may not be a useful tool in the study of the effect of antipsychotics on dopamine synthesis in human subjects...
  57. ncbi Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia
    Ofer Agid
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1209-15. 2007
    ....
  58. ncbi Radiosynthesis, ex vivo and in vivo evaluation of [11C]preclamol as a partial dopamine D2 agonist radioligand for positron emission tomography
    Neil Vasdev
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, M5T 1R8
    Synapse 60:314-8. 2006
    ..6). The binding potential value was only 0.34 over a 1 hour time course, suggesting that [11C]preclamol is not suitable for cerebral PET studies...
  59. ncbi Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Cereb Blood Flow Metab 26:330-44. 2006
    ..These results indicate the suitability of using [(11)C]-harmine for quantitative evaluation of MAO-A densities using PET and should enable further studies of potential MAO-A dysregulation in several psychiatric and neurologic illnesses...