Aristotle N Voineskos

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. pmc Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia
    Aristotle N Voineskos
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Cereb Cortex 23:2044-57. 2013
  2. doi The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease
    Aristotle N Voineskos
    Department of Psychiatry, Geriatric Mental Health Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 68:198-206. 2011
  3. pmc Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    PLoS ONE 6:e20982. 2011
  4. pmc The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 36:1871-8. 2011
  5. pmc Diffusion tensor tractography findings in schizophrenia across the adult lifespan
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada
    Brain 133:1494-504. 2010
  6. doi The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response
    Tristram A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 132:121-4. 2011
  7. doi Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia
    Clement C Zai
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur Neuropsychopharmacol 19:317-28. 2009
  8. pmc Alterations of superficial white matter in schizophrenia and relationship to cognitive performance
    Arash Nazeri
    Kimel Family Translational Imaging Genetics Laboratory, Toronto, ON, Canada
    Neuropsychopharmacology 38:1954-62. 2013
  9. doi Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur Neuropsychopharmacol 20:688-94. 2010
  10. doi Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 34:50-6. 2010

Collaborators

Detail Information

Publications35

  1. pmc Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia
    Aristotle N Voineskos
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Cereb Cortex 23:2044-57. 2013
    ....
  2. doi The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease
    Aristotle N Voineskos
    Department of Psychiatry, Geriatric Mental Health Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 68:198-206. 2011
    ..Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder...
  3. pmc Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    PLoS ONE 6:e20982. 2011
    ..However, the manner in which NRXN1 gene variation may be related to brain morphology to confer risk for ASD or schizophrenia is unknown...
  4. pmc The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 36:1871-8. 2011
    ..Our findings link genetic, imaging, and cognitive susceptibility relevant to both schizophrenia and bipolar disorder...
  5. pmc Diffusion tensor tractography findings in schizophrenia across the adult lifespan
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada
    Brain 133:1494-504. 2010
    ..The absence of accelerated age-related decline, or differences between older community-dwelling patients and controls, suggests that these patients may possess resilience to white matter disruption...
  6. doi The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response
    Tristram A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 132:121-4. 2011
    ..079). In the post hoc analysis, a significant association between BPRS negative symptoms score and genotype was observed (p=0.033). These results suggest that the rs1045881 NRXN1 polymorphism may influence clozapine response...
  7. doi Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia
    Clement C Zai
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur Neuropsychopharmacol 19:317-28. 2009
    ..007). We also found evidence of interaction between BDNF and DRD3 polymorphisms. Further studies are needed to confirm these findings...
  8. pmc Alterations of superficial white matter in schizophrenia and relationship to cognitive performance
    Arash Nazeri
    Kimel Family Translational Imaging Genetics Laboratory, Toronto, ON, Canada
    Neuropsychopharmacology 38:1954-62. 2013
    ..SWM may be an important neurobiological substrate of cognitive performance and a novel cortical treatment target for cognitive deficits in schizophrenia patients...
  9. doi Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur Neuropsychopharmacol 20:688-94. 2010
    ..These findings should be read with caution particularly before independent replication...
  10. doi Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 34:50-6. 2010
    ..2000) reported an association between TD and the Manganese superoxide dismutase SOD2 (MnSOD) gene Ala9Val (rs4880) polymorphism in a Japanese sample, but most research groups failed to replicate their positive findings...
  11. doi Can repetitive magnetic stimulation improve cognition in schizophrenia? Pilot data from a randomized controlled trial
    Mera S Barr
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 73:510-7. 2013
    ..The objectives were to evaluate the effects of rTMS on working memory performance in schizophrenia patients and evaluate whether rTMS normalizes performance to healthy subject levels...
  12. pmc Cognitive performance of individuals with schizophrenia across seven decades: a study using the MATRICS consensus cognitive battery
    Tarek K Rajji
    Centre for Addiction and Mental Health, Toronto, Canada
    Am J Geriatr Psychiatry 21:108-18. 2013
    ..The objectives of this study were to determine the effect of aging, schizophrenia, and their interaction on cognitive function...
  13. ncbi Prolactin as a biomarker for treatment response and tardive dyskinesia in schizophrenia subjects: old thoughts revisited from a genetic perspective
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 26:21-7. 2011
    ..Our results suggest that more studies in this context are required to shed light in the molecular mechanisms underlying antipsychotic response and tardive dyskinesia occurrence...
  14. doi The catechol-O-methyl-transferase gene in tardive dyskinesia
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    World J Biol Psychiatry 11:803-12. 2010
    ..Changes in dopamine neurotransmission have been implicated in the etiology of TD, and catechol-O-methyl-transferase (COMT) is an enzyme that metabolizes dopamine...
  15. doi Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia
    Gabriela Novak
    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychiatr Genet 20:39-43. 2010
    ..Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD...
  16. ncbi Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    J Psychiatr Res 47:1760-5. 2013
    ..001), supporting the dopamine hypothesis of TD. Pending further replication, VMAT2 may be considered a therapeutic target for the treatment and/or prevention of TD...
  17. pmc Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Aging 33:21-34. 2012
    ..e., splenium) of the corpus callosum with memory and executive function. Our findings suggest that decline in the microstructural integrity of white matter fibers can account for cognitive decline in normal aging...
  18. doi Cholinergic pathways and cognition in patients with schizophrenia: a pilot study
    Tarek K Rajji
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 139:46-52. 2012
    ..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia...
  19. doi Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis
    Geoffrey N Smith
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Schizophr Res 134:253-9. 2012
    ..Secondary analyses explored age-related associations and the relationship between Val66Met and memory...
  20. doi Neuroimaging evidence for the deficit subtype of schizophrenia
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada
    JAMA Psychiatry 70:472-80. 2013
    ..Dividing schizophrenia into "deficit" and "nondeficit" subtypes may reduce heterogeneity and facilitate identification of neurobiological markers of disease...
  21. doi Neuregulin 1 and age of onset in the major psychoses
    Daphne Voineskos
    Centre for Addiction and Mental Health, 250 College Street, R 30, Toronto, ON, M5T 1R8, Canada
    J Neural Transm 116:479-86. 2009
    ..Ours was the first study to investigate the NRG1 core haplotype with age of onset of major psychoses, and despite our preliminary negative findings, this area deserves further investigation...
  22. pmc Quantitative examination of a novel clustering method using magnetic resonance diffusion tensor tractography
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Canada
    Neuroimage 45:370-6. 2009
    ..The clustering method avoids biases of ROI drawing and placement, and, not limited by a priori predictions, may be a more robust and efficient way to identify and measure white matter tracts of interest...
  23. ncbi Disrupted prefrontal interhemispheric structural coupling in schizophrenia related to working memory performance
    Anne L Wheeler
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Schizophr Bull 40:914-24. 2014
    ..In contrast, little is known regarding alterations of structural coupling between regions in schizophrenia and how these alterations may be related to cognitive impairments in this disorder...
  24. ncbi Derivation of high-resolution MRI atlases of the human cerebellum at 3T and segmentation using multiple automatically generated templates
    Min Tae M Park
    Kimel Family Translational Imaging Genetics Research Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada Electronic address
    Neuroimage 95:217-31. 2014
    ..camh.ca/cerebellum) and can be customized to the unique neuroanatomy of different subjects using the proposed segmentation pipeline (https://github.com/pipitone/MAGeTbrain). ..
  25. pmc DISC1 and Striatal Volume: A Potential Risk Phenotype For mental Illness
    M Mallar Chakravarty
    Kimel Family Translational Imaging Genetics Research Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health Toronto, ON, Canada
    Front Psychiatry 3:57. 2012
    ..Taken together with animal data that this gene influences D2 receptor levels in striatum, a key risk pathway for mental illnesses such as schizophrenia and bipolar disorder may be conferred via DISC1's effects on the striatum...
  26. pmc Myelin-associated glycoprotein gene and brain morphometry in schizophrenia
    Daniel Felsky
    Neuroscience Research Department, Centre for Addiction and Mental Health, University of Toronto Toronto, ON, Canada
    Front Psychiatry 3:40. 2012
    ....
  27. ncbi Brain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids
    Bart D Peters
    Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York 11004, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada, Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York 11030, and Department of Communication Sciences and Disorders, School of Applied Sciences, University of Mississippi, University, Mississippi 38766
    J Neurosci 34:6367-76. 2014
    ..05). These findings suggest that LC-PUFAs are involved in human brain WM development from childhood into adulthood. This haplotype and LC-PUFAs may play a role in myelin-related disorders of neurodevelopmental origin...
  28. doi A novel in vivo atlas of human hippocampal subfields using high-resolution 3 T magnetic resonance imaging
    Julie L Winterburn
    Kimel Family Translational Imaging Genetics Research Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Neuroimage 74:254-65. 2013
    ..php/Hippocampus) and can be coupled with novel computational neuroanatomy techniques that will allow for them to be customized to the unique neuroanatomy of different subjects, and ultimately be utilized in different analysis pipelines...
  29. pmc Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: a diffusion tensor imaging study
    Stephanie H Ameis
    Department of Psychiatry, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e28044. 2011
    ..Here, we used diffusion tensor imaging (DTI) and tract based spatial statistics (TBSS) to evaluate white matter microstructure in ASD...
  30. doi Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia
    Clement C Zai
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 106:248-52. 2008
    ..AKT1 polymorphisms and haplotypes were not significantly associated with TD. However, we detected a significant interaction between rs6275 of DRD2 and rs3730358 of AKT1 (p<1 x 10(-5))...
  31. doi A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Psychiatr Genet 18:143-6. 2008
    ..003). No CNP-MAG gene-gene interaction conferred increased risk for schizophrenia. Our finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population...
  32. doi Treating working memory deficits in schizophrenia: a review of the neurobiology
    Tristram A Lett
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada Institute of Medical Science, Toronto, Ontario, Canada
    Biol Psychiatry 75:361-70. 2014
    ..Despite the drawbacks of current approaches, the advances in neurobiological and translational treatment strategies suggest that clinical application of these methods will occur in the near future. ..
  33. doi The role of the corpus callosum in transcranial magnetic stimulation induced interhemispheric signal propagation
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Biol Psychiatry 68:825-31. 2010
    ..The corpus callosum, the main interhemispheric connection in the brain, may serve to preserve functional asymmetry between homologous cortical regions...
  34. ncbi Changes in brain functional connectivity after chronic haloperidol in rats: a network analysis
    Anne L Wheeler
    Research Imaging Centre, Centre for Addiction and Mental Health, Canada
    Int J Neuropsychopharmacol 17:1129-38. 2014
    ....
  35. doi Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009
    ..The relationship between MAO-A levels and selective serotonin reuptake inhibitor (SSRI) treatment, recovery, and recurrence in MDD is unknown...