Junchao Tong

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi Decreased striatal dopamine D1 receptor-stimulated adenylyl cyclase activity in human methamphetamine users
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 160:896-903. 2003
  2. ncbi Identification of a noradrenaline-rich subdivision of the human nucleus accumbens
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Neurochem 96:349-54. 2006
  3. pmc Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Cereb Blood Flow Metab 33:863-71. 2013
  4. ncbi Dopamine D1-stimulated adenylyl cyclase activity in cerebral cortex of autopsied human brain
    J Tong
    Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health Clarke Division, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Neurochem Int 39:117-25. 2001
  5. pmc Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:2065-75. 2011
  6. ncbi Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, Toronto, Canada
    Ann Neurol 55:125-9. 2004
  7. pmc Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain
    Junchao Tong
    Addiction Imaging Research Group, Vivian Rakoff PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neurobiol Dis 41:458-68. 2011
  8. doi Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 62:873-6. 2008
  9. ncbi Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: a possible neuroprotective role for noradrenaline
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Arch Neurol 63:1724-8. 2006
  10. ncbi Marked dissociation between high noradrenaline versus low noradrenaline transporter levels in human nucleus accumbens
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Neurochem 102:1691-702. 2007

Detail Information

Publications27

  1. ncbi Decreased striatal dopamine D1 receptor-stimulated adenylyl cyclase activity in human methamphetamine users
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 160:896-903. 2003
    ..To establish whether dopamine D(1) receptor function might be altered in human methamphetamine users, the authors measured dopamine-stimulated adenylyl cyclase activity in the brain of chronic human users of the drug...
  2. ncbi Identification of a noradrenaline-rich subdivision of the human nucleus accumbens
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Neurochem 96:349-54. 2006
    ..The presence of very high, localized noradrenaline concentrations in the caudomedial nucleus accumbens implies a special biological role for this neurotransmitter in human brain motivational processes...
  3. pmc Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Cereb Blood Flow Metab 33:863-71. 2013
    ..However, compared with in vitro data, the latter PET measures underestimated regional contrast by ∼2-fold. Further studies are needed to address cause of the in vivo vs. in vitro nonproportionality...
  4. ncbi Dopamine D1-stimulated adenylyl cyclase activity in cerebral cortex of autopsied human brain
    J Tong
    Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health Clarke Division, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Neurochem Int 39:117-25. 2001
    ..We conclude that dopamine stimulated AC can be measured in cerebral cortex of human brain allowing for the possibility that this process can be examined in human brain disorders in which dopaminergic abnormalities are suspected...
  5. pmc Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:2065-75. 2011
    ....
  6. ncbi Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, Toronto, Canada
    Ann Neurol 55:125-9. 2004
    ..The supersensitive dopamine D(1) receptors in both striatum and cerebral cortex in PD might compensate for dopamine deficiency, but could also contribute to long-term complications of levodopa therapy...
  7. pmc Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain
    Junchao Tong
    Addiction Imaging Research Group, Vivian Rakoff PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neurobiol Dis 41:458-68. 2011
    ..Further investigation will be required to establish whether this pattern, which was inversely correlated with the pattern of dopamine loss in PD, is involved to any extent in the pathophysiology of this degenerative disorder...
  8. doi Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 62:873-6. 2008
    ..We suggest that in vivo (+)-[11C]DTBZ binding in imaging studies is subject to competition by vesicular dopamine and, in this respect, is not a "stable" dopamine biomarker as is generally assumed...
  9. ncbi Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: a possible neuroprotective role for noradrenaline
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Arch Neurol 63:1724-8. 2006
    ..Experimental findings using animal models of Parkinson disease (PD) suggest that noradrenaline might protect dopamine neurons from damage...
  10. ncbi Marked dissociation between high noradrenaline versus low noradrenaline transporter levels in human nucleus accumbens
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Neurochem 102:1691-702. 2007
    ..This suggests that noradrenaline signalling is much less spatially and temporally restricted in the caudomedial accumbens than in other noradrenaline-rich brain areas...
  11. doi Brain serotonin transporter in human methamphetamine users
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 202:649-61. 2009
    ....
  12. doi Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Synapse 64:417-20. 2010
    ..Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required...
  13. doi Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
    ....
  14. pmc Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase
    Justin W Hicks
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Nucl Med Biol 40:740-6. 2013
    ..We report herein the preparation and preclinical evaluation of [(11)C-carbonyl]PF-04457845, an isotopologue of the potent irreversible FAAH inhibitor...
  15. ncbi Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain 131:120-31. 2008
    ....
  16. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
    ..Pharmacological studies are needed to establish whether normalization of D3 receptor function could reduce vulnerability to relapse in stimulant abuse...
  17. pmc Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography
    Alan A Wilson
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
    J Med Chem 56:201-9. 2013
    ..These promising results are discussed in terms of the requirements of a suitable radiotracer for the in vivo imaging of FAAH using PET...
  18. doi Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
    ..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine...
  19. pmc Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Brain 133:1779-97. 2010
    ....
  20. ncbi Is brain gliosis a characteristic of chronic methamphetamine use in the human?
    Junchao Tong
    Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addiction Imaging Research Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Neurobiol Dis 67:107-18. 2014
    ..However, a logistically more difficult quantitative histopathological study is needed to confirm whether glial changes occur or do not occur in brain of human methamphetamine (and amphetamine) users. ..
  21. pmc Heightened D(3) dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [(11)C]-(+)-PHNO
    Doris E Payer
    1 Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Research Imaging Centre and Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 39:311-8. 2014
    ..D3 upregulation is emerging as a biomarker in preclinical models of addiction, and human PET studies of this receptor system can help guide novel pharmacological strategies for treatment. ..
  22. pmc Mapping human brain fatty acid amide hydrolase activity with PET
    Pablo M Rusjan
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:407-14. 2013
    ..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake...
  23. ncbi Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 32:123-8. 2005
    ..However, there has been no consistency in the selection of a "SERT-free" reference region for the estimation of free and nonspecific binding, as occipital cortex, cerebellum and white matter have all been employed...
  24. ncbi Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetamine
    Paul S Fitzmaurice
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    J Pharmacol Exp Ther 319:703-9. 2006
    ..This provides evidence for involvement of oxygen-based free radicals in the action of MA in both dopamine-rich (caudate) and -poor (cerebral cortex) areas of human brain...
  25. doi Low striatal serotonin transporter protein in a human polydrug MDMA (ecstasy) user: a case study
    S J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    J Psychopharmacol 24:281-4. 2010
    ....
  26. doi [11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Nucl Med Biol 38:247-53. 2011
    ..We here determine the suitability of a novel carbon-11-labeled inhibitor of FAAH via ex vivo biodistribution studies in rat brain in conjunction with pharmacological challenges...
  27. ncbi Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain
    J Tong
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 276:40917-25. 2001
    ..These results suggest that netrin-stimulated phosphorylation of RCM Tyr(568) recruits Shp2 to the cell membrane where it can potentially modify RCM phosphorylation and function...