Research Topics
Genomes and GenesSpecies | Junchao TongSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
|
Detail Information
Publications
Decreased striatal dopamine D1 receptor-stimulated adenylyl cyclase activity in human methamphetamine usersJunchao Tong
Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
Am J Psychiatry 160:896-903. 2003..Decreased dopamine D(1) receptor function might underlie part of the known (drug withdrawal syndrome) or expected (drug tolerance) consequences of methamphetamine exposure in humans...- Identification of a noradrenaline-rich subdivision of the human nucleus accumbensJunchao Tong
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Neurochem 96:349-54. 2006..The presence of very high, localized noradrenaline concentrations in the caudomedial nucleus accumbens implies a special biological role for this neurotransmitter in human brain motivational processes... - Dopamine D1-stimulated adenylyl cyclase activity in cerebral cortex of autopsied human brainJ Tong
Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health Clarke Division, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
Neurochem Int 39:117-25. 2001..We conclude that dopamine stimulated AC can be measured in cerebral cortex of human brain allowing for the possibility that this process can be examined in human brain disorders in which dopaminergic abnormalities are suspected... 
Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentrationJunchao Tong
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Synapse 62:873-6. 2008..We suggest that in vivo (+)-[11C]DTBZ binding in imaging studies is subject to competition by vesicular dopamine and, in this respect, is not a "stable" dopamine biomarker as is generally assumed...
Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studiesJunchao Tong
Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Cereb Blood Flow Metab 31:2065-75. 2011....- Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsyJunchao Tong
Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, Toronto, Canada
Ann Neurol 55:125-9. 2004..The supersensitive dopamine D(1) receptors in both striatum and cerebral cortex in PD might compensate for dopamine deficiency, but could also contribute to long-term complications of levodopa therapy... - Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brainJunchao Tong
Addiction Imaging Research Group, Vivian Rakoff PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Neurobiol Dis 41:458-68. 2011..Further investigation will be required to establish whether this pattern, which was inversely correlated with the pattern of dopamine loss in PD, is involved to any extent in the pathophysiology of this degenerative disorder... - Marked dissociation between high noradrenaline versus low noradrenaline transporter levels in human nucleus accumbensJunchao Tong
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Neurochem 102:1691-702. 2007..This suggests that noradrenaline signalling is much less spatially and temporally restricted in the caudomedial accumbens than in other noradrenaline-rich brain areas... - Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: a possible neuroprotective role for noradrenalineJunchao Tong
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Arch Neurol 63:1724-8. 2006..Experimental findings using animal models of Parkinson disease (PD) suggest that noradrenaline might protect dopamine neurons from damage... - Brain serotonin transporter in human methamphetamine usersStephen J Kish
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
Psychopharmacology (Berl) 202:649-61. 2009.... - Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humansIsabelle Boileau
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Synapse 64:417-20. 2010..Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required... - Preferential loss of serotonin markers in caudate versus putamen in Parkinson's diseaseStephen J Kish
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
Brain 131:120-31. 2008.... - Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's diseaseIsabelle Boileau
Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
Brain 132:1366-75. 2009.... - Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography studyIsabelle Boileau
Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
J Neurosci 32:1353-9. 2012..Pharmacological studies are needed to establish whether normalization of D3 receptor function could reduce vulnerability to relapse in stimulant abuse... - Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomographyAlan A Wilson
Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
J Med Chem 56:201-9. 2013..These promising results are discussed in terms of the requirements of a suitable radiotracer for the in vivo imaging of FAAH using PET... - Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?Isabelle Boileau
Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
J Neurosci 28:9850-6. 2008..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine... - Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging studyStephen J Kish
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
Brain 133:1779-97. 2010.... - Mapping human brain fatty acid amide hydrolase activity with PETPablo M Rusjan
Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Cereb Blood Flow Metab 33:407-14. 2013..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake... - Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetaminePaul S Fitzmaurice
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
J Pharmacol Exp Ther 319:703-9. 2006..This provides evidence for involvement of oxygen-based free radicals in the action of MA in both dopamine-rich (caudate) and -poor (cerebral cortex) areas of human brain... - Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?Stephen J Kish
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8
Nucl Med Biol 32:123-8. 2005..However, there has been no consistency in the selection of a "SERT-free" reference region for the estimation of free and nonspecific binding, as occipital cortex, cerebellum and white matter have all been employed... - Low striatal serotonin transporter protein in a human polydrug MDMA (ecstasy) user: a case studyS J Kish
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
J Psychopharmacol 24:281-4. 2010.... - [11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomographyAlan A Wilson
PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Nucl Med Biol 38:247-53. 2011..We here determine the suitability of a novel carbon-11-labeled inhibitor of FAAH via ex vivo biodistribution studies in rat brain in conjunction with pharmacological challenges... - Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomainJ Tong
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
J Biol Chem 276:40917-25. 2001..These results suggest that netrin-stimulated phosphorylation of RCM Tyr(568) recruits Shp2 to the cell membrane where it can potentially modify RCM phosphorylation and function...