Affiliation: Centre for Addiction and Mental Health
- Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PETJ Tauscher
PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Neuropsychopharmacology 24:522-30. 2001..Hence, careful age matching may be recommended for future studies using PET and [11C]WAY-100635 to examine 5-HT1A receptors...
- Choosing the right dose of antipsychotics in schizophrenia: lessons from neuroimaging studiesJ Tauscher
Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
CNS Drugs 15:671-8. 2001..This seems to be particularly important in individuals experiencing a first episode of schizophrenia, as they appear to be especially responsive to pharmacotherapy and quite sensitive to adverse effects...
- A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophreniaN P Verhoeff
PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, ON, M5T 1R8, Toronto, Canada
Psychiatry Res 99:123-35. 2000..Thus, in agreement with the previous ROI studies, voxel-by-voxel analysis confirmed the lack of substantial 5-HT(2A)R BP differences between schizophrenic patients and control subjects...
- Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humansN P L G Verhoeff
Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Mol Psychiatry 7:233, 322-8. 2002..Thus, while DA depletion "uncovers" D(2)receptors, it does not do so for D(1) receptors. The implications of this finding for measuring endogenous DA and its effects on in vivo receptor binding in humans are discussed...