Gwenn S Smith

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. doi request reprint Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 63:1-6. 2009
  2. pmc Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression: a randomized, placebo-controlled study
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Psychiatry Res 171:1-9. 2009
  3. ncbi request reprint Translational research in late-life mood disorders: implications for future intervention and prevention research
    Gwenn S Smith
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 32:1857-75. 2007
  4. pmc Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression
    Andreea Oliviana Diaconescu
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
    Hum Brain Mapp 32:1677-91. 2011
  5. pmc Serotonin modulation of cerebral glucose metabolism in depressed older adults
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA
    Biol Psychiatry 66:259-66. 2009
  6. pmc Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Brain 132:392-401. 2009
  7. ncbi request reprint Effects of serotonin transporter promoter polymorphisms on serotonin function
    Gwenn S Smith
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:2226-34. 2004
  8. ncbi request reprint Serotonin modulation of cerebral glucose metabolism in normal aging
    Sara Goldberg
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neurobiol Aging 25:167-74. 2004
  9. ncbi request reprint Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital and the Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:715-23. 2002
  10. pmc The functional neuroanatomy of geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA
    Int J Geriatr Psychiatry 24:798-808. 2009

Research Grants

  1. Monoamiergic Function in Geriatric Psychiatry
    Gwenn Smith; Fiscal Year: 2007
  2. Serotonin Modulation in Geriatric Depression
    Gwenn Smith; Fiscal Year: 2006

Detail Information

Publications23

  1. doi request reprint Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 63:1-6. 2009
    ....
  2. pmc Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression: a randomized, placebo-controlled study
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Psychiatry Res 171:1-9. 2009
    ....
  3. ncbi request reprint Translational research in late-life mood disorders: implications for future intervention and prevention research
    Gwenn S Smith
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 32:1857-75. 2007
    ..Geriatric depression could serve as a model for translational research integrating basic and clinical neuroscience approaches that would have implications for the study of other neuropsychiatric disorders...
  4. pmc Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression
    Andreea Oliviana Diaconescu
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
    Hum Brain Mapp 32:1677-91. 2011
    ..Thus, alterations in specific brain networks associated with improvement of affective symptoms and cognitive function are observed during citalopram treatment in geriatric depression...
  5. pmc Serotonin modulation of cerebral glucose metabolism in depressed older adults
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA
    Biol Psychiatry 66:259-66. 2009
    ..The hypothesis was tested that smaller decreases in metabolism would be observed in cortical and limbic regions in depressed older adults relative to control subjects...
  6. pmc Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Brain 132:392-401. 2009
    ..The combined cerebral metabolic effects of galantamine and citalopram suggest, consistent with preclinical data, a synergistic interaction of cholinergic and serotonergic systems...
  7. ncbi request reprint Effects of serotonin transporter promoter polymorphisms on serotonin function
    Gwenn S Smith
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:2226-34. 2004
    ....
  8. ncbi request reprint Serotonin modulation of cerebral glucose metabolism in normal aging
    Sara Goldberg
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neurobiol Aging 25:167-74. 2004
    ..These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation...
  9. ncbi request reprint Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital and the Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:715-23. 2002
    ....
  10. pmc The functional neuroanatomy of geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA
    Int J Geriatr Psychiatry 24:798-808. 2009
    ....
  11. ncbi request reprint Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  12. doi request reprint Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography
    Serge Sevy
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
    Psychopharmacology (Berl) 197:549-56. 2008
    ....
  13. doi request reprint A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
    Adrian W Laxton
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 68:521-34. 2010
    ..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits...
  14. ncbi request reprint Neuroendocrine response to intravenous citalopram in healthy control subjects: pharmacokinetic influences
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 178:268-75. 2005
    ..The neuroendocrine response to intravenous citalopram may provide an acute, functional, in vivo measure of the neural serotonin (5-HT) system...
  15. ncbi request reprint Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital, Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 45:105-12. 2002
    ..Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression...
  16. pmc Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's dementia
    Sarah K Tighe
    Johns Hopkins University School of Medicine, Department of Psychiatry, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 24:484-8. 2012
    ..Further imaging studies are necessary to elucidate the role of the AC in the pathophysiology of neuropsychiatric symptoms in AD and MCI...
  17. pmc Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    BMC Med Imaging 9:12. 2009
    ..Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart...
  18. ncbi request reprint Relevance of assessing drug concentration exposure in pharmacogenetic and imaging studies
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychopharmacol 20:33-40. 2006
    ..For the design and interpretation of neuroimaging, pharmacogenetic, and behavioural studies, the assessment of drug concentration exposure is therefore feasible and has potentially important ramifications...
  19. pmc Functional neuroimaging in geriatric depression
    Faith M Gunning
    Department of Psychiatry, Institute of Geriatric Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Psychiatr Clin North Am 34:403-22, viii. 2011
    ..Furthermore, geriatric depression provides a logical context within which to study the role of specific functional abnormalities in both antidepressant response and key behavioral and cognitive abnormalities of mood disorders...
  20. ncbi request reprint Applications of neuroreceptor imaging to psychiatry research
    Gwenn S Smith
    Department of Psychiatry Research, Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychopharmacol Bull 37:26-65. 2003
    ..These data will provide important insights into the neurochemical substrates of treatment response variability in psychiatric disorders that will have important implications for the refinement of pharmacotherapy...
  21. doi request reprint Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: a phase 1 pilot trial
    Nir Lipsman
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Lancet 381:1361-70. 2013
    ..We aimed to assess the safety of DBS to modulate the activity of limbic circuits and to examine how this might affect the clinical features of anorexia nervosa...
  22. doi request reprint Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury
    Vani Rao
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 24:309-15. 2012
    ..These preliminary results highlight the need for additional studies, including studies using a larger sample and appropriate controls...
  23. ncbi request reprint Evidence for a role of the arachidonic acid cascade in affective disorders: a review
    M Elizabeth Sublette
    Psychiatry Department, The Zucker Hillside Hospital North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Bipolar Disord 6:95-105. 2004
    ..Possible links between this and other prevailing hypotheses are considered, and implications for further research and for treatment are discussed...

Research Grants2

  1. Monoamiergic Function in Geriatric Psychiatry
    Gwenn Smith; Fiscal Year: 2007
    ..The Independent Scientist Award will enable the candidate to continue to firmly focus her research and mentorship activities in the area of geriatric neuropsychiatry. ..
  2. Serotonin Modulation in Geriatric Depression
    Gwenn Smith; Fiscal Year: 2006
    ..abstract_text> ..