Research Topics
| Zindel SegalSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
Research Grants
| Collaborators
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Detail Information
Publications
Metacognitive awareness and prevention of relapse in depression: empirical evidenceJohn D Teasdale
Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
J Consult Clin Psychol 70:275-87. 2002..CT and MBCT may reduce relapse by changing relationships to negative thoughts rather than by changing belief in thought content...
The DARE study of relapse prevention in depression: design for a phase 1/2 translational randomised controlled trial involving mindfulness-based cognitive therapy and supported self monitoringFrances Shawyer
School of Psychology and Psychiatry, Monash University, Clayton Victoria 3800, Australia
BMC Psychiatry 12:3. 2012..Secondary aims of the project involve extending the phase 1 agenda to an examination of the effects of co-morbidity and mechanisms of action...- Efficacy of combined, sequential and crossover psychotherapy and pharmacotherapy in improving outcomes in depressionZindel Segal
Department of Psychiatry, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 27:281-90. 2002..These approaches warrant greater attention; they may present another route for enhancing long-term recovery from major depression... - Challenges in preventing relapse in major depression. Report of a National Institute of Mental Health Workshop on state of the science of relapse prevention in major depressionZindel V Segal
Centre for Addiction and Mental Health, Cognitive Behaviour Therapy Unit, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8
J Affect Disord 77:97-108. 2003.... - Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depressionZindel V Segal
Centre for Addiction and Mental Health, Toronto, ON, Canada
Arch Gen Psychiatry 67:1256-64. 2010..Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse... - Cognitive reactivity to sad mood provocation and the prediction of depressive relapseZindel V Segal
Department of Psychiatry, University of Toronto, Toronto, Ontario
Arch Gen Psychiatry 63:749-55. 2006..Episode remission in unipolar major depression, while distinguished by minimal symptom burden, can also be a period of marked sensitivity to emotional stress as well as an increased risk of relapse... - Changes in autobiographical memory specificity following cognitive behavior therapy and pharmacotherapy for major depressionCarolina McBride
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Psychopathology 40:147-52. 2007..Overgeneral memory is considered as a stable cognitive trait that is intrinsically linked with depression and independent of mood state. Previous studies show that autobiographical memory is modifiable... - Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trialSidney H Kennedy
University of Toronto, The University Health Network, Toronto, Ontario, Canada
J Clin Psychiatry 64:439-44. 2003..Despite increasing evidence that full symptomatic remission is the optimal goal of antidepressant therapy, there have been few comparisons between disparate treatment approaches to achieve this goal... - Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapyKimberly Goldapple
Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Arch Gen Psychiatry 61:34-41. 2004..Unique directional changes in frontal cortex, cingulate, and hippocampus with CBT relative to paroxetine may reflect modality-specific effects with implications for understanding mechanisms underlying different treatment strategies... 
A novel examination of atypical major depressive disorder based on attachment theoryRobert D Levitan
Department of Psychiatry, University of Toronto, Mood and Anxiety Division, Centre for Addiction and Mental Health, c o CAMH, Toronto, Ontario, Canada
J Clin Psychiatry 70:879-87. 2009..As gender has been an important consideration in prior work on atypical depression, this same hypothesis was further tested in female subjects only...- The Toronto Mindfulness Scale: development and validationMark A Lau
Centre for Addiction and Mental Health and the University of Toronto
J Clin Psychol 62:1445-67. 2006..Thus, the TMS is a promising measure of the mindfulness state with good psychometric properties and predictive of treatment outcome... - Teasdale's differential activation hypothesis: implications for mechanisms of depressive relapse and suicidal behaviourMark A Lau
Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Ontario, Canada M5T 1R8
Behav Res Ther 42:1001-17. 2004..Furthermore, we extend the application of this model to the problem of suicidal relapse/recurrence including a review of preliminary support for this approach... - Cognitive therapy for schizophrenia: a preliminary randomized controlled trialNeil A Rector
Mood and Anxiety Program, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8
Schizophr Res 63:1-11. 2003.... - Personality and differential treatment response in major depression: a randomized controlled trial comparing cognitive-behavioural therapy and pharmacotherapyR Michael Bagby
Centre for Addiction and Mental Health, Toronto, Ontario
Can J Psychiatry 53:361-70. 2008..The objective of this investigation was to determine if patient personality characteristics are predictive of response to either cognitive-behavioural therapy (CBT) or pharmacotherapy (PHT)... - Minding one's emotions: mindfulness training alters the neural expression of sadnessNorman A S Farb
Department of Psychology, University of Toronto, Toronto, Ontario, Canada
Emotion 10:25-33. 2010..Restoring balance between affective and sensory neural networks-supporting conceptual and body based representations of emotion-could be one path through which mindfulness reduces vulnerability to dysphoric reactivity... - Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. II. Psychotherapy alone or in combination with antidepressant medicationSagar V Parikh
University of Toronto, Canada
J Affect Disord 117:S15-25. 2009..This article, one of five in the series, reviews new studies of psychotherapy in the acute and maintenance phase of MDD, including computer-based and telephone-delivered psychotherapy... - Inhibitory deficits for negative information in persons with major depressive disorderMark A Lau
Center for Addiction and Mental Health, Toronto, Ontario, Canada
Psychol Med 37:1249-59. 2007..The authors posit the theory that inhibitory dysfunction may influence the degree to which activated self-schemas result in the production of depressive cognition... - Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trialSidney H Kennedy
University Health Network, Institute of Medical Science, University of Toronto, Department of Psychiatry, and Toronto General Hospital, 200 Elizabeth St, Eaton North Wing 8 222, Toronto, Ontario M5G 2C4, Canada
Am J Psychiatry 164:778-88. 2007..In this study, the authors report changes in fluorine-18-fluorodeoxyglucose PET in responders to CBT or venlafaxine during a randomized controlled trial... - Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depressionMichael C Gemar
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Depress Anxiety 24:597-601. 2007..Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability... - Initial psychometric properties of the experiences questionnaire: validation of a self-report measure of decenteringDavid M Fresco
Department of Psychology, 226 Kent Hall Annex, Kent State University, Kent, OH 44242, USA
Behav Ther 38:234-46. 2007..Findings from this series of studies offer initial support for the EQ as a measure of decentering... - Relationship of posttreatment decentering and cognitive reactivity to relapse in major depressionDavid M Fresco
Department of Psychology, Kent State University, Kent, OH 44242, USA
J Consult Clin Psychol 75:447-55. 2007..In addition, high post acute treatment levels of decentering and low cognitive reactivity were associated with the lowest rates of relapse in the 18-month follow-up period... - Extreme response style in recurrent and chronically depressed patients: change with antidepressant administration and stability during continuation treatmentTimothy J Peterson
Rhode Island Hospital Department of Psychiatry, Mood Disorders Program, Providence, RI 02903, USA
J Consult Clin Psychol 75:145-53. 2007..These results are consistent with recent findings suggesting that metacognitive factors may be as important as changes in thought content when treating depression... - A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorderColleen E Carney
Duke Insomnia and Sleep Research Program, Duke University Medical Center, Durham, NC 27710, USA
J Clin Psychiatry 68:254-60. 2007..This study was the first to date to examine residual insomnia after cognitive-behavioral therapy (CBT) for depression and to compare CBT with pharmacotherapy for depression on residual insomnia rates... - Beliefs about sleep in disorders characterized by sleep and mood disturbanceColleen E Carney
Duke Insomnia and Sleep Research Program, Duke University Medical Center, Durham, NC 27710, USA
J Psychosom Res 62:179-88. 2007.... - Cognitive reactivity and vulnerability: empirical evaluation of construct activation and cognitive diatheses in unipolar depressionChristine D Scher
Department of Psychology, California State University, San Bernardino, 5500 University Parkway, San Bernardino, CA 92407, USA
Clin Psychol Rev 25:487-510. 2005..Research that examines direct links between cognitive vulnerability and depression onset, relapse, and recurrence and the attachment origins of cognitive vulnerability is also accruing, although at a slower pace...
Research Grants
- Prevention of Relapse in Recurrent Depression with MBCTZindel Segal; Fiscal Year: 2007....