Zindel Segal

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Metacognitive awareness and prevention of relapse in depression: empirical evidence
    John D Teasdale
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    J Consult Clin Psychol 70:275-87. 2002
  2. pmc The DARE study of relapse prevention in depression: design for a phase 1/2 translational randomised controlled trial involving mindfulness-based cognitive therapy and supported self monitoring
    Frances Shawyer
    School of Psychology and Psychiatry, Monash University, Clayton Victoria 3800, Australia
    BMC Psychiatry 12:3. 2012
  3. pmc Efficacy of combined, sequential and crossover psychotherapy and pharmacotherapy in improving outcomes in depression
    Zindel Segal
    Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:281-90. 2002
  4. ncbi request reprint Challenges in preventing relapse in major depression. Report of a National Institute of Mental Health Workshop on state of the science of relapse prevention in major depression
    Zindel V Segal
    Centre for Addiction and Mental Health, Cognitive Behaviour Therapy Unit, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8
    J Affect Disord 77:97-108. 2003
  5. pmc Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression
    Zindel V Segal
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Arch Gen Psychiatry 67:1256-64. 2010
  6. ncbi request reprint Cognitive reactivity to sad mood provocation and the prediction of depressive relapse
    Zindel V Segal
    Department of Psychiatry, University of Toronto, Toronto, Ontario
    Arch Gen Psychiatry 63:749-55. 2006
  7. ncbi request reprint Changes in autobiographical memory specificity following cognitive behavior therapy and pharmacotherapy for major depression
    Carolina McBride
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychopathology 40:147-52. 2007
  8. ncbi request reprint Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trial
    Sidney H Kennedy
    University of Toronto, The University Health Network, Toronto, Ontario, Canada
    J Clin Psychiatry 64:439-44. 2003
  9. ncbi request reprint Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy
    Kimberly Goldapple
    Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Arch Gen Psychiatry 61:34-41. 2004
  10. doi request reprint A novel examination of atypical major depressive disorder based on attachment theory
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Mood and Anxiety Division, Centre for Addiction and Mental Health, c o CAMH, Toronto, Ontario, Canada
    J Clin Psychiatry 70:879-87. 2009

Research Grants

Detail Information

Publications25

  1. ncbi request reprint Metacognitive awareness and prevention of relapse in depression: empirical evidence
    John D Teasdale
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    J Consult Clin Psychol 70:275-87. 2002
    ..CT and MBCT may reduce relapse by changing relationships to negative thoughts rather than by changing belief in thought content...
  2. pmc The DARE study of relapse prevention in depression: design for a phase 1/2 translational randomised controlled trial involving mindfulness-based cognitive therapy and supported self monitoring
    Frances Shawyer
    School of Psychology and Psychiatry, Monash University, Clayton Victoria 3800, Australia
    BMC Psychiatry 12:3. 2012
    ..Secondary aims of the project involve extending the phase 1 agenda to an examination of the effects of co-morbidity and mechanisms of action...
  3. pmc Efficacy of combined, sequential and crossover psychotherapy and pharmacotherapy in improving outcomes in depression
    Zindel Segal
    Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:281-90. 2002
    ..These approaches warrant greater attention; they may present another route for enhancing long-term recovery from major depression...
  4. ncbi request reprint Challenges in preventing relapse in major depression. Report of a National Institute of Mental Health Workshop on state of the science of relapse prevention in major depression
    Zindel V Segal
    Centre for Addiction and Mental Health, Cognitive Behaviour Therapy Unit, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8
    J Affect Disord 77:97-108. 2003
    ....
  5. pmc Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression
    Zindel V Segal
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Arch Gen Psychiatry 67:1256-64. 2010
    ..Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse...
  6. ncbi request reprint Cognitive reactivity to sad mood provocation and the prediction of depressive relapse
    Zindel V Segal
    Department of Psychiatry, University of Toronto, Toronto, Ontario
    Arch Gen Psychiatry 63:749-55. 2006
    ..Episode remission in unipolar major depression, while distinguished by minimal symptom burden, can also be a period of marked sensitivity to emotional stress as well as an increased risk of relapse...
  7. ncbi request reprint Changes in autobiographical memory specificity following cognitive behavior therapy and pharmacotherapy for major depression
    Carolina McBride
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychopathology 40:147-52. 2007
    ..Overgeneral memory is considered as a stable cognitive trait that is intrinsically linked with depression and independent of mood state. Previous studies show that autobiographical memory is modifiable...
  8. ncbi request reprint Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trial
    Sidney H Kennedy
    University of Toronto, The University Health Network, Toronto, Ontario, Canada
    J Clin Psychiatry 64:439-44. 2003
    ..Despite increasing evidence that full symptomatic remission is the optimal goal of antidepressant therapy, there have been few comparisons between disparate treatment approaches to achieve this goal...
  9. ncbi request reprint Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy
    Kimberly Goldapple
    Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Arch Gen Psychiatry 61:34-41. 2004
    ..Functional imaging studies of major depressive disorder demonstrate response-specific regional changes following various modes of antidepressant treatment...
  10. doi request reprint A novel examination of atypical major depressive disorder based on attachment theory
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Mood and Anxiety Division, Centre for Addiction and Mental Health, c o CAMH, Toronto, Ontario, Canada
    J Clin Psychiatry 70:879-87. 2009
    ..As gender has been an important consideration in prior work on atypical depression, this same hypothesis was further tested in female subjects only...
  11. ncbi request reprint The Toronto Mindfulness Scale: development and validation
    Mark A Lau
    Centre for Addiction and Mental Health and the University of Toronto
    J Clin Psychol 62:1445-67. 2006
    ..Thus, the TMS is a promising measure of the mindfulness state with good psychometric properties and predictive of treatment outcome...
  12. ncbi request reprint Teasdale's differential activation hypothesis: implications for mechanisms of depressive relapse and suicidal behaviour
    Mark A Lau
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Ontario, Canada M5T 1R8
    Behav Res Ther 42:1001-17. 2004
    ..Furthermore, we extend the application of this model to the problem of suicidal relapse/recurrence including a review of preliminary support for this approach...
  13. ncbi request reprint Cognitive therapy for schizophrenia: a preliminary randomized controlled trial
    Neil A Rector
    Mood and Anxiety Program, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8
    Schizophr Res 63:1-11. 2003
    ....
  14. pmc Personality and differential treatment response in major depression: a randomized controlled trial comparing cognitive-behavioural therapy and pharmacotherapy
    R Michael Bagby
    Centre for Addiction and Mental Health, Toronto, Ontario
    Can J Psychiatry 53:361-70. 2008
    ..The objective of this investigation was to determine if patient personality characteristics are predictive of response to either cognitive-behavioural therapy (CBT) or pharmacotherapy (PHT)...
  15. doi request reprint Minding one's emotions: mindfulness training alters the neural expression of sadness
    Norman A S Farb
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Emotion 10:25-33. 2010
    ..Restoring balance between affective and sensory neural networks-supporting conceptual and body based representations of emotion-could be one path through which mindfulness reduces vulnerability to dysphoric reactivity...
  16. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. II. Psychotherapy alone or in combination with antidepressant medication
    Sagar V Parikh
    University of Toronto, Canada
    J Affect Disord 117:S15-25. 2009
    ..This article, one of five in the series, reviews new studies of psychotherapy in the acute and maintenance phase of MDD, including computer-based and telephone-delivered psychotherapy...
  17. ncbi request reprint Inhibitory deficits for negative information in persons with major depressive disorder
    Mark A Lau
    Center for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychol Med 37:1249-59. 2007
    ..The authors posit the theory that inhibitory dysfunction may influence the degree to which activated self-schemas result in the production of depressive cognition...
  18. ncbi request reprint Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trial
    Sidney H Kennedy
    University Health Network, Institute of Medical Science, University of Toronto, Department of Psychiatry, and Toronto General Hospital, 200 Elizabeth St, Eaton North Wing 8 222, Toronto, Ontario M5G 2C4, Canada
    Am J Psychiatry 164:778-88. 2007
    ..In this study, the authors report changes in fluorine-18-fluorodeoxyglucose PET in responders to CBT or venlafaxine during a randomized controlled trial...
  19. ncbi request reprint Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depression
    Michael C Gemar
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Depress Anxiety 24:597-601. 2007
    ..Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability...
  20. ncbi request reprint Initial psychometric properties of the experiences questionnaire: validation of a self-report measure of decentering
    David M Fresco
    Department of Psychology, 226 Kent Hall Annex, Kent State University, Kent, OH 44242, USA
    Behav Ther 38:234-46. 2007
    ..Findings from this series of studies offer initial support for the EQ as a measure of decentering...
  21. ncbi request reprint Relationship of posttreatment decentering and cognitive reactivity to relapse in major depression
    David M Fresco
    Department of Psychology, Kent State University, Kent, OH 44242, USA
    J Consult Clin Psychol 75:447-55. 2007
    ..In addition, high post acute treatment levels of decentering and low cognitive reactivity were associated with the lowest rates of relapse in the 18-month follow-up period...
  22. ncbi request reprint Extreme response style in recurrent and chronically depressed patients: change with antidepressant administration and stability during continuation treatment
    Timothy J Peterson
    Rhode Island Hospital Department of Psychiatry, Mood Disorders Program, Providence, RI 02903, USA
    J Consult Clin Psychol 75:145-53. 2007
    ..These results are consistent with recent findings suggesting that metacognitive factors may be as important as changes in thought content when treating depression...
  23. ncbi request reprint A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder
    Colleen E Carney
    Duke Insomnia and Sleep Research Program, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychiatry 68:254-60. 2007
    ..This study was the first to date to examine residual insomnia after cognitive-behavioral therapy (CBT) for depression and to compare CBT with pharmacotherapy for depression on residual insomnia rates...
  24. ncbi request reprint Beliefs about sleep in disorders characterized by sleep and mood disturbance
    Colleen E Carney
    Duke Insomnia and Sleep Research Program, Duke University Medical Center, Durham, NC 27710, USA
    J Psychosom Res 62:179-88. 2007
    ....
  25. ncbi request reprint Cognitive reactivity and vulnerability: empirical evaluation of construct activation and cognitive diatheses in unipolar depression
    Christine D Scher
    Department of Psychology, California State University, San Bernardino, 5500 University Parkway, San Bernardino, CA 92407, USA
    Clin Psychol Rev 25:487-510. 2005
    ..Research that examines direct links between cognitive vulnerability and depression onset, relapse, and recurrence and the attachment origins of cognitive vulnerability is also accruing, although at a slower pace...

Research Grants7