ART PETRONIS

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Phenotypic differences in genetically identical organisms: the epigenetic perspective
    Albert H C Wong
    The Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
    Hum Mol Genet 14:R11-8. 2005
  2. ncbi request reprint Epigenetics and twins: three variations on the theme
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto Ontario, M5T 1R8, Canada
    Trends Genet 22:347-50. 2006
  3. pmc Epigenetic approaches to psychiatric disorders
    Carolyn Ptak
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Dialogues Clin Neurosci 12:25-35. 2010
  4. pmc Microarray-based DNA methylation profiling: technology and applications
    Axel Schumacher
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8
    Nucleic Acids Res 34:528-42. 2006
  5. pmc Single nucleotide extension technology for quantitative site-specific evaluation of metC/C in GC-rich regions
    Zachary A Kaminsky
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health Toronto, ON, Canada M5T 1R8
    Nucleic Acids Res 33:e95. 2005
  6. pmc 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
    Tarang Khare
    The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Nat Struct Mol Biol 19:1037-43. 2012
  7. ncbi request reprint Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Nature 465:721-7. 2010
  8. ncbi request reprint Schizophrenia: an epigenetic puzzle?
    A Petronis
    Department of Psychiatry, University of Toronto, Centre of Addiction and Mental Health, Ontario, Canada
    Schizophr Bull 25:639-55. 1999
  9. ncbi request reprint The genes for major psychosis: aberrant sequence or regulation?
    A Petronis
    Neurogenetics Section, Centre of Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 23:1-12. 2000
  10. ncbi request reprint Epigenetics and bipolar disorder: new opportunities and challenges
    Arturas Petronis
    Center for Addiction and Mental Health, University of Toronto, Toornto, Canada
    Am J Med Genet C Semin Med Genet 123:65-75. 2003

Research Grants

  1. DNA METHYLOME STUDY IN TYPE 1 DIABETES
    ART PETRONIS; Fiscal Year: 2009
  2. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2009
  3. DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER
    ART PETRONIS; Fiscal Year: 2010
  4. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2005
  5. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2006
  6. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2007
  7. DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER
    ART PETRONIS; Fiscal Year: 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Phenotypic differences in genetically identical organisms: the epigenetic perspective
    Albert H C Wong
    The Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
    Hum Mol Genet 14:R11-8. 2005
    ....
  2. ncbi request reprint Epigenetics and twins: three variations on the theme
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto Ontario, M5T 1R8, Canada
    Trends Genet 22:347-50. 2006
    ..Analyses of epigenetic twin differences and similarities might yet challenge the fundamental principles of complex biology, primarily the dogma that complex phenotypes result from DNA sequence variants interacting with the environment...
  3. pmc Epigenetic approaches to psychiatric disorders
    Carolyn Ptak
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Dialogues Clin Neurosci 12:25-35. 2010
    ....
  4. pmc Microarray-based DNA methylation profiling: technology and applications
    Axel Schumacher
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8
    Nucleic Acids Res 34:528-42. 2006
    ..The principles developed in this work will help to make epigenetic profiling of the entire human genome a routine procedure...
  5. pmc Single nucleotide extension technology for quantitative site-specific evaluation of metC/C in GC-rich regions
    Zachary A Kaminsky
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health Toronto, ON, Canada M5T 1R8
    Nucleic Acids Res 33:e95. 2005
    ..Given the relative simplicity of the method and the possibility to multiplex C/T and G/A interrogations, the SNaPshot approach may become a useful tool for large-scale mapping of metC...
  6. pmc 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
    Tarang Khare
    The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Nat Struct Mol Biol 19:1037-43. 2012
    ..Moreover, in human frontal cortex, constitutive exons contained higher levels of 5-hmC relative to alternatively spliced exons. Our study suggests a new role for 5-hmC in RNA splicing and synaptic function in the brain...
  7. ncbi request reprint Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Nature 465:721-7. 2010
    ..Epigenetics can provide a new framework for the search of aetiological factors in complex traits and diseases...
  8. ncbi request reprint Schizophrenia: an epigenetic puzzle?
    A Petronis
    Department of Psychiatry, University of Toronto, Centre of Addiction and Mental Health, Ontario, Canada
    Schizophr Bull 25:639-55. 1999
    ..In addition, the epigenetic model may lead to experiments investigating the molecular substrates of genetic-environmental interactions...
  9. ncbi request reprint The genes for major psychosis: aberrant sequence or regulation?
    A Petronis
    Neurogenetics Section, Centre of Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 23:1-12. 2000
    ..In addition to this, if epimutations are detected in major psychosis, epigenetic treatment directed at correction of epigenetic status of a specific brain gene may eventually be developed...
  10. ncbi request reprint Epigenetics and bipolar disorder: new opportunities and challenges
    Arturas Petronis
    Center for Addiction and Mental Health, University of Toronto, Toornto, Canada
    Am J Med Genet C Semin Med Genet 123:65-75. 2003
    ..All this serves the goal of demonstrating that epiG factors cannot be ignored anymore in complex phenotypes such as BD, and systematic large-scale epiG studies of BD have to be initiated...
  11. ncbi request reprint Human morbid genetics revisited: relevance of epigenetics
    A Petronis
    Neurogenetics Section Rm28, Centre for Addiction and Mental Health, 250 College Street, Ontario, Toronto, Canada M5T 1R8
    Trends Genet 17:142-6. 2001
    ....
  12. ncbi request reprint Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
    Schizophr Bull 29:169-78. 2003
    ..Epigenetic studies should provide insight into the molecular causes of differential susceptibility to a disease in genetically identical organisms that may generalize to singletons...
  13. doi request reprint DNA methylation profiles in monozygotic and dizygotic twins
    Zachary A Kaminsky
    Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
    Nat Genet 41:240-5. 2009
    ....
  14. pmc Environmental studies of schizophrenia through the prism of epigenetics
    Gabriel Oh
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Schizophr Bull 34:1122-9. 2008
    ..In this article, we argue that molecular epigenetic studies can overcome the complexities of traditional epidemiological studies and may become a productive line of research in understanding the nongenetic mechanisms of schizophrenia...
  15. ncbi request reprint The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Center of Addiction and Mental Health, and University of Toronto, Ontario, Canada
    Biol Psychiatry 55:965-70. 2004
    ....
  16. pmc Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    Jonathan Mill
    Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 82:696-711. 2008
    ..Our data are consistent with the epigenetic theory of major psychosis and suggest that DNA-methylation changes are important to the etiology of schizophrenia and bipolar disorder...
  17. doi request reprint Epigenetics of personality traits: an illustrative study of identical twins discordant for risk-taking behavior
    Zachary Kaminsky
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Twin Res Hum Genet 11:1-11. 2008
    ..We found that use of epigenomic microarray profiling in a relatively small number (15-25) of phenotypically discordant twin pairs has sufficient power to detect 1.2 fold epigenetic changes...
  18. ncbi request reprint Epigenetics and complex disease: from etiology to new therapeutics
    Carolyn Ptak
    Center for Addiction and Mental Health, The Krembil Family Epigenetics Laboratory, Toronto, Ontario, Canada
    Annu Rev Pharmacol Toxicol 48:257-76. 2008
    ..Here we present a review of the epigenetic theory of complex disease and an evaluation of current epigenetic therapies, as well as predictions of the future directions in this expanding field...
  19. pmc Intra- and interindividual epigenetic variation in human germ cells
    James M Flanagan
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Am J Hum Genet 79:67-84. 2006
    ....
  20. ncbi request reprint Epigenetic studies of genomic retroelements in major psychosis
    Pei Xiang Kan
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, University of Toronto, Room 28, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Schizophr Res 67:95-106. 2004
    ..A substantial portion of the cloned Alu's are located close to or within the genes that may be interesting targets for further genetic, transcription, and epigenetic studies...
  21. doi request reprint Methylation SNaPshot: a method for the quantification of site-specific DNA methylation levels
    Zachary Kaminsky
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Toronto, Ontario, Canada
    Methods Mol Biol 507:241-55. 2009
    ..The following protocol outlines the steps necessary to design and perform Ms-SNuPE experiments using the SNaPshot chemistry and associated capillary electrophoresis platforms available through Applied Biosystems...
  22. doi request reprint Profiling DNA methylation from small amounts of genomic DNA starting material: efficient sodium bisulfite conversion and subsequent whole-genome amplification
    Jonathan Mill
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Methods Mol Biol 507:371-81. 2009
    ....
  23. ncbi request reprint Complex disease, gender and epigenetics
    Zachary Kaminsky
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Ann Med 38:530-44. 2006
    ..The new experimental strategies, especially the high throughput microarray-based epigenetic profiling, can be used for testing the epigenetic hypothesis of gender effects in complex diseases...
  24. ncbi request reprint Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources
    Jonathan Mill
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Biotechniques 41:603-7. 2006
    ..The average difference in methylation percentage calculated from the two sets of template using MS-SNuPE was 4%. If our results are replicated on other genomic loci, WGA may become a useful technique in DNA methylation studies...
  25. doi request reprint Application of microarrays for DNA methylation profiling
    Axel Schumacher
    Epigenetics Lab, Department of Medicine II, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Methods Mol Biol 439:109-29. 2008
    ....

Research Grants9

  1. DNA METHYLOME STUDY IN TYPE 1 DIABETES
    ART PETRONIS; Fiscal Year: 2009
    ..This effort may have a major impact on our understanding of autoimmune mechanisms in T1D and lead to new strategies in diagnostics and treatment of the disease. ..
  2. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2009
    ..controls in both within and between all the listed comparisons. If the null hypotheses cannot be rejected, the study will provide a new perspective on the fundamental issues in MDD and other complex diseases. ..
  3. DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER
    ART PETRONIS; Fiscal Year: 2010
    ..Also, this effort may have a dramatic impact on our understanding of the molecular mechanisms of the disturbed brain and lead to new strategies in diagnostics and treatment of major psychiatric illness. ..
  4. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2005
    ..controls in both within and between all the listed comparisons. If the null hypotheses cannot be rejected, the study will provide a new perspective on the fundamental issues in MDD and other complex diseases. ..
  5. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2006
    ..controls in both within and between all the listed comparisons. If the null hypotheses cannot be rejected, the study will provide a new perspective on the fundamental issues in MDD and other complex diseases. ..
  6. Molecular Epigenetic Studies of Major Depression
    ART PETRONIS; Fiscal Year: 2007
    ..controls in both within and between all the listed comparisons. If the null hypotheses cannot be rejected, the study will provide a new perspective on the fundamental issues in MDD and other complex diseases. ..
  7. DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER
    ART PETRONIS; Fiscal Year: 2009
    ..Also, this effort may have a dramatic impact on our understanding of the molecular mechanisms of the disturbed brain and lead to new strategies in diagnostics and treatment of major psychiatric illness. ..