Benoit Mulsant

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. pmc Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD II
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Toronto, Canada
    BMC Psychiatry 13:38. 2013
  2. pmc Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    BMC Med Imaging 9:12. 2009
  3. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
  4. ncbi request reprint Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
  5. ncbi request reprint Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, UPMC Health System, Thomas Detre Hall, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 129:209-15. 2004
  6. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
  7. pmc Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression: a randomized, placebo-controlled study
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Psychiatry Res 171:1-9. 2009
  8. ncbi request reprint Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features
    Carmen Andreescu
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:194-200. 2007
  9. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
  10. pmc Diffusion tensor tractography findings in schizophrenia across the adult lifespan
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada
    Brain 133:1494-504. 2010

Detail Information

Publications91

  1. pmc Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD II
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Toronto, Canada
    BMC Psychiatry 13:38. 2013
    ..On the other hand, premature discontinuation of antipsychotic medication has the potential risk of early relapse of a severe disorder...
  2. pmc Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    BMC Med Imaging 9:12. 2009
    ..Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart...
  3. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  4. ncbi request reprint Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
    ..This study evaluated the time course and potential risk factors for falls in a treatment protocol for late-life depression to identify specific at-risk periods and risk factors for falls in this population...
  5. ncbi request reprint Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, UPMC Health System, Thomas Detre Hall, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 129:209-15. 2004
    ..No significant treatment differences were found. We conclude that attention to the missing-data mechanism should be an integral part in analysis of clinical trial data...
  6. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  7. pmc Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression: a randomized, placebo-controlled study
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Psychiatry Res 171:1-9. 2009
    ....
  8. ncbi request reprint Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features
    Carmen Andreescu
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:194-200. 2007
    ..We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations...
  9. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  10. pmc Diffusion tensor tractography findings in schizophrenia across the adult lifespan
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada
    Brain 133:1494-504. 2010
    ..The absence of accelerated age-related decline, or differences between older community-dwelling patients and controls, suggests that these patients may possess resilience to white matter disruption...
  11. ncbi request reprint Are antipsychotic prescribing patterns different in older and younger adults?: a survey of 1357 psychiatric inpatients in Toronto
    Beth A Sproule
    Centre for Addiction and Mental Health, Toronto, Ontario
    Can J Psychiatry 55:248-54. 2010
    ..To compare antipsychotic prescribing patterns in younger (aged 59 years or younger) and older (aged 60 years or older) patients with psychotic or mood disorders...
  12. ncbi request reprint Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
    ..To explore clinical and treatment-response variability in late-onset vs early-onset non-bipolar, non-psychotic major depression...
  13. doi request reprint The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease
    Aristotle N Voineskos
    Department of Psychiatry, Geriatric Mental Health Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 68:198-206. 2011
    ..Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder...
  14. ncbi request reprint Apathy and executive function in depressed elderly
    Robert S Marin
    The Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 16:112-6. 2003
    ..Correlations may have been reduced by low variance for the variables of interest and by psychometric limitations of the ApHRSD...
  15. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  16. ncbi request reprint Time course of response to antidepressants in late-life major depression: therapeutic implications
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 21:531-54. 2004
    ..Better understanding of factors related to such differences may suggest new intervention strategies to accelerate response...
  17. ncbi request reprint Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  18. ncbi request reprint A delusion assessment scale for psychotic major depression: Reliability, validity, and utility
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University, New York Presbyterian Hospital Westchester Division, West Chester, New York 10605, USA
    Biol Psychiatry 60:1336-42. 2006
    ..The development and assessment of the Delusional Assessment Scale (DAS) are described...
  19. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions...
  20. ncbi request reprint Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1634-41. 2004
    ....
  21. ncbi request reprint Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine
    Benoit H Mulsant
    Western Psychiatric Institute and Clinic, Department of Psychiatry, Division of Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1708-14. 2004
    ..Older individuals with dementia are highly sensitive to the effects of muscarinic receptor blockade...
  22. ncbi request reprint A model of anticholinergic activity of atypical antipsychotic medications
    Marci L Chew
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Schizophr Res 88:63-72. 2006
    ..However, it is difficult with the available data to predict the likelihood of anticholinergic effects occurring with various doses of an atypical antipsychotic...
  23. ncbi request reprint Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..Cognitive impairment in late-life depression (LLD) is prevalent, disabling, and persists despite the remission of depressive symptoms. This article characterizes neuropsychologic functioning during remission in LLD...
  24. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  25. ncbi request reprint Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy
    Mary Amanda Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:892-9. 2007
    ..The authors examined likelihood, speed, and predictors of recovery in older adults receiving augmentation pharmacotherapy after inadequate response to standardized treatment with paroxetine plus interpersonal psychotherapy...
  26. pmc High worry severity is associated with poorer acute and maintenance efficacy of antidepressants in late-life depression
    Carmen Andreescu
    The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 26:266-72. 2009
    ..We explored the impact of the dimensions of worry and panic on acute and maintenance treatment outcomes in LLD...
  27. ncbi request reprint Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Arch Gen Psychiatry 60:198-203. 2003
    ..To our knowledge, there has not yet been any systematic study of the prevalence of SAA and its effect on cognition in a community-based population...
  28. pmc A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  29. ncbi request reprint Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine
    Robert D Nebes
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychiatr Res 37:99-108. 2003
    ..The present results suggest that cognitive dysfunction persists in older depressed patients even after their mood disorder has responded to antidepressant medications...
  30. ncbi request reprint Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    JAMA 291:1081-91. 2004
    ..Depression is the strongest risk factor for late-life suicide and for suicide's precursor, suicidal ideation...
  31. pmc Remission in depressed geriatric primary care patients: a report from the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
    Am J Psychiatry 162:718-24. 2005
    ..In addition, it sought to identify risk factors for nonremission that could guide treatment planning and referral to care managers or specialists...
  32. ncbi request reprint Effects of nortriptyline and paroxetine on postural sway in depressed elderly patients
    David C Mamo
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 10:199-205. 2002
    ..Further studies with other SSRIs are needed...
  33. pmc Developing a community-academic partnership to improve recognition and treatment of depression in underserved African American and white elders
    Deborah Dobransky-Fasiska
    Research Network Develop Core, The Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Geriatr Psychiatry 17:953-64. 2009
    ..The authors describe the process and challenges of developing a community/academic research partnership to address these disparities...
  34. ncbi request reprint Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
    ..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death...
  35. ncbi request reprint Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
    ..Anxiety disorders are common in later life, but little is known about the long-term benefits and risks of pharmacotherapy...
  36. pmc The longitudinal course of cognition in older adults with bipolar disorder
    Ariel G Gildengers
    Intervention Research Center for Late life Mood Disorders and the Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:744-52. 2009
    ....
  37. pmc Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Int Clin Psychopharmacol 25:37-45. 2010
    ..Our findings of intolerance of a second-generation antipsychotics and persistence of psychosis in patients with low-expression alleles needs to be replicated...
  38. pmc Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY 10605, USA
    Am J Psychiatry 166:882-90. 2009
    ..This is the first report of outcomes over a 2-year period...
  39. pmc The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorder
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States University Center for Social and Urban Research, Pittsburgh, PA, United States
    Psychiatry Res 168:67-77. 2009
    ..It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics...
  40. ncbi request reprint Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients
    Bruce G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 159:460-5. 2002
    ....
  41. pmc Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remission
    Meera Sheffrin
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 70:208-13. 2009
    ....
  42. ncbi request reprint The evidence for electroconvulsive therapy (ECT) in the treatment of severe late-life depression. ECT: the preferred treatment for severe depression in late life
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Int Psychogeriatr 19:10-4, 27-35; discussion 24-6. 2007
  43. doi request reprint Weight gain during olanzapine treatment for psychotic depression: effects of dose and age
    Eric Smith
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Int Clin Psychopharmacol 23:130-7. 2008
    ..14-1.05 kg). Cumulative olanzapine dose was also significantly associated with weight gain (P<0.0001). Approximately 60% of completers of the 12-week trial experienced clinically significant weight gain (> or =7% of baseline weight)...
  44. pmc A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    The Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 23:693-8. 2008
    ..To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder...
  45. ncbi request reprint Comorbid anxiety disorder in late life depression: association with memory decline over four years
    Alison K DeLuca
    The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:848-54. 2005
    ..The purpose of this study was to determine whether comorbid GAD or PD was associated with poorer long-term outcomes of late-life MDD, in terms of symptoms, functional disability, and cognitive status...
  46. ncbi request reprint Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age
    Katalin Szanto
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania 15213, United States
    J Affect Disord 98:153-61. 2007
    ..To determine the rate and clinical correlates of emergent, persistent, and resolved suicidal ideation during treatment of major depression in the elderly...
  47. ncbi request reprint Trajectories of treatment response in late-life depression: psychosocial and clinical correlates
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S8-13. 2005
    ..Further study focusing on risk factors associated with slower response may help optimize treatment in elderly patients who do not respond quickly to first-line therapies...
  48. ncbi request reprint Clinical outcome of ECT in patients with major depression and comorbid borderline personality disorder
    Ulrike Feske
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:2073-80. 2004
    ..The authors compared the acute outcome of ECT in depressed patients with borderline personality disorder, with personality disorders other than borderline personality disorder, and with no personality disorder...
  49. ncbi request reprint Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and VA Healthcare System, PA, USA
    Am J Psychiatry 162:146-50. 2005
    ..Anxiety disorders are highly prevalent in elderly persons. However, to date, the efficacy of selective serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety disorders in this age group has not been established...
  50. ncbi request reprint Adverse effects of depression and cognitive impairment on rehabilitation participation and recovery from hip fracture
    Eric J Lenze
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 19:472-8. 2004
    ..Our goal was to determine whether any association of depression and cognitive impairment with rehabilitation outcome is accounted for by more immediate effects of these variables on rehabilitation participation...
  51. ncbi request reprint A randomized comparison of high-charge right unilateral electroconvulsive therapy and bilateral electroconvulsive therapy in older depressed patients who failed to respond to 5 to 8 moderate-charge right unilateral treatments
    James D Tew
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 63:1102-5. 2002
    ....
  52. ncbi request reprint Does education moderate neuropsychological impairment in late-life depression?
    Rishi K Bhalla
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Geriatr Psychiatry 20:413-7. 2005
    ..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression...
  53. ncbi request reprint Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late Life and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate...
  54. ncbi request reprint Identification of suicidal ideation and prevention of suicidal behaviour in the elderly
    Katalin Szanto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 19:11-24. 2002
    ..Prevention and treatment trials are underway to detect the effectiveness of improved treatment of depression by primary care physicians as a means of reducing the prevalence of depressive symptoms, hopelessness and suicidal ideation...
  55. ncbi request reprint Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation
    Charles F Reynolds
    Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:353-8. 2005
    ..Authors tested the hypothesis that one night of total sleep deprivation (TSD) would accelerate antidepressant response to paroxetine, as compared with TSD+placebo (PBO) and paroxetine-alone, in late-life major depression...
  56. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  57. pmc Empirically derived decision trees for the treatment of late-life depression
    Carmen Andreescu
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:855-62. 2008
    ..The aim of this analysis was to develop a clinically useful algorithm that would allow clinicians to predict which patients will likely respond to treatment and thereby guide clinical decision making...
  58. pmc Incomplete response in late-life depression: getting to remission
    Eric J Lenze
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA
    Dialogues Clin Neurosci 10:419-30. 2008
    ..Such studies may advance us toward the goal of personalized treatment in late-life depression...
  59. ncbi request reprint Intent-to-treat analysis for clinical trials: use of data collected after termination of treatment protocol
    Sati Mazumdar
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Psychiatr Res 36:153-64. 2002
    ..Statistical inference is based on bootstrap sampling procedures. We have illustrated this methodology using data from a drug trial comparing nortriptyline and paroxetine in the treatment of major depression in older patients...
  60. ncbi request reprint Achieving long-term optimal outcomes in geriatric depression and anxiety
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Spectr 8:27-34. 2003
    ....
  61. ncbi request reprint Cognitive functioning in late-life bipolar disorder
    Ariel G Gildengers
    Information Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 161:736-8. 2004
    ..This study characterized cognitive functioning in elderly patients with bipolar disorder...
  62. ncbi request reprint Occurrence and course of suicidality during short-term treatment of late-life depression
    Katalin Szanto
    Department of Psychiatry, The Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA, USA
    Arch Gen Psychiatry 60:610-7. 2003
    ....
  63. ncbi request reprint Body pain and treatment response in late-life depression
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:188-94. 2005
    ..They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation...
  64. ncbi request reprint Generalized anxiety disorder in late life: lifetime course and comorbidity with major depressive disorder
    Eric J Lenze
    Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:77-80. 2005
    ..The authors assessed the course and comorbidity of late-life GAD and MDD...
  65. ncbi request reprint Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
    ..The objective of this study was to describe the correlates of prior antidepressant exposure and its association with response to protocolized treatment in older patients with major depression...
  66. ncbi request reprint Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances
    Robert R Bies
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Geriatr Pharmacother 3:87-91. 2005
    ..This study was intended to compare the consistency of risperidone exposure in patients who have dementia and behavioral disturbances treated in a psychiatric hospital versus a community care setting...
  67. ncbi request reprint Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 10:321-7. 2002
    ..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment...
  68. ncbi request reprint A pilot study of standardized treatment in geriatric bipolar disorder
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, the Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine 15213, USA
    Am J Geriatr Psychiatry 13:319-23. 2005
    ..The authors sought to determine the feasibility of treating elderly adults with bipolar disorder under standardized-treatment conditions...
  69. ncbi request reprint Clinically relevant behaviors in elderly hip fracture inpatients
    Helen H Dorra
    University of Pittsburgh School of Medicine, USA
    Int J Psychiatry Med 32:249-59. 2002
    ..To examine the range of behaviors documented by inpatient rehabilitation staff and the association of these behaviors with functional outcome, in elderly persons undergoing rehabilitation after hip fracture...
  70. ncbi request reprint Verification of scale sub-domains in elderly patients with dementia: a confirmatory factor-analytic approach
    Kari B Kastango
    Department of Biostatistics, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:706-14. 2002
    ....
  71. ncbi request reprint Anxiety symptoms in elderly patients with depression: what is the best approach to treatment?
    Eric J Lenze
    Department of Psychiatry, Intervention Research Center in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Drugs Aging 19:753-60. 2002
    ..Therefore, optimism should be maintained when treating the depressed elderly individual, even when comorbid anxiety is present...
  72. ncbi request reprint Response speed and rate of remission in primary and specialty care of elderly patients with depression
    Leslie Thomas
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:583-91. 2002
    ....
  73. ncbi request reprint Predictors of adequacy of depression management in the primary care setting
    Jin H Joo
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychiatr Serv 56:1524-8. 2005
    ..This study examined the adequacy of antidepressant treatment and overall depression management by primary care physicians and identified patient characteristics related to inadequate care...
  74. ncbi request reprint Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  75. ncbi request reprint Post stroke depression: epidemiology, pathophysiology, and biological treatment
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 52:253-64. 2002
    ..The authors conclude that the available evidence supports poststroke depression as being multifactorial in origin and consistent with the biopsychosocial model of mental illness...
  76. ncbi request reprint Assessment of late life depression
    George S Alexopoulos
    Weil Medical College, Cornell University GSA, White Plains, New York 10605, USA
    Biol Psychiatry 52:164-74. 2002
    ..Care managers working together with primary care physicians can improve the recognition and treatment of depressed elderly patients by obtaining the training in using validated instruments and treatment algorithms...
  77. ncbi request reprint Elevation in plasma Abeta42 in geriatric depression: a pilot study
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Neurochem Res 31:341-9. 2006
    ....
  78. pmc The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
    Hillary R Bogner
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Geriatr Psychiatry 22:922-9. 2007
    ..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients...
  79. ncbi request reprint Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:550-4. 2006
    ..The objective of this study was to examine the relative speed of improvement in sleep disturbance and anxiety symptoms compared with core mood symptoms in acute treatment of late-life major depression...
  80. ncbi request reprint Actors' portrayals of depression to test interrater reliability in clinical trials
    Jules Rosen
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Psychiatry 161:1909-11. 2004
    ..This study determined if actors could portray depressed patients to establish the interrater reliability of raters using the Hamilton Depression Rating Scale (HDRS)...
  81. ncbi request reprint Family caregiver functioning in late-life bipolar disorder
    Lynn M Martire
    Am J Geriatr Psychiatry 12:335-6. 2004
  82. ncbi request reprint Relapse during continuation pharmacotherapy after acute response to ECT: a comparison of usual care versus protocolized treatment
    James D Tew
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA USA
    Ann Clin Psychiatry 19:1-4. 2007
    ..quot; This study compares the effectiveness of usual care versus protocolized pharmacotherapy in preventing relapse following ECT...
  83. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  84. ncbi request reprint Depression after stroke: a prospective epidemiological study
    Ellen M Whyte
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 52:774-8. 2004
    ..To elucidate the relationship between stroke and depressive symptoms and to determine whether disability or cerebrovascular risk factors mediate that relationship...
  85. pmc Statistical analysis of longitudinal psychiatric data with dropouts
    Sati Mazumdar
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Psychiatr Res 41:1032-41. 2007
    ....
  86. ncbi request reprint Biomarkers in geriatric psychiatry
    Eric J Lenze
    Am J Geriatr Psychiatry 15:827-31. 2007
  87. ncbi request reprint Missed diagnosis of psychotic depression at 4 academic medical centers
    Anthony J Rothschild
    Department of Psychiatry, University of Massachusetts Medical School, and UMass Memorial Healthcare, Worcester, MA 01605, USA
    J Clin Psychiatry 69:1293-6. 2008
    ..Major depressive disorder with psychotic features (psychotic depression), though occurring relatively frequently in the general population, is a commonly missed psychiatric diagnosis...
  88. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  89. ncbi request reprint Predictors of remission after electroconvulsive therapy in unipolar major depression
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Clin Psychiatry 66:1043-9. 2005
    ..Electroconvulsive therapy (ECT) is the most effective biological treatment for major depression. However, there is little agreement about clinically useful predictors of acute ECT outcomes...
  90. doi request reprint Correlates of suicidality among patients with psychotic depression
    Ayal Schaffer
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Suicide Life Threat Behav 38:403-14. 2008
    ..These findings reinforce the evidence that patients with psychotic depression are at high risk for suicide and underscore the importance of examining correlates of suicidality specific to patients with psychotic depression...
  91. ncbi request reprint Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...

Research Grants9

  1. GERIATRIC DEPRESSION--METHODS FOR EFFECTIVENESS TRIALS
    Benoit Mulsant; Fiscal Year: 2002
    ....
  2. Electroacupuncture for Major Depression: A Pilot Study
    Benoit Mulsant; Fiscal Year: 2004
    ..abstract_text> ..
  3. Acute Pharmacotherapy of Unipolar Psychotic Depression
    Benoit Mulsant; Fiscal Year: 2006
    ..Remitted subjects are also followed during stabilization to determine the stability of remission and predictors of clinical and functional deterioration. ..
  4. Complex Trials for Severe Geriatric Mood Disorders
    Benoit Mulsant; Fiscal Year: 2007
    ..With the support of this award, additional work proposed in this application will focus on improving recruitment and retention of older minority subjects with severe mood disorders in this and other trials. ..
  5. Acute Pharmacotherapy of Late-Life Mania
    Benoit Mulsant; Fiscal Year: 2007
    ..The sites have a history of successful collaborative research, including demanding geriatric studies. ..
  6. 3/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Benoit Mulsant; Fiscal Year: 2009
    ..There are is no evidence-based pharmacotherapy for TRLLD; thus, this study seeks to address a major gap in the evidence base for treating depression. ..
  7. 3/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Benoit H Mulsant; Fiscal Year: 2010
    ..There are is no evidence-based pharmacotherapy for TRLLD;thus, this study seeks to address a major gap in the evidence base for treating depression. ..