Romina Mizrahi

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Phenomenology and clinical correlates of delusions in Alzheimer disease
    Romina Mizrahi
    PET Center for Addiction and Mental Health, Clarke Division, Toronto, Canada
    Am J Geriatr Psychiatry 14:573-81. 2006
  2. ncbi request reprint The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disorders
    Romina Mizrahi
    CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Schizophr Res 88:111-8. 2006
  3. doi request reprint The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics
    Romina Mizrahi
    Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
    Int J Neuropsychopharmacol 12:715-21. 2009
  4. pmc Dopamine response to psychosocial stress in chronic cannabis users: a PET study with [11C]-+-PHNO
    Romina Mizrahi
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 38:673-82. 2013
  5. pmc Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA
    Romina Mizrahi
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 32:968-72. 2012
  6. doi request reprint Increased stress-induced dopamine release in psychosis
    Romina Mizrahi
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 71:561-7. 2012
  7. doi request reprint Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNO
    Romina Mizrahi
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 131:63-8. 2011
  8. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
  9. ncbi request reprint Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    Am J Psychiatry 164:630-7. 2007
  10. ncbi request reprint Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study
    David Mamo
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Am J Psychiatry 164:1411-7. 2007

Detail Information

Publications31

  1. ncbi request reprint Phenomenology and clinical correlates of delusions in Alzheimer disease
    Romina Mizrahi
    PET Center for Addiction and Mental Health, Clarke Division, Toronto, Canada
    Am J Geriatr Psychiatry 14:573-81. 2006
    ....
  2. ncbi request reprint The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disorders
    Romina Mizrahi
    CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Schizophr Res 88:111-8. 2006
    ....
  3. doi request reprint The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics
    Romina Mizrahi
    Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
    Int J Neuropsychopharmacol 12:715-21. 2009
    ..90 (S.D.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA D2 occupancy (82-99%), in contrast to the effects of antagonist antipsychotics on subjective well-being...
  4. pmc Dopamine response to psychosocial stress in chronic cannabis users: a PET study with [11C]-+-PHNO
    Romina Mizrahi
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 38:673-82. 2013
    ..566, p=0.044), with no effect in any other brain region. In conclusion, despite an increase in striatal BP(ND) observed during the control task, chronic cannabis use is not associated with alterations in stress-induced DA release...
  5. pmc Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA
    Romina Mizrahi
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 32:968-72. 2012
    ..Testing for the rs6971 polymorphism may allow quantitative interpretation of TSPO PET studies with new generation of TSPO PET radioligands...
  6. doi request reprint Increased stress-induced dopamine release in psychosis
    Romina Mizrahi
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 71:561-7. 2012
    ..However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis...
  7. doi request reprint Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNO
    Romina Mizrahi
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 131:63-8. 2011
    ..11)C]-(+)-PHNO offer new opportunities for exploring the potential therapeutic significance of the D(3) receptor in schizophrenia and the action of antipsychotics...
  8. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
    ..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease...
  9. ncbi request reprint Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    Am J Psychiatry 164:630-7. 2007
    ..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience...
  10. ncbi request reprint Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study
    David Mamo
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Am J Psychiatry 164:1411-7. 2007
    ..The authors conducted a positron emission tomography (PET) study to characterize the simultaneous effects of aripiprazole at the D(2), 5-HT(2), and 5-HT(1A) receptors in patients with schizophrenia or schizoaffective disorder...
  11. doi request reprint Whole body biodistribution and radiation dosimetry in humans of a new PET ligand, [(18)F]-FEPPA, to image translocator protein (18 kDa)
    Romina Mizrahi
    Vivian M Rakoff PET Centre, Research Imaging Centre, Centre for Addiction and Mental Health CAMH, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Mol Imaging Biol 15:353-9. 2013
    ..18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism...
  12. doi request reprint The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 34:1078-86. 2009
    ..It is possible that receptors with high affinity are not accessible by [(11)C]-(+)-PHNO because they are occupied by endogenous dopamine, a possibility that can be ruled out in future experiments...
  13. ncbi request reprint Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Center for Addiction and Mental Health, Toronto, Canada
    J Neurochem 97:1089-103. 2006
    ....
  14. ncbi request reprint 'Jumping to conclusions' and delusions in psychosis: relationship and response to treatment
    Mahesh Menon
    Schizophrenia Program and PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Canada
    Schizophr Res 98:225-31. 2008
    ..The findings suggest that JTC might moderate the effects of treatment on symptomatology, but it does not mediate the treatment induced reduction in delusional intensity...
  15. doi request reprint Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traits
    Ivonne Suridjan
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Psychiatr Res 46:890-7. 2012
    ..Previous studies have reported inter-individual variability in the dopamine (DA) response to stress. This variability might be related to individual differences in the vulnerability to experience the negative effect of stress...
  16. pmc Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task
    Ivonne Suridjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
    J Psychiatry Neurosci 38:98-106. 2013
    ..Preclinical studies in animal models of psychosis have shown a selective increase of D2 high as the common factor in psychosis, and the D3 receptor has been suggested to be involved in the pathophysiology of schizophrenia...
  17. doi request reprint Whole-body distribution and radiation dosimetry of 11C-(+)-PHNO, a D2/3 agonist ligand
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Nucl Med 53:1802-6. 2012
    ..Using PET, we measured the whole-body distribution of (11)C-(+)-PHNO ((11)C-(+)-4-propyl-9-hydroxynaphthoxazine), a D(2/3) agonist, as a function of time in adult subjects in order to determine the internal radiation dose...
  18. pmc Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography
    Pablo M Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1807-16. 2011
    ..The excellent identifiability of V(T) values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of V(T) as an appropriate and feasible outcome measure for [(18)F]-FEPPA...
  19. doi request reprint Attribution style as a factor in psychosis and symptom resolution
    Romina Mizrahi
    CAMH, PET Centre, Toronto, Ontario, Canada
    Schizophr Res 104:220-7. 2008
    ....
  20. pmc Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PET
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    J Cereb Blood Flow Metab 33:348-50. 2013
    ..We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume...
  21. ncbi request reprint The effect of antipsychotic treatment on Theory of Mind
    Romina Mizrahi
    Centre for Addiction and Mental Health, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Psychol Med 37:595-601. 2007
    ..However, it remains unclear whether TOM deficits constitute a trait- or a state-related deficit and whether they respond to antipsychotic treatment, and also whether the change in TOM and change in psychosis are associated...
  22. pmc How antipsychotics work-from receptors to reality
    Shitij Kapur
    Centre for Addiction and Mental Health, Toronto, Canada M5S 1A1 University of Toronto, Toronto, Canada
    NeuroRx 3:10-21. 2006
    ..The implications of these findings for clinical care, animal models, future target discovery and drug development are discussed...
  23. pmc Mapping human brain fatty acid amide hydrolase activity with PET
    Pablo M Rusjan
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:407-14. 2013
    ..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake...
  24. ncbi request reprint From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis
    Shitij Kapur
    Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 79:59-68. 2005
    ..The article discusses the caveats, limitations as well as the clinical implications of the salience framework...
  25. ncbi request reprint Epidemiology and management of apathy in patients with Alzheimer's disease
    Romina Mizrahi
    PET Center, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
    Drugs Aging 24:547-54. 2007
    ..In this context, acetylcholinesterase inhibitors and psychosocial interventions are the only available modalities for treating apathy in AD with some efficacy...
  26. doi request reprint The four dimensions: a model for the social aetiology of psychosis
    Jai Shah
    Centre for Addictions and Mental Health, Suite 300, University of Toronto, Toronto M5S 2G8, Canada
    Br J Psychiatry 199:11-4. 2011
    ....
  27. ncbi request reprint How antipsychotics work: the patients' perspective
    Romina Mizrahi
    Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 29:859-64. 2005
    ..Most previous studies of the patient's perspective have focused on drug tolerability and acceptability-rather than their effects on psychosis per se...
  28. ncbi request reprint The construct of minor and major depression in Alzheimer's disease
    Sergio E Starkstein
    Fremantle Hospital, Education Building T 7, Fremantle, 6959 Western Australia, Australia
    Am J Psychiatry 162:2086-93. 2005
    ....
  29. pmc Neuropsychological correlates of normal variation in emotional response to visual stimuli
    Robert G Robinson
    University of Iowa, Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    J Nerv Ment Dis 195:112-8. 2007
    ..The role of these differences in intensity of induced emotion and impairment in executive function in daily social and vocational activity should be investigated...
  30. ncbi request reprint Depression in Alzheimer's disease
    Sergio E Starkstein
    University of Western Australia, Education Building T 7, School of Psychiatry and Clinical Neurosciences, and Fremantle Hospital, Western Australia, Australia
    Expert Rev Neurother 6:887-95. 2006
    ..Other psychoactive compounds may be useful as well, but careful consideration must be given to potentially serious side effects...
  31. ncbi request reprint Specificity of symptoms of depression in Alzheimer disease: a longitudinal analysis
    Sergio E Starkstein
    Education Building T 7, Fremantle Hospital, Fremantle, 6959 WA, Australia
    Am J Geriatr Psychiatry 13:802-7. 2005
    ..Authors examined the temporal stability of symptoms of major and minor depression and apathy in dementia...