Research Topics
Species | Romina MizrahiSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
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Detail Information
Publications
Phenomenology and clinical correlates of delusions in Alzheimer diseaseRomina Mizrahi
PET Center for Addiction and Mental Health, Clarke Division, Toronto, Canada
Am J Geriatr Psychiatry 14:573-81. 2006....- The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disordersRomina Mizrahi
CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Schizophr Res 88:111-8. 2006.... 
The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychoticsRomina Mizrahi
Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
Int J Neuropsychopharmacol 12:715-21. 2009..90 (S.D.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA D2 occupancy (82-99%), in contrast to the effects of antagonist antipsychotics on subjective well-being...
Dopamine response to psychosocial stress in chronic cannabis users: a PET study with [(11)C]-(+)-PHNORomina Mizrahi
Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 38:673-82. 2013..566, p=0.044), with no effect in any other brain region. In conclusion, despite an increase in striatal BP(ND) observed during the control task, chronic cannabis use is not associated with alterations in stress-induced DA release...- Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPARomina Mizrahi
PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Cereb Blood Flow Metab 32:968-72. 2012..Testing for the rs6971 polymorphism may allow quantitative interpretation of TSPO PET studies with new generation of TSPO PET radioligands... - Increased stress-induced dopamine release in psychosisRomina Mizrahi
Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Biol Psychiatry 71:561-7. 2012..However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis... - Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNORomina Mizrahi
PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 131:63-8. 2011..11)C]-(+)-PHNO offer new opportunities for exploring the potential therapeutic significance of the D(3) receptor in schizophrenia and the action of antipsychotics... - Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humansAriel Graff-Guerrero
PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Hum Brain Mapp 29:400-10. 2008..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease... - Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophreniaRomina Mizrahi
Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
Am J Psychiatry 164:630-7. 2007..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience... - Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET studyDavid Mamo
Department of Psychiatry, University of Toronto, Toronto, Canada
Am J Psychiatry 164:1411-7. 2007..The authors conducted a positron emission tomography (PET) study to characterize the simultaneous effects of aripiprazole at the D(2), 5-HT(2), and 5-HT(1A) receptors in patients with schizophrenia or schizoaffective disorder... - The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET studyAriel Graff-Guerrero
PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
Neuropsychopharmacology 34:1078-86. 2009..It is possible that receptors with high affinity are not accessible by [(11)C]-(+)-PHNO because they are occupied by endogenous dopamine, a possibility that can be ruled out in future experiments... - 'Jumping to conclusions' and delusions in psychosis: relationship and response to treatmentMahesh Menon
Schizophrenia Program and PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Canada
Schizophr Res 98:225-31. 2008..The findings suggest that JTC might moderate the effects of treatment on symptomatology, but it does not mediate the treatment induced reduction in delusional intensity... - Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traitsIvonne Suridjan
Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
J Psychiatr Res 46:890-7. 2012..Previous studies have reported inter-individual variability in the dopamine (DA) response to stress. This variability might be related to individual differences in the vulnerability to experience the negative effect of stress... - Whole-body distribution and radiation dosimetry of 11C-(+)-PHNO, a D2/3 agonist ligandRomina Mizrahi
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Nucl Med 53:1802-6. 2012..Using PET, we measured the whole-body distribution of (11)C-(+)-PHNO ((11)C-(+)-4-propyl-9-hydroxynaphthoxazine), a D(2/3) agonist, as a function of time in adult subjects in order to determine the internal radiation dose... - Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomographyPablo M Rusjan
PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Cereb Blood Flow Metab 31:1807-16. 2011..The excellent identifiability of V(T) values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of V(T) as an appropriate and feasible outcome measure for [(18)F]-FEPPA... - Attribution style as a factor in psychosis and symptom resolutionRomina Mizrahi
CAMH, PET Centre, Toronto, Ontario, Canada
Schizophr Res 104:220-7. 2008.... - Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomographyNathalie Ginovart
The Vivian Rakoff Positron Emission Tomography Unit, Center for Addiction and Mental Health, Toronto, Canada
J Neurochem 97:1089-103. 2006.... - Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PETJi Hyun Ko
Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
J Cereb Blood Flow Metab 33:348-50. 2013..We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume... - The effect of antipsychotic treatment on Theory of MindRomina Mizrahi
Centre for Addiction and Mental Health, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Psychol Med 37:595-601. 2007..However, it remains unclear whether TOM deficits constitute a trait- or a state-related deficit and whether they respond to antipsychotic treatment, and also whether the change in TOM and change in psychosis are associated... - Whole Body Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand, [(18)F]-FEPPA, to Image Translocator Protein (18 kDa)Romina Mizrahi
Vivian M Rakoff PET Centre, Research Imaging Centre, Centre for Addiction and Mental Health CAMH, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
Mol Imaging Biol 15:353-9. 2013..18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism... - How antipsychotics work-from receptors to realityShitij Kapur
Centre for Addiction and Mental Health, Toronto, Canada M5S 1A1 University of Toronto, Toronto, Canada
NeuroRx 3:10-21. 2006..The implications of these findings for clinical care, animal models, future target discovery and drug development are discussed... - Mapping human brain fatty acid amide hydrolase activity with PETPablo M Rusjan
Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Cereb Blood Flow Metab 33:407-14. 2013..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake... - Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive taskIvonne Suridjan
PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
J Psychiatry Neurosci 38:98-106. 2013..Preclinical studies in animal models of psychosis have shown a selective increase of D2 high as the common factor in psychosis, and the D3 receptor has been suggested to be involved in the pathophysiology of schizophrenia... - From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosisShitij Kapur
Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 79:59-68. 2005..The article discusses the caveats, limitations as well as the clinical implications of the salience framework... - Epidemiology and management of apathy in patients with Alzheimer's diseaseRomina Mizrahi
PET Center, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
Drugs Aging 24:547-54. 2007..In this context, acetylcholinesterase inhibitors and psychosocial interventions are the only available modalities for treating apathy in AD with some efficacy... - How antipsychotics work: the patients' perspectiveRomina Mizrahi
Centre for Addiction and Mental Health-CAMH, Toronto, Ontario, Canada M5T 1R8
Prog Neuropsychopharmacol Biol Psychiatry 29:859-64. 2005.... - The four dimensions: a model for the social aetiology of psychosisJai Shah
Centre for Addictions and Mental Health, Suite 300, University of Toronto, Toronto M5S 2G8, Canada
Br J Psychiatry 199:11-4. 2011.... - The construct of minor and major depression in Alzheimer's diseaseSergio E Starkstein
Fremantle Hospital, Education Building T 7, Fremantle, 6959 Western Australia, Australia
Am J Psychiatry 162:2086-93. 2005.... - Specificity of symptoms of depression in Alzheimer disease: a longitudinal analysisSergio E Starkstein
Education Building T 7, Fremantle Hospital, Fremantle, 6959 WA, Australia
Am J Geriatr Psychiatry 13:802-7. 2005..Authors examined the temporal stability of symptoms of major and minor depression and apathy in dementia... - Depression in Alzheimer's diseaseSergio E Starkstein
University of Western Australia, Education Building T 7, School of Psychiatry and Clinical Neurosciences, and Fremantle Hospital, Western Australia, Australia
Expert Rev Neurother 6:887-95. 2006..Other psychoactive compounds may be useful as well, but careful consideration must be given to potentially serious side effects... - Neuropsychological correlates of normal variation in emotional response to visual stimuliRobert G Robinson
University of Iowa, Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
J Nerv Ment Dis 195:112-8. 2007..The role of these differences in intensity of induced emotion and impairment in executive function in daily social and vocational activity should be investigated...