J Mill

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet 114:269-71. 2002
  2. ncbi request reprint Molecular studies of major depressive disorder: the epigenetic perspective
    J Mill
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 12:799-814. 2007
  3. ncbi request reprint Rodent models: utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD)
    Jonathan Mill
    Centre for Addiction and Mental Health, Toronto, Canada
    J Neurosci Methods 166:294-305. 2007
  4. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
  5. ncbi request reprint Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 63:462-9. 2006
  6. ncbi request reprint Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:11-3. 2005
  7. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
  8. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
  9. ncbi request reprint Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene
    Ursula M D'Souza
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box Number P082, Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 56:691-7. 2004
  10. ncbi request reprint Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:38-42. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet 114:269-71. 2002
    ..Within-family tests of linkage and association confirmed these findings. Further work is needed to ascertain the role of SNAP-25 in ADHD and assess the functional significance of this polymorphism...
  2. ncbi request reprint Molecular studies of major depressive disorder: the epigenetic perspective
    J Mill
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 12:799-814. 2007
    ..Despite these difficulties, the study of DNA methylation and histone modifications has the potential to transform our understanding about the molecular aetiology of complex diseases...
  3. ncbi request reprint Rodent models: utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD)
    Jonathan Mill
    Centre for Addiction and Mental Health, Toronto, Canada
    J Neurosci Methods 166:294-305. 2007
    ....
  4. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
    ..57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD...
  5. ncbi request reprint Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 63:462-9. 2006
    ..A principal aim of genetic research is to provide new information that can resolve such clinical heterogeneity and that can be incorporated into diagnostic practice...
  6. ncbi request reprint Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:11-3. 2005
    ..Although we found some evidence for the preferential transmission of a rare haplotype (long-allele/9-repeat-allele/T-allele; chi2 = 4.5, P = 0.034), we concluded that this most likely occurred by chance factors alone...
  7. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
    ..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
  8. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
    ....
  9. ncbi request reprint Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene
    Ursula M D'Souza
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box Number P082, Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 56:691-7. 2004
    ..The location of the polymorphism in the 5'regulatory region of the DRD4 gene and the fact that it consists of potential transcription factor binding sites suggest that it might confer differential transcriptional activity of the alleles...
  10. ncbi request reprint Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:38-42. 2004
    ..A global test incorporating all alleles of this marker, however, was not significant and thus this finding needs replication before any conclusions can be made...
  11. pmc Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes
    Naomi Lowe
    Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 74:348-56. 2004
    ..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...
  12. ncbi request reprint Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, PO82, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neuroreport 14:1463-6. 2003
    ....
  13. ncbi request reprint Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
    Jonathan Mill
    Social, Genetic, and Developmental Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Med Genet 114:975-9. 2002
    ..These data provide direct evidence that the VNTR, or another polymorphism in linkage disequilibrium with the VNTR, is involved in regulating expression of this gene...
  14. ncbi request reprint Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults...
  15. pmc Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    Jonathan Mill
    Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 82:696-711. 2008
    ..Our data are consistent with the epigenetic theory of major psychosis and suggest that DNA-methylation changes are important to the etiology of schizophrenia and bipolar disorder...