Jeffrey H Meyer

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study
    J H Meyer
    Clarke Division, Centre for Addictions and Mental Health, Department ofPsychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:78-85. 2001
  2. ncbi request reprint Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study
    J H Meyer
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:1843-9. 2001
  3. ncbi request reprint Bupropion occupancy of the dopamine transporter is low during clinical treatment
    Jeffrey H Meyer
    Department of Psychiatry, PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Psychopharmacology (Berl) 163:102-5. 2002
  4. ncbi request reprint Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Clarke Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St, Toronto, ON, M5T 1R8, Canada
    Am J Psychiatry 160:90-9. 2003
  5. ncbi request reprint Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study
    Jeffrey H Meyer
    Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 161:826-35. 2004
  6. doi request reprint Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009
  7. pmc Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, Toronto, Canada
    J Cereb Blood Flow Metab 32:443-6. 2012
  8. ncbi request reprint Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre and Mood and Anxiety Disorders Division, Clarke Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 63:1209-16. 2006
  9. ncbi request reprint Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography
    Aristotle N Voineskos
    Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 193:539-45. 2007
  10. ncbi request reprint Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 61:1271-9. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study
    J H Meyer
    Clarke Division, Centre for Addictions and Mental Health, Department ofPsychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:78-85. 2001
    ..The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT(2A) receptors in depressed patients...
  2. ncbi request reprint Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study
    J H Meyer
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:1843-9. 2001
    ..This study measured the proportion of 5-HTT sites blocked during paroxetine and citalopram treatment of depression and assessed the relationship between serum paroxetine levels and the proportion of 5-HTT sites blocked...
  3. ncbi request reprint Bupropion occupancy of the dopamine transporter is low during clinical treatment
    Jeffrey H Meyer
    Department of Psychiatry, PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Psychopharmacology (Berl) 163:102-5. 2002
    ..The validity of this mechanism has been questioned because the affinity of bupropion for the DAT is quite low...
  4. ncbi request reprint Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Clarke Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St, Toronto, ON, M5T 1R8, Canada
    Am J Psychiatry 160:90-9. 2003
    ....
  5. ncbi request reprint Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study
    Jeffrey H Meyer
    Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 161:826-35. 2004
    ..The relationship between dose and occupancy was also investigated...
  6. doi request reprint Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009
    ..The relationship between MAO-A levels and selective serotonin reuptake inhibitor (SSRI) treatment, recovery, and recurrence in MDD is unknown...
  7. pmc Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, Toronto, Canada
    J Cereb Blood Flow Metab 32:443-6. 2012
    ..007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels...
  8. ncbi request reprint Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre and Mood and Anxiety Disorders Division, Clarke Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 63:1209-16. 2006
    ..Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine...
  9. ncbi request reprint Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography
    Aristotle N Voineskos
    Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 193:539-45. 2007
    ..11)C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine positron emission tomography ([(11)C]DASB PET) is currently the best method available to quantify 5-HTT occupancy in humans...
  10. ncbi request reprint Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 61:1271-9. 2004
    ..Our recent publication of increased serotonin2 BP in MDE with severely negativistic dysfunctional attitudes suggests that this subgroup of MDE subjects has very low levels of extracellular serotonin...
  11. ncbi request reprint [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 47:123-33. 2003
    ..These studies indicate that [(11)C]-DASB is a suitable PET radioligand for measuring drug occupancy of the SERT in vivo and has potential for monitoring in vivo changes in serotonin levels...
  12. ncbi request reprint Effects of tryptophan depletion on the serotonin transporter in healthy humans
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Canada
    Biol Psychiatry 58:825-30. 2005
    ..Adaptive decreases in 5-HTT density and/or affinity during TD would be a possible compensatory mechanism to maintain sufficient extracellular serotonin levels during TD, thereby preventing a depressive relapse...
  13. ncbi request reprint Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff Positron Emission Tomography Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 62:327-31. 2007
    ..We examined the possible influence of the long (A/G) variant on 5-HTT density in the living human brain using 3-(11)C-amino-4-(2-dimethylaminomethylphenyl-sulfanyl) benzonitrile ([(11)C]DASB) positron emission tomography...
  14. ncbi request reprint Kinetic modeling of the monoamine oxidase B radioligand [(11)C]SL25.1188 in human brain with high-resolution positron emission tomography
    Pablo M Rusjan
    Research Imaging Centre, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 34:883-9. 2014
    ..9). Specific binding would account from 70% to 90% of VT. Hence, VT measurement of [(11)C]SL25.1(1)88 PET is an excellent estimation of MAO-B concentration. ..
  15. pmc Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 36:375-82. 2011
    ..John's wort, an herb purported to have MAO-A inhibitor properties...
  16. doi request reprint Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1776-80. 2008
    ....
  17. doi request reprint Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking
    Ingrid Bacher
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College St, Toronto, ON, Canada
    Arch Gen Psychiatry 68:817-26. 2011
    ..Dysphoria during cigarette withdrawal predicts relapse. It is unknown whether MAO-A binding increases during early cigarette withdrawal...
  18. doi request reprint Elevated brain monoamine oxidase A binding in the early postpartum period
    Julia Sacher
    Vivian M Rakoff PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 67:468-74. 2010
    ..However, MAO-A levels have never been measured in the early postpartum period...
  19. ncbi request reprint Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre and the Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 56:587-91. 2004
    ..This 5-HT(1A)BP measurement is sensitive to changes in extracellular 5-HT in animal models...
  20. ncbi request reprint Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
    ..It was hypothesized that putamen D(2) binding potential would be higher during major depressive episodes featuring motor retardation...
  21. pmc Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Cereb Blood Flow Metab 33:863-71. 2013
    ..However, compared with in vitro data, the latter PET measures underestimated regional contrast by ∼2-fold. Further studies are needed to address cause of the in vivo vs. in vitro nonproportionality...
  22. doi request reprint Development of new radiopharmaceuticals for imaging monoamine oxidase B
    Neil Vasdev
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 38:933-43. 2011
    ....
  23. doi request reprint Synthesis and preliminary evaluation of [(18)F]-fluoro-(2S)-Exaprolol for imaging cerebral beta-adrenergic receptors with PET
    Karin A Stephenson
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Neurochem Int 53:173-9. 2008
    ..These results indicate that [(18)F]-(2S)-1 is not a suitable candidate for PET imaging of cerebral beta-ARs...
  24. ncbi request reprint Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Cereb Blood Flow Metab 26:330-44. 2006
    ..These results indicate the suitability of using [(11)C]-harmine for quantitative evaluation of MAO-A densities using PET and should enable further studies of potential MAO-A dysregulation in several psychiatric and neurologic illnesses...
  25. doi request reprint Convergent effects of acute stress and glucocorticoid exposure upon MAO-A in humans
    Alexandra Soliman
    CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Neurosci 32:17120-7. 2012
    ..Since MAO-A metabolizes monoamines, this phenomenon may explain why acute stressors benefit healthy animals even though chronic stress is associated with illness...
  26. ncbi request reprint Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 32:123-8. 2005
    ..However, there has been no consistency in the selection of a "SERT-free" reference region for the estimation of free and nonspecific binding, as occipital cortex, cerebellum and white matter have all been employed...
  27. pmc Serotonin2A receptor binding potential in people with aggressive and violent behaviour
    Jeffrey H Meyer
    Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 33:499-508. 2008
    ..The objective of this study was to investigate prefrontal cortex 5-HT2A binding potential (BPND), an index of 5-HT2A density, in an unbiased sample of people with violent aggressive behaviour...
  28. ncbi request reprint Imaging cAMP-specific phosphodiesterase-4 in human brain with R-[11C]rolipram and positron emission tomography
    Jean N DaSilva
    PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Eur J Nucl Med Mol Imaging 29:1680-3. 2002
    ..R-[(11)C]Rolipram is thus suitable for imaging PDE4 and possibly cAMP signal transduction in the living human brain with PET...
  29. ncbi request reprint Greater monoamine oxidase a binding in alcohol dependence
    Brittany A Matthews
    Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 75:756-64. 2014
    ....
  30. pmc Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography
    Pablo M Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1807-16. 2011
    ..The excellent identifiability of V(T) values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of V(T) as an appropriate and feasible outcome measure for [(18)F]-FEPPA...
  31. doi request reprint Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide
    Neil Vasdev
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ont, Canada M5T 1R8
    Bioorg Med Chem 16:5277-84. 2008
    ..Radioactivity from all excised brain regions was <0.2%ID/g at all time points. The modest brain penetration of [(11)C]5 may limit its use for studying PKA in the central nervous system...
  32. doi request reprint Seasonal variation in human brain serotonin transporter binding
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada
    Arch Gen Psychiatry 65:1072-8. 2008
    ..The serotonin transporter is a key element in regulating intensity and spread of the serotonin signal...
  33. ncbi request reprint Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies
    Neil Vasdev
    PET Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, Ont, Canada M5T 1R8
    Bioorg Med Chem Lett 15:5270-3. 2005
    ..Furthermore, the specific pharmacological mechanism(s) of antidepressant-like activity attributed to AR-A014418 should be investigated...
  34. pmc Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
    Jeffrey H Meyer
    Neurochemical Imaging Program in Mood Disorders, PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
    J Psychiatry Neurosci 32:86-102. 2007
    ..Implications of 5-HTT imaging findings for understanding major depressive disorder and antidepressant treatment will be discussed...
  35. doi request reprint Facile radiosynthesis of fluorine-18 labeled beta-blockers. Synthesis, radiolabeling, and ex vivo biodistribution of [18F]-(2S and 2R)-1-(1-fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol
    Karin A Stephenson
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
    J Med Chem 51:5093-100. 2008
    ..9-1.1 Ci/micromol (EOS). Ex vivo biodistribution studies with the radiotracers demonstrated excessively rapid washout that may limit their use for cerebral PET imaging...
  36. doi request reprint Elevated monoamine oxidase a binding during major depressive episodes is associated with greater severity and reversed neurovegetative symptoms
    Lina Chiuccariello
    CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, Pharmacology and Toxicology, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 39:973-80. 2014
    ..As MAO-A creates oxidative stress, facilitates apoptosis, and metabolizes monoamines, therapeutics opposing these processes are predicted to best treat MDE with greater severity and reversed neurovegetative symptoms. ..
  37. doi request reprint Applying neuroimaging ligands to study major depressive disorder
    Jeffrey H Meyer
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Semin Nucl Med 38:287-304. 2008
    ....
  38. ncbi request reprint Effect of dysfunctional attitudes and postpartum state on vulnerability to depressed mood
    Yekta Dowlati
    CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada Institute of Medical Science, University of Toronto, Canada
    J Affect Disord 161:16-20. 2014
    ..The aim is to assess whether day-5 postpartum blues and severity of dysfunctional attitudes predicts vulnerability to depressed mood...
  39. doi request reprint Neurochemical imaging and depressive behaviours
    Jeffrey H Meyer
    Department of Psychiatry, University of Toronto, Canada
    Curr Top Behav Neurosci 14:101-34. 2013
    ....
  40. ncbi request reprint PET and SPECT imaging in psychiatric disorders
    Robert B Zipursky
    Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario
    Can J Psychiatry 52:146-57. 2007
    ..To review recent findings from positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigate the pathophysiology and treatment of schizophrenia, depression, and dementia...
  41. ncbi request reprint Misunderstandings about how to choose a reference region
    Jeffrey H Meyer
    Biol Psychiatry 61:1314; author reply 1314-5. 2007
  42. ncbi request reprint Smoking-induced ventral striatum dopamine release
    Arthur L Brody
    Veterans Affairs Greater Los Angeles Healthcare, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Am J Psychiatry 161:1211-8. 2004
    ..The authors used [(11)C]raclopride bolus-plus-continuous-infusion positron emission tomography (PET) to determine smoking-induced ventral striatum dopamine release in humans...