R S McIntyre

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Acute treatment of patients with bipolar mixed episodes
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, and the Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada
    J Clin Psychiatry 69:e10. 2008
  2. ncbi request reprint Antipsychotic metabolic effects: weight gain, diabetes mellitus, and lipid abnormalities
    R S McIntyre
    Centre for Addiction and Mental Health, Clarke Site, Mood and Anxiety Disorders Program, 250 College Street, Toronto, ON M5T 1R8
    Can J Psychiatry 46:273-81. 2001
  3. ncbi request reprint Topiramate versus bupropion SR when added to mood stabilizer therapy for the depressive phase of bipolar disorder: a preliminary single-blind study
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Mood and Anxiety Disorders Program, Center for Addiction and Mental Health, Clarke Site, Ontario, Canada
    Bipolar Disord 4:207-13. 2002
  4. pmc Assessing full remission
    Roger McIntyre
    Mood and Anxiety Disorders Program, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:235-9. 2002
  5. ncbi request reprint Psychotropic drugs and adverse events in the treatment of bipolar disorders revisited
    Roger S McIntyre
    Mood Disorders Program, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Ontario, Canada
    J Clin Psychiatry 63:15-20. 2002
  6. ncbi request reprint Mechanisms of antipsychotic-induced weight gain
    R S McIntyre
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Ontario, Canada
    J Clin Psychiatry 62:23-9. 2001
  7. ncbi request reprint Lithium revisited
    R S McIntyre
    Bipolar Clinic, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8
    Can J Psychiatry 46:322-7. 2001
  8. ncbi request reprint Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle
    V S Basile
    Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Ontario, Canada
    J Clin Psychiatry 62:45-66. 2001
  9. doi request reprint The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder
    C Y Yim
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    Eur Psychiatry 27:223-8. 2012
  10. ncbi request reprint Measuring depressive symptoms in the naturalistic primary-care setting
    R S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Int J Clin Pract 61:1278-82. 2007

Detail Information

Publications70

  1. ncbi request reprint Acute treatment of patients with bipolar mixed episodes
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, and the Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada
    J Clin Psychiatry 69:e10. 2008
    ..As more medications become available in the treatment of bipolar disorder, algorithms can help clinicians make the appropriate treatment choices by offering recommendations for sequencing agents...
  2. ncbi request reprint Antipsychotic metabolic effects: weight gain, diabetes mellitus, and lipid abnormalities
    R S McIntyre
    Centre for Addiction and Mental Health, Clarke Site, Mood and Anxiety Disorders Program, 250 College Street, Toronto, ON M5T 1R8
    Can J Psychiatry 46:273-81. 2001
    ..To review published and nonpublished literature describing changes in weight, glucose homeostasis, and lipid milieu with antipsychotics...
  3. ncbi request reprint Topiramate versus bupropion SR when added to mood stabilizer therapy for the depressive phase of bipolar disorder: a preliminary single-blind study
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Mood and Anxiety Disorders Program, Center for Addiction and Mental Health, Clarke Site, Ontario, Canada
    Bipolar Disord 4:207-13. 2002
    ....
  4. pmc Assessing full remission
    Roger McIntyre
    Mood and Anxiety Disorders Program, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:235-9. 2002
    ..A score of 3 or less on the Toronto HAM-D7 was found to correlate with the 17-item HAM-D definition of full remission (i.e., score of 7 or less)...
  5. ncbi request reprint Psychotropic drugs and adverse events in the treatment of bipolar disorders revisited
    Roger S McIntyre
    Mood Disorders Program, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Ontario, Canada
    J Clin Psychiatry 63:15-20. 2002
    ..Most of their adverse effects can be avoided by slow titration toward the recommended doses. In contrast to carbamazepine and valproic acid, topiramate may be associated with weight loss...
  6. ncbi request reprint Mechanisms of antipsychotic-induced weight gain
    R S McIntyre
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Ontario, Canada
    J Clin Psychiatry 62:23-9. 2001
    ..Research success in this area may invite novel prevention strategies and hint at potential mechanisms of antipsychotic drug action...
  7. ncbi request reprint Lithium revisited
    R S McIntyre
    Bipolar Clinic, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8
    Can J Psychiatry 46:322-7. 2001
    ..To review lithium's utility in the treatment of mood disorders...
  8. ncbi request reprint Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle
    V S Basile
    Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Ontario, Canada
    J Clin Psychiatry 62:45-66. 2001
    ....
  9. doi request reprint The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder
    C Y Yim
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    Eur Psychiatry 27:223-8. 2012
    ..This sub-group post-hoc analysis preliminarily explores and examines the association between overweight/obesity and cognitive function in euthymic individuals with bipolar disorder...
  10. ncbi request reprint Measuring depressive symptoms in the naturalistic primary-care setting
    R S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Int J Clin Pract 61:1278-82. 2007
    ..A quantifiable critical objective in the management of depression is to achieve and sustain full symptomatic remission. The HAMD-7 is a depression metric validated in both tertiary and primary-care settings...
  11. ncbi request reprint The effect of bipolar I disorder and major depressive disorder on workforce function
    R S McIntyre
    Department of Psychiatry, University of Toronto, ON, Canada
    Chronic Dis Can 28:84-91. 2008
    ..5 to 0.9). The data herein underscore the pernicious effect of BD on workforce function, and suggest that opportunistic screening for BD in all individuals utilizing employment assistance programs for depression might be warranted...
  12. ncbi request reprint Sleep architecture variation: a mediator of metabolic disturbance in individuals with major depressive disorder
    P A Kudlow
    Department of Psychiatry, University of Toronto, Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada Electronic address
    Sleep Med 14:943-9. 2013
    ..Validation of this marker would have broad clinical implications, such as primary, secondary, and tertiary preventative health strategies. ..
  13. ncbi request reprint Improving outcomes in depression: a focus on somatic symptoms
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    J Psychosom Res 60:279-82. 2006
    ..It is hypothesized that somatic symptom alleviation is a significant predictor of overall outcome in depressed primary care patients...
  14. pmc Bipolar depression: trial-based insights to guide patient care
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Dialogues Clin Neurosci 10:181-92. 2008
    ..A pragmatic clinical approach is presented for management of the depressed phase of bipolar disorder...
  15. ncbi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada
    Bipolar Disord 8:721-39. 2006
    ..The importance of comorbid psychiatric and medical conditions cannot be understated, and this update provides an expanded look at the prevalence, impact and management of comorbid conditions in patients with bipolar disorder...
  16. ncbi request reprint Open-label adjunctive topiramate in the treatment of unstable bipolar disorder
    Roger S McIntyre
    Mood Disorders Psychoparmacology Unit, University Health Network, Toronto, Ontario
    Can J Psychiatry 50:415-22. 2005
    ..To assess open-label adjunctive topiramate in the treatment of outpatients with unstable bipolar disorder (BD)...
  17. ncbi request reprint Bipolar disorder and suicide: research synthesis and clinical translation
    Roger S McIntyre
    Department of Psychiatry and Pharmacology, University of Toronto, Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Curr Psychiatry Rep 10:66-72. 2008
    ..A nascent database suggests that adjunctive psychosocial interventions may further reduce suicide risk in bipolar individuals...
  18. ncbi request reprint Obesity in bipolar disorder and major depressive disorder: results from a national community health survey on mental health and well-being
    Roger S McIntyre
    Department of Psychiatry and Pharmacology, University of Toronto, Ontario
    Can J Psychiatry 51:274-80. 2006
    ..We further aimed to examine the likelihood of an association between obesity and MD, while controlling for the influence of sociodemographic variables...
  19. doi request reprint Validity of conclusions about quetiapine
    Roger S McIntyre
    Am J Health Syst Pharm 65:114-5; author reply 115-6. 2008
  20. ncbi request reprint Differentiating bipolar disorders from major depressive disorders: treatment implications
    David J Muzina
    Cleveland Clinic Neurological Institute, Psychiatry and Psychology, Cleveland, OH 44195, USA
    Ann Clin Psychiatry 19:305-12. 2007
    ..Bipolar disorder is a highly prevalent mood disorder, frequently misdiagnosed as unipolar major depressive disorder...
  21. ncbi request reprint Residual anxiety symptoms in depressed primary care patients
    Roger S McIntyre
    University of Toronto, Toronto, Ontario, Canada
    J Psychiatr Pract 13:125-8. 2007
    ..The goal of this study was to characterize the burden of anxiety among residual depressive symptoms in naturalistic primary care settings...
  22. ncbi request reprint Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 68:1480-91. 2007
    ..Efficacy and tolerability of aripiprazole for relapse prevention in bipolar I disorder was, therefore, evaluated for 100 weeks...
  23. ncbi request reprint Maintenance treatment in bipolar disorder: a focus on aripiprazole
    Roger S McIntyre
    University of Toronto, Department of Psychiatry, Department of Pharmacology, Toronto, ON, Canada
    Expert Rev Neurother 7:919-25. 2007
    ..This article provides a succinct review of treatments approved by the US FDA for maintenance in bipolar disorders, with a focus on the most recently approved atypical antipsychotic, aripiprazole...
  24. ncbi request reprint Comorbidity in bipolar disorder: a framework for rational treatment selection
    Roger S McIntyre
    Mood Disorder Psychopharmacology Unit, University of Toronto, University Health Network Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S9, Canada
    Hum Psychopharmacol 19:369-86. 2004
    ..This schema should be further informed by the treatment data for comorbid and accessory conditions. The authors propose a schema to provide the impetus for further work in the area...
  25. ncbi request reprint Antipsychotic-induced weight gain: bipolar disorder and leptin
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 23:323-7. 2003
    ..05). The temporal association between weight increase and leptin changes does not support the notion that leptin is a primary promoter of antipsychotic-induced weight gain; however, a secondary perpetuating role cannot be ruled out...
  26. ncbi request reprint The human cost of not achieving full remission in depression
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 49:10S-16S. 2004
    ....
  27. pmc Treating bipolar disorder. Evidence-based guidelines for family medicine
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Ont
    Can Fam Physician 50:388-94. 2004
    ..To provide an evidence-based summary of medications commonly used for bipolar disorders and a practical approach to managing bipolar disorders in the office...
  28. pmc An approach to managing depression. Defining and measuring outcomes
    Atul Khullar
    Department of Psychiatry, University of Alberta, Edmonton
    Can Fam Physician 50:1374-80. 2004
    ....
  29. ncbi request reprint The antidepressant effects of risperidone and olanzapine in bipolar disorder
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Ontario
    Can J Clin Pharmacol 11:e218-26. 2004
    ..To describe the antidepressant effectiveness of olanzapine and risperidone and compare their tolerability when employed adjunctively in bipolar I/II disorder...
  30. ncbi request reprint Antidepressant augmentation with raloxifene
    Sophie Grigoriadis
    J Clin Psychopharmacol 25:96-8. 2005
  31. ncbi request reprint Tolerability profiles of atypical antipsychotics in the treatment of bipolar disorder
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Clin Psychiatry 66:28-36. 2005
    ..This article reviews relevant adverse events attributable to the use of atypical antipsychotic agents, with particular consideration of the bipolar disorder population...
  32. ncbi request reprint Quetiapine in the treatment of acute bipolar mania: efficacy across a broad range of symptoms
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    J Affect Disord 100:S5-14. 2007
    ..This post-hoc analysis aims to extend our understanding of quetiapine's antimanic efficacy by evaluating its therapeutic effect across the full spectrum of manic symptoms...
  33. pmc What to do if an initial antidepressant fails?
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Ont
    Can Fam Physician 49:449-57. 2003
    ..To provide family physicians with practical ways of managing depressed patients responding insufficiently to initial antidepressant treatment...
  34. doi request reprint Metabolic and cardiovascular adverse events associated with antipsychotic treatment in children and adolescents
    Roger S McIntyre
    Department of Psychiatry and Pharmacology, Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada
    Arch Pediatr Adolesc Med 162:929-35. 2008
    ..To identify factors associated with incident cardiovascular events and metabolic disturbance in children and adolescents treated with antipsychotics...
  35. ncbi request reprint Comparing features of bipolar disorder to major depressive disorder in a tertiary mood disorders clinic
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, Canada
    Ann Clin Psychiatry 19:313-7. 2007
    ..We sought to describe features that distinguish individuals with bipolar disorder from major depressive disorder...
  36. ncbi request reprint Editorial: sharpening the focus in mood disorders: from disease models to individualized measurement-based care
    Roger S McIntyre
    Ann Clin Psychiatry 19:213-4. 2007
  37. ncbi request reprint Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Ontario, Canada
    J Clin Psychiatry 68:1352-7. 2007
    ..This investigation was undertaken to explore the relationship between alcohol/illicit drug dependence and overweight/obesity in individuals with bipolar I disorder...
  38. ncbi request reprint Should Depressive Syndromes Be Reclassified as "Metabolic Syndrome Type II"?
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, Canada
    Ann Clin Psychiatry 19:257-64. 2007
    ..A nascent explanatory theory regarding the pathophysiology of major depressive disorder posits that alterations in metabolic networks (e.g., insulin and glucocorticoid signaling) mediate allostasis...
  39. ncbi request reprint Considering wellness in managing patients with bipolar disorder
    Roger S McIntyre
    University of Toronto, Toronto, Canada
    CNS Spectr 13:7-8. 2008
  40. doi request reprint Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder
    Jakub Z Konarski
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Bipolar Disord 10:1-37. 2008
    ..Patient and methodological variability complicates the comparison of neuroimaging study results and limits heuristic model development and a biologically-based diagnostic schema...
  41. pmc Medical and substance-related comorbidity in bipolar disorder: translational research and treatment opportunities
    Roger S McIntyre
    Department of Psychiatry and Pharmacology, University of Toronto, ON, Canada
    Dialogues Clin Neurosci 10:203-13. 2008
    ..Subphenotyping bipolar disorder as a function of comorbidity and temporality of onset may provide an opportunity for refining disease pathophysiological models and developing innovative disease-modifying therapies...
  42. doi request reprint Adverse events in children and adolescents treated with antipsychotic medications
    Jeanette M Jerrell
    Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, South Carolina 29203, USA
    Hum Psychopharmacol 23:283-90. 2008
    ..To report the odds of developing adverse events associated with antipsychotic treatment among children and adolescents...
  43. ncbi request reprint Assessing the prevalence of depression among individuals with diabetes in a Medicaid managed-care program
    Linda S Kahn
    State University of New York at Buffalo, USA
    Int J Psychiatry Med 38:13-29. 2008
    ....
  44. ncbi request reprint The hepatic safety profile of duloxetine: a review
    Roger S McIntyre
    University Health Network, Mood Disorders Psychopharmacology Unit, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Expert Opin Drug Metab Toxicol 4:281-5. 2008
    ..Hepatotoxicity related to the use of duloxetine resulted in rewording of the US product insert...
  45. ncbi request reprint Comorbid somatic illnesses in patients with severe mental disorders: clinical, policy, and research challenges
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    J Clin Psychiatry 69:514-9. 2008
    ....
  46. ncbi request reprint Bipolar depression: best practices for the outpatient
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    CNS Spectr 12:1-14. 2007
    ..Two case studies are presented to elucidate the best practices for the varying clinical states of bipolar disorder...
  47. ncbi request reprint Relationship between regional brain metabolism, illness severity and age in depressed subjects
    Jakub Z Konarski
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Psychiatry Res 155:203-10. 2007
    ..The age-dependent changes documented herein may influence the distinct clinical presentation and treatment response described in older-age depression...
  48. pmc Measuring the severity of depression and remission in primary care: validation of the HAMD-7 scale
    Roger S McIntyre
    University of Toronto, Toronto, Ont
    CMAJ 173:1327-34. 2005
    ..We evaluated a 7-item abbreviated version (HAMD-7) of the 17-item Hamilton Depression Rating Scale (HAMD-17) in a randomized controlled clinical trial of patients with major depressive disorder being cared for in primary care settings...
  49. ncbi request reprint Quetiapine or haloperidol as monotherapy for bipolar mania--a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Canada
    Eur Neuropsychopharmacol 15:573-85. 2005
    ..The primary efficacy outcome variable was change from baseline to Day 21 in Young Mania Rating Scale (YMRS) score...
  50. ncbi request reprint Bipolar disorder and diabetes mellitus: epidemiology, etiology, and treatment implications
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada
    Ann Clin Psychiatry 17:83-93. 2005
    ..Preliminary investigations indicate that patients who suffer from BD with comorbid DM have a more severe course and outcome, lower quality of life, higher prevalence of medical comorbidity and higher cost of illness...
  51. pmc Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?
    Jakub Z Konarski
    Institute of Medical Science, University of Toronto, Canada
    J Psychiatry Neurosci 30:178-86. 2005
    ..The available evidence suggests that a functional role for the cerebellum should be considered in future neuropsychiatric studies...
  52. ncbi request reprint Duloxetine: pharmacoeconomic implications of an antidepressant that alleviates painful physical symptoms
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Expert Opin Pharmacother 6:707-13. 2005
    ..Pharmacoeconomic and cost-impact modelling analyses should be reformulated to consider duloxetine's symptom-alleviating effect on the somatic dimension of depressive illness...
  53. pmc Hormone replacement therapy and antidepressant prescription patterns: a reciprocal relationship
    Roger S McIntyre
    University Health Network, and Department of Psychiatry, University of Toronto, Toronto, Ont
    CMAJ 172:57-9. 2005
  54. ncbi request reprint Bipolar disorder: a national health concern
    Roger S McIntyre
    University Health Network, Edith Cavell Wing 3D 003, 399 Bathurst St, M5T 2S8, Ontario, Canada
    CNS Spectr 9:6-15. 2004
    ....
  55. pmc Reboxetine: a preliminary report on its use through the Special Access Program
    Sidney H Kennedy
    University Health Network, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:418-22. 2002
    ..To describe the effectiveness and tolerability of reboxetine under Special Access Program conditions in Canada in a group of patients with refractory depressive disorders...
  56. ncbi request reprint Valproate, bipolar disorder and polycystic ovarian syndrome
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada
    Bipolar Disord 5:28-35. 2003
    ..Recent data suggest that valproic acid, a commonly prescribed mood stabilizer, may be associated with polycystic ovarian syndrome (PCOS). This adverse event has not been systematically studied in bipolar disorder...
  57. pmc Antipsychotic drugs and diabetes
    Roger S McIntyre
    CMAJ 168:673. 2003
  58. ncbi request reprint The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms
    Roger S McIntyre
    University of Toronto, Department of Psychiatry, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Expert Opin Drug Saf 5:157-68. 2006
    ..To synthesise results from investigations reporting on the effect of antidepressants on glucose-insulin homeostasis...
  59. ncbi request reprint The effect of antidepressants on lipid homeostasis: a cardiac safety concern?
    Roger S McIntyre
    University of Toronto, Department of Psychiatry, Toronto, ON, Canada
    Expert Opin Drug Saf 5:523-37. 2006
    ..The authors sought to summarise and synthesise results from investigations which report on the effect of antidepressants on serum lipid homeostasis...
  60. ncbi request reprint A preclinical and clinical rationale for quetiapine in mood syndromes
    Roger S McIntyre
    University of Toronto, Department of Psychiatry, Toronto, ON, Canada
    Expert Opin Pharmacother 8:1211-9. 2007
    ..The in vitro pharmacodynamic profile of quetiapine is predictive of antidepressant activity in mood syndromes. Available clinical evidence has established quetiapine as an effective monotherapy in bipolar depression...
  61. ncbi request reprint Medical comorbidity in bipolar disorder: re-prioritizing unmet needs
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Psychiatry 20:406-16. 2007
    ..The aim of this review is to synthesize results from extant investigations which report on the co-occurrence of bipolar disorder and medical comorbidity...
  62. ncbi request reprint Aripiprazole: pharmacology and evidence in bipolar disorder
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Expert Opin Pharmacother 8:1001-9. 2007
    ..Aripiprazole constitutes an alternative mood-stabilizing pharmacologic avenue in bipolar disorder; its comparative efficacy in long-term recurrence prevention and bipolar depression is a future research vista...
  63. ncbi request reprint Predictors of self-reported antidepressant adherence
    Tara A Burra
    Faculty of Medicine, University of Toronto, Ontario, Canada
    Behav Med 32:127-34. 2007
    ..Clinicians should be cognizant of this complexity and address not only issues related to medication efficacy and tolerability, but also social mediators and health beliefs when prescribing antidepressants...
  64. ncbi request reprint Problem gambling in bipolar disorder: results from the Canadian Community Health Survey
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    J Affect Disord 102:27-34. 2007
    ..This investigation was undertaken to explore the prevalence and associated features of problem gambling amongst individuals with bipolar I disorder...
  65. ncbi request reprint Sex differences in antidepressant response in a Canadian primary-care sample
    Sophie Grigoriadis
    J Clin Psychopharmacol 27:95-8. 2007
  66. ncbi request reprint Measurable outcomes in psychiatric disorders: remission as a marker of wellness
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 28:1882-91. 2006
    ..Collectively, they are associated with significant morbidity, mortality, and economic cost. Wellness is the optimal outcome in the management of chronic medical and psychiatric disorders...
  67. ncbi request reprint Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder
    Chun Xu
    Laboratory of Cellular and Molecular Pathophysiology, Centre for Addiction and Mental Health, University of Toronto, 150 College Street, Toronto, Ontario, Canada M5T 1R8
    Am J Med Genet B Neuropsychiatr Genet 141:36-43. 2006
    ..These findings suggest genetic variants of the TRPM2 gene increase risk for BD and support the notion that TRPM2 may be involved in the pathophysiology of BD...
  68. ncbi request reprint Anxiety disorders and bipolar disorder: a review
    Roger S McIntyre
    Department of Psychiatry and Pharmacology, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada
    Bipolar Disord 8:665-76. 2006
    ..Anxiety comorbidity in the BPD population poses a serious hazard. For example, it is associated with an intensification of symptoms, non-recovery, substance use comorbidity and harmful dysfunction (e.g., suicidality)...
  69. ncbi request reprint Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street Toronto, ON, M5T 2S8, Canada
    Expert Opin Pharmacother 7:1305-21. 2006
    ..Antidiabetic treatments, which maintain euglycaemia, hold promise as potent and clinically significant therapeutic interventions for several neuropsychiatric disorders...
  70. ncbi request reprint Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects
    Sidney H Kennedy
    Centre for Addiction and Mental Health, and the Department of Psychiatry, University of Toronto, Ontario, Canada
    J Clin Psychiatry 63:181-6. 2002
    ....