David C Mamo

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders
    David C Mamo
    Centre for Addiction and Mental Health, Toronto, Canada
    Int J Geriatr Psychiatry 17:1012-7. 2002
  2. ncbi request reprint Quetiapine extended-release versus immediate-release formulation: a positron emission tomography study
    David C Mamo
    Centre for Addiction and Mental Health, PET Centre, Toronto, Ontario, Canada
    J Clin Psychiatry 69:81-6. 2008
  3. doi request reprint Effects of age and age of onset on prescribed antipsychotic dose in schizophrenia spectrum disorders: a survey of 1,418 patients in Japan
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan
    Am J Geriatr Psychiatry 16:584-93. 2008
  4. ncbi request reprint Monthly administration of long-acting injectable risperidone and striatal dopamine D2 receptor occupancy for the management of schizophrenia
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychiatry 69:1281-6. 2008
  5. ncbi request reprint Managing suicidality in schizophrenia
    David C Mamo
    Centre for Addiction and Mental Health, Assisstant Professor of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 52:59S-70S. 2007
  6. ncbi request reprint Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study
    David Mamo
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Am J Psychiatry 164:1411-7. 2007
  7. doi request reprint Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms
    Hiroyuki Uchida
    Schizophrenia Research Group, PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 17:255-63. 2009
  8. doi request reprint Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophrenia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 20:53-60. 2012
  9. doi request reprint Clozapine and global cognition in schizophrenia
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Canada
    J Clin Psychopharmacol 30:431-6. 2010
  10. doi request reprint Time course of improvement with antipsychotic medication in treatment-resistant schizophrenia
    Takefumi Suzuki
    Centre for Addiction and Mental Health, Geriatric Mental Health Program and Multimodal Imaging Group, and Department of Psychiatry, University of Toronto, Ontario, Canada, and Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
    Br J Psychiatry 199:275-80. 2011

Research Grants

Detail Information

Publications41

  1. ncbi request reprint The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders
    David C Mamo
    Centre for Addiction and Mental Health, Toronto, Canada
    Int J Geriatr Psychiatry 17:1012-7. 2002
    ..It has been suggested, therefore, that older patients with schizophrenia could be maintained on reduced doses of conventional neuroleptics...
  2. ncbi request reprint Quetiapine extended-release versus immediate-release formulation: a positron emission tomography study
    David C Mamo
    Centre for Addiction and Mental Health, PET Centre, Toronto, Ontario, Canada
    J Clin Psychiatry 69:81-6. 2008
    ..An extended-release (XR) formulation of quetiapine is currently being developed to achieve similar efficacy using a once-daily dosing regimen. We compared the central D(2) receptor binding between the IR and XR formulations...
  3. doi request reprint Effects of age and age of onset on prescribed antipsychotic dose in schizophrenia spectrum disorders: a survey of 1,418 patients in Japan
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan
    Am J Geriatr Psychiatry 16:584-93. 2008
    ..The objective of this study was to better evaluate these age effects on antipsychotic dose prescribed in these patients across a broad age range...
  4. ncbi request reprint Monthly administration of long-acting injectable risperidone and striatal dopamine D2 receptor occupancy for the management of schizophrenia
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychiatry 69:1281-6. 2008
    ..The objective of this positron emission tomography (PET) study was to examine the striatal dopamine D(2) binding of long-acting risperidone administered intramuscularly once a month...
  5. ncbi request reprint Managing suicidality in schizophrenia
    David C Mamo
    Centre for Addiction and Mental Health, Assisstant Professor of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 52:59S-70S. 2007
    ..The primary objective of this review article is to provide a coherent, systematic synthesis of the literature on the management of suicidality in schizophrenia that is relevant to the front-line clinician...
  6. ncbi request reprint Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study
    David Mamo
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Am J Psychiatry 164:1411-7. 2007
    ..The authors conducted a positron emission tomography (PET) study to characterize the simultaneous effects of aripiprazole at the D(2), 5-HT(2), and 5-HT(1A) receptors in patients with schizophrenia or schizoaffective disorder...
  7. doi request reprint Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms
    Hiroyuki Uchida
    Schizophrenia Research Group, PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 17:255-63. 2009
    ..The objective of this study was to examine whether this sensitivity is due to a central pharmacokinetic (i.e., higher occupancy for a given plasma level) or pharmacodynamic (i.e., greater functional effects for a given occupancy) effect...
  8. doi request reprint Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophrenia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 20:53-60. 2012
    ..The objective of this study was to assess the magnitude and variability of plasma concentrations of clozapine and norclozapine across the lifespan in a real-world clinical setting...
  9. doi request reprint Clozapine and global cognition in schizophrenia
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Canada
    J Clin Psychopharmacol 30:431-6. 2010
    ..The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies...
  10. doi request reprint Time course of improvement with antipsychotic medication in treatment-resistant schizophrenia
    Takefumi Suzuki
    Centre for Addiction and Mental Health, Geriatric Mental Health Program and Multimodal Imaging Group, and Department of Psychiatry, University of Toronto, Ontario, Canada, and Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
    Br J Psychiatry 199:275-80. 2011
    ..Improvements are greatest in the earlier weeks of antipsychotic treatment of patients with non-resistant schizophrenia...
  11. doi request reprint D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia
    Hiroyuki Uchida
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 29:571-5. 2009
    ....
  12. doi request reprint Long-term stability of measuring D(2) receptors in schizophrenia patients treated with antipsychotics
    Hiroyuki Uchida
    PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8
    Schizophr Res 109:130-3. 2009
    ....
  13. doi request reprint Cholinergic pathways and cognition in patients with schizophrenia: a pilot study
    Tarek K Rajji
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 139:46-52. 2012
    ..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia...
  14. ncbi request reprint Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    Am J Psychiatry 164:630-7. 2007
    ..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience...
  15. doi request reprint Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 26:1300-8. 2011
    ....
  16. doi request reprint Treatment resistant schizophrenia and response to antipsychotics: a review
    Takefumi Suzuki
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Schizophr Res 133:54-62. 2011
    ..There remains a lack of agreement regarding criteria for treatment-resistant schizophrenia (TRS) and definition of response...
  17. ncbi request reprint A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone
    David Mamo
    Department of Psychiatry, University of Toronto, Montreal, Canada
    Am J Psychiatry 161:818-25. 2004
    ..The affinity of ziprasidone for these receptors in vivo in patients was examined in a positron emission tomography (PET) study...
  18. doi request reprint Management of schizophrenia in late life with antipsychotic medications: a qualitative review
    Takefumi Suzuki
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, ON, Canada
    Drugs Aging 28:961-80. 2011
    ..However, data on geriatric patients with schizophrenia are generally scarce, particularly for treatment-resistant subpopulations, underscoring the need for more research in this important area...
  19. doi request reprint Impact of feedback from pharmacists in reducing antipsychotic polypharmacy in schizophrenia
    Monica Hazra
    Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Psychiatry Clin Neurosci 65:676-8. 2011
    ..A three-fold decrease in the prevalence of antipsychotic polypharmacy was observed between 2006 (18.3%) and 2008 (6.6%). Thus, active monitoring of prescriptions with educational interventions could reduce antipsychotic polypharmacy...
  20. ncbi request reprint Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Positron Emission Tomography Centre, Ontario, Canada
    J Clin Psychiatry 70:397-405. 2009
    ....
  21. ncbi request reprint Predicting hospital length of stay for geriatric patients with mood disorders
    Zahinoor Ismail
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Can J Psychiatry 57:696-703. 2012
    ..To determine predictors of hospital length of stay (LOS) for adult and geriatric patients with mood disorders admitted to inpatient psychiatric beds...
  22. doi request reprint Clozapine exposure and the impact of smoking and gender: a population pharmacokinetic study
    Wenzie Ng
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario M5T 1R8, Canada
    Ther Drug Monit 31:360-6. 2009
    ..These findings may account for some of the variability in clozapine exposure and have important implications for individualized drug dosing and therapeutic drug monitoring...
  23. doi request reprint An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP
    Erik M van Oosten
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
    Appl Radiat Isot 67:611-6. 2009
    ..This methodology offers higher yields, faster synthesis times, an optimized precursor, and simpler automation than previously reported...
  24. ncbi request reprint Are antipsychotic prescribing patterns different in older and younger adults?: a survey of 1357 psychiatric inpatients in Toronto
    Beth A Sproule
    Centre for Addiction and Mental Health, Toronto, Ontario
    Can J Psychiatry 55:248-54. 2010
    ..To compare antipsychotic prescribing patterns in younger (aged 59 years or younger) and older (aged 60 years or older) patients with psychotic or mood disorders...
  25. ncbi request reprint The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disorders
    Romina Mizrahi
    CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Schizophr Res 88:111-8. 2006
    ....
  26. doi request reprint Sensitivity to antipsychotic drugs in older adults
    Chloe Leon
    Centre for Addiction and Mental Health, Multimodal Imaging Group, PET Centre, 250 College Street, Toronto, ON M5T1R8, Canada
    Curr Psychiatry Rep 12:28-33. 2010
    ..Implications of recent research findings for individualized pharmacotherapy are discussed...
  27. ncbi request reprint Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia
    Ofer Agid
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1209-15. 2007
    ....
  28. doi request reprint Predicting plasma concentration of risperidone associated with dosage change: a population pharmacokinetic study
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
    Ther Drug Monit 34:182-7. 2012
    ..Using population pharmacokinetic methods, the authors therefore sought to predict plasma concentrations of risperidone (RIS) plus 9-hydroxyrisperidone (9-OH-RIS) before a dosage change...
  29. doi request reprint Dosing of antipsychotics in schizophrenia across the life-spectrum
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, PET Centre, Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 33:917-20. 2009
    ..This age-related antipsychotic sensitivity highlights the importance of finding the lowest possible effective dose of antipsychotic drugs as patients age to enhance therapeutic effects as well as minimize their side effects...
  30. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
    ..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease...
  31. ncbi request reprint A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone
    Gary Remington
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 163:396-401. 2006
    ..The present study used positron emission tomography (PET) to evaluate its dopamine D(2) binding profile at doses of 25, 50, or 75 mg administered every 2 weeks...
  32. pmc Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    BMC Med Imaging 9:12. 2009
    ..Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart...
  33. ncbi request reprint D2 receptor occupancy of olanzapine pamoate depot using positron emission tomography: an open-label study in patients with schizophrenia
    David Mamo
    Center for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 33:298-304. 2008
    ..However, supplemental oral olanzapine or another dosing strategy may be necessary to maintain adequate therapeutic response during the first few injection cycles...
  34. ncbi request reprint EMD 281014, a specific and potent 5HT2 antagonist in humans: a dose-finding PET study
    David Mamo
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Psychopharmacology (Berl) 175:382-8. 2004
    ..The data suggest that daily dosing of > or =3 mg EMD 281014 should be sufficient to provide sustained high levels of 5HT2-receptor occupancy in future clinical trials...
  35. ncbi request reprint Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosine
    David Mamo
    Department of Psychiatry, University of Toronto, Canada
    Synapse 52:153-62. 2004
    ..Our results suggest that 6-[18F]-L-m-tyrosine PET may not be a useful tool in the study of the effect of antipsychotics on dopamine synthesis in human subjects...
  36. doi request reprint The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics
    Romina Mizrahi
    Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
    Int J Neuropsychopharmacol 12:715-21. 2009
    ..90 (S.D.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA D2 occupancy (82-99%), in contrast to the effects of antagonist antipsychotics on subjective well-being...
  37. ncbi request reprint Half a century of antipsychotics and still a central role for dopamine D2 receptors
    Shitij Kapur
    Schizophrenia Program, CAMH, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1081-90. 2003
    ..g., positive, negative, cognitive, and affective) that can be flexibly used and titrated in the service of patients' presenting psychopathology...
  38. pmc The intersection of pharmacology, imaging, and genetics in the development of personalized medicine
    Philip Gerretsen
    Centre for Addiction and Mental Health, University of Toronto, Canada
    Dialogues Clin Neurosci 11:363-76. 2009
    ..In this review we discuss the most promising markers of treatment response and adverse effects emerging from the areas of pharmacogenetics and neuroimaging in depression and schizophrenia...
  39. doi request reprint Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [(18)F]setoperone PET study
    Philip Gerretsen
    University of Toronto, Toronto, Canada
    Soc Neurosci 5:375-83. 2010
    ..501, p = .017). These correlations were corroborated by a voxel-wise analysis. These results suggest that the serotonergic system may have a regulatory effect on the OFC and ACC for establishing and maintaining social relationships...
  40. ncbi request reprint An automated method for the extraction of regional data from PET images
    Pablo Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychiatry Res 147:79-89. 2006
    ....
  41. doi request reprint Adjunctive versus monotherapeutic treatment for schizophrenia: addressing antipsychotic side effects
    Monica Hazra
    Am J Psychiatry 165:396-7; author reply 397-8. 2008

Research Grants1

  1. Optimal Dosing of Antipsychotic Drugs in Late Life
    David Mamo; Fiscal Year: 2010
    ..Studying the extent of antipsychotic drug binding to brain receptors using positron emission tomography (PET) will allow for the prediction of the lowest effective dose required to maintain wellness in older patients. ..