Research Topics
| David C MamoSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
Research Grants
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Detail Information
Publications
The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disordersDavid C Mamo
Centre for Addiction and Mental Health, Toronto, Canada
Int J Geriatr Psychiatry 17:1012-7. 2002..CONCLUSION: The results of this study highlight the need for prospective assessments of depot neuroleptic dose requirements in older patients suffering from primary psychotic disorders...- Quetiapine extended-release versus immediate-release formulation: a positron emission tomography studyDavid C Mamo
Centre for Addiction and Mental Health, PET Centre, Toronto, Ontario, Canada
J Clin Psychiatry 69:81-6. 2008..An extended-release (XR) formulation of quetiapine is currently being developed to achieve similar efficacy using a once-daily dosing regimen. We compared the central D(2) receptor binding between the IR and XR formulations... 
Effects of age and age of onset on prescribed antipsychotic dose in schizophrenia spectrum disorders: a survey of 1,418 patients in JapanHiroyuki Uchida
Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan
Am J Geriatr Psychiatry 16:584-93. 2008..The objective of this study was to better evaluate these age effects on antipsychotic dose prescribed in these patients across a broad age range...- Monthly administration of long-acting injectable risperidone and striatal dopamine D2 receptor occupancy for the management of schizophreniaHiroyuki Uchida
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Clin Psychiatry 69:1281-6. 2008..The objective of this positron emission tomography (PET) study was to examine the striatal dopamine D(2) binding of long-acting risperidone administered intramuscularly once a month... - Managing suicidality in schizophreniaDavid C Mamo
Centre for Addiction and Mental Health, Assisstant Professor of Psychiatry, University of Toronto, Ontario
Can J Psychiatry 52:59S-70S. 2007..The primary objective of this review article is to provide a coherent, systematic synthesis of the literature on the management of suicidality in schizophrenia that is relevant to the front-line clinician... - Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET studyDavid Mamo
Department of Psychiatry, University of Toronto, Toronto, Canada
Am J Psychiatry 164:1411-7. 2007..The authors conducted a positron emission tomography (PET) study to characterize the simultaneous effects of aripiprazole at the D(2), 5-HT(2), and 5-HT(1A) receptors in patients with schizophrenia or schizoaffective disorder... - Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanismsHiroyuki Uchida
Schizophrenia Research Group, PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 17:255-63. 2009..The objective of this study was to examine whether this sensitivity is due to a central pharmacokinetic (i.e., higher occupancy for a given plasma level) or pharmacodynamic (i.e., greater functional effects for a given occupancy) effect... - Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophreniaZahinoor Ismail
Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 20:53-60. 2012..The objective of this study was to assess the magnitude and variability of plasma concentrations of clozapine and norclozapine across the lifespan in a real-world clinical setting... - Clozapine and global cognition in schizophreniaTarek K Rajji
Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Canada
J Clin Psychopharmacol 30:431-6. 2010..The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies... - Time course of improvement with antipsychotic medication in treatment-resistant schizophreniaTakefumi Suzuki
Centre for Addiction and Mental Health, Geriatric Mental Health Program and Multimodal Imaging Group, and Department of Psychiatry, University of Toronto, Ontario, Canada, and Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
Br J Psychiatry 199:275-80. 2011..Improvements are greatest in the earlier weeks of antipsychotic treatment of patients with non-resistant schizophrenia... - D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophreniaHiroyuki Uchida
PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Clin Psychopharmacol 29:571-5. 2009.... - Long-term stability of measuring D(2) receptors in schizophrenia patients treated with antipsychoticsHiroyuki Uchida
PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8
Schizophr Res 109:130-3. 2009.... - Cholinergic pathways and cognition in patients with schizophrenia: a pilot studyTarek K Rajji
Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 139:46-52. 2012..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia... - Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophreniaRomina Mizrahi
Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
Am J Psychiatry 164:630-7. 2007..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience... - Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume correctionsHiroyuki Uchida
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Int J Geriatr Psychiatry 26:1300-8. 2011.... - Treatment resistant schizophrenia and response to antipsychotics: a reviewTakefumi Suzuki
Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
Schizophr Res 133:54-62. 2011..There remains a lack of agreement regarding criteria for treatment-resistant schizophrenia (TRS) and definition of response... - A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidoneDavid Mamo
Department of Psychiatry, University of Toronto, Montreal, Canada
Am J Psychiatry 161:818-25. 2004.... - Management of schizophrenia in late life with antipsychotic medications: a qualitative reviewTakefumi Suzuki
Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, ON, Canada
Drugs Aging 28:961-80. 2011..However, data on geriatric patients with schizophrenia are generally scarce, particularly for treatment-resistant subpopulations, underscoring the need for more research in this important area... - Impact of feedback from pharmacists in reducing antipsychotic polypharmacy in schizophreniaMonica Hazra
Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
Psychiatry Clin Neurosci 65:676-8. 2011..A three-fold decrease in the prevalence of antipsychotic polypharmacy was observed between 2006 (18.3%) and 2008 (6.6%). Thus, active monitoring of prescriptions with educational interventions could reduce antipsychotic polypharmacy... - Increased antipsychotic sensitivity in elderly patients: evidence and mechanismsHiroyuki Uchida
Centre for Addiction and Mental Health, Positron Emission Tomography Centre, Ontario, Canada
J Clin Psychiatry 70:397-405. 2009.... - Predicting hospital length of stay for geriatric patients with mood disordersZahinoor Ismail
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Can J Psychiatry 57:696-703. 2012..To determine predictors of hospital length of stay (LOS) for adult and geriatric patients with mood disorders admitted to inpatient psychiatric beds... - Clozapine exposure and the impact of smoking and gender: a population pharmacokinetic studyWenzie Ng
Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario M5T 1R8, Canada
Ther Drug Monit 31:360-6. 2009..These findings may account for some of the variability in clozapine exposure and have important implications for individualized drug dosing and therapeutic drug monitoring... - An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTPErik M van Oosten
Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
Appl Radiat Isot 67:611-6. 2009..This methodology offers higher yields, faster synthesis times, an optimized precursor, and simpler automation than previously reported... - Are antipsychotic prescribing patterns different in older and younger adults?: a survey of 1357 psychiatric inpatients in TorontoBeth A Sproule
Centre for Addiction and Mental Health, Toronto, Ontario
Can J Psychiatry 55:248-54. 2010..To compare antipsychotic prescribing patterns in younger (aged 59 years or younger) and older (aged 60 years or older) patients with psychotic or mood disorders... - The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disordersRomina Mizrahi
CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Schizophr Res 88:111-8. 2006.... - Sensitivity to antipsychotic drugs in older adultsChloe Leon
Centre for Addiction and Mental Health, Multimodal Imaging Group, PET Centre, 250 College Street, Toronto, ON M5T1R8, Canada
Curr Psychiatry Rep 12:28-33. 2010..Implications of recent research findings for individualized pharmacotherapy are discussed... - Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophreniaOfer Agid
Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 32:1209-15. 2007.... - Predicting plasma concentration of risperidone associated with dosage change: a population pharmacokinetic studyHiroyuki Uchida
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
Ther Drug Monit 34:182-7. 2012..Using population pharmacokinetic methods, the authors therefore sought to predict plasma concentrations of risperidone (RIS) plus 9-hydroxyrisperidone (9-OH-RIS) before a dosage change... - Dosing of antipsychotics in schizophrenia across the life-spectrumHiroyuki Uchida
Centre for Addiction and Mental Health, PET Centre, Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, Canada
Prog Neuropsychopharmacol Biol Psychiatry 33:917-20. 2009..This age-related antipsychotic sensitivity highlights the importance of finding the lowest possible effective dose of antipsychotic drugs as patients age to enhance therapeutic effects as well as minimize their side effects... - Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humansAriel Graff-Guerrero
PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Hum Brain Mapp 29:400-10. 2008..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease... - A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidoneGary Remington
Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ont M5T 1R8, Canada
Am J Psychiatry 163:396-401. 2006..The present study used positron emission tomography (PET) to evaluate its dopamine D(2) binding profile at doses of 25, 50, or 75 mg administered every 2 weeks... 
Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adultsTiffany W Chow
The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
BMC Med Imaging 9:12. 2009..Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart...- D2 receptor occupancy of olanzapine pamoate depot using positron emission tomography: an open-label study in patients with schizophreniaDavid Mamo
Center for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 33:298-304. 2008..However, supplemental oral olanzapine or another dosing strategy may be necessary to maintain adequate therapeutic response during the first few injection cycles... - EMD 281014, a specific and potent 5HT2 antagonist in humans: a dose-finding PET studyDavid Mamo
Department of Psychiatry, University of Toronto, Toronto, Canada
Psychopharmacology (Berl) 175:382-8. 2004..The data suggest that daily dosing of > or =3 mg EMD 281014 should be sufficient to provide sustained high levels of 5HT2-receptor occupancy in future clinical trials... - Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosineDavid Mamo
Department of Psychiatry, University of Toronto, Canada
Synapse 52:153-62. 2004..Our results suggest that 6-[18F]-L-m-tyrosine PET may not be a useful tool in the study of the effect of antipsychotics on dopamine synthesis in human subjects... - The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychoticsRomina Mizrahi
Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
Int J Neuropsychopharmacol 12:715-21. 2009..90 (S.D.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA D2 occupancy (82-99%), in contrast to the effects of antagonist antipsychotics on subjective well-being... - Half a century of antipsychotics and still a central role for dopamine D2 receptorsShitij Kapur
Schizophrenia Program, CAMH, Toronto, ON, Canada
Prog Neuropsychopharmacol Biol Psychiatry 27:1081-90. 2003..g., positive, negative, cognitive, and affective) that can be flexibly used and titrated in the service of patients' presenting psychopathology... - The intersection of pharmacology, imaging, and genetics in the development of personalized medicinePhilip Gerretsen
Centre for Addiction and Mental Health, University of Toronto, Canada
Dialogues Clin Neurosci 11:363-76. 2009..In this review we discuss the most promising markers of treatment response and adverse effects emerging from the areas of pharmacogenetics and neuroimaging in depression and schizophrenia... - Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [(18)F]setoperone PET studyPhilip Gerretsen
University of Toronto, Toronto, Canada
Soc Neurosci 5:375-83. 2010..501, p = .017). These correlations were corroborated by a voxel-wise analysis. These results suggest that the serotonergic system may have a regulatory effect on the OFC and ACC for establishing and maintaining social relationships... - An automated method for the extraction of regional data from PET imagesPablo Rusjan
PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
Psychiatry Res 147:79-89. 2006.... - Adjunctive versus monotherapeutic treatment for schizophrenia: addressing antipsychotic side effectsMonica Hazra
Am J Psychiatry 165:396-7; author reply 397-8. 2008
Research Grants
- Optimal Dosing of Antipsychotic Drugs in Late LifeDavid Mamo; Fiscal Year: 2010..Studying the extent of antipsychotic drug binding to brain receptors using positron emission tomography (PET) will allow for the prediction of the lowest effective dose required to maintain wellness in older patients. ..