R D Levitan

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. pmc Low-dose dexamethasone challenge in women with atypical major depression: pilot study
    Robert D Levitan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:47-51. 2002
  2. doi request reprint Obesity comorbidity in unipolar major depressive disorder: refining the core phenotype
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Canada
    J Clin Psychiatry 73:1119-24. 2012
  3. ncbi request reprint A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis
    Robert D Levitan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 31:2498-503. 2006
  4. pmc The chronobiology and neurobiology of winter seasonal affective disorder
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Canada
    Dialogues Clin Neurosci 9:315-24. 2007
  5. ncbi request reprint The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: an evolutionary perspective
    Robert D Levitan
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, 250 College Street, Room 1126, Toronto, Ontario M5T 1R8, Canada
    Biol Psychiatry 56:665-9. 2004
  6. pmc A season-of-birth/DRD4 interaction predicts maximal body mass index in women with bulimia nervosa
    Robert D Levitan
    Mood and Anxiety Division, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 35:1729-33. 2010
  7. doi request reprint A novel examination of atypical major depressive disorder based on attachment theory
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Mood and Anxiety Division, Centre for Addiction and Mental Health, c o CAMH, Toronto, Ontario, Canada
    J Clin Psychiatry 70:879-87. 2009
  8. ncbi request reprint Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
  9. ncbi request reprint The serotonin-1Dbeta receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa
    R D Levitan
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Canada
    Eur Neuropsychopharmacol 16:1-6. 2006
  10. ncbi request reprint Childhood adversities associated with major depression and/or anxiety disorders in a community sample of Ontario: issues of co-morbidity and specificity
    Robert D Levitan
    Clarke Division of the Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Depress Anxiety 17:34-42. 2003

Detail Information

Publications50

  1. pmc Low-dose dexamethasone challenge in women with atypical major depression: pilot study
    Robert D Levitan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 27:47-51. 2002
    ..To examine if atypical depression may be associated with hypersuppression of the hypothalamic-pituitary-adrenal (HPA) axis...
  2. doi request reprint Obesity comorbidity in unipolar major depressive disorder: refining the core phenotype
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Canada
    J Clin Psychiatry 73:1119-24. 2012
    ....
  3. ncbi request reprint A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis
    Robert D Levitan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 31:2498-503. 2006
    ..We speculate that these data may reflect the vestigial expression of a seasonal thrifty phenotype that contributed to the positive selection of the 7R allele over the past 40,000 years...
  4. pmc The chronobiology and neurobiology of winter seasonal affective disorder
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Canada
    Dialogues Clin Neurosci 9:315-24. 2007
    ..Models of SAD that emphasize its potential role in human evolution will also be discussed...
  5. ncbi request reprint The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: an evolutionary perspective
    Robert D Levitan
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, 250 College Street, Room 1126, Toronto, Ontario M5T 1R8, Canada
    Biol Psychiatry 56:665-9. 2004
    ..In this study, we examined whether binge eating behavior mediated this putative association...
  6. pmc A season-of-birth/DRD4 interaction predicts maximal body mass index in women with bulimia nervosa
    Robert D Levitan
    Mood and Anxiety Division, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 35:1729-33. 2010
    ..9 vs 8.8%, respectively, p=0.008). These data offer further evidence that season of birth interacts with the 7R allele of DRD4 to influence body weight regulation in female overeating populations...
  7. doi request reprint A novel examination of atypical major depressive disorder based on attachment theory
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Mood and Anxiety Division, Centre for Addiction and Mental Health, c o CAMH, Toronto, Ontario, Canada
    J Clin Psychiatry 70:879-87. 2009
    ..As gender has been an important consideration in prior work on atypical depression, this same hypothesis was further tested in female subjects only...
  8. ncbi request reprint Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
    ....
  9. ncbi request reprint The serotonin-1Dbeta receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa
    R D Levitan
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Canada
    Eur Neuropsychopharmacol 16:1-6. 2006
    ..We thus hypothesized that, among a heterogenous group of probands with bulimia nervosa (BN), this same G allele might predict the presence and/or severity of OCD pathology...
  10. ncbi request reprint Childhood adversities associated with major depression and/or anxiety disorders in a community sample of Ontario: issues of co-morbidity and specificity
    Robert D Levitan
    Clarke Division of the Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Depress Anxiety 17:34-42. 2003
    ..A particularly strong association between early sexual abuse and co-morbid depression/anxiety was found...
  11. pmc Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects
    R D Levitan
    Clarke Division, Centre for Addiction and Mental Health, Toronto, Ont
    J Psychiatry Neurosci 25:337-46. 2000
    ....
  12. ncbi request reprint Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder
    R D Levitan
    Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    J Affect Disord 71:229-33. 2002
    ..The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD...
  13. ncbi request reprint Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa
    R D Levitan
    Depression Clinic, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    Biol Psychiatry 50:640-3. 2001
    ..In the current study, we examined whether genetic variation of the serotonin-1B receptor was associated with minimum and maximum lifetime body mass indices (BMIs) in a sample of women with bulimia nervosa (BN)...
  14. doi request reprint Opiates, overeating and obesity: a psychogenetic analysis
    C Davis
    Kinesiology and Health Sciences, Faculty of Health Sciences, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Int J Obes (Lond) 35:1347-54. 2011
    ..We also anticipated that these food preferences would be positively associated with binge eating, hedonic eating and emotionally driven eating-patterns of overeating that would, in turn, predict higher body mass index (BMI)...
  15. ncbi request reprint Rumination and distraction in major depression: assessing response to pharmacological treatment
    R M Bagby
    Department of Psychiatry, University of Toronto, Canada
    J Affect Disord 55:225-9. 1999
    ..RST has been shown to predict prolonged depression in samples of non-clinical, untreated individuals with mild to moderate depression but has not been tested in samples of depressed patients undergoing treatment...
  16. ncbi request reprint The role of depression and childhood trauma on cortisol suppression in women with bulimia nervosa: a pilot study
    Z Yilmaz
    Institute of Medical Science, University of Toronto, and Clinical Research Department, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Eat Weight Disord 17:e17-21. 2012
    ..The purpose of this pilot study is to explore the role of current vs behaviorally recovered BN, as well as depression and childhood trauma in cortisol suppression in BN...
  17. ncbi request reprint Reversed neurovegetative symptoms of depression: a community study of Ontario
    R D Levitan
    Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 154:934-40. 1997
    ..The goal of this study was to delineate the epidemiology of reversed symptoms in a large community sample and to use other symptom patterns for comparison...
  18. ncbi request reprint Self-report ratings and informants' ratings of personalities of depressed outpatients
    R M Bagby
    Section on Personality and Psychopathology, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 155:437-8. 1998
    ..This study sought to determine whether personality traits of depressed patients could be assessed similarly by informants and self-reports of the patients themselves...
  19. ncbi request reprint Personality and eating behaviors: a case-control study of binge eating disorder
    Caroline Davis
    York University, Toronto, Canada
    Int J Eat Disord 41:243-50. 2008
    ..Our purpose was to ascertain whether BED individuals differed in important ways from nonbinging obese adults...
  20. doi request reprint Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder
    Caroline Davis
    Kinesiology and Health Sciences, York University, Toronto, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 32:620-8. 2008
    ..The present study addressed this issue by implementing psychological and biological markers of reward sensitivity in the assessment protocol...
  21. ncbi request reprint Psychic and somatic anxiety differentially predict response to light therapy in women with seasonal affective disorder
    Bronwyn Mackenzie
    Centre for Addiction and Mental Health and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Affect Disord 88:163-6. 2005
    ..To examine whether psychic and/or somatic anxiety predict responsiveness to light therapy in women with winter Seasonal Affective Disorder (SAD)...
  22. ncbi request reprint Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificity
    R M Bagby
    Department of Psychiatry, University of Toronto and McMaster University Medical School, Ontario, Canada
    Psychiatry Res 86:211-6. 1999
    ....
  23. doi request reprint A psycho-genetic study of associations between the symptoms of binge eating disorder and those of attention deficit (hyperactivity) disorder
    Caroline Davis
    Faculty of Health Sciences, York University, Centre for Addiction and Mental Health, 343 Bethune College, 4700 Keele Street, Toronto, ON, Canada
    J Psychiatr Res 43:687-96. 2009
    ..We also assessed the role of the dopamine D3 receptor in ADHD symptoms since the DRD3 gene has been associated with impulsivity and drug addiction - both relevant features of ADHD...
  24. ncbi request reprint A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosa
    Allan S Kaplan
    Eating Disorders Program, Toronto General Hospital, Toronto, Canada
    Int J Eat Disord 41:22-8. 2008
    ....
  25. doi request reprint Sex differences in hormonal responses to a social stressor in chronic major depression
    Kevin K Chopra
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychoneuroendocrinology 34:1235-41. 2009
    ..The current study evaluated cortisol stress responses to a social challenge in chronic major depressive disorder (CMDD)...
  26. ncbi request reprint A dimensional approach to personality in atypical depression
    Kevin K Chopra
    Department of Psychiatry, University of Toronto, c o CAMH Room 1121, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Psychiatry Res 134:161-7. 2005
    ..In sum, the FFM provides a new understanding of which unique personality characteristics may be associated with atypical depression...
  27. ncbi request reprint Personality and seasonal affective disorder: results from the CAN-SAD study
    Murray W Enns
    Department of Psychiatry, University of Manitoba, Canada
    J Affect Disord 93:35-42. 2006
    ..The present study investigated the relationship between the five-factor model of personality (neuroticism, extraversion, openness, agreeableness, conscientiousness) and SAD...
  28. pmc Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression
    Zindel V Segal
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Arch Gen Psychiatry 67:1256-64. 2010
    ..Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse...
  29. ncbi request reprint Symptoms of attention deficit hyperactivity disorder in severely obese women
    J P Fleming
    University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    Eat Weight Disord 10:e10-3. 2005
    ..Past and current symptoms of Attention Deficit Hyperactivity Disorder (ADHD) were assessed in a clinical sample of severely obese females...
  30. doi request reprint Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eating
    Caroline A Davis
    Department of Kinesiology and Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada
    Obesity (Silver Spring) 17:1220-5. 2009
    ....
  31. ncbi request reprint Lifetime rates of alcoholism in adults with anxiety, depression, or co-morbid depression/anxiety: a community survey of Ontario
    David Gratzer
    Centre for Addiction and Mental Health and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Affect Disord 79:209-15. 2004
    ..In the current study we examined the possible confounding and/or additive effects of co-morbid depression/anxiety in understanding these relationships...
  32. ncbi request reprint An open trial of light therapy in adult attention-deficit/hyperactivity disorder
    Yuri E Rybak
    Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychiatry 67:1527-35. 2006
    ..This study examined whether a chronobiologically based treatment, i.e., morning bright light therapy (LT), might have utility as an adjunctive treatment for adult ADHD in the fall/ winter period...
  33. ncbi request reprint Associations among overeating, overweight, and attention deficit/hyperactivity disorder: a structural equation modelling approach
    Caroline Davis
    Departments of Kinesiology and Health Science and Psychology, Bethune College, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3
    Eat Behav 7:266-74. 2006
    ..Some recent studies have reported strong links between obesity and ADHD in adults; however, to date, little work has focussed on possible behavioural mechanisms that could account for this association...
  34. ncbi request reprint Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trial
    Sidney H Kennedy
    University of Toronto, The University Health Network, Toronto, Ontario, Canada
    J Clin Psychiatry 64:439-44. 2003
    ..Despite increasing evidence that full symptomatic remission is the optimal goal of antidepressant therapy, there have been few comparisons between disparate treatment approaches to achieve this goal...
  35. ncbi request reprint Investigating associations between cortisol and cognitive reactivity to sad mood provocation and the prediction of relapse in remitted major depression
    K K Chopra
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Centre for Addiction and Mental Health, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Asian J Psychiatr 1:33-6. 2008
    ..The current analysis examined whether salivary cortisol levels could also predict relapse in these same individuals...
  36. ncbi request reprint Seasonality and circadian preference in adult attention-deficit/hyperactivity disorder: clinical and neuropsychological correlates
    Yuri E Rybak
    Mood and Anxiety Division of the Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, M5T 1R8 Canada
    Compr Psychiatry 48:562-71. 2007
    ..The objective of the study was to measure both seasonal mood change and circadian preference, and their clinical and neuropsychological correlates, in adults with ADHD during the fall/winter months...
  37. doi request reprint Dopamine receptors D1 and D2 are related to observed maternal behavior
    V Mileva-Seitz
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Genes Brain Behav 11:684-94. 2012
    ..The findings also highlight the importance of exploring multiple dimensions of the complex human mothering phenotype...
  38. ncbi request reprint Seasonality and seasonal affective disorder (SAD): an evolutionary viewpoint tied to energy conservation and reproductive cycles
    Caroline Davis
    York University, 343 Bethune College, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
    J Affect Disord 87:3-10. 2005
    ..The adaptive value of such a pattern, and its putative role in natural selection in humans, is also discussed...
  39. ncbi request reprint A naturalistic visual scanning approach to assess selective attention in major depressive disorder
    Moshe Eizenman
    Department of Electrical and Computer Engineering, 4 Taddle Creek Rd, Rosebrugh Building, Room 407, Toronto, Ont, M5S 3G9 Canada
    Psychiatry Res 118:117-28. 2003
    ..The above results suggest that subjects with depressive disorder selectively attend to mood-congruent material and that depression appears to influence the elaborative stages of processing when dysphoric images are viewed...
  40. ncbi request reprint Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD study
    Erin E Michalak
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychol Med 37:727-36. 2007
    ..We report here on results from the Can-SAD trial, which assessed the impact of treatment with either antidepressant medication or light therapy upon QoL in patients diagnosed with SAD...
  41. ncbi request reprint Decision-making deficits and overeating: a risk model for obesity
    Caroline Davis
    York University, 343 Bethune College, 4700 Keele Street, Toronto, ON M3J 1P3, Canada
    Obes Res 12:929-35. 2004
    ..That is, they choose immediate rewards in the face of future long-term negative consequences...
  42. pmc The effects of nefazodone on women with seasonal affective disorder: clinical and polysomnographic analyses
    Jianhua Shen
    Department of Psychiatry, University of Toronto, University Health Network, Toronto, ON
    J Psychiatry Neurosci 30:11-6. 2005
    ..To outline the clinical and polysomnographic changes induced by nefazodone in patients with seasonal affective disorder...
  43. ncbi request reprint Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case-control study of binge eating disorder
    Caroline Davis
    Department of Kinesiology and Health Sciences, York University, Toronto, ON, Canada
    Neuropsychopharmacology 32:2199-206. 2007
    ..The current findings have implications for treatment response to drugs currently in use (or being developed) for the treatment of overeating and overweight...
  44. pmc What is the optimal implementation of bright light therapy for seasonal affective disorder (SAD)?
    Robert D Levitan
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 30:72. 2005
  45. ncbi request reprint Therapeutic mechanism in seasonal affective disorder: do fluoxetine and light operate through advancing circadian phase?
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
    Chronobiol Int 22:937-43. 2005
    ..The study therefore provides no evidence that circadian phase advance mediates the therapeutic mechanism in patients with SAD. Findings are discussed in terms of the limitations of the circadian measures employed...
  46. ncbi request reprint The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder
    Raymond W Lam
    Mood Disorders Centre, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
    Am J Psychiatry 163:805-12. 2006
    ..This study compared the effectiveness of light therapy and an antidepressant within a single trial...
  47. ncbi request reprint Do adverse life events trigger atypical symptoms?
    Robert D Levitan
    Am J Psychiatry 165:533; author reply 533-4. 2008
  48. ncbi request reprint Quality of life in patients with seasonal affective disorder: summer vs winter scores
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:292-5. 2005
    ..To compare perceived quality of life (QoL) in patients diagnosed with seasonal affective disorder (SAD) during the winter and summer months...
  49. ncbi request reprint O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleep
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, PO Box 218 John St, Hawthorn 3122 Melbourne, Victoria, Australia
    J Affect Disord 90:227-31. 2006
    ..Findings are discussed in terms of the study's limitations and the experimental challenge of parsing independent and interacting contributions of sleep and circadian phase...
  50. ncbi request reprint Hard times and good friends: negative life events and social support in patients with seasonal and nonseasonal depression
    Erin E Michalak
    Department of Psychiatry, University of British Columbia UBC Hospital, VCHA, Vancouver, British Columbia
    Can J Psychiatry 49:408-11. 2004
    ..This study aimed to compare baseline levels of negative life events (NLEs) and perceived social support (SS) in patients with seasonal and nonseasonal depression...