Research Topics
Species | R D LevitanSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
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Publications
Low-dose dexamethasone challenge in women with atypical major depression: pilot studyRobert D Levitan
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 27:47-51. 2002..To examine if atypical depression may be associated with hypersuppression of the hypothalamic-pituitary-adrenal (HPA) axis...
Obesity comorbidity in unipolar major depressive disorder: refining the core phenotypeRobert D Levitan
Department of Psychiatry, University of Toronto, Canada
J Clin Psychiatry 73:1119-24. 2012....
A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesisRobert D Levitan
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Neuropsychopharmacology 31:2498-503. 2006..We speculate that these data may reflect the vestigial expression of a seasonal thrifty phenotype that contributed to the positive selection of the 7R allele over the past 40,000 years...- The chronobiology and neurobiology of winter seasonal affective disorderRobert D Levitan
Department of Psychiatry, University of Toronto, Canada
Dialogues Clin Neurosci 9:315-24. 2007..Models of SAD that emphasize its potential role in human evolution will also be discussed... - The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: an evolutionary perspectiveRobert D Levitan
Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, 250 College Street, Room 1126, Toronto, Ontario M5T 1R8, Canada
Biol Psychiatry 56:665-9. 2004..In this study, we examined whether binge eating behavior mediated this putative association... - A season-of-birth/DRD4 interaction predicts maximal body mass index in women with bulimia nervosaRobert D Levitan
Mood and Anxiety Division, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
Neuropsychopharmacology 35:1729-33. 2010..9 vs 8.8%, respectively, p=0.008). These data offer further evidence that season of birth interacts with the 7R allele of DRD4 to influence body weight regulation in female overeating populations... - A novel examination of atypical major depressive disorder based on attachment theoryRobert D Levitan
Department of Psychiatry, University of Toronto, Mood and Anxiety Division, Centre for Addiction and Mental Health, c o CAMH, Toronto, Ontario, Canada
J Clin Psychiatry 70:879-87. 2009..As gender has been an important consideration in prior work on atypical depression, this same hypothesis was further tested in female subjects only... - Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorderR D Levitan
Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
Neuropsychopharmacology 29:179-86. 2004.... - The serotonin-1Dbeta receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosaR D Levitan
Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Canada
Eur Neuropsychopharmacol 16:1-6. 2006..We thus hypothesized that, among a heterogenous group of probands with bulimia nervosa (BN), this same G allele might predict the presence and/or severity of OCD pathology... - Childhood adversities associated with major depression and/or anxiety disorders in a community sample of Ontario: issues of co-morbidity and specificityRobert D Levitan
Clarke Division of the Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Depress Anxiety 17:34-42. 2003..A particularly strong association between early sexual abuse and co-morbid depression/anxiety was found... - Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effectsR D Levitan
Clarke Division, Centre for Addiction and Mental Health, Toronto, Ont
J Psychiatry Neurosci 25:337-46. 2000.... - Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorderR D Levitan
Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
J Affect Disord 71:229-33. 2002..The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD... - Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosaR D Levitan
Depression Clinic, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
Biol Psychiatry 50:640-3. 2001..In the current study, we examined whether genetic variation of the serotonin-1B receptor was associated with minimum and maximum lifetime body mass indices (BMIs) in a sample of women with bulimia nervosa (BN)... - Opiates, overeating and obesity: a psychogenetic analysisC Davis
Kinesiology and Health Sciences, Faculty of Health Sciences, York University, 4700 Keele Street, Toronto, Ontario, Canada
Int J Obes (Lond) 35:1347-54. 2011..We also anticipated that these food preferences would be positively associated with binge eating, hedonic eating and emotionally driven eating-patterns of overeating that would, in turn, predict higher body mass index (BMI)... - Rumination and distraction in major depression: assessing response to pharmacological treatmentR M Bagby
Department of Psychiatry, University of Toronto, Canada
J Affect Disord 55:225-9. 1999..RST has been shown to predict prolonged depression in samples of non-clinical, untreated individuals with mild to moderate depression but has not been tested in samples of depressed patients undergoing treatment... - The role of depression and childhood trauma on cortisol suppression in women with bulimia nervosa: a pilot studyZ Yilmaz
Institute of Medical Science, University of Toronto, and Clinical Research Department, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
Eat Weight Disord 17:e17-21. 2012..The purpose of this pilot study is to explore the role of current vs behaviorally recovered BN, as well as depression and childhood trauma in cortisol suppression in BN... - Reversed neurovegetative symptoms of depression: a community study of OntarioR D Levitan
Clarke Institute of Psychiatry, Toronto, Ont, Canada
Am J Psychiatry 154:934-40. 1997..The goal of this study was to delineate the epidemiology of reversed symptoms in a large community sample and to use other symptom patterns for comparison... - Self-report ratings and informants' ratings of personalities of depressed outpatientsR M Bagby
Section on Personality and Psychopathology, Clarke Institute of Psychiatry, Toronto, Ont, Canada
Am J Psychiatry 155:437-8. 1998..This study sought to determine whether personality traits of depressed patients could be assessed similarly by informants and self-reports of the patients themselves... - Personality and eating behaviors: a case-control study of binge eating disorderCaroline Davis
York University, Toronto, Canada
Int J Eat Disord 41:243-50. 2008..Our purpose was to ascertain whether BED individuals differed in important ways from nonbinging obese adults... - Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorderCaroline Davis
Kinesiology and Health Sciences, York University, Toronto, Canada
Prog Neuropsychopharmacol Biol Psychiatry 32:620-8. 2008..The present study addressed this issue by implementing psychological and biological markers of reward sensitivity in the assessment protocol... - Psychic and somatic anxiety differentially predict response to light therapy in women with seasonal affective disorderBronwyn Mackenzie
Centre for Addiction and Mental Health and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Affect Disord 88:163-6. 2005..These findings may be an important consideration in the design and interpretation of light therapy studies of SAD... - Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificityR M Bagby
Department of Psychiatry, University of Toronto and McMaster University Medical School, Ontario, Canada
Psychiatry Res 86:211-6. 1999.... - A psycho-genetic study of associations between the symptoms of binge eating disorder and those of attention deficit (hyperactivity) disorderCaroline Davis
Faculty of Health Sciences, York University, Centre for Addiction and Mental Health, 343 Bethune College, 4700 Keele Street, Toronto, ON, Canada
J Psychiatr Res 43:687-96. 2009..We also assessed the role of the dopamine D3 receptor in ADHD symptoms since the DRD3 gene has been associated with impulsivity and drug addiction - both relevant features of ADHD... - A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosaAllan S Kaplan
Eating Disorders Program, Toronto General Hospital, Toronto, Canada
Int J Eat Disord 41:22-8. 2008.... - Sex differences in hormonal responses to a social stressor in chronic major depressionKevin K Chopra
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Psychoneuroendocrinology 34:1235-41. 2009..The current study evaluated cortisol stress responses to a social challenge in chronic major depressive disorder (CMDD)... - A dimensional approach to personality in atypical depressionKevin K Chopra
Department of Psychiatry, University of Toronto, c o CAMH Room 1121, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Psychiatry Res 134:161-7. 2005..In sum, the FFM provides a new understanding of which unique personality characteristics may be associated with atypical depression... - Personality and seasonal affective disorder: results from the CAN-SAD studyMurray W Enns
Department of Psychiatry, University of Manitoba, Canada
J Affect Disord 93:35-42. 2006..The present study investigated the relationship between the five-factor model of personality (neuroticism, extraversion, openness, agreeableness, conscientiousness) and SAD... - Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depressionZindel V Segal
Centre for Addiction and Mental Health, Toronto, ON, Canada
Arch Gen Psychiatry 67:1256-64. 2010..Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse... - Symptoms of attention deficit hyperactivity disorder in severely obese womenJ P Fleming
University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
Eat Weight Disord 10:e10-3. 2005..Past and current symptoms of Attention Deficit Hyperactivity Disorder (ADHD) were assessed in a clinical sample of severely obese females... - Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eatingCaroline A Davis
Department of Kinesiology and Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada
Obesity (Silver Spring) 17:1220-5. 2009.... - Lifetime rates of alcoholism in adults with anxiety, depression, or co-morbid depression/anxiety: a community survey of OntarioDavid Gratzer
Centre for Addiction and Mental Health and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Affect Disord 79:209-15. 2004..Furthermore, no single temporal pattern of onset was identified in individuals with all three disorders, suggesting no obvious cause-effect relationship among them... - An open trial of light therapy in adult attention-deficit/hyperactivity disorderYuri E Rybak
Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Clin Psychiatry 67:1527-35. 2006..This study examined whether a chronobiologically based treatment, i.e., morning bright light therapy (LT), might have utility as an adjunctive treatment for adult ADHD in the fall/ winter period... - Associations among overeating, overweight, and attention deficit/hyperactivity disorder: a structural equation modelling approachCaroline Davis
Departments of Kinesiology and Health Science and Psychology, Bethune College, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3
Eat Behav 7:266-74. 2006..Some recent studies have reported strong links between obesity and ADHD in adults; however, to date, little work has focussed on possible behavioural mechanisms that could account for this association... - Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trialSidney H Kennedy
University of Toronto, The University Health Network, Toronto, Ontario, Canada
J Clin Psychiatry 64:439-44. 2003..Despite increasing evidence that full symptomatic remission is the optimal goal of antidepressant therapy, there have been few comparisons between disparate treatment approaches to achieve this goal... - Investigating associations between cortisol and cognitive reactivity to sad mood provocation and the prediction of relapse in remitted major depressionK K Chopra
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Centre for Addiction and Mental Health, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Asian J Psychiatr 1:33-6. 2008..The current analysis examined whether salivary cortisol levels could also predict relapse in these same individuals... - Seasonality and circadian preference in adult attention-deficit/hyperactivity disorder: clinical and neuropsychological correlatesYuri E Rybak
Mood and Anxiety Division of the Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, M5T 1R8 Canada
Compr Psychiatry 48:562-71. 2007..The objective of the study was to measure both seasonal mood change and circadian preference, and their clinical and neuropsychological correlates, in adults with ADHD during the fall/winter months... - Dopamine receptors D1 and D2 are related to observed maternal behaviorV Mileva-Seitz
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Genes Brain Behav 11:684-94. 2012..The findings also highlight the importance of exploring multiple dimensions of the complex human mothering phenotype... - Seasonality and seasonal affective disorder (SAD): an evolutionary viewpoint tied to energy conservation and reproductive cyclesCaroline Davis
York University, 343 Bethune College, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
J Affect Disord 87:3-10. 2005..The adaptive value of such a pattern, and its putative role in natural selection in humans, is also discussed... - A naturalistic visual scanning approach to assess selective attention in major depressive disorderMoshe Eizenman
Department of Electrical and Computer Engineering, 4 Taddle Creek Rd, Rosebrugh Building, Room 407, Toronto, Ont, M5S 3G9 Canada
Psychiatry Res 118:117-28. 2003..The above results suggest that subjects with depressive disorder selectively attend to mood-congruent material and that depression appears to influence the elaborative stages of processing when dysphoric images are viewed... - Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD studyErin E Michalak
Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, Canada
Psychol Med 37:727-36. 2007..We report here on results from the Can-SAD trial, which assessed the impact of treatment with either antidepressant medication or light therapy upon QoL in patients diagnosed with SAD... - Decision-making deficits and overeating: a risk model for obesityCaroline Davis
York University, 343 Bethune College, 4700 Keele Street, Toronto, ON M3J 1P3, Canada
Obes Res 12:929-35. 2004..That is, they choose immediate rewards in the face of future long-term negative consequences... - The effects of nefazodone on women with seasonal affective disorder: clinical and polysomnographic analysesJianhua Shen
Department of Psychiatry, University of Toronto, University Health Network, Toronto, ON
J Psychiatry Neurosci 30:11-6. 2005..To outline the clinical and polysomnographic changes induced by nefazodone in patients with seasonal affective disorder... - Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case-control study of binge eating disorderCaroline Davis
Department of Kinesiology and Health Sciences, York University, Toronto, ON, Canada
Neuropsychopharmacology 32:2199-206. 2007..The current findings have implications for treatment response to drugs currently in use (or being developed) for the treatment of overeating and overweight... - What is the optimal implementation of bright light therapy for seasonal affective disorder (SAD)?Robert D Levitan
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 30:72. 2005 - Therapeutic mechanism in seasonal affective disorder: do fluoxetine and light operate through advancing circadian phase?Greg Murray
Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
Chronobiol Int 22:937-43. 2005..The study therefore provides no evidence that circadian phase advance mediates the therapeutic mechanism in patients with SAD. Findings are discussed in terms of the limitations of the circadian measures employed... - The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorderRaymond W Lam
Mood Disorders Centre, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
Am J Psychiatry 163:805-12. 2006..This study compared the effectiveness of light therapy and an antidepressant within a single trial... - Do adverse life events trigger atypical symptoms?Robert D Levitan
Am J Psychiatry 165:533; author reply 533-4. 2008 - Quality of life in patients with seasonal affective disorder: summer vs winter scoresErin E Michalak
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 50:292-5. 2005..To compare perceived quality of life (QoL) in patients diagnosed with seasonal affective disorder (SAD) during the winter and summer months... - O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleepGreg Murray
Faculty of Life and Social Sciences, Swinburne University of Technology, PO Box 218 John St, Hawthorn 3122 Melbourne, Victoria, Australia
J Affect Disord 90:227-31. 2006..Findings are discussed in terms of the study's limitations and the experimental challenge of parsing independent and interacting contributions of sleep and circadian phase... - Hard times and good friends: negative life events and social support in patients with seasonal and nonseasonal depressionErin E Michalak
Department of Psychiatry, University of British Columbia UBC Hospital, VCHA, Vancouver, British Columbia
Can J Psychiatry 49:408-11. 2004..This study aimed to compare baseline levels of negative life events (NLEs) and perceived social support (SS) in patients with seasonal and nonseasonal depression...