Bernard Le Foll

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Rimonabant, a CB1 antagonist, blocks nicotine-conditioned place preferences
    Bernard Le Foll
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroreport 15:2139-43. 2004
  2. ncbi request reprint Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Pharmacology and Psychiatry, Institutes of Medical Sciences, University of Toronto, Toronto, Canada
    Biol Psychiatry 68:265-71. 2010
  3. pmc Varenicline decreases nicotine self-administration and cue-induced reinstatement of nicotine-seeking behaviour in rats when a long pretreatment time is used
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neuropsychopharmacol 15:1265-74. 2012
  4. pmc Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats
    Bernard Le Foll
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Neurosci Lett 443:236-40. 2008
  5. pmc Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 65:714-6. 2009
  6. ncbi request reprint Dopamine D3 receptor ligands for the treatment of tobacco dependence
    Bernard Le Foll
    Center for Addiction and Mental Health, Department of Family and Community Medicine, Psychiatry and Pharmacology, University of Toronto, 33 Russell Street, Toronto, ON M5S 2S1, Ontario, Canada
    Expert Opin Investig Drugs 16:45-57. 2007
  7. pmc High reinforcing efficacy of nicotine in non-human primates
    Bernard Le Foll
    Preclinical Pharmacology Section, National Institute on Drug Abuse, National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 2:e230. 2007
  8. pmc Treatment of tobacco dependence: integrating recent progress into practice
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
    CMAJ 177:1373-80. 2007
  9. pmc Topiramate does not alter nicotine or cocaine discrimination in rats
    Bernard Le Foll
    Preclinical Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA
    Behav Pharmacol 19:13-20. 2008
  10. pmc Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Addict Biol 13:239-52. 2008

Detail Information

Publications70

  1. ncbi request reprint Rimonabant, a CB1 antagonist, blocks nicotine-conditioned place preferences
    Bernard Le Foll
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroreport 15:2139-43. 2004
    ....
  2. ncbi request reprint Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Pharmacology and Psychiatry, Institutes of Medical Sciences, University of Toronto, Toronto, Canada
    Biol Psychiatry 68:265-71. 2010
    ..However, the effect of an inactivation of this structure in an animal model of nicotine addiction has yet to be evaluated...
  3. pmc Varenicline decreases nicotine self-administration and cue-induced reinstatement of nicotine-seeking behaviour in rats when a long pretreatment time is used
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neuropsychopharmacol 15:1265-74. 2012
    ..The ability of varenicline to reduce both nicotine-taking and nicotine-seeking behaviour can contribute to its relatively high efficacy in treating human smokers...
  4. pmc Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats
    Bernard Le Foll
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Neurosci Lett 443:236-40. 2008
    ..These experiments, along with previous reports that baclofen can reduce intravenous nicotine self-administration behavior, confirm the potential utility of baclofen as a tool for smoking cessation...
  5. pmc Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 65:714-6. 2009
    ..However, no study has been performed evaluating the impact of interindividual differences in midbrain nAChR levels on motivation to self-administer nicotine...
  6. ncbi request reprint Dopamine D3 receptor ligands for the treatment of tobacco dependence
    Bernard Le Foll
    Center for Addiction and Mental Health, Department of Family and Community Medicine, Psychiatry and Pharmacology, University of Toronto, 33 Russell Street, Toronto, ON M5S 2S1, Ontario, Canada
    Expert Opin Investig Drugs 16:45-57. 2007
    ..These preclinical studies suggest that the clinical evaluation of DRD3 ligands should be performed with clinical trials designed specifically to evaluate the relapse phenomena...
  7. pmc High reinforcing efficacy of nicotine in non-human primates
    Bernard Le Foll
    Preclinical Pharmacology Section, National Institute on Drug Abuse, National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 2:e230. 2007
    ..This supports the use of nicotinic ligands for the treatment of smokers, and this novel preclinical model offers opportunities to test future medications for the treatment of nicotine dependence...
  8. pmc Treatment of tobacco dependence: integrating recent progress into practice
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
    CMAJ 177:1373-80. 2007
    ..Specifically, we discuss the use of nicotine replacement therapy, bupropion and varenicline in primary care settings...
  9. pmc Topiramate does not alter nicotine or cocaine discrimination in rats
    Bernard Le Foll
    Preclinical Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA
    Behav Pharmacol 19:13-20. 2008
    ..These experiments indicate that topiramate does not enhance or reduce the ability of rats to discriminate the effects of nicotine or cocaine...
  10. pmc Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Addict Biol 13:239-52. 2008
    ..Rimonabant also appears to decrease relapse rates in smokers. These findings indicate significant, but limited, utility of rimonabant for smoking cessation...
  11. pmc [Future medications for tobacco and cannabis dependence]
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Bull Acad Natl Med 192:45-56; discussion 56-7. 2008
    ..These promising approaches warrant clinical trials in the treatment of tobacco and marijuana dependence...
  12. doi request reprint Genetics of dopamine receptors and drug addiction: a comprehensive review
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Behav Pharmacol 20:1-17. 2009
    ..Overall, this review indicates that different aspects of the addiction phenotype are critically influenced by dopaminergic receptors and that variants of those genes seem to influence some addiction phenotypes in humans...
  13. pmc The future of endocannabinoid-oriented clinical research after CB1 antagonists
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, ON, Canada
    Psychopharmacology (Berl) 205:171-4. 2009
    ..Great interest has been shown by the medical community and the public in the cannabinoid CB(1) receptor antagonists, such as rimonabant, for treatment of obesity, metabolic syndrome, and possibly drug addiction...
  14. pmc The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats
    Maria Scherma
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Br J Pharmacol 165:2539-48. 2012
    ..Since recent evidence indicates that PPAR-α can modulate nicotine reward, it is unclear whether AEA plays a role in the effects of URB597 on nicotine reward...
  15. pmc Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors
    Paola Mascia
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Medications Discovery Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 69:633-41. 2011
    ..Here, we evaluated whether directly acting PPAR-α agonists can modulate reward-related effects of nicotine...
  16. pmc AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada
    J Psychopharmacol 27:564-71. 2013
    ..Our results indicate that AM404 could be a potential promising therapeutic option for the prevention of relapse to nicotine-seeking in abstinent smokers...
  17. pmc Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 35:1751-60. 2010
    ..The findings point to alpha(1) adrenoceptor blockade as a potential new approach to the treatment of tobacco dependence in humans...
  18. doi request reprint Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Canada
    Addict Biol 17:47-61. 2012
    ..Thus, modulating CB1-receptor signalling might have therapeutic value for treating nicotine dependence...
  19. doi request reprint The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking
    Maram A T M Khaled
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neuropsychopharmacol 13:181-90. 2010
    ..These findings validate the role of DRD3 on reactivity to drug-associated stimuli and suggest that the DRD3 antagonist, but perhaps not the DRD3 partial agonist, could be used to prevent relapse in tobacco smokers...
  20. doi request reprint Cannabis use and mental health-related quality of life among individuals with anxiety disorders
    Shaul Lev-Ran
    Social Aetiology of Mental Illness SAMI CIHR Training Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Anxiety Disord 26:799-810. 2012
    ..Out results highlight the importance of taking into account direct functional and emotional outcomes, as well as frequency of cannabis used, when assessing the impact of cannabis use among individuals with anxiety disorders...
  21. pmc Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats
    Yijin Yan
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health Addiction CAMH, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 37:685-96. 2012
    ....
  22. ncbi request reprint Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB(1) receptor blockade
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health CAMH, Toronto, Canada, M5S 2S1
    Psychopharmacology (Berl) 205:613-24. 2009
    ..Therefore, there is a great need to develop alternative ways of modulating the cannabinoid system that will be better tolerated...
  23. doi request reprint Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 25:582-5. 2010
    ..We observed a trend toward association of clozapine response with the rs12467557 (permuted p = 0.051). These results should be read with caution before independent replication...
  24. ncbi request reprint Validation of an extracerebral reference region approach for the quantification of brain nicotinic acetylcholine receptors in squirrel monkeys with PET and 2-18F-fluoro-A-85380
    Bernard Le Foll
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
    J Nucl Med 48:1492-500. 2007
    ..The aim of the present study was to explore the applicability of an extracerebral reference region for the quantification of cerebral receptors with PET...
  25. ncbi request reprint Bipolar disorder and co-occurring cannabis use disorders: characteristics, co-morbidities and clinical correlates
    Shaul Lev-Ran
    Social Aetiology of Mental Illness SAMI CIHR Training Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Psychiatry Res 209:459-65. 2013
    ..Comprehensive evaluation of patients with bipolar disorder should include a systematic assessment of CUD. ..
  26. doi request reprint Cannabis use and cannabis use disorders among individuals with mental illness
    Shaul Lev-Ran
    Social Aetiology of Mental Illness CIHR Training Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Compr Psychiatry 54:589-98. 2013
    ..However, this subject has not been sufficiently investigated, particularly given limitations in diagnostic tools used and lack of data pertaining to frequency of cannabis used...
  27. doi request reprint Analysis of treatment-resistant schizophrenia and 384 markers from candidate genes
    Celine Teo
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Toronto, Canada
    Pharmacogenet Genomics 22:807-11. 2012
    ..However, this phenotype can be assessed retrospectively in cross-sectional studies and these preliminary results point out the importance of choosing alternative phenotypes in psychiatric pharmacogenetics...
  28. pmc Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats
    Maria Scherma
    Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 327:482-90. 2008
    ..These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence...
  29. pmc Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction
    Yijin Yan
    Translational Addiction Research Laboratory, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Behav Brain Res 230:34-9. 2012
    ..Future work will utilize these models to evaluate nicotine-taking and relapsing behavior in genetically-altered mice...
  30. ncbi request reprint Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effects
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:720-30. 2005
    ....
  31. doi request reprint Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia
    Gabriela Novak
    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Ann Hum Genet 74:291-8. 2010
    ..01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour...
  32. pmc The endocannabinoid system: a new molecular target for the treatment of tobacco addiction
    Maria Scherma
    Psychobiology Section, Medications Discovery Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    CNS Neurol Disord Drug Targets 7:468-81. 2008
    ....
  33. pmc The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Br J Pharmacol 164:1652-60. 2011
    ..In this study, we have tested the selective anadamide uptake inhibitor, VDM11, which elevates anandamide levels without affecting levels of OEA/PEA, on nicotine-taking and nicotine-seeking behaviour...
  34. pmc Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    PLoS ONE 7:e29900. 2012
    ..Administration of the CB2 ligands did not affect either nicotine-taking nicotine-seeking behavior. Our results do not support the involvement of CB2 receptors in nicotine-taking or nicotine-seeking behavior...
  35. ncbi request reprint Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Behav Pharmacol 17:195-9. 2006
    ..The present findings suggest, moreover, that nicotine pre-exposure alters the qualitative nature of rewarding effects and accentuates aversive effects of Delta-9-tetrahydrocannabinol...
  36. ncbi request reprint Nicotine as a typical drug of abuse in experimental animals and humans
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 184:367-81. 2006
    ....
  37. pmc Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats
    Zuzana Justinova
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 203:355-67. 2009
    ..Adenosine receptors are involved in cocaine and methamphetamine discrimination and exposure to caffeine can affect behavioral effects of nicotine in rats...
  38. pmc Translational strategies for therapeutic development in nicotine addiction: rethinking the conventional bench to bedside approach
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada Department of Psychiatry and Institute of Medical Sciences, University of Toronto, Toronto, Canada Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 52:86-93. 2014
    ....
  39. pmc Elevation of dopamine induced by cigarette smoking: novel insights from a [(11)C]-(+)-PHNO PET study in humans
    Bernard Le Foll
    1 Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada 3 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada 4 Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada 5 Department of Pharmacology, University of Toronto, Toronto, ON, Canada 6 Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada 7 Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 39:415-24. 2014
    ..We propose that due to the robust effect of smoking on [(11)C]-(+)-PHNO binding, this radiotracer represents an ideal translational tool to investigate novel therapeutic strategies targeting DA transmission. ..
  40. doi request reprint Self-reported psychotic disorders among Individuals with substance use disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Addict 21:531-5. 2012
    ..Most reports to-date focus on the prevalence of SUDs among clinical populations of patients with PDs, and there is a lack of data pertaining to rates of PDs among individuals with substance use and SUDs...
  41. doi request reprint Gender differences in health-related quality of life among cannabis users: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Drug Alcohol Depend 123:190-200. 2012
    ..Cannabis is the most widely used illicit substance worldwide. The aim of the present study was to assess self-reported Quality of Life (QoL) among cannabis users in a large representative sample...
  42. doi request reprint Obesity and cannabis use: results from 2 representative national surveys
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Epidemiol 174:929-33. 2011
    ..Additionally, after adjustment for sex and age, the use of cannabis was associated with body mass index differences in both samples. The authors conclude that the prevalence of obesity is lower in cannabis users than in nonusers...
  43. ncbi request reprint Gender differences in prevalence of substance use disorders among individuals with lifetime exposure to substances: results from a large representative sample
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Addict 22:7-13. 2013
    ..In this study, we explored gender differences in prevalence of SUDs among individuals with lifetime exposure to substances using a single diagnostic category (abuse or dependence)...
  44. pmc The potential role of dopamine D₃ receptor neurotransmission in cognition
    Shinichiro Nakajima
    Multimodal Imaging Group Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Canada M5T 1R8
    Eur Neuropsychopharmacol 23:799-813. 2013
    ..Clinical trials are needed to confirm these effects...
  45. doi request reprint Analysis of CpG SNPs in 34 genes: association test with suicide attempt in schizophrenia
    Ali Bani-Fatemi
    CAMH, Department of Psychiatry, University of Toronto, Canada
    Schizophr Res 147:262-8. 2013
    ..To date, there are no robust genetic or epigenetic predictors of suicide or suicide attempt in this specific population...
  46. pmc Peroxisome proliferator-activated receptor (PPAR) agonists as promising new medications for drug addiction: preclinical evidence
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Curr Drug Targets 14:768-76. 2013
    ..Finally, studies that investigated the effects of PPAR agonists on neural pathways of addiction are reviewed. Taken together these preclinical data indicate that PPAR agonists are promising new medications for drug addiction treatment...
  47. pmc Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors
    Abhiram Pushparaj
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health CAMH, Toronto, ON, Canada
    Neuropsychopharmacology 38:690-8. 2013
    ..Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored...
  48. pmc Presentation of smoking-associated cues does not elicit dopamine release after one-hour smoking abstinence: A [11C]-(+)-PHNO PET study
    Lina Chiuccariello
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    PLoS ONE 8:e60382. 2013
    ....
  49. doi request reprint Exploring the association between lifetime prevalence of mental illness and transition from substance use to substance use disorders: results from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC)
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Addict 22:93-8. 2013
    ..This may be important as increased prevalence of substance use among individuals with MI may partially explain the strong association between SUDs and MI...
  50. ncbi request reprint Pharmacotherapy of alcohol use disorders and concurrent psychiatric disorders: a review
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Can J Psychiatry 57:342-9. 2012
    ..Several prevalent psychiatric disorders have not been studied when co-occurring with AUDs. Further research of pharmacological treatments for concurrent AUDs and psychiatric diagnoses is urgently needed...
  51. pmc Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
    Taryn E Grieder
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 3E1
    Proc Natl Acad Sci U S A 109:3101-6. 2012
    ....
  52. doi request reprint Child marriage in the United States and its association with mental health in women
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pediatrics 128:524-30. 2011
    ..This article presents nationally representative data on the prevalence, sociodemographic correlates, and psychiatric comorbidity of child marriage among women in the United States...
  53. doi request reprint Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia
    Gabriela Novak
    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychiatr Genet 20:39-43. 2010
    ..Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD...
  54. doi request reprint Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity
    Gabriela Novak
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neurosci 120:691-7. 2010
    ..We suggest that nicotine-induced elevation in D2(High) levels could be participating in hypersensitivity to dopamine following nicotine exposure...
  55. ncbi request reprint How generalisable to community samples are clinical trial results for treatment of nicotine dependence: a comparison of common eligibility criteria with respondents of a large representative general population survey
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Tob Control 20:338-43. 2011
    ..To examine the generalisability of findings from clinical trials of individuals with nicotine dependence to a large general population sample...
  56. ncbi request reprint Nicotine induces conditioned place preferences over a large range of doses in rats
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 178:481-92. 2005
    ..Conditioned place preference (CPP) procedures provide one measure of potential rewarding effects of abused drugs. Many attempts to induce CPP with nicotine have been unsuccessful...
  57. ncbi request reprint The dopamine D3 receptor and drug dependence: effects on reward or beyond?
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 49:525-41. 2005
    ..All these findings suggest that DRD3 ligands may represent a useful strategy for decreasing relapse in abstinent drug-abusers...
  58. ncbi request reprint Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence
    Bernard Le Foll
    Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 312:875-83. 2005
    ..Findings from both clinical and preclinical studies suggest that ligands blocking CB(1) receptors offer a novel approach for patients suffering from drug dependence that may be efficacious across different classes of abused drugs...
  59. ncbi request reprint Ethanol does not affect discriminative-stimulus effects of nicotine in rats
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD, USA
    Eur J Pharmacol 519:96-102. 2005
    ....
  60. ncbi request reprint Control of the reinforcing effects of nicotine by associated environmental stimuli in animals and humans
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Trends Pharmacol Sci 26:287-93. 2005
    ..Innovative medications that target cannabinoid CB(1) and dopamine D(3) receptors and might block specifically the influence of such conditioned environmental stimuli in smokers are in development...
  61. doi request reprint Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
    Med Hypotheses 80:564-7. 2013
    ..We therefore propose the seemingly paradoxical hypothesis that THC or a THC/cannabidiol combination drug may produce weight loss and may be a useful therapeutic for the treatment of obesity and its complications...
  62. pmc Extinction bursts in rats trained to self-administer nicotine or food in 1-h daily sessions
    Abhiram Pushparaj
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto, Canada
    Am J Transl Res 4:422-31. 2012
    ..This study supports the presence of a loading phase in rats trained to self-administer nicotine in 1-r daily sessions and the presence of a transient extinction burst...
  63. doi request reprint Association study of BDNF and DRD3 genes in schizophrenia diagnosis using matched case-control and family based study designs
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 34:1412-8. 2010
    ..We did not find a statistically significant association with the other DRD3 and BDNF polymorphisms. Taken together, the results from the present study suggest that BDNF and DRD3 may not be involved in SCZ susceptibility...
  64. doi request reprint Prevalence and correlates of major depressive episode in pregnant and postpartum women in the United States
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Affect Disord 135:128-38. 2011
    ..This study presents nationally representative data on the prevalence, correlates, and psychiatric comorbidities of depression in women during pregnancy and postpartum in the United States...
  65. doi request reprint Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study
    Gabriela Novak
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health and the University of Toronto, Toronto, Ontario, Canada
    World J Biol Psychiatry 10:929-35. 2009
    ....
  66. ncbi request reprint Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice
    Bernard Le Foll
    Unité de Neurobiologie et Pharmacologie Moléculaire INSERM U 573, Centre Paul Broca, 75014 Paris, France
    Eur J Neurosci 15:2016-26. 2002
    ....
  67. ncbi request reprint [Behavioral and cognitive therapy to break the smoking habit. Review of the literature]
    Bernard Le Foll
    Unité de Neurobiologie et Pharmacologie Moléculaire de l INSERM, Centre Paul Broca, 2 ter, rue d Alesia, 75014 Paris, France
    Ann Med Interne (Paris) 153:1S32-40. 2002
    ..This article reviews these techniques and presents the results of a recent meta-analysis evaluating their efficacy. These results confirm the efficacy of behavioral and cognitive therapy in smoking cessation...
  68. ncbi request reprint A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning
    Bernard Le Foll
    Neuroreport 16:175-8. 2005
    ..Nicotine had more limited effects. Abused drugs increase acutely BDNF expression, which leads to subsequent long-lasting elevation of Drd3 in the nucleus accumbens that may facilitate responding to drug-associated stimuli...
  69. ncbi request reprint Increased dopamine D3 receptor expression accompanying behavioral sensitization to nicotine in rats
    Bernard Le Foll
    Unité de Neurobiologie et Pharmacologie Moléculaire INSERM U 573, Centre Paul Broca, 75014 Paris, France
    Synapse 47:176-83. 2003
    ..We propose that a similar mechanism is responsible for behavioral sensitization to nicotine...
  70. ncbi request reprint Gender and stimulus difference in cue-induced responses in abstinent heroin users
    Jiang Yu
    Tangshan Mental Health Hospital, Tangshan, China
    Pharmacol Biochem Behav 86:485-92. 2007
    ..This study examined whether two different stimuli, drug-related imagery scripts and drug-related paraphernalia, produce similar or different patterns of cue reactivity in heroin-dependent men and women...