Ji Hyun Ko

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. pmc Analysis of variance in neuroreceptor ligand imaging studies
    Ji Hyun Ko
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e23298. 2011
  2. pmc Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Hum Brain Mapp 34:1591-604. 2013
  3. doi Pathological gambling in patients with Parkinson's disease is associated with fronto-striatal disconnection: a path modeling analysis
    Roberto Cilia
    Division of Brain, Imaging and Behaviorur Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:225-33. 2011
  4. pmc Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: a [11C] FLB-457 and PET study
    Nicola J Ray
    Morton and Gloria Shulman Movement Disorder Unit and E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Dis 48:519-25. 2012
  5. doi Extrastriatal dopaminergic dysfunction in tourette syndrome
    Thomas D L Steeves
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Neurol 67:170-81. 2010
  6. pmc Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making
    Sang Soo Cho
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada
    Brain Stimul 5:116-23. 2012
  7. doi Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling
    Roberto Cilia
    Toronto Western Research Institute and Hospital, UHN, University of Toronto, Ontario, Canada
    Neurobiol Dis 39:98-104. 2010
  8. pmc Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level
    Sang Soo Cho
    PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Brain Stimul 3:170-6. 2010
  9. ncbi Dopamine-agonists and impulsivity in Parkinson's disease: impulsive choices vs. impulsive actions
    Francesca Antonelli
    Morton and Gloria Shulman Movement Disorder Unit, E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Hum Brain Mapp 35:2499-506. 2014
  10. pmc Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: a [11C]FLB 457 PET study
    Ji Hyun Ko
    PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuroimage 46:516-21. 2009

Collaborators

Detail Information

Publications14

  1. pmc Analysis of variance in neuroreceptor ligand imaging studies
    Ji Hyun Ko
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e23298. 2011
    ..The test will therefore allow us to reliably test hypotheses in the smaller sample sizes often used in explorative PET studies...
  2. pmc Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Hum Brain Mapp 34:1591-604. 2013
    ..These observations provide important insights on the pathophysiology of cognitive dysfunction in PD...
  3. doi Pathological gambling in patients with Parkinson's disease is associated with fronto-striatal disconnection: a path modeling analysis
    Roberto Cilia
    Division of Brain, Imaging and Behaviorur Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:225-33. 2011
    ..Neuroimaging studies have suggested an abnormal dopamine transmission within the reward system, but the changes in the neural network characterizing PD patients with pathological gambling have never been investigated...
  4. pmc Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: a [11C] FLB-457 and PET study
    Nicola J Ray
    Morton and Gloria Shulman Movement Disorder Unit and E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Dis 48:519-25. 2012
    ..Thus, altered striatal and cortical DA homeostasis may incur vulnerability for the development of PG in PD, linked with the impulsive personality trait...
  5. doi Extrastriatal dopaminergic dysfunction in tourette syndrome
    Thomas D L Steeves
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Neurol 67:170-81. 2010
    ..A substantial body of evidence has also accrued to implicate regions outside the striatum in the generation of tics...
  6. pmc Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making
    Sang Soo Cho
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada
    Brain Stimul 5:116-23. 2012
    ..These findings suggest that transcranial magnetic stimulation of the DLPFC influences the neural network underlying impulsive decision making behavior...
  7. doi Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling
    Roberto Cilia
    Toronto Western Research Institute and Hospital, UHN, University of Toronto, Ontario, Canada
    Neurobiol Dis 39:98-104. 2010
    ..The latter hypothesis is most likely given that the functional reduction of presynaptic reuptake would be more consistent with the increased dopamine levels in the ventral striatum recently reported in PD gamblers...
  8. pmc Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level
    Sang Soo Cho
    PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Brain Stimul 3:170-6. 2010
    ..These observations may provide some insights into the role of the right DLPFC in modulating impulsivity level and calculating reward value at different time scales under less ambiguous circumstances...
  9. ncbi Dopamine-agonists and impulsivity in Parkinson's disease: impulsive choices vs. impulsive actions
    Francesca Antonelli
    Morton and Gloria Shulman Movement Disorder Unit, E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Hum Brain Mapp 35:2499-506. 2014
    ..Here we report how these different subcomponents of inhibition/impulsivity are differentially sensitive to DA treatment with pramipexole influencing mainly the neural network underlying impulsive choices but not impulsive action...
  10. pmc Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: a [11C]FLB 457 PET study
    Ji Hyun Ko
    PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuroimage 46:516-21. 2009
    ..These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia...
  11. pmc Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PET
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    J Cereb Blood Flow Metab 33:348-50. 2013
    ..We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume...
  12. pmc Dopaminergic neurotransmission in the human brain: new lessons from perturbation and imaging
    Ji Hyun Ko
    PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Neuroscientist 18:149-68. 2012
    ..Furthermore, it may also aid the development of alternative treatment approaches for various neurological and psychiatric conditions...
  13. ncbi Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse
    Rob M A De Bie
    Movement Disorder Center, University of Toronto, Ontaio, Canada
    Arch Neurol 64:886-9. 2007
    ..A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone)...
  14. ncbi Subdural motor cortex stimulation in Parkinson's disease does not modify movement-related rCBF pattern
    Antonio P Strafella
    Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 22:2113-6. 2007
    ..We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD...