Research Topics
Species | S H KennedySummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
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Publications
Quality of life: an important dimension in assessing the treatment of depression?S H Kennedy
Mood and Anxiety Disorders Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 26:S23-8. 2001..Despite the limitations of these questionnaires, they provide an important additional dimension to the evaluation of treatment with antidepressant medications...
Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depressionS H Kennedy
Mood and Anxiety Disorders Program, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario M5T 1R8, Canada
Am J Psychiatry 158:899-905. 2001..The aim of the present study was to assess the effects of successful paroxetine treatment on regional glucose metabolism in patients with major depression...- Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxineS H Kennedy
Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Ontario, Canada
J Clin Psychiatry 61:276-81. 2000.... - Differential pharmacological treatment response in high angry hostile and low angry hostile depressed patients: a retrospective analysisR M Bagby
Clarke Institute of Psychiatry, Toronto, Ontario, Canada
J Affect Disord 45:161-6. 1997..A 2 (high angry hostile/low angry hostile) x 3 (medication type) analysis of variance (ANOVA) was non-significant, indicating no differential treatment effects... - Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging studyJ H Meyer
Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, Ont, Canada
Am J Psychiatry 156:1029-34. 1999..The objective of this study was to evaluate 5-HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts... - The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging studyJ H Meyer
Clarke Division, Centre for Addictions and Mental Health, Department ofPsychiatry, University of Toronto, Ontario, Canada
Am J Psychiatry 158:78-85. 2001..The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT(2A) receptors in depressed patients... - Rumination and distraction in major depression: assessing response to pharmacological treatmentR M Bagby
Department of Psychiatry, University of Toronto, Canada
J Affect Disord 55:225-9. 1999..RST has been shown to predict prolonged depression in samples of non-clinical, untreated individuals with mild to moderate depression but has not been tested in samples of depressed patients undergoing treatment... - Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificityR M Bagby
Department of Psychiatry, University of Toronto and McMaster University Medical School, Ontario, Canada
Psychiatry Res 86:211-6. 1999.... - Reversed neurovegetative symptoms of depression: a community study of OntarioR D Levitan
Clarke Institute of Psychiatry, Toronto, Ont, Canada
Am J Psychiatry 154:934-40. 1997..The goal of this study was to delineate the epidemiology of reversed symptoms in a large community sample and to use other symptom patterns for comparison... - Comparisons of men with full or partial eating disorders, men without eating disorders, and women with eating disorders in the communityD B Woodside
Department of Psychiatry, The Toronto Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Am J Psychiatry 158:570-4. 2001..The authors compared 62 men who met all or most of the DSM-III-R criteria for eating disorders with 212 women who had similar eating disorders and 3,769 men who had no eating disorders on a wide variety of clinical and historical variables... 
The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorderC Y Yim
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
Eur Psychiatry 27:223-8. 2012..This sub-group post-hoc analysis preliminarily explores and examines the association between overweight/obesity and cognitive function in euthymic individuals with bipolar disorder...- Sexual dysfunction before antidepressant therapy in major depressionS H Kennedy
Department of Psychiatry, University of Toronto, Ontario, Canada
J Affect Disord 56:201-8. 1999..The purpose of this report is to define the frequency of sexual dysfunction (SD) in 134 patients with MD and examine the relationship between SD and demographic, clinical and personality variables... - Self-report ratings and informants' ratings of personalities of depressed outpatientsR M Bagby
Section on Personality and Psychopathology, Clarke Institute of Psychiatry, Toronto, Ont, Canada
Am J Psychiatry 155:437-8. 1998..This study sought to determine whether personality traits of depressed patients could be assessed similarly by informants and self-reports of the patients themselves... - Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorderJ H Meyer
The Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Clarke Division, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
Psychiatry Res 98:133-43. 2000..Functional pathology in the left parietal-superior temporal cortex in panic disorder may be related to abnormal modulation by serotonin... - Treating each and every depressed patientS H Kennedy
University Health Network, University of Toronto, Toronto, Ontario, Canada
J Psychopharmacol 22:19-23. 2008.... - Measuring depressive symptoms in the naturalistic primary-care settingR S McIntyre
Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Int J Clin Pract 61:1278-82. 2007..A quantifiable critical objective in the management of depression is to achieve and sustain full symptomatic remission. The HAMD-7 is a depression metric validated in both tertiary and primary-care settings... - Psychopharmacotherapy of anorexia nervosa, bulimia nervosa and binge-eating disorderS Kruger
Centre for Addiction and Mental Health, Clarke Institute of Psychiatry, Mood and Anxiety Disorders Division, Toronto, Ont
J Psychiatry Neurosci 25:497-508. 2000..We review the current status of psychopharmacotherapy for anorexia nervosa, bulimia nervosa and binge-eating disorder and evaluate the merits of newer agents in the treatment of these disorders... - Clinical guidelines for the treatment of depressive disorders. V. Combining psychotherapy and pharmacotherapyZ V Segal
Department of Psychiatry and Psychology, University of Toronto, Toronto, Ontario
Can J Psychiatry 46:59S-62S. 2001..CONCLUSIONS: Combined treatment with psychotherapy and pharmacotherapy is widely used in clinical practice. The recommendations for use of combined treatment are, however, based on only a limited evidence base... - Personality and symptom profiles of the angry hostile depressed patientR M Bagby
Clarke Institute of Psychiatry, Toronto, Ontario, Canada
J Affect Disord 45:155-60. 1997..The high angry hostile patients were rated as less interpersonally agreeable and less conscientious than low angry hostile patients. These results provide only partial support for the angry hostile subtype of depression... - Lower dopamine transporter binding potential in striatum during depressionJ H Meyer
PET Imaging Centre, and Mood Division, Centre for Addiction and Mental Health, Department of Psychiatry and University of Toronto, 250 College St, Toronto, Ont. M5T1R8, Canada
Neuroreport 12:4121-5. 2001..Lower DAT BP itself reduces extracellular clearance of dopamine. Patients who did not decrease their striatal DAT BP failed to compensate for low dopamine and showed greater impairment on dopamine related tests... - Clinical guidelines for the treatment of depressive disorders. IV. Medications and other biological treatmentsS H Kennedy
Department of Psychiatry, University of Toronto, Toronto, Ontario
Can J Psychiatry 46:38S-58S. 2001..There is limited evidence for the use of specific medications to treat subtypes of MDD. There is emerging evidence to support augmentation and combination strategies for patients previously nonresponsive to medication... - Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effectsR D Levitan
Clarke Division, Centre for Addiction and Mental Health, Toronto, Ont
J Psychiatry Neurosci 25:337-46. 2000.... - A trial of isocarboxazid in the treatment of bulimia nervosaS H Kennedy
Department of Psychiatry, University of Toronto, Ontario, Canada
J Clin Psychopharmacol 8:391-6. 1988..There were no serious adverse effects from this monoamine oxidase inhibitor therapy, although over 50% of patients elected to discontinue isocarboxazid 1 year after the study... - Investigating associations between cortisol and cognitive reactivity to sad mood provocation and the prediction of relapse in remitted major depressionK K Chopra
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Centre for Addiction and Mental Health, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Asian J Psychiatr 1:33-6. 2008..The current analysis examined whether salivary cortisol levels could also predict relapse in these same individuals... - Lithium revisitedR S McIntyre
Bipolar Clinic, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8
Can J Psychiatry 46:322-7. 2001..To review lithium's utility in the treatment of mood disorders... - Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detectionC T Lai
Department of Psychiatry, Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Canada
J Chromatogr B Biomed Sci Appl 749:275-9. 2000..The calibration curves were linear, with typical r2 values >0.99. The assay was highly reproducible and gave peaks with excellent chromatographic properties... - Antipsychotic metabolic effects: weight gain, diabetes mellitus, and lipid abnormalitiesR S McIntyre
Centre for Addiction and Mental Health, Clarke Site, Mood and Anxiety Disorders Program, 250 College Street, Toronto, ON M5T 1R8
Can J Psychiatry 46:273-81. 2001..To review published and nonpublished literature describing changes in weight, glucose homeostasis, and lipid milieu with antipsychotics... - The effect of bipolar I disorder and major depressive disorder on workforce functionR S McIntyre
Department of Psychiatry, University of Toronto, ON, Canada
Chronic Dis Can 28:84-91. 2008..5 to 0.9). The data herein underscore the pernicious effect of BD on workforce function, and suggest that opportunistic screening for BD in all individuals utilizing employment assistance programs for depression might be warranted... - Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorderR D Levitan
Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
Neuropsychopharmacology 29:179-86. 2004.... - Recent developments in the psychobiology and pharmacotherapy of depression: optimising existing treatments and novel approaches for the futureP Farvolden
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
Expert Opin Investig Drugs 12:65-86. 2003..In order to better understand the neurobiology and treatment response of MDD, it is probable that more sophisticated theory-driven typologies of MDD will have to be developed... - Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorderR D Levitan
Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
J Affect Disord 71:229-33. 2002..The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD... - Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosaR D Levitan
Depression Clinic, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
Biol Psychiatry 50:640-3. 2001..In the current study, we examined whether genetic variation of the serotonin-1B receptor was associated with minimum and maximum lifetime body mass indices (BMIs) in a sample of women with bulimia nervosa (BN)... - Placebo-controlled trial of agomelatine in the treatment of major depressive disorderS H Kennedy
University Health Network, Toronto, ON, Canada
Eur Neuropsychopharmacol 16:93-100. 2006..These results support the prescription of agomelatine 25 mg as the usual therapeutic dose, and suggest that increasing the dose to 50 mg may be beneficial for some patients without reducing tolerability... - Clinical guidelines for the treatment of depressive disorders. VII. ComorbidityM W Enns
Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba
Can J Psychiatry 46:77S-90S. 2001..CONCLUSIONS: Comorbidity can influence the course and outcome of both associated conditions. Depression-specific psychotherapy and/or pharmacotherapy should be considered when comorbid depression is diagnosed... - Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1R M Hadfield
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Mol Hum Reprod 7:1073-8. 2001..However, there was no evidence of linkage, suggesting that this region may not be implicated in disease susceptibility... - Toward developing a genome-wide microsatellite marker set for linkage analysis in the rhesus macaque (Macaca mulatta): identification of 76 polymorphic markersR M Hadfield
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
Am J Primatol 54:223-31. 2001..65 in the rhesus macaques. This study provides preliminary data, which could be used toward the development of a linkage mapping set in this species. There would be a need, however, to confirm the Mendelian inheritance of the markers...