J L Kennedy

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity
    S O Zakharkin
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Obes (Lond) 29:872-4. 2005
  2. ncbi The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings
    E Mundo
    Neurogenetics Section, R 31, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 58:539-44. 2001
  3. ncbi Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia
    A K Tiwari
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 12:260-6. 2012
  4. ncbi Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region
    K G Wigg
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 7:877-86. 2008
  5. ncbi Linkage study of polymorphisms in the gene for myelin oligodendrocyte glycoprotein located on chromosome 6p and attention deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 105:250-4. 2001
  6. ncbi Association study of CREB1 and childhood-onset mood disorders
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005
  7. ncbi Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD)
    J Mill
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:866-73. 2009
  8. ncbi Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:227-33. 2006
  9. ncbi Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain
    D J Muller
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 12:156-64. 2012
  10. ncbi Association of the GABRD gene and childhood-onset mood disorders
    Y Feng
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 9:668-72. 2010

Detail Information

Publications89

  1. ncbi Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity
    S O Zakharkin
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Obes (Lond) 29:872-4. 2005
    ..To investigate whether genetic variation in the cyclic GMP-dependent protein kinase gene (PRKG1) is associated with obesity...
  2. ncbi The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings
    E Mundo
    Neurogenetics Section, R 31, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 58:539-44. 2001
    ..The 5-HTT gene (SLC6A4) has 2 known polymorphisms. The aim of this study was to investigate the role of the SLC6A4 variants in the pathogenesis of antidepressant-induced mania in BP...
  3. ncbi Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia
    A K Tiwari
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 12:260-6. 2012
    ..These results indicate a possible role of CNR1 in the development of TD in our patient population. However, these observations are marginal after correcting for multiple testing and need to be replicated in a larger patient population...
  4. ncbi Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region
    K G Wigg
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 7:877-86. 2008
    ..These findings, while preliminary, identify association of ADHD to a gene that potentially plays a role in cell migration and axon growth...
  5. ncbi Linkage study of polymorphisms in the gene for myelin oligodendrocyte glycoprotein located on chromosome 6p and attention deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 105:250-4. 2001
    ..We did not observe biased transmission of the alleles at either polymorphism to ADHD probands or siblings. Our findings using this sample do not support the role of the MOG gene in ADHD...
  6. ncbi Association study of CREB1 and childhood-onset mood disorders
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005
    ..Further, we found no sex-specific relationship. Our results, therefore, do not support the previous evidence for this gene as a major factor contributing to depression...
  7. ncbi Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD)
    J Mill
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:866-73. 2009
    ....
  8. ncbi Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:227-33. 2006
    ..The results in the present sample indicate that these nine genes are unlikely to be major susceptibility genes contributing to COMD...
  9. ncbi Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain
    D J Muller
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 12:156-64. 2012
    ..The other genes were primarily negative. We provide evidence that dopamine receptor DRD2 gene variants might be associated with antipsychotic-induced weight gain in chronic schizophrenia patients...
  10. ncbi Association of the GABRD gene and childhood-onset mood disorders
    Y Feng
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 9:668-72. 2010
    ..These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding...
  11. ncbi Altered TRPC7 gene expression in bipolar-I disorder
    I S Yoon
    Section of Biochemical Psychiatry, Centre for Addiction and Mental Health-Clarke Site, Toronto, Ontario, Canada
    Biol Psychiatry 50:620-6. 2001
    ..35, p =.027). CONCLUSIONS: Reduced TRPC7 gene expression may be a trait associated with pathophysiological disturbances of Ca(2+) homeostasis in a subgroup of BD-I patients...
  12. ncbi Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle
    V S Basile
    Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Ontario, Canada
    J Clin Psychiatry 62:45-66. 2001
    ....
  13. ncbi Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders
    V L Misener
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Neuropsychobiology 58:71-80. 2008
    ..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders...
  14. ncbi Linkage study of catechol-O-methyltransferase and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Am J Med Genet 88:710-3. 1999
    ..A total of 77 nuclear families collected from Toronto were genotyped. We find no evidence for linkage of this polymorphism and ADHD in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:710-713, 1999...
  15. ncbi Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Mol Psychiatry 10:861-7. 2005
    ..These results provide evidence that BDNF variants affect liability to juvenile-onset mood disorders, supported by data from two independent samples...
  16. ncbi Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder
    K M Dorval
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 6:444-52. 2007
    ..Our data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait...
  17. ncbi Association of HPA axis genes with suicidal behaviour in schizophrenia
    V De Luca
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 24:677-82. 2010
    ..This is to our knowledge the first study on suicidal behaviour investigating the interaction among the HPA axis genes...
  18. ncbi Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant
    R Hwang
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenomics J 10:200-18. 2010
    ..Other DRD3 variants and haplotypes of possible interest were also identified for replication in future studies...
  19. ncbi Association study of tardive dyskinesia and five DRD4 polymorphisms in schizophrenia patients
    C C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 9:168-74. 2009
    ..This study suggests that DRD4 may be involved in TD in the Caucasian population, although further replication studies are needed...
  20. ncbi Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene
    A H C Wong
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Mol Psychiatry 8:156-66. 2003
    ....
  21. ncbi Linkage study of two polymorphisms at the dopamine D3 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Am J Med Genet 96:114-7. 2000
    ..Our findings using this particular sample do not support the role of the dopamine D3 gene in ADHD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:114-117, 2000...
  22. ncbi Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Ontario, Canada
    Mol Psychiatry 6:334-7. 2001
    ..We conclude that the alleles at the polymorphisms tested in these two genes are not linked to the ADHD phenotype in this sample of families...
  23. ncbi Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder
    R D Levitan
    Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    J Affect Disord 71:229-33. 2002
    ..The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD...
  24. ncbi A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia
    V S Basile
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health CAMH, University of Toronto, Toronto, ON, Canada
    Mol Psychiatry 5:410-7. 2000
    ..Further studies in independent samples are warranted to evaluate the applicability of our findings to the general patient population receiving antipsychotic medications...
  25. ncbi Untranslated region haplotype in dysbindin gene: analysis in schizophrenia
    V De Luca
    Department of Psychiatry, Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont, Canada
    J Neural Transm 112:1263-7. 2005
    ..The sample size of our study is 117 families. No biased transmission towards the disorder was detected by haplotype analysis using TRANSMIT...
  26. ncbi Dopamine system genes not linked to social phobia
    J L Kennedy
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Psychiatr Genet 11:213-7. 2001
    ..Additional studies of dopamine system genes will be necessary to define clearly their role in social phobia...
  27. ncbi p75(NTR) gene and suicide attempts in young adults with a history of childhood-onset mood disorder
    S McGregor
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:696-700. 2007
    ..Our results do not support an association of the p75(NTR) S205L polymorphism with risk for COMD or SA in COMD...
  28. ncbi Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, 250 College Str, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 131:16-9. 2004
    ....
  29. ncbi The 5HT1Dbeta receptor gene in bipolar disorder: a family-based association study
    E Mundo
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Site, University of Toronto, ON, Toronto, Canada
    Neuropsychopharmacology 25:608-13. 2001
    ..Further investigations combining genetic and pharmacological strategies are warranted...
  30. ncbi Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder
    G Novak
    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Genes Brain Behav 9:910-7. 2010
    ..04), providing an important confirmation of the involvement of the NR4A3 gene in nicotine addiction in patients with mental health disease, a population significantly at risk for nicotine addiction...
  31. ncbi Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia
    V De Luca
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Acta Psychiatr Scand 114:211-5. 2006
    ..CONCLUSION: This correlation is driven by the bipolar group (r = 0.43; P = 0.009), and is absent in schizophrenia and unaffected controls, suggesting an alteration in the CHRNA7:CHRFAM7A ratio in bipolar disorder...
  32. ncbi Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia
    V S Basile
    Neurogenetics Section, Clarke Institute of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Mol Psychiatry 6:230-4. 2001
    ..Further studies evaluating in tandem multiple candidate genes relevant for the serotonergic system are warranted to dissect the genetic basis of the complex TD phenotype...
  33. ncbi Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder
    E Mundo
    Neurogenetics Section, Centre for Addiction and Mental Health CAMH, Department of Psychiatry, University of Toronto, Clarke Site R 31, Toronto, Ontario, Canada M5T 1R8
    Mol Psychiatry 8:241-5. 2003
    ..The role of the gene variants in predicting the response to mood stabilizers in BP should also be investigated...
  34. ncbi Opiates, overeating and obesity: a psychogenetic analysis
    C Davis
    Kinesiology and Health Sciences, Faculty of Health Sciences, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Int J Obes (Lond) 35:1347-54. 2011
    ..We also anticipated that these food preferences would be positively associated with binge eating, hedonic eating and emotionally driven eating-patterns of overeating that would, in turn, predict higher body mass index (BMI)...
  35. ncbi Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications
    T A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 17:242-66. 2012
    ..More research is required before genetically informed, personalized medicine can be applied to antipsychotic treatment; nevertheless, inroads have been made towards assessing genetic liability and plausible clinical application...
  36. ncbi Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4
    P Muglia
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ontario, Canada M5T 1R8
    Mol Psychiatry 7:860-6. 2002
    ..Although replication of our study is necessary, the fact that DRD4 exhibit POE and is located on 11p15.5, in close proximity to a cluster of imprinted genes, suggests that genomic imprinting may be operating in bipolar disorder...
  37. ncbi Investigation of cholecystokinin system genes in panic disorder
    J L Kennedy
    Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Mol Psychiatry 4:284-5. 1999
    ..Our genetic dissection of the CCK system thus far suggests that the CCK-B receptor gene variation may contribute to the neurobiology of panic disorder...
  38. ncbi Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania
    V De Luca
    Neurogenetics Section, Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 3:297-9. 2003
    ..No association between antidepressant-induced mania and the MDR1 alleles or genotypes was found (chi2=1.85, 2 df, P=0.39; chi2=0.13, 1 df, P=0.72)...
  39. ncbi PedSplit: pedigree management for stratified analysis
    M B Lanktree
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, Toronto M5T 1R8, Canada
    Bioinformatics 20:2315-6. 2004
    ..AVAILABILITY: Executables, C++ source code and documentation for PedSplit can be downloaded from http://www.pharmacogenetics.ca in the links and software section...
  40. ncbi Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder
    V L Misener
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Mol Psychiatry 9:500-9. 2004
    ..DNA from 41 children was analysed, and no sequence variations were identified, indicating that the putative DRD1 risk variant for ADHD resides outside of the coding region of the gene...
  41. ncbi A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder
    Z Kaminsky
    The Krembil Family Epigenetics Laboratory, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 17:728-40. 2012
    ..018) with BPD at one of the regions demonstrating epigenetic changes in the post-mortem brain and peripheral blood samples. The consistent multi-tissue epigenetic differences at HCG9 argue for a causal association with BPD...
  42. ncbi Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa
    R D Levitan
    Depression Clinic, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    Biol Psychiatry 50:640-3. 2001
    ..In the current study, we examined whether genetic variation of the serotonin-1B receptor was associated with minimum and maximum lifetime body mass indices (BMIs) in a sample of women with bulimia nervosa (BN)...
  43. ncbi The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses
    V De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 5:107-10. 2006
    ..These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behaviour...
  44. ncbi 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study
    E Mundo
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    Mol Psychiatry 7:805-9. 2002
    ..Further genetic investigations on this marker considering additional polymorphisms and other quantitative phenotypes related to OCD are warranted...
  45. ncbi Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain
    E J Brandl
    Centre of Addiction and Mental Health, Neurogenetics Section, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 38:134-41. 2012
    ..Thus, we investigated polymorphisms in both genes for an association with AIWG...
  46. ncbi An Alu sequence interrupts a human 5-hydroxytryptamine1D receptor pseudogene
    T Nguyen
    Addiction Research Foundation, Toronto, Ontario, Canada
    Gene 124:295-301. 1993
    ..Sequence analysis also revealed that the coding sequence of this pseudogene is disrupted by insertion of a 283-bp Alu repeat sequence...
  47. ncbi Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
    ....
  48. ncbi The serotonin-1Dbeta receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa
    R D Levitan
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Canada
    Eur Neuropsychopharmacol 16:1-6. 2006
    ..We thus hypothesized that, among a heterogenous group of probands with bulimia nervosa (BN), this same G allele might predict the presence and/or severity of OCD pathology...
  49. ncbi Schizophrenia: an epigenetic puzzle?
    A Petronis
    Department of Psychiatry, University of Toronto, Centre of Addiction and Mental Health, Ontario, Canada
    Schizophr Bull 25:639-55. 1999
    ..In addition, the epigenetic model may lead to experiments investigating the molecular substrates of genetic-environmental interactions...
  50. ncbi Long repeat tracts at SCA8 in major psychosis
    J B Vincent
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Med Genet 96:873-6. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:873-876, 2000...
  51. ncbi Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia
    M Masellis
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario M5T 1R8, Canada
    Schizophr Res 47:49-58. 2001
    ..Overall, our findings do not support a role for the T-->C 267 polymorphism of the 5-HT6 receptor gene in response to clozapine, although replication is required to confirm this finding...
  52. ncbi Clinical implications of pharmacogenomics for tardive dyskinesia
    D J Muller
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Pharmacogenomics J 4:77-87. 2004
  53. ncbi Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder
    I S Yoon
    Section of Biochemical Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Mol Psychiatry 6:678-83. 2001
    ..025, n = 4/group). Collectively, these observations suggest a potential sex-dependent link between abnormalities in IMPA2 expression and calcium homeostasis in the pathophysiology of BD...
  54. ncbi Identification of a processed pseudogene related to the functional gene encoding the GM2 activator protein: localization of the pseudogene to human chromosome 3 and the functional gene to human chromosome 5
    B Xie
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 14:796-8. 1992
    ..Our data indicate that the functional activator locus can still be considered a candidate site for defects causing some forms of spinal muscular atrophy...
  55. ncbi A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
    B F O'Dowd
    Addiction Research Foundation, Toronto, Ontario, Canada
    Gene 136:355-60. 1993
    ..PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluorescence in situ hybridization (FISH) sublocalized APJ on band q12...
  56. ncbi Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis
    P Sklar
    Department of Psychiatry, Harvard Medical School, and Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Psychiatry 9:213-8. 2004
    ..03, P=0.0012 at D5S820), suggesting that this locus may be responsible for the psychotic symptoms observed in both diseases. Molecular Psychiatry (2004) 9, 213-218. doi:10.1038/sj.mp.4001418 Published online 30 December 2003..
  57. ncbi A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6
    L Demchyshyn
    Department of Psychiatry, University of Toronto, ON, Canada
    Proc Natl Acad Sci U S A 89:5522-6. 1992
    ..The 5HT1D beta gene maps to human chromosome 6. The existence of multiple neuronal 5HT1D-like receptors may help account for some of the complexities associated with [3H]serotonin binding patterns in native membranes...
  58. ncbi Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder
    J Lee
    Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Genes Brain Behav 7:53-60. 2008
    ..Based on our results and others, CHRNA4 may be involved in ADHD; however, its role in ADHD symptomatology remains to be clarified...
  59. ncbi Pharmacogenetic studies in depression: a proposal for methodologic guidelines
    A Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Pharmacogenomics J 8:90-100. 2008
    ..We reviewed the state-of-the-art methodology and suggested possible guideline for future studies...
  60. ncbi Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families
    J Xu
    Behavioral Health Care Line, VA Western New York Healthcare System and Department of Psychiatry, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Am J Med Genet 105:669-74. 2001
    ..028). No parent-of-origin effect was found in D15S165. Overall, our results suggest that the CHRNA7 may play a role in schizophrenia in these families. A parent of origin effect may be present and requires further study...
  61. ncbi Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients
    C C Zai
    Mol Psychiatry 12:794-5. 2007
  62. ncbi Multiple variants of the DRD3, but not BDNF gene, influence age-at-onset of schizophrenia
    J Renou
    Mol Psychiatry 12:1058-60. 2007
  63. ncbi No evidence of association between a functional polymorphism in the MTHFR gene and childhood-onset mood disorders
    E L Dempster
    Mol Psychiatry 12:1063-4. 2007
  64. ncbi Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder
    G J LaHoste
    Department of Physical Medicine and Rehabilitation, University of California, Irvine 92717 4550, USA
    Mol Psychiatry 1:121-4. 1996
    ....
  65. ncbi Association between homozygosity at the COMT gene locus and obsessive compulsive disorder
    K M Schindler
    Department of Psychiatry, State University of New York at Buffalo, New York 14214, USA
    Am J Med Genet 96:721-4. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:721-724, 2000...
  66. ncbi No preferential transmission of paternal alleles at risk genes in attention-deficit hyperactivity disorder
    N Laurin
    Mol Psychiatry 12:226-9. 2007
  67. ncbi Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Canada
    Biol Psychiatry 49:333-9. 2001
    ..This association was later replicated in additional studies...
  68. ncbi Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11
    Carlos N Pato
    Veterans Affairs Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 127:30-4. 2004
    ..Our findings provide additional support for a susceptibility locus for bipolar disorder on 6q, as well as, suggesting the importance of denser scans. Published 2004 Wiley-Liss, Inc...
  69. ncbi Association between the BDNF gene and schizophrenia
    P Muglia
    Mol Psychiatry 8:146-7. 2003
  70. ncbi Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region
    J Adams
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 9:494-9. 2004
    ..There was no significant evidence of linkage between GRIN2A and these phenotypes. While the results were not significant in our sample, the previous association finding suggests that further study of this gene is warranted...
  71. ncbi MAOA and persistent, pervasive childhood aggression
    J H Beitchman
    Mol Psychiatry 9:546-7. 2004
  72. ncbi Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22
    F A Middleton
    Department of Neuroscience and Physiology, State University of New York (SUNY, Syracuse, NY, USA
    Am J Hum Genet 74:886-97. 2004
    ....
  73. ncbi D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine
    S G Potkin
    Department of Psychiatry and Human Behavior, University of Caliornia, Irvine 92697 3960, USA
    Mol Psychiatry 8:109-13. 2003
    ..05). In this preliminary study, brain metabolic and clinical response to clozapine are related to the D1 receptor genotype...
  74. ncbi The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder
    J F Quist
    Neurogentics Section, Centre for Addiction and Mental Health, Clarke Division, and Department of Psychiatry, University of Toronto, Canada
    Mol Psychiatry 8:98-102. 2003
    ..80, P = 0.03) to the affected child. Although preliminary, results from this study provide additional evidence that serotonin genes may be important risk factors for the development of ADHD...
  75. ncbi Association study of serotonin-2A receptor gene polymorphism and panic disorder in patients from Canada and Germany
    C Rothe
    Department of Psychiatry, University of Ottawa and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
    Neurosci Lett 363:276-9. 2004
    ..Our data suggest thus that this polymorphism is unlikely to play a major role in the pathogenesis of panic disorder...
  76. ncbi BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorder
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, ON M6S 3R4, Canada
    Neuromolecular Med 5:181-92. 2004
    ..41, df = 4, 58, p = 0.0035) were associated with more optimal performance on the memory tasks. This study did not provide evidence supporting an association between BDNF and COMT genes and declarative memory phenotypes...
  77. ncbi Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia
    G Zai
    Neurogenetics Section, Centre for Addiction and Mental Health Clarke Site, Department of Psychiatry, University of Toronto, Canada
    Genes Brain Behav 4:2-9. 2005
    ..233, P=0.408; C1334T: z-score=0.703, P=0.241; C10991T: z-score=0.551, P=0.291] were also not significant. Although our data are negative, the intriguing hypothesis for MOG in SCZ may warrant further investigation of this gene...
  78. ncbi Association and linkage disequilibrium between a functional polymorphism of the dopamine-2 receptor gene and schizophrenia in a genetically homogeneous Portuguese population
    K M Schindler
    Center for Psychiatric and Molecular Genetics, SUNY Upstate Medical University and Behavioral Health Care Line, VISN 2, Veterans Administration, Syracuse, New York, USA
    Mol Psychiatry 7:1002-5. 2002
    ....
  79. ncbi Analysis of the novel TPH2 gene in bipolar disorder and suicidality
    V De Luca
    Mol Psychiatry 9:896-7. 2004
  80. ncbi The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder
    Y Feng
    Department of Psychiatry, Cellular and Molecular Division, The Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 10:998-1005, 973. 2005
    ..Our findings continue to support SNAP25 in the susceptibility to ADHD...
  81. ncbi Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder
    N Laurin
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 10:1117-25. 2005
    ..These findings support the proposed involvement of the calcyon gene in ADHD and implicate haplotype C1 as containing a risk allele...
  82. ncbi Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families
    C Xu
    Department of Psychiatry, Division of Cellular and Molecular Biology, The Toronto Western Hospital, Toronto, Canada
    Am J Med Genet 105:159-62. 2001
    ..We found no evidence for linkage of the ADRA2A gene with ADHD, using the transmission disequilibrium test in this set of families...
  83. ncbi Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder
    T B Barrett
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Mol Psychiatry 8:546-57. 2003
    ..7 (chi(2)=9.6, one-sided P value=0.0019). Altogether, these data support the hypothesis that a dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of BPD...
  84. ncbi Guidelines and algorithms for the use of methylphenidate in children with Attention-Deficit/ Hyperactivity Disorder
    L Greenhill
    New York State Psychiatric Institute Columbia University, New York 10032, USA
    J Atten Disord 6:S89-100. 2002
    ..To review published algorithms for guiding the use of methylphenidate (MPH) in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adolescents...
  85. ncbi Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor
    J R Bunzow
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Mol Pharmacol 60:1181-8. 2001
    ....
  86. ncbi CYP1A2 activity as measured by a caffeine test predicts clozapine and active metabolite steady-state concentrationin patients with schizophrenia
    V Ozdemir
    Department of Pharmacology, University of Toronto, Ontario, Canada
    J Clin Psychopharmacol 21:398-407. 2001
    ..CYP1A2 phenotyping with a simple caffeine test may contribute to individualization of clozapine dosage and differentiate between treat ment noncompliance and high CYP1A2 activity...
  87. ncbi The unstable trinucleotide repeat story of major psychosis
    J B Vincent
    Department of Genetics at the Hospital for Sick Children, Toronto, Canada
    Am J Med Genet 97:77-97. 2000
    ..These findings, reviewed here, suggest that, although a major role for unstable trinucleotides in psychosis is unlikely, involvement at a more modest level in a minority of cases cannot be excluded, and warrants further investigation...
  88. ncbi The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS
    J Gelernter
    Yale University School of Medicine, New Haven, Connecticut
    Genomics 13:208-10. 1992
    ..Crossovers identified in one kindred place DRD4 distal to TH, providing further evidence for its location close to HRAS, making DRD4 one of the most telomeric of 11p markers. (This also places DRD4 in band 11p15.5.)..
  89. ncbi Family history of depression is associated with younger age of onset in patients with recurrent depression
    F Tozzi
    Medical Genetics, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline R and D, Verona, Italy
    Psychol Med 38:641-9. 2008
    ..The present study tested whether the presence of FH for depression or anxiety in first-degree relatives determines younger age of onset for depression...