S Houle

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi Imaging the 5-HT(1A) receptors with PET: WAY-100635 and analogues
    S Houle
    Vivian M Rakoff PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Nucl Med Biol 27:463-6. 2000
  2. ncbi Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines
    A A Wilson
    PET Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Med Chem 43:3103-10. 2000
  3. ncbi The D2 receptor occupancy profile of loxapine determined using PET
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, ON, Canada
    Neuropsychopharmacology 15:562-6. 1996
  4. ncbi Influence of L-dopa and pramipexole on striatal dopamine transporter in early PD
    M Guttman
    Centre for Addiction and Mental Health, Division of Neurology, Department of Psychiatry, University of Toronto, Ontario, Canada
    Neurology 56:1559-64. 2001
  5. ncbi Derivatives of WAY 100635 as potential imaging agents for 5-HT1A receptors: syntheses, radiosyntheses, and in vitro and in vivo evaluation
    A A Wilson
    PET Centre, Clarke Institute of Psychiatry, Toronto, Ontario, Canada
    Nucl Med Biol 25:769-76. 1998
  6. ncbi High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study
    S Kapur
    PET Centre, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 153:948-50. 1996
  7. ncbi Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies
    N Ginovart
    PET Center, Center for Addiction and Mental Health, and University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 21:1342-53. 2001
  8. ncbi Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorder
    J H Meyer
    The Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Clarke Division, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
    Psychiatry Res 98:133-43. 2000
  9. ncbi Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study
    J H Meyer
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:1843-9. 2001
  10. ncbi Dopamine D1 agonist R-[11C]SKF 82957: synthesis and in vivo characterization in rats
    J N DaSilva
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Nucl Med Biol 26:537-42. 1999

Collaborators

Detail Information

Publications24

  1. ncbi Imaging the 5-HT(1A) receptors with PET: WAY-100635 and analogues
    S Houle
    Vivian M Rakoff PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Nucl Med Biol 27:463-6. 2000
    ....
  2. ncbi Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines
    A A Wilson
    PET Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Med Chem 43:3103-10. 2000
    ..Two of the tested radiotracers, 15 and 16, have highly favorable properties for imaging SERT and will be used in pilot human PET imaging studies...
  3. ncbi The D2 receptor occupancy profile of loxapine determined using PET
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, ON, Canada
    Neuropsychopharmacology 15:562-6. 1996
    ..This dose range is much lower than that used in most clinical settings and points to the potential efficacy of loxapine at lower doses...
  4. ncbi Influence of L-dopa and pramipexole on striatal dopamine transporter in early PD
    M Guttman
    Centre for Addiction and Mental Health, Division of Neurology, Department of Psychiatry, University of Toronto, Ontario, Canada
    Neurology 56:1559-64. 2001
    ..DAT changes could influence the response to therapy in PD...
  5. ncbi Derivatives of WAY 100635 as potential imaging agents for 5-HT1A receptors: syntheses, radiosyntheses, and in vitro and in vivo evaluation
    A A Wilson
    PET Centre, Clarke Institute of Psychiatry, Toronto, Ontario, Canada
    Nucl Med Biol 25:769-76. 1998
    ..Blocking studies with a variety of drugs demonstrated that the binding of [11C]-7 in vivo was selective for 5-HT1A receptors. [11C]-7 is a promising candidate as a ligand for imaging 5-HT1A receptors by PET...
  6. ncbi High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study
    S Kapur
    PET Centre, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 153:948-50. 1996
    ..The purpose of this study was to determine the dopamine D2 receptor occupancy induced by low-dose haloperidol treatment in a prospective trial...
  7. ncbi Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies
    N Ginovart
    PET Center, Center for Addiction and Mental Health, and University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 21:1342-53. 2001
    ....
  8. ncbi Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorder
    J H Meyer
    The Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Clarke Division, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
    Psychiatry Res 98:133-43. 2000
    ..Functional pathology in the left parietal-superior temporal cortex in panic disorder may be related to abnormal modulation by serotonin...
  9. ncbi Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study
    J H Meyer
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:1843-9. 2001
    ..This study measured the proportion of 5-HTT sites blocked during paroxetine and citalopram treatment of depression and assessed the relationship between serum paroxetine levels and the proportion of 5-HTT sites blocked...
  10. ncbi Dopamine D1 agonist R-[11C]SKF 82957: synthesis and in vivo characterization in rats
    J N DaSilva
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Nucl Med Biol 26:537-42. 1999
    ..No labeled metabolites were detected in rat brain. These results indicate that R-[11C]SKF 82957 will provide more sensitive measurements of D1 receptors in in vivo studies than the racemic mixture...
  11. ncbi Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method
    A A Wilson
    PET Centre, The Centre for Addiction and Mental Health and Dept of Psychiatry, University of Toronto Faculty of Medicine, 250 College St, Toronto, ON M5T 1R8, Canada
    Nucl Med Biol 27:529-32. 2000
    ....
  12. ncbi 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 155:921-8. 1998
    ..The purpose of this study was to investigate olanzapine's binding to the serotonin 5-HT2 and dopamine D2 receptors in schizophrenic patients being treated with clinically relevant doses...
  13. ncbi Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression
    S H Kennedy
    Mood and Anxiety Disorders Program, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 158:899-905. 2001
    ..The aim of the present study was to assess the effects of successful paroxetine treatment on regional glucose metabolism in patients with major depression...
  14. ncbi Carbon-11 labelled cholecystokininB antagonists: radiosynthesis and evaluation in rats
    A A Wilson
    PET Centre, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Life Sci 68:1223-30. 2001
    ..In light of the very poor brain penetration of these compounds, reports on the central nervous system activity of this class of CCKB antagonists should be viewed with caution...
  15. ncbi Characterization of r-(11)C]rolipram for PET imaging of phosphodieterase-4: in vito binding, metabolism, and dosimetry studies in rats
    C M Lourenco
    Vivian M. Rakoff Pet Centre, Centre for Addiction and Mental Health, Department of Pharmacology, University of Toronto, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
    Nucl Med Biol 28:347-58. 2001
    ..Additionally, the estimated absorbed radiation dose extrapolated to humans was low. These results support further investigation of R-[(11)C]rolipram in studying PDE4 in vivo by positron emission tomography imaging...
  16. ncbi Lower dopamine transporter binding potential in striatum during depression
    J H Meyer
    PET Imaging Centre, and Mood Division, Centre for Addiction and Mental Health, Department of Psychiatry and University of Toronto, 250 College St, Toronto, Ont. M5T1R8, Canada
    Neuroreport 12:4121-5. 2001
    ..Lower DAT BP itself reduces extracellular clearance of dopamine. Patients who did not decrease their striatal DAT BP failed to compensate for low dopamine and showed greater impairment on dopamine related tests...
  17. ncbi An admonition when measuring the lipophilicity of radiotracers using counting techniques
    A A Wilson
    The Vivian M Rackoff PET Centre, Centre for Addiction and Mental Health, Toronto, Ont, Canada
    Appl Radiat Isot 54:203-8. 2001
    ..However, pre-washing the radiotracer-containing organic phase with aqueous phase can, in many cases, allay doubts about the validity of such measurements...
  18. ncbi Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits
    A Soliman
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychol Med 41:1051-60. 2011
    ..We hypothesized that prefrontal MAOA binding would correlate negatively with angry-hostility, a trait related to aggression/anger, and positively with traits intuitively related to adaptive investigative behavior...
  19. ncbi The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study
    J H Meyer
    Clarke Division, Centre for Addictions and Mental Health, Department ofPsychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:78-85. 2001
    ..The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT(2A) receptors in depressed patients...
  20. ncbi Noradrenergic dysfunction in the prefrontal cortex in depression: an [15O] H2O PET study of the neuromodulatory effects of clonidine
    C H Fu
    Centre for Addiction and Mental Health, Clarke Site, University of Toronto, Toronto, Canada
    Biol Psychiatry 49:317-25. 2001
    ....
  21. ncbi Neural correlates of semantic associative encoding in episodic memory
    M Lepage
    Rotman Research Institute of Baycrest Centre for Geriatric Care, 3560 Bathurst Street, University of Toronto, Toronto, ON, Canada
    Brain Res Cogn Brain Res 9:271-80. 2000
    ..These regions have been consistently reported in previous functional neuroimaging studies of associative encoding and may constitute key structures in association formation...
  22. ncbi Convergence of neural systems processing stimulus associations and coordinating motor responses
    A R McIntosh
    Rotman Research Institute of Baycrest Centre, Toronto, Ontario, Canada
    Cereb Cortex 8:648-59. 1998
    ....
  23. ncbi Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans
    N P L G Verhoeff
    Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Mol Psychiatry 7:233, 322-8. 2002
    ..Thus, while DA depletion "uncovers" D(2)receptors, it does not do so for D(1) receptors. The implications of this finding for measuring endogenous DA and its effects on in vivo receptor binding in humans are discussed...
  24. ncbi Brain serotonin transporter binding in non-depressed patients with Parkinson's disease
    M Guttman
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Eur J Neurol 14:523-8. 2007
    ..Further investigation will be required to establish whether SERT binding is more or less decreased in those patients with PD who also have major depressive disorder...