Nathalie Ginovart

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 27:857-71. 2007
  2. ncbi request reprint Effects of amphetamine and evoked dopamine release on [11C]raclopride binding in anesthetized cats
    Nathalie Ginovart
    CERMEP Cyclotron Unit, 59 Boulevard Pinel, 69003 Lyon, France
    Neuropsychopharmacology 27:72-84. 2002
  3. ncbi request reprint [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 47:123-33. 2003
  4. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
  5. ncbi request reprint Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Center for Addiction and Mental Health, Toronto, Canada
    J Neurochem 97:1089-103. 2006
  6. ncbi request reprint In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system
    Laurent Galineau
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 60:172-83. 2006
  7. ncbi request reprint Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study
    Jeffrey H Meyer
    Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 161:826-35. 2004
  8. ncbi request reprint First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 33:279-89. 2008
  9. ncbi request reprint Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre and Mood and Anxiety Disorders Division, Clarke Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 63:1209-16. 2006
  10. ncbi request reprint Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff Positron Emission Tomography Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 62:327-31. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 27:857-71. 2007
    ..This study demonstrates that [11C]-(+)-PHNO can be used for the quantitative measurement of D2/3 densities and should enable further studies of potential D2/3 dysregulation in several important psychiatric and neurologic illnesses...
  2. ncbi request reprint Effects of amphetamine and evoked dopamine release on [11C]raclopride binding in anesthetized cats
    Nathalie Ginovart
    CERMEP Cyclotron Unit, 59 Boulevard Pinel, 69003 Lyon, France
    Neuropsychopharmacology 27:72-84. 2002
    ..It is suggested that the affinity state of receptors is a factor to be considered in in vivo ligand-activation studies...
  3. ncbi request reprint [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 47:123-33. 2003
    ..These studies indicate that [(11)C]-DASB is a suitable PET radioligand for measuring drug occupancy of the SERT in vivo and has potential for monitoring in vivo changes in serotonin levels...
  4. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
    ..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease...
  5. ncbi request reprint Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Center for Addiction and Mental Health, Toronto, Canada
    J Neurochem 97:1089-103. 2006
    ....
  6. ncbi request reprint In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system
    Laurent Galineau
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 60:172-83. 2006
    ..These results substantiate the use of [11C]-(+)-PHNO as an agonist radiotracer for D2-imaging. The sensitivity of its binding to competition with endogenous DA suggests an association with the subset of high affinity state D2-receptors...
  7. ncbi request reprint Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study
    Jeffrey H Meyer
    Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 161:826-35. 2004
    ..The relationship between dose and occupancy was also investigated...
  8. ncbi request reprint First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 33:279-89. 2008
    ..11)C]-(+)-PHNO PET might be a superior measure for release of endogenous dopamine than PET employing conventional D(2/3) antagonist radioligands...
  9. ncbi request reprint Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre and Mood and Anxiety Disorders Division, Clarke Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 63:1209-16. 2006
    ..Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine...
  10. ncbi request reprint Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff Positron Emission Tomography Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 62:327-31. 2007
    ..We examined the possible influence of the long (A/G) variant on 5-HTT density in the living human brain using 3-(11)C-amino-4-(2-dimethylaminomethylphenyl-sulfanyl) benzonitrile ([(11)C]DASB) positron emission tomography...
  11. ncbi request reprint High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 59:389-94. 2006
    ....
  12. ncbi request reprint Amphetamine pretreatment induces a change in both D2-Receptor density and apparent affinity: a [11C]raclopride positron emission tomography study in cats
    Nathalie Ginovart
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 55:1188-94. 2004
    ..To test this, we used PET and a Scatchard approach to investigate whether the decrease in [11C]raclopride binding following amphetamine results from competitive or noncompetitive interactions with DA...
  13. ncbi request reprint Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Ontario, Canada
    J Med Chem 48:4153-60. 2005
    ....
  14. doi request reprint D2-receptor upregulation is dependent upon temporal course of D2-occupancy: a longitudinal [11C]-raclopride PET study in cats
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health and University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 34:662-71. 2009
    ..This suggests that as far as antipsychotics are concerned, not only dose but disbursment throughout the day have an impact on eventual pharmacodynamic and behavioral outcomes...
  15. ncbi request reprint In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 29:509-15. 2002
    ..Together with previous studies, the present findings indicate that [11C]-DASB is a very useful radiopharmaceutical for probing changes in SERT densities using PET imaging in the living human brain...
  16. ncbi request reprint Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia
    Ofer Agid
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1209-15. 2007
    ....
  17. ncbi request reprint Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Cereb Blood Flow Metab 26:330-44. 2006
    ..These results indicate the suitability of using [(11)C]-harmine for quantitative evaluation of MAO-A densities using PET and should enable further studies of potential MAO-A dysregulation in several psychiatric and neurologic illnesses...
  18. doi request reprint Isoflurane anaesthesia differentially affects the amphetamine sensitivity of agonist and antagonist D2/D3 positron emission tomography radiotracers: implications for in vivo imaging of dopamine release
    Patrick Neil McCormick
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Mol Imaging Biol 13:737-46. 2011
    ..Herein we tested whether isoflurane differentially affects the AMPH sensitivity of [(11)C]-(+)-PHNO and [(3)H]-raclopride...
  19. ncbi request reprint Effects of tryptophan depletion on the serotonin transporter in healthy humans
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Canada
    Biol Psychiatry 58:825-30. 2005
    ..Adaptive decreases in 5-HTT density and/or affinity during TD would be a possible compensatory mechanism to maintain sufficient extracellular serotonin levels during TD, thereby preventing a depressive relapse...
  20. ncbi request reprint Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 30:85-92. 2003
    ..S,S)-[(11)C]-MeNER has the potential to be the first successful PET ligand to image NET...
  21. ncbi request reprint Antiparkinson concentrations of pramipexole and PHNO occupy dopamine D2(high) and D3(high) receptors
    Philip Seeman
    Department of Pharmacology, Medical Sciences Building, Toronto, Ontario, Canada
    Synapse 58:122-8. 2005
    ..The D3(High) receptors are less selectively occupied by +PHNO, bromocriptine, apomorphine, and -NPA...
  22. ncbi request reprint An automated method for the extraction of regional data from PET images
    Pablo Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychiatry Res 147:79-89. 2006
    ....
  23. ncbi request reprint Quantitative validation of an intracerebral beta-sensitive microprobe system to determine in vivo drug-induced receptor occupancy using [11C]raclopride in rats
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Synapse 52:89-99. 2004
    ....
  24. ncbi request reprint Imaging the dopamine system with in vivo [11C]raclopride displacement studies: understanding the true mechanism
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, M5T 1R8, Toronto, Ontario, Canada
    Mol Imaging Biol 7:45-52. 2005
    ....
  25. ncbi request reprint PET study of the [11C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow
    Wadad Hassoun
    CERMEP, Lyon, France
    Eur J Nucl Med Mol Imaging 30:141-8. 2003
    ..These results are the first to be obtained on this topic in awake cats, and show that the BP(raclo) is greatly dependent on alterations in the CBF...
  26. doi request reprint In vivo quantification of 5-HT1A-[18F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe
    Philippe Millet
    Psychiatric Neuroimaging Unit, Division of Neuropsychiatry, Department of Psychiatry, University Hospital of Geneva, Switzerland
    Neuroimage 41:823-34. 2008
    ..895) and YAP-(S)PET (r=0.695). The YAP-(S)PET system underestimated the [18F]MPPF binding levels in brain due to limited resolution (i.e. partial volume), but led to similar conclusions...
  27. ncbi request reprint Striatal dopamine during sensorial stimulations: a [18F]FDOPA PET study in human and cats
    Wadad Hassoun
    Physiologie Int├ęgrative Cellulaire et Mol├ęculaire, CNRS UMR5123, Villeurbanne, France
    Neurosci Lett 383:63-7. 2005
    ..These results support the hypothesis that sensory stimulations activate a non-synaptic mode of dopamine release...
  28. ncbi request reprint Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography
    Aristotle N Voineskos
    Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 193:539-45. 2007
    ..11)C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine positron emission tomography ([(11)C]DASB PET) is currently the best method available to quantify 5-HTT occupancy in humans...
  29. ncbi request reprint Misunderstandings about how to choose a reference region
    Jeffrey H Meyer
    Biol Psychiatry 61:1314; author reply 1314-5. 2007
  30. ncbi request reprint Effect of sensory stimulus on striatal dopamine release in humans and cats: a [(11)C]raclopride PET study
    Stephane Thobois
    Service de Neurologie D and INSERM U 534, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Neurosci Lett 368:46-51. 2004
    ..Sensory stimulation of the forelimb extremities constitutes a well-established experimental model that has consistently shown to activate dopamine (DA) neurotransmission in the mammals' forebrain...
  31. ncbi request reprint Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 32:123-8. 2005
    ..However, there has been no consistency in the selection of a "SERT-free" reference region for the estimation of free and nonspecific binding, as occipital cortex, cerebellum and white matter have all been employed...
  32. ncbi request reprint Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 61:1271-9. 2004
    ..Our recent publication of increased serotonin2 BP in MDE with severely negativistic dysfunctional attitudes suggests that this subgroup of MDE subjects has very low levels of extracellular serotonin...