Anh Dzung Lê

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. pmc Role of corticotropin-releasing factor in the median raphe nucleus in yohimbine-induced reinstatement of alcohol seeking in rats
    A D Le
    Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada
    Addict Biol 18:448-51. 2013
  2. pmc Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
    A D Le
    Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
    Psychopharmacology (Berl) 218:89-99. 2011
  3. pmc The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats
    Anh Dzung Lê
    Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Canada
    Psychopharmacology (Berl) 204:477-88. 2009
  4. ncbi request reprint Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward
    ANH DZUNG LE
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
    Psychopharmacology (Berl) 195:605-15. 2008
  5. ncbi request reprint Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats
    ANH DZUNG LE
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada
    Psychopharmacology (Berl) 186:82-92. 2006
  6. ncbi request reprint Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake
    A D Le
    Department of Neuroscience, Center for Addiction and Mental Health, Toronto, Ontario, M5S 2S1, Canada
    J Neurosci 26:1872-9. 2006
  7. ncbi request reprint Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats
    A D Le
    Department of Neuroscience, Center for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada, M5S 2S1
    Psychopharmacology (Berl) 179:366-73. 2005
  8. ncbi request reprint Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats
    A D Le
    Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    Psychopharmacology (Berl) 168:216-21. 2003
  9. ncbi request reprint The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol
    A D Le
    Department of Neuroscience, Center for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    J Neurosci 22:7844-9. 2002
  10. ncbi request reprint Neurobiology of relapse to alcohol in rats
    A Le
    Department of Neurosciences, Biobehavioral Pharmacology Section, Centre for Addiction and Mental Health, 33 Russell Street, M5S 2S1, Toronto, Canada
    Pharmacol Ther 94:137-56. 2002

Research Grants

Detail Information

Publications12

  1. pmc Role of corticotropin-releasing factor in the median raphe nucleus in yohimbine-induced reinstatement of alcohol seeking in rats
    A D Le
    Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada
    Addict Biol 18:448-51. 2013
    ..Results indicate an important role of MRN CRF receptors in yohimbine-induced reinstatement of alcohol seeking but not yohimbine-induced increases in alcohol intake...
  2. pmc Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
    A D Le
    Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
    Psychopharmacology (Berl) 218:89-99. 2011
    ..Here, we further addressed this issue by studying the effect of the alpha-1 adrenoceptor antagonist prazosin and the alpha-2 adrenoceptor agonist guanfacine on yohimbine-induced reinstatement...
  3. pmc The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats
    Anh Dzung Lê
    Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Canada
    Psychopharmacology (Berl) 204:477-88. 2009
    ..Here, we determined the contributions of the alpha-2 and 5-HT1A properties of yohimbine to its effects on alcohol seeking...
  4. ncbi request reprint Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward
    ANH DZUNG LE
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
    Psychopharmacology (Berl) 195:605-15. 2008
    ..In this study, we further explored the role of the MRN by examining the effect of inhibition of MRN neurons, by injecting the GABA-A receptor agonist muscimol, on the reinstatement of alcohol seeking...
  5. ncbi request reprint Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats
    ANH DZUNG LE
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada
    Psychopharmacology (Berl) 186:82-92. 2006
    ....
  6. ncbi request reprint Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake
    A D Le
    Department of Neuroscience, Center for Addiction and Mental Health, Toronto, Ontario, M5S 2S1, Canada
    J Neurosci 26:1872-9. 2006
    ..The present findings provide experimental evidence for the hypothesis that a shared genetic determinant accounts for the co-abuse of nicotine and alcohol...
  7. ncbi request reprint Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats
    A D Le
    Department of Neuroscience, Center for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada, M5S 2S1
    Psychopharmacology (Berl) 179:366-73. 2005
    ..We also tested the effect of lofexidine and yohimbine on alcohol self-administration. Lofexidine is used clinically for treating opiate withdrawal symptoms and yohimbine induces stress-like responses in humans and non-humans...
  8. ncbi request reprint Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats
    A D Le
    Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    Psychopharmacology (Berl) 168:216-21. 2003
    ..Here, we studied whether nicotine would reinstate alcohol-taking behavior in drug-free rats and whether this effect would be enhanced by prior exposure to nicotine during alcohol self-administration training...
  9. ncbi request reprint The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol
    A D Le
    Department of Neuroscience, Center for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    J Neurosci 22:7844-9. 2002
    ..These data suggest that an interaction between CRF and 5-HT neurons within the MRN is involved in footshock stress-induced reinstatement of alcohol seeking...
  10. ncbi request reprint Neurobiology of relapse to alcohol in rats
    A Le
    Department of Neurosciences, Biobehavioral Pharmacology Section, Centre for Addiction and Mental Health, 33 Russell Street, M5S 2S1, Toronto, Canada
    Pharmacol Ther 94:137-56. 2002
    ..Subsequently, we will describe potential neuronal circuits that may underlie relapse to alcohol. Finally, future directions and clinical implications of the study of relapse to alcohol in laboratory animals will be discussed briefly...
  11. ncbi request reprint Genetic selection for high and low alcohol consumption in a limited-access paradigm
    A D Le
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Alcohol Clin Exp Res 25:1613-20. 2001
    ..For these reasons, selective breeding for high- and low-alcohol consumption (HARF and LARF, respectively) based on a LAP was conducted...
  12. ncbi request reprint Involvement of nicotinic receptors in alcohol self-administration
    A D Le
    Centre for Addiction and Mental Health, University of Toronto, Ontario Canada
    Alcohol Clin Exp Res 24:155-63. 2000
    ..Nicotinic receptors also have been implicated in alcohol action. We designed the present study to examine the possible involvement of nicotinic receptors in alcohol self-administration...

Research Grants8

  1. Stress-induced relapse to alcohol in a rat model
    ANH DZUNG LE; Fiscal Year: 2010
    ..We hope that data from our preclinical model will lead to the development of medications for the treatment of alcohol addiction. ..
  2. Role of Serotonin in Stress-Induced Relapse to Alcohol
    Dzung Le; Fiscal Year: 2005
    ..Characterization of the relapse process in our preclinical model may lead to the development of medications for relapse prevention in humans...
  3. Stress-induced relapse to alcohol in a rat model
    Dzung Le; Fiscal Year: 2007
    ..We hope that data from our preclinical model will lead to the development of medications for the treatment of alcohol addiction. ..