Research Topics
Species | Anh Dzung LêSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
Research Grants
| Collaborators |
Detail Information
Publications
Involvement of nicotinic receptors in alcohol self-administrationA D Le
Centre for Addiction and Mental Health, University of Toronto, Ontario Canada
Alcohol Clin Exp Res 24:155-63. 2000..Nicotinic receptors also have been implicated in alcohol action. We designed the present study to examine the possible involvement of nicotinic receptors in alcohol self-administration...- The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in ratsAnh Dzung Lê
Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Canada
Psychopharmacology (Berl) 204:477-88. 2009..Here, we determined the contributions of the alpha-2 and 5-HT1A properties of yohimbine to its effects on alcohol seeking... - Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and rewardANH DZUNG LE
Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
Psychopharmacology (Berl) 195:605-15. 2008..In this study, we further explored the role of the MRN by examining the effect of inhibition of MRN neurons, by injecting the GABA-A receptor agonist muscimol, on the reinstatement of alcohol seeking... - Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in ratsANH DZUNG LE
Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada
Psychopharmacology (Berl) 186:82-92. 2006.... - Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intakeA D Le
Department of Neuroscience, Center for Addiction and Mental Health, Toronto, Ontario, M5S 2S1, Canada
J Neurosci 26:1872-9. 2006..The present findings provide experimental evidence for the hypothesis that a shared genetic determinant accounts for the co-abuse of nicotine and alcohol... - Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in ratsA D Le
Department of Neuroscience, Center for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada, M5S 2S1
Psychopharmacology (Berl) 179:366-73. 2005..We also tested the effect of lofexidine and yohimbine on alcohol self-administration. Lofexidine is used clinically for treating opiate withdrawal symptoms and yohimbine induces stress-like responses in humans and non-humans... - Nicotine increases alcohol self-administration and reinstates alcohol seeking in ratsA D Le
Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
Psychopharmacology (Berl) 168:216-21. 2003..Here, we studied whether nicotine would reinstate alcohol-taking behavior in drug-free rats and whether this effect would be enhanced by prior exposure to nicotine during alcohol self-administration training... - The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcoholA D Le
Department of Neuroscience, Center for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
J Neurosci 22:7844-9. 2002..These data suggest that an interaction between CRF and 5-HT neurons within the MRN is involved in footshock stress-induced reinstatement of alcohol seeking... - Neurobiology of relapse to alcohol in ratsA Le
Department of Neurosciences, Biobehavioral Pharmacology Section, Centre for Addiction and Mental Health, 33 Russell Street, M5S 2S1, Toronto, Canada
Pharmacol Ther 94:137-56. 2002..Subsequently, we will describe potential neuronal circuits that may underlie relapse to alcohol. Finally, future directions and clinical implications of the study of relapse to alcohol in laboratory animals will be discussed briefly... - Genetic selection for high and low alcohol consumption in a limited-access paradigmA D Le
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
Alcohol Clin Exp Res 25:1613-20. 2001..For these reasons, selective breeding for high- and low-alcohol consumption (HARF and LARF, respectively) based on a LAP was conducted... - Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in ratsA D Le
Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
Psychopharmacology (Berl) 218:89-99. 2011..Here, we further addressed this issue by studying the effect of the alpha-1 adrenoceptor antagonist prazosin and the alpha-2 adrenoceptor agonist guanfacine on yohimbine-induced reinstatement...
Research Grants
- Stress-induced relapse to alcohol in a rat modelANH DZUNG LE; Fiscal Year: 2010..We hope that data from our preclinical model will lead to the development of medications for the treatment of alcohol addiction. ..
- Role of Serotonin in Stress-Induced Relapse to AlcoholDzung Le; Fiscal Year: 2005..Characterization of the relapse process in our preclinical model may lead to the development of medications for relapse prevention in humans...
- Stress-induced relapse to alcohol in a rat modelDzung Le; Fiscal Year: 2007..We hope that data from our preclinical model will lead to the development of medications for the treatment of alcohol addiction. ..